公开(公告)号：US20070154950A1

公开(公告)日：2007-07-05

申请号：US11633345

申请日：2006-12-04

申请人： Masataka Kinjo ,  Motohiro Horiuchi ,  Fumihiko Fujii ,  Hiroshi Sakata ,  Mamoru Tamura ,  Masayoshi Ueno ,  Takayuki Yanagiya

发明人： Masataka Kinjo ,  Motohiro Horiuchi ,  Fumihiko Fujii ,  Hiroshi Sakata ,  Mamoru Tamura ,  Masayoshi Ueno ,  Takayuki Yanagiya

IPC分类号： G01N33/53

CPC分类号： G01N33/6896 ,  G01N33/536 ,  G01N33/582 ,  G01N33/6857 ,  G01N2800/2828

摘要： The present invention provides a method of quickly and accurately detecting and/or assaying an antigen using fluorescence correlation spectroscopy (FCS), which involves a fluorescence-labeled antibody fragment and a non-fluorescence-labeled intact antibody that form a complex with the antigen. There is a significant difference in diffusion rate between the fluorescence-labeled antibody fragment not bonded to the antigen and the complex formed by the the fluorescence-labeled antibody fragment, the antigen, and the non-fluorescence-labeled intact antibody, and this diffusion rate can be determined using FCS. The antigen can be an antigenic protein, such as an abnormal prion or a harmful protein contained in a food material. According to this method, antigens over a wide scope can be assayed regardless of the shape or molecular weight.

摘要翻译： 本发明提供使用荧光相关光谱法（FCS）快速准确地检测和/或测定抗原的方法，其包括与抗原形成复合物的荧光标记的抗体片段和非荧光标记的完整抗体。 未结合抗原的荧光标记的抗体片段与由荧光标记的抗体片段，抗原和非荧光标记的完整抗体形成的复合物之间的扩散速率存在显着差异，并且该扩散速率 可以使用FCS确定。 抗原可以是抗原蛋白，例如食物中含有的异常朊病毒或有害蛋白质。 根据该方法，无论形状或分子量如何，可以测定广泛范围内的抗原。

公开(公告)号：US07476545B2

公开(公告)日：2009-01-13

申请号：US11633345

申请日：2006-12-04

申请人： Masataka Kinjo ,  Motohiro Horiuchi ,  Fumihiko Fujii ,  Hiroshi Sakata ,  Mamoru Tamura ,  Masayoshi Ueno ,  Takayuki Yanagiya

发明人： Masataka Kinjo ,  Motohiro Horiuchi ,  Fumihiko Fujii ,  Hiroshi Sakata ,  Mamoru Tamura ,  Masayoshi Ueno ,  Takayuki Yanagiya

IPC分类号： G01N21/76

CPC分类号： G01N33/6896 ,  G01N33/536 ,  G01N33/582 ,  G01N33/6857 ,  G01N2800/2828

摘要： The present invention provides a method of quickly and accurately detecting and/or assaying an antigen using fluorescence correlation spectroscopy (FCS), which involves a fluorescence-labeled antibody fragment and a non-fluorescence-labeled intact antibody that form a complex with the antigen. There is a significant difference in diffusion rate between the fluorescence-labeled antibody fragment not bonded to the antigen and the complex formed by the the fluorescence-labeled antibody fragment, the antigen, and the non-fluorescence-labeled intact antibody, and this diffusion rate can be determined using FCS. The antigen can be an antigenic protein, such as an abnormal prion or a harmful protein contained in a food material. According to this method, antigens over a wide scope can be assayed regardless of the shape or molecular weight.

摘要翻译： 本发明提供使用荧光相关光谱法（FCS）快速准确地检测和/或测定抗原的方法，其包括与抗原形成复合物的荧光标记的抗体片段和非荧光标记的完整抗体。 未结合抗原的荧光标记的抗体片段与由荧光标记的抗体片段，抗原和非荧光标记的完整抗体形成的复合物之间的扩散速率存在显着差异，并且该扩散速率 可以使用FCS确定。 抗原可以是抗原蛋白，例如食物中含有的异常朊病毒或有害蛋白质。 根据该方法，无论形状或分子量如何，可以测定广泛范围内的抗原。

公开(公告)号：US20080099728A1

公开(公告)日：2008-05-01

申请号：US11663545

申请日：2005-09-22

申请人： Takashi Jin ,  Masataka Kinjo ,  Mamoru Tamura ,  Fumihiko Fujii ,  Hiroshi Sakata

发明人： Takashi Jin ,  Masataka Kinjo ,  Mamoru Tamura ,  Fumihiko Fujii ,  Hiroshi Sakata

IPC分类号： C09K11/02

CPC分类号： A61K49/0067 ,  A61K49/0058 ,  B82Y5/00 ,  B82Y30/00 ,  C09K11/025 ,  C09K11/06 ,  C09K2211/1425

摘要： The present invention provides a water-soluble fluorescent material having a luminescent region at a visible range and having excellent luminescent efficiency. The present invention relates to a water-soluble fluorescent material having a semiconductor nanocrystal; a linear or cyclic phenol compound having hydrophilic group and hydrophobic group that coats at least a portion of the surface of the semiconductor nanocrystal; and a coordinating organic compound coating at least a portion of the surface of the semiconductor nanocrystal.

摘要翻译： 本发明提供一种水溶性荧光材料，其具有可见光范围的发光区域，发光效率优异。 本发明涉及具有半导体纳米晶体的水溶性荧光材料; 具有亲水基团和疏水基团的直链或环状酚化合物，其涂覆半导体纳米晶体的至少一部分表面; 以及在半导体纳米晶体的表面的至少一部分上的配位有机化合物涂层。

公开(公告)号：US20090253217A1

公开(公告)日：2009-10-08

申请号：US12066284

申请日：2006-09-08

申请人： Kenta Saito ,  Hiroshi Sakata ,  Fumihiko Fujii ,  Masataka Kinjo ,  Mamoru Tamura

发明人： Kenta Saito ,  Hiroshi Sakata ,  Fumihiko Fujii ,  Masataka Kinjo ,  Mamoru Tamura

IPC分类号： G01N33/566

CPC分类号： G01N33/536 ,  G01N33/582 ,  G01N33/6896 ,  G01N2021/6439 ,  G01N2800/2828

摘要： The present invention is to provide a method of quickly detecting an antigen at an arbitrary concentration in an antigen sample, without a multi-stage examination of the concentration ratio between a detection reagent and an antigen to be detected, particularly when the concentration of the antigen in the sample is unknown, in the method of detecting an antigen using fluorescence correlation spectroscopy (FCS) or fluorescence cross-correlation spectroscopy (FCCS). By preparing (1) a series to which only a detection reagent is added and (2) a series to which an antigen and the detection reagent are added to achieve a maximum trimer concentration, and by performing a fluorescence spectroscopic analysis, the presence or absence of the antigen in the detection sample is quickly detected by the presence or absence of a trimer detection signal from a detector in the cases of (1) and (2), in a method of detecting an antigen by FCS or FCCS using as a detection reagent a fluorescent-labeled intact antibody or fluorescent-labeled antibody fragment targeted to an epitope of the antigen to be detected, and a non-fluorescent-labeled intact antibody or fluorescent-labeled intact antibody or fluorescent-labeled antibody fragment targeted to another epitope of the antigen.

摘要翻译： 本发明提供一种在抗原样品中以任意浓度快速检测抗原的方法，而不需要对检测试剂和待检测抗原之间的浓度比进行多阶段检查，特别是当抗原浓度 在样品中，在使用荧光相关光谱法（FCS）或荧光相关光谱法（FCCS）检测抗原的方法中是未知的。 通过制备（1）仅添加检测试剂的系列和（2）添加抗原和检测试剂以达到最大三聚体浓度的一系列序列，通过进行荧光光谱分析，存在或不存在 在（1）和（2）的情况下，通过检测器的三聚体检测信号的存在或不存在，通过FCS或FCCS检测抗原的方法来检测检测样品中的抗原， 试剂荧光标记的完整抗体或靶向要检测的抗原表位的荧光标记的抗体片段，以及靶向另一表位的非荧光标记的完整抗体或荧光标记的完整抗体或荧光标记的抗体片段 抗原。

公开(公告)号：US07064603B2

公开(公告)日：2006-06-20

申请号：US10855379

申请日：2004-05-28

申请人： Hiroshi Sakata

发明人： Hiroshi Sakata

IPC分类号： H03F3/38

CPC分类号： H03K17/063

摘要： A pulse generation part outputs a first ON pulse signal for turning a switching device on to a control part on based on the leading edge of a signal from the outside of a semiconductor device. The pulse generation part subsequently outputs a second ON pulse signal for turning the switching device on to the control part based on the same leading edge of the signal as the first ON pulse signal after a lapse of prescribed time after outputting the first ON pulse signal. Even if the control part cannot output an ON signal to the switching device based on the first ON pulse signal, the control part can output an ON signal based on the second ON pulse signal.

摘要翻译： 脉冲发生部分基于来自半导体器件的外部的信号的前沿，输出用于将开关器件导通到控制部分的第一ON脉冲信号。 脉冲发生部分随后在输出第一导通脉冲信号之后，在经过规定时间之后，基于与第一ON脉冲信号相同的信号前沿，输出用于将开关装置导通到控制部分的第二ON脉冲信号。 即使控制部根据第一ON脉冲信号不能向开关装置输出ON信号，控制部也可以基于第二导通脉冲信号输出ON信号。

公开(公告)号：US06709296B2

公开(公告)日：2004-03-23

申请号：US10155318

申请日：2002-05-24

申请人： Kouichi Shiroyama ,  Toshihiro Ichihashi ,  Katsuhiko Namiki ,  Yoshimasa Ito ,  Hiroshi Sakata ,  Eiichiro Takemasa

发明人： Kouichi Shiroyama ,  Toshihiro Ichihashi ,  Katsuhiko Namiki ,  Yoshimasa Ito ,  Hiroshi Sakata ,  Eiichiro Takemasa

IPC分类号： H01R637

CPC分类号： H01R13/514 ,  H01R12/716 ,  H01R12/721

摘要： The module-type connector according to the present invention defines the connectable connectors with a rigid supporting plate which extends along the connecting direction in order to make it easy to properly fit a male connector to a female connector. In the module-type connector, the contacting portions of the contacts that are shifted in the separation direction of the corresponding terminal with which the contacting portions contact are almost uniformly distributed. Further, the male connector that receives a preliminary load from different levels in the direction so that opposing elastic contacting portions are widened by engaging between the first end portion of each contact within a housing and the different levels of the housing, has at least a protruding portion that protrudes from the contacting surface of the plurality of contacts toward the contacting surface thereof and that is provided between contacts.

摘要翻译： 根据本发明的模块型连接器限定了可连接的连接器，其具有沿着连接方向延伸的刚性支撑板，以便容易地将公连接器适当地装配到阴连接器。 在模块型连接器中，在接触部分接触的相应端子的分离方向上移动的触头的接触部分几乎均匀分布。 此外，阳连接器通过在壳体内的每个触点的第一端部与壳体的不同水平面之间的接合而使相对的弹性接触部分变宽的方向接收来自不同级别的初步负载，具有至少突出的 从多个触点的接触表面向其接触表面突出并且设置在触点之间的部分。

公开(公告)号：USRE37852E1

公开(公告)日：2002-09-17

申请号：US09172024

申请日：1998-10-14

申请人： Shigeru Aso ,  Hiroshi Sakata ,  Yoshihiro Sugo ,  Hidehiro Hosaka

发明人： Shigeru Aso ,  Hiroshi Sakata ,  Yoshihiro Sugo ,  Hidehiro Hosaka

IPC分类号： A61B500

CPC分类号： A61B5/02255 ,  A61B5/0285

摘要： A blood pressure monitoring system includes a blood pressure measurement device for measuring blood pressure using a cuff, a memory for storing an externally inputted pulse wave propagation time fluctuation threshold, a time interval detection reference point detection section for detecting a time interval detection reference point in a pulse wave on the side of aortae of a living organism, a pulse wave detection section for detecting a pulse wave on the side of peripheral blood vessels appearing with a time lag with respect to the pulse wave on the side of aortae, a pulse wave propagation time measurement section for measuring a pulse wave propagation time based on respective detected outputs from the time interval detection reference point detection section and the pulse wave detection section, an operation device for calculating a pulse wave propagation fluctuation from two measured pulse wave propagation times, a judgment device for judging whether or not the calculated pulse wave propagation time fluctuation exceeds the pulse wave propagation time fluctuation threshold read from the memory, and a control device for controlling the blood pressure measurement device based on an output of the judgment device so that the blood pressure of a subject is measured using the cuff.

摘要翻译： 一种血压监视系统，包括使用袖带测量血压的血压测量装置，用于存储外部输入的脉搏波传播时间波动阈值的存储器，用于检测时间间隔检测基准点的时间间隔检测基准点检测部 生物体的主动脉侧的脉波，脉波检测部，用于检测相对于主动脉侧的脉搏波出现的与时间差相关的外周血管侧的脉波，脉波 传播时间测量部分，用于基于来自时间间隔检测参考点检测部分和脉搏波检测部分的各个检测到的输出来测量脉搏波传播时间;操作装置，用于从两个测量的脉搏波传播时间计算脉搏波传播波动， 用于判断计算出的脉搏波的判断装置 传播时间波动超过从存储器读取的脉搏波传播时间波动阈值，以及控制装置，用于根据判断装置的输出控制血压测量装置，从而使用袖带测量被检者的血压。

公开(公告)号：US5564427A

公开(公告)日：1996-10-15

申请号：US413850

申请日：1995-03-30

申请人： Shigeru Aso ,  Hiroshi Sakata ,  Yoshihiro Sugo ,  Hidehiro Hosaka

发明人： Shigeru Aso ,  Hiroshi Sakata ,  Yoshihiro Sugo ,  Hidehiro Hosaka

IPC分类号： A61B5/022 ,  A61B5/0225 ,  A61B5/0285 ,  A61B5/00

CPC分类号： A61B5/02255 ,  A61B5/0285

摘要： A blood pressure monitoring system includes a blood pressure measurement device for measuring blood pressure using a cuff, a memory for storing an externally inputted pulse wave propagation time fluctuation threshold, a time interval detection reference point detection section for detecting a time interval detection reference point in a pulse wave on the side of aortae of a living organism, a pulse wave detection section for detecting a pulse wave on the side of peripheral blood vessels appearing with a time lag with respect to the pulse wave on the side of aortae, a pulse wave propagation time measurement section for measuring a pulse wave propagation time based on respective detected outputs from the time interval detection reference point detection section and the pulse wave detection section, an operation device for calculating a pulse wave propagation fluctuation from two measured pulse wave propagation times, a judgment device for judging whether or not the calculated pulse wave propagation time fluctuation exceeds the pulse wave propagation time fluctuation threshold read from the memory, and a control device for controlling the blood pressure measurement device based on an output of the judgment device so that the blood pressure of a subject is measured using the cuff.

公开(公告)号：US4569737A

公开(公告)日：1986-02-11

申请号：US597089

申请日：1984-04-05

申请人： Hiroshi Sakata

发明人： Hiroshi Sakata

IPC分类号： B01J19/08 ,  B01J19/12 ,  F02M27/04 ,  F02M27/06

CPC分类号： F02M27/045 ,  B01J19/087 ,  B01J19/12 ,  F02M27/06 ,  B01J2219/0852 ,  B01J2219/0867

摘要： The efficiency of liquid hydrocarbon fuel is increased by subjecting it to both magnetic forces and radioactive or laser rays. The fuel may be treated by the magnetic forces and rays either simultaneously or alternately. Furthermore, the magnetic forces and radioactive rays can be applied once or can be repeatedly applied. Devices are shown which accomplish these procedures.

摘要翻译： 液态碳氢燃料的效率通过使其受到磁力和放射性或激光的影响而增加。 燃料可以通过同时或交替的磁力和射线进行处理。 此外，磁力和放射线可以施加一次或可以重复施加。 显示完成这些程序的装置。

公开(公告)号：US4152477A

公开(公告)日：1979-05-01

申请号：US759806

申请日：1977-01-17

申请人： Youichi Haruta ,  Teruyo Noguchi ,  Hiroshi Yasuda ,  Hiroshi Sakata

发明人： Youichi Haruta ,  Teruyo Noguchi ,  Hiroshi Yasuda ,  Hiroshi Sakata

IPC分类号： H05K3/18 ,  C23C18/16 ,  C23C18/18 ,  C23C18/20 ,  C23C18/22 ,  C23C18/30 ,  C23C18/31 ,  C23C18/34 ,  C23C18/40 ,  C23C18/44 ,  C23C18/52 ,  H05K3/38 ,  C23C3/02 ,  H05K3/00

CPC分类号： H05K3/387 ,  C23C18/1641 ,  C23C18/2033 ,  C23C18/2086 ,  C23C18/285 ,  C23C18/30 ,  H05K2201/0133 ,  H05K2201/0212 ,  H05K2203/0773 ,  Y10S428/901 ,  Y10T428/12396 ,  Y10T428/24893 ,  Y10T428/24917 ,  Y10T428/249986 ,  Y10T428/254

摘要： A printed circuit board made by providing on an insulating substrate an adhesive coating comprising a butadiene-based rubber and a phenolic resin finely dispersed therein, etching the surface layer of said coating with an oxidizing agent to expose the microcapsules having phenolic resin shells, which have been formed during the setting of said adhesive coating, and forming a chemically deposited metal layer on said adhesive coating.

摘要翻译： 一种印刷电路板，其通过在绝缘基板上提供包含丁二烯基橡胶和细分散在其中的酚醛树脂的粘合剂涂层，用氧化剂蚀刻所述涂层的表面层以暴露具有酚醛树脂壳的微胶囊，其具有 在所述粘合剂涂层的设置期间形成，并且在所述粘合剂涂层上形成化学沉积的金属层。