公开(公告)号：US5746953A

公开(公告)日：1998-05-05

申请号：US418129

申请日：1995-04-06

申请人： Masashi Sakurai ,  Masaru Nakanishi ,  Hiroshi Tamura ,  Takehiko Kubo ,  Takashi Nakamura ,  Tatsuya Fujita

发明人： Masashi Sakurai ,  Masaru Nakanishi ,  Hiroshi Tamura ,  Takehiko Kubo ,  Takashi Nakamura ,  Tatsuya Fujita

IPC分类号： H01B17/00 ,  B29C33/02 ,  B29C33/36 ,  B29C39/06 ,  B29C39/24 ,  B29C39/44 ,  H01B19/00 ,  B29C35/02

CPC分类号： B29C39/24 ,  B29C39/06 ,  B29C39/44 ,  B29C2037/90 ,  B29C33/02 ,  B29C33/36 ,  B29K2105/16

摘要： It is an object of the invention to provide a casting method for forming a resin molding which is able to cast the resin molding according to an assembly line production system while completely eliminating variations in quality between products. In the casting method according to the present invention, a plurality of metal molds are circulated at a given time difference in the order of a step of casting a hardenable resin composition into a preheated metal mold, a step of heating and hardening the casted resin composition, and a step of releasing the hardened product from the metal mold and assembling the metal mold. There are provided a plurality of heating devices and, while one metal mold in the hardening step is being heated by one of the heating devices, the other metal mold is heated at the above given time difference by the other of the heating devices.

摘要翻译： 本发明的目的是提供一种用于形成树脂模制品的铸造方法，该树脂模制品能够在完全消除产品之间的质量变化的同时，根据组装线生产系统浇注树脂模制品。 在本发明的铸造方法中，多个金属模具以给定的时间差循环，按照将可硬化树脂组合物浇铸到预热的金属模具中的步骤的顺序，对铸造的树脂组合物进行加热硬化的步骤 以及从金属模具脱模硬化物并组装金属模具的步骤。 提供多个加热装置，并且当硬化步骤中的一个金属模具被加热装置中的一个加热时，另一个金属模具通过另一个加热装置以上述给定的时间差加热。

公开(公告)号：US4821135A

公开(公告)日：1989-04-11

申请号：US844495

申请日：1986-03-26

申请人： Masaru Nakanishi ,  Arata Kitamura ,  Masashi Sakurai ,  Masaaki Asanuma

发明人： Masaru Nakanishi ,  Arata Kitamura ,  Masashi Sakurai ,  Masaaki Asanuma

IPC分类号： G11B15/60 ,  G11B23/087 ,  G11B23/02

CPC分类号： G11B23/08757 ,  G11B15/605

摘要： A tape guide for magnetic tape cassettes, comprising a thermosetting resin composition, such as a polyester resin having a glass transition point of not lower than 100.degree. C. containing an inorganic filler such as silicon powder and, optionally, a resin powder such as a tetrafluorethylene resin powder in a proportion of from 60 to 75% by weight based on the total composition. The tape guide has an increased thermal conductivity of 10.times.10.sup.-4 cal/cm.deg.sec or more and a low coefficient of friction and is, therefore, free from undesirable frictional heat generation.

摘要翻译： 一种用于磁带盒的磁带引导件，包括热固性树脂组合物，例如玻璃化转变点不低于100℃的聚酯树脂，其含有无机填料如硅粉末和任选的树脂粉末如 四氟乙烯树脂粉末的比例为60〜75重量％。 磁带引导件具有10x10-4cal / cm.deg.sec以上的增加的热导率和低摩擦系数，因此没有不希望的摩擦发热。

公开(公告)号：US08809615B2

公开(公告)日：2014-08-19

申请号：US12588721

申请日：2009-10-26

申请人： Kiyomi Tsuruda ,  Shinji Yamasoto ,  Kouki Shoho ,  Masaru Nakanishi

发明人： Kiyomi Tsuruda ,  Shinji Yamasoto ,  Kouki Shoho ,  Masaru Nakanishi

IPC分类号： B32B7/12 ,  B32B15/04 ,  C08G61/02 ,  C08J3/00 ,  A61K6/083 ,  A61K8/72 ,  C08L15/00 ,  A61K6/00 ,  C09J4/00 ,  C09J101/00 ,  C09J201/00 ,  A61F13/00 ,  A61F15/00 ,  A61L15/16 ,  A61K9/70 ,  B32B25/02

CPC分类号： A61L15/44 ,  A61F13/00 ,  A61F15/00 ,  A61K9/7053 ,  A61K9/7076 ,  A61K31/045 ,  A61K31/618 ,  A61K31/695 ,  A61L15/24 ,  A61L15/58 ,  A61L2300/216 ,  B32B7/12 ,  Y10T428/28 ,  Y10T428/2852 ,  Y10T442/2738 ,  Y10T442/3561

摘要： An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m2·24 hr measured at a temperature of 40° C. and a relative humidity of 90%, and the methyl salicylate has a plasma AUC0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean±standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean±standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m2 and a contact area is 280 cm2.

摘要翻译： 一种粘合剂制剂，其包含层压在所述载体的至少一侧的可拉伸载体和粘合剂层，其中所述可拉伸载体包括进行压接加工的互锁织物，所述粘合剂层包含10质量％以上的水杨酸甲酯， 相对于该层的总质量，整个粘合剂在40℃，相对湿度90％的温度下测得的透湿度为1〜350g / m 2·24小时，水杨酸甲酯的血浆AUC 0 -24的范围为3.0〜60.0ng·hr / mL，以水杨酸甲酯为代表的水杨酸的血浆AUC 0-24为5000〜13000ng·hr / mL，以 当将粘合剂制剂施用于人类皮肤8小时，使得施加的粘合剂层的施用量为50至300g / m 2，接触面积为280cm 2时，其平均值为±标准偏差。

公开(公告)号：US08455376B2

公开(公告)日：2013-06-04

申请号：US12227066

申请日：2007-08-01

申请人： Kiyomi Tsuruda ,  Shinji Yamasoto ,  Kouki Shoho ,  Masaru Nakanishi

发明人： Kiyomi Tsuruda ,  Shinji Yamasoto ,  Kouki Shoho ,  Masaru Nakanishi

IPC分类号： B32B25/02 ,  A61F13/00 ,  A61L15/16 ,  A61K9/70

CPC分类号： A61L15/44 ,  A61F13/00 ,  A61F15/00 ,  A61K9/7053 ,  A61K9/7076 ,  A61K31/045 ,  A61K31/618 ,  A61K31/695 ,  A61L15/24 ,  A61L15/58 ,  A61L2300/216 ,  B32B7/12 ,  Y10T428/28 ,  Y10T428/2852 ,  Y10T442/2738 ,  Y10T442/3561

摘要： An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m2·24 hr measured at a temperature of 40° C. and a relative humidity of 90%, and the methyl salicylate has a plasma AUC0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean±standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean±standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m2 and a contact area is 280 cm2.

摘要翻译： 一种粘合剂制剂，其包含层压在所述载体的至少一侧的可拉伸载体和粘合剂层，其中所述可拉伸载体包括进行压接加工的互锁织物，所述粘合剂层包含10质量％以上的水杨酸甲酯， 相对于该层的总质量，整个粘合剂在40℃，相对湿度90％的温度下测得的透湿度为1〜350g / m 2·24小时，水杨酸甲酯的血浆AUC 0 -24的范围为3.0〜60.0ng·hr / mL，以水杨酸甲酯为代表的水杨酸的血浆AUC 0-24为5000〜13000ng·hr / mL，以 当将粘合剂制剂施用于人类皮肤8小时，使得施加的粘合剂层的施用量为50至300g / m 2，接触面积为280cm 2时，其平均值为±标准偏差。

公开(公告)号：US07572227B2

公开(公告)日：2009-08-11

申请号：US11902350

申请日：2007-09-20

申请人： Akira Kondo ,  Takashi Watanabe ,  Masaru Nakanishi ,  Shuichi Oonishi ,  Hitoshi Ozawa ,  Koichiro Asama ,  Shinji Mino

发明人： Akira Kondo ,  Takashi Watanabe ,  Masaru Nakanishi ,  Shuichi Oonishi ,  Hitoshi Ozawa ,  Koichiro Asama ,  Shinji Mino

IPC分类号： A61B5/02

CPC分类号： A61B5/6838 ,  A61B5/02225 ,  A61B5/02241 ,  A61B5/6815 ,  A61B2562/0233

摘要： This invention provides a blood pressure measuring apparatus capable of stably measuring the blood pressure in even the tragus while suppressing the degree of invasion.An attaching portion (3) of the blood pressure measuring apparatus has an inner cuff (6), an outer cuff (7), and a holding member (10) which holds the inner cuff (6) and outer cuff (7), and the holding member has a “U” shape. The end portions of the holding member (10) where the inner cuff (6) and outer cuff (7) are arranged are almost parallel to each other, and the inner cuff (6) and outer cuff (7) oppose each other. An auxiliary member (80) which comes in contact with a predetermined position of the ear of a person to be measured and increases the attachment stability of the inner cuff (6) and outer cuff (7) at the tragus is attached to the holding member (10).

摘要翻译： 本发明提供能够在抑制入侵程度的同时稳定地测量耳屏中的血压的血压测量装置。 血压测量装置的安装部分（3）具有内箍（6），外箍（7）和保持内箍（6）和外箍（7）的保持构件（10），以及 保持构件具有“U”形状。 其中内侧袖带（6）和外侧袖口（7）的配置的保持构件（10）的端部大致平行，内侧袖带（6）与外侧袖口（7）相对。 与被测量人的耳朵的预定位置接触并且增加内耳套（6）和外袖带（7）在耳屏处的附着稳定性的辅助构件（80）附接到保持构件 （10）。

公开(公告)号：US20090175929A1

公开(公告)日：2009-07-09

申请号：US12227201

申请日：2007-05-08

申请人： Takaaki Terahara ,  Yasunari Michinaka ,  Kazunosuke Aida ,  Masaru Nakanishi ,  Wataru Hattori ,  Takao Kuroda

发明人： Takaaki Terahara ,  Yasunari Michinaka ,  Kazunosuke Aida ,  Masaru Nakanishi ,  Wataru Hattori ,  Takao Kuroda

IPC分类号： A61K9/70 ,  A61K31/4353

CPC分类号： A61K9/7053 ,  A61K9/7061 ,  A61K31/445 ,  A61K47/02 ,  A61K47/12 ,  A61K47/20 ,  C07D211/32

摘要： Disclosed is a donepezil-containing transdermally absorbable preparation which develops reduced adverse side effects and shows a satisfactory level of therapeutic effect. The preparation comprises an adhesive and a donepezil component (containing crystalline donepezil having type-B crystal polymorphism) and/or a salt thereof, wherein the donepezil component or the salt thereof is contained in an amount of 9 to 50% by mass relative to the total weight of the adhesive. The preparation (particularly, one having a non-aqueous adhesive layer) shows an excellent penetration of donepezil and/or a salt thereof into the skin, retains good stability of the active ingredient therein, and is remarkably reduced in local stimulation and adverse side effects.

摘要翻译： 公开了一种含多奈哌齐的透皮吸收制剂，其具有减少的副作用，并显示令人满意的治疗效果。 该制剂包含粘合剂和多奈哌齐组分（含有具有B型晶体多晶型的结晶多奈哌齐）和/或其盐，其中所述多奈哌齐组分或其盐的含量相对于所述组合物为9〜50质量％ 粘合剂的总重量。 该制剂（特别是具有非水性粘合剂层的制剂）显示出多奈哌齐和/或其盐对皮肤的渗透性优异，保持其中活性成分的良好稳定性，并且局部刺激和不良副作用显着降低 。

公开(公告)号：US20090149794A1

公开(公告)日：2009-06-11

申请号：US12227066

申请日：2007-08-01

申请人： Kiyomi Tsuruda ,  Shinji Yamasoto ,  Kouki Shoho ,  Masaru Nakanishi

发明人： Kiyomi Tsuruda ,  Shinji Yamasoto ,  Kouki Shoho ,  Masaru Nakanishi

IPC分类号： A61F13/02

CPC分类号： A61L15/44 ,  A61F13/00 ,  A61F15/00 ,  A61K9/7053 ,  A61K9/7076 ,  A61K31/045 ,  A61K31/618 ,  A61K31/695 ,  A61L15/24 ,  A61L15/58 ,  A61L2300/216 ,  B32B7/12 ,  Y10T428/28 ,  Y10T428/2852 ,  Y10T442/2738 ,  Y10T442/3561

摘要： An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m2·24 hr measured at a temperature of 40° C. and a relative humidity of 90%, and the methyl salicylate has a plasma AUC0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean±standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean±standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m2 and a contact area is 280 cm2.

摘要翻译： 一种粘合剂制剂，其包含层压在所述载体的至少一侧的可拉伸载体和粘合剂层，其中所述可拉伸载体包括进行压接加工的互锁织物，所述粘合剂层包含10质量％以上的水杨酸甲酯， 相对于该层的总质量，整个粘合剂制剂在40℃的温度和90％的相对湿度下测得的透湿度为1〜350g / m 2·24小时，水杨酸甲酯的血浆AUC 0 -24范围为3.0至60.0ng.hr/mL，以平均值±标准偏差计，水杨酸作为水杨酸甲酯的代谢物具有5000至13000ng.hr/mL的血浆AUC 0-24，以 当将粘合剂制剂施用于人类皮肤8小时，使得施加的粘合剂层的施用量为50至300g / m 2，接触面积为280cm 2时，其平均值为±标准偏差。

公开(公告)号：US20080091112A1

公开(公告)日：2008-04-17

申请号：US11902350

申请日：2007-09-20

申请人： Akira Kondo ,  Takashi Watanabe ,  Masaru Nakanishi ,  Shuichi Oonishi ,  Hitoshi Ozawa ,  Koichiro Asama ,  Shinji Mino

发明人： Akira Kondo ,  Takashi Watanabe ,  Masaru Nakanishi ,  Shuichi Oonishi ,  Hitoshi Ozawa ,  Koichiro Asama ,  Shinji Mino

IPC分类号： A61B5/021

CPC分类号： A61B5/6838 ,  A61B5/02225 ,  A61B5/02241 ,  A61B5/6815 ,  A61B2562/0233

摘要： This invention provides a blood pressure measuring apparatus capable of stably measuring the blood pressure in even the tragus while suppressing the degree of invasion. An attaching portion (3) of the blood pressure measuring apparatus has an inner cuff (6), an outer cuff (7), and a holding member (10) which holds the inner cuff (6) and outer cuff (7), and the holding member has a “U” shape. The end portions of the holding member (10) where the inner cuff (6) and outer cuff (7) are arranged are almost parallel to each other, and the inner cuff (6) and outer cuff (7) oppose each other. An auxiliary member (80) which comes in contact with a predetermined position of the ear of a person to be measured and increases the attachment stability of the inner cuff (6) and outer cuff (7) at the tragus is attached to the holding member (10).

摘要翻译： 本发明提供能够在抑制入侵程度的同时稳定地测量耳屏中的血压的血压测量装置。 血压测量装置的安装部分（3）具有内箍（6），外箍（7）和保持内箍（6）和外箍（7）的保持构件（10），以及 保持构件具有“U”形状。 其中内侧袖带（6）和外侧袖口（7）的配置的保持构件（10）的端部大致平行，内侧袖带（6）与外侧袖口（7）相对。 与被测量人的耳朵的预定位置接触并且增加内耳套（6）和外袖带（7）在耳屏处的附着稳定性的辅助构件（80）附接到保持构件 （10）。

公开(公告)号：US06214378B1

公开(公告)日：2001-04-10

申请号：US09230844

申请日：1999-03-08

申请人： Norifumi Tanida ,  Jun Aoki ,  Masaru Nakanishi

发明人： Norifumi Tanida ,  Jun Aoki ,  Masaru Nakanishi

IPC分类号： A61K948

CPC分类号： A61K9/4858 ,  A61K9/4891

摘要： This invention offers capsules for oral preparation which is useful for colon diseases such as colon cancer, ulcerative colitis, constipation and diarrhea and for systemic diseases such as osteoporosis and which does not undergo any change at all in stomach and in small intestine but firstly start to disintegrate upon arriving at large intestine and, at the same time, quickly release the drug therefrom wherein the capsule base therefor is hydroxypropylmethylcellulose (HPMC) or polyethyleneglycol-compounded HPMC, gelatin or agar and, on the surface of said capsule base in which powder or liquid containing a pharmacologically active substance is encapsulated, a double-coated structure comprising an inner layer consisting of a cationic copolymer and an outer layer consisting of anionic copolymer is formed.

摘要翻译： 本发明提供口服制剂用胶囊，其可用于结肠癌，溃疡性结肠炎，便秘和腹泻等结肠疾病，以及全身性疾病如骨质疏松症，并且在胃和小肠中均不发生任何变化，但首先开始 在到达大肠时分解，同时快速释放出药物，其中胶囊基为羟丙基甲基纤维素（HPMC）或聚乙二醇复合HPMC，明胶或琼脂，并且在所述胶囊基质的表面上，粉末或 含有药理活性物质的液体被包封，形成包含由阳离子共聚物和由阴离子共聚物组成的外层的内层的双层结构。

公开(公告)号：US5654004A

公开(公告)日：1997-08-05

申请号：US432202

申请日：1995-05-05

申请人： Minenobu Okayama ,  Masaru Nakanishi

发明人： Minenobu Okayama ,  Masaru Nakanishi

IPC分类号： A61K9/20 ,  A61K9/28 ,  A61K9/30 ,  A61K9/32 ,  A61K9/50

CPC分类号： A61K9/5073 ,  A61K9/2018 ,  A61K9/2886

摘要： An oral pharmaceutical preparation releasable in the lower digestive tract, characterized by having a double-coated structure wherein a solid drug having a core containing an active ingredient is covered with both an inner coat made of a cationic polymer and an outer coat made of an anionic polymer.

摘要翻译： PCT No.PCT / JP93 / 01608 Sec。 371日期：1995年5月5日 102（e）日期1995年5月5日PCT 1993年11月5日PCT公布。 出版物WO94 / 10983 日期1994年5月26日可在下消化道中释放的口服药物制剂，其特征在于具有双层结构，其中具有含有活性成分的核心的固体药物被阳离子聚合物制成的内衣和外涂层 由阴离子聚合物制成。