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1.SUBSTITUTED AZOLE AROMATIC HETEROCYCLES AS INHIBITORS OF 11BETA-HSD-1 失效
标题翻译: 作为11BETA-HSD-1的抑制剂的替代的AZOLE AROMATIC HETEROCYCLES公开(公告)号:US20080021022A1
公开(公告)日:2008-01-24
申请号:US11779599
申请日:2007-07-18
申请人: Michael Bartberger , Christopher Fotsch , Martin Haraldsson , David St. Jean , Lars Johansson , Marianne Nilsson , Lori Sutin , Katrina Flyren
发明人: Michael Bartberger , Christopher Fotsch , Martin Haraldsson , David St. Jean , Lars Johansson , Marianne Nilsson , Lori Sutin , Katrina Flyren
IPC分类号: A61K31/42 , A61K31/443 , A61K31/4525 , A61K31/497 , A61K31/499 , A61K31/5377 , A61K31/541 , A61P17/02 , A61P19/10 , A61P25/28 , A61P27/06 , A61P3/04 , A61P3/10 , A61P37/00 , A61P9/12 , C07D261/08 , C07D413/06 , C07D413/14 , C07D417/14
CPC分类号: C07D403/06 , C07D413/06 , C07D413/12
摘要: Compounds of formula I and IV are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorder: wherein the variables A-B, R1, R2, m, and Q are described herein.
摘要翻译: 描述了式I和IV的化合物,并且具有治疗效用,特别是在治疗糖尿病,肥胖症和相关病症和病症中:其中变量AB,R 1,R 2, >,m和Q。
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公开(公告)号:US20080045503A1
公开(公告)日:2008-02-21
申请号:US11819607
申请日:2007-06-28
申请人: Martin Henriksson , Evert Homan , Lars Johansson , Jerk Vallgarda , Meredith Williams , Eric Bercot , Christopher Fotsch , Aiwen Li , Guolin Cai , Randall Hungate , Chester Yuan , Christopher Tegley , David St. Jean , Nianhe Han , Qi Huang , Qingyian Liu , Michael Bartberger , George Moniz , Matthew Frizzle
发明人: Martin Henriksson , Evert Homan , Lars Johansson , Jerk Vallgarda , Meredith Williams , Eric Bercot , Christopher Fotsch , Aiwen Li , Guolin Cai , Randall Hungate , Chester Yuan , Christopher Tegley , David St. Jean , Nianhe Han , Qi Huang , Qingyian Liu , Michael Bartberger , George Moniz , Matthew Frizzle
IPC分类号: C07D277/34 , A61K31/421 , A61K31/426 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/55 , A61P25/00 , C07D277/62 , C12N9/99 , C07D417/00 , C07D413/00 , C07D401/00 , A61P3/00 , A61P37/00 , A61P9/00 , C07D211/06 , C07D221/20 , C07D263/36 , C07D263/52
CPC分类号: C07D417/06 , C07D263/34 , C07D263/48 , C07D275/03 , C07D277/42 , C07D277/54 , C07D277/60 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D513/10 , C07F7/1804
摘要: The present invention relates to compounds with the formula (I), (II), (III) or (IV): wherein R1, R2, R3, R4, R5, R6, R7, X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-β-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.
摘要翻译: 本发明涉及具有式(I),(II),(III)或(IV)的化合物:其中R 1,R 2,R 2, 3,R 4,R 5,R 6,R 7,X和Z分别为 以及包含该化合物的药物组合物的使用方法,以及该化合物用于治疗与人类11-β-羟基类固醇脱氢酶1型酶相关的病症和用于制备作用于人的药物的方法 11-β-羟基类固醇脱氢酶1型酶。
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公开(公告)号:US20070197598A1
公开(公告)日:2007-08-23
申请号:US11598238
申请日:2006-11-13
申请人: Martin Henriksson , Evert Homan , Lars Johansson , Jerk Vallgarda , Meredith Williams , Eric Bercot , Christopher Fotsch , Aiwen Li , Guolin Cai , Randall Hungate , Chester Yuan , Christopher Tegley , David Jean , Nianhe Han , Qi Huang , Qingyian Liu , Michael Bartberger , George Moniz , Matthew Frizzle , Teresa Marshall
发明人: Martin Henriksson , Evert Homan , Lars Johansson , Jerk Vallgarda , Meredith Williams , Eric Bercot , Christopher Fotsch , Aiwen Li , Guolin Cai , Randall Hungate , Chester Yuan , Christopher Tegley , David Jean , Nianhe Han , Qi Huang , Qingyian Liu , Michael Bartberger , George Moniz , Matthew Frizzle , Teresa Marshall
IPC分类号: A61K31/454 , A61K31/4439 , A61K31/426 , C07D417/02 , C07D277/34
CPC分类号: C07D277/54 , C07D277/60 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14
摘要: The present invention relates to thiazolinones and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-β-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.
摘要翻译: 本发明涉及噻唑啉酮以及包含该化合物的药物组合物,以及该化合物用于治疗与人类11-β-羟基类固醇脱氢酶1型酶有关的病症的用途的方法以及用于制备作用于 人类11-β-羟基类固醇脱氢酶1型酶。
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公开(公告)号:US20060142357A1
公开(公告)日:2006-06-29
申请号:US11135662
申请日:2005-05-24
申请人: Martin Henriksson , Evert Homan , Lars Johansson , Jerk Vallgarda , Meredith Williams , Eric Bercot , Christopher Fotsch , Aiwen Li , Guolin Cai , Randall Hungate , Chester Yuan , Christopher Tegley , David Jean , Nianhe Han , Qi Huang , Qingyian Liu , Michael Bartberger , George Moniz , Matthew Frizzle
发明人: Martin Henriksson , Evert Homan , Lars Johansson , Jerk Vallgarda , Meredith Williams , Eric Bercot , Christopher Fotsch , Aiwen Li , Guolin Cai , Randall Hungate , Chester Yuan , Christopher Tegley , David Jean , Nianhe Han , Qi Huang , Qingyian Liu , Michael Bartberger , George Moniz , Matthew Frizzle
IPC分类号: A61K31/426 , A61K31/421 , C07D277/04 , C07D263/04
CPC分类号: C07D417/06 , C07D263/34 , C07D263/48 , C07D275/03 , C07D277/42 , C07D277/54 , C07D277/60 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D513/10 , C07F7/1804
摘要: The present invention relates to compounds with the formula (I), (II), (III) or (IV): wherein R1, R2, R3, R4, R5, R6, R7, X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-β-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.
摘要翻译: 本发明涉及具有式(I),(II),(III)或(IV)的化合物:其中R 1,R 2,R 2, 3,R 4,R 5,R 6,R 7,X和Z分别为 以及包含该化合物的药物组合物的使用方法,以及该化合物用于治疗与人类11-β-羟基类固醇脱氢酶1型酶相关的病症和用于制备作用于人的药物的方法 11-β-羟基类固醇脱氢酶1型酶。
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5.Derivatives of urea and related diamines, methods for their manufacture, and uses therefor 有权
标题翻译: 脲和相关二胺的衍生物,其制造方法及其用途公开(公告)号:US08324396B2
公开(公告)日:2012-12-04
申请号:US12218228
申请日:2008-07-10
申请人: Pierre Deprez , Christopher Fotsch , Paul Harrington , Sarah Lively , Kanaka Pattabiraman , David St. Jean , Taoues Temal-Laib
发明人: Pierre Deprez , Christopher Fotsch , Paul Harrington , Sarah Lively , Kanaka Pattabiraman , David St. Jean , Taoues Temal-Laib
IPC分类号: C07D277/32 , A61K31/425
CPC分类号: C07D277/82 , C07D277/46 , C07D417/12 , C07D417/14
摘要: The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders related to the function of the calcium sensing receptor. The invention also relates to processes for making such compounds and to intermediates useful in these processes.
摘要翻译: 本发明一般涉及式I所示的化合物,包含它们的药物组合物以及治疗与钙敏感受体的功能有关的疾病或病症的方法。 本发明还涉及制备这些化合物和在这些方法中有用的中间体的方法。
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6.Derivatives of urea and related diamines, methods for their manufacture, and uses therefor 有权
标题翻译: 脲和相关二胺的衍生物,其制造方法及其用途公开(公告)号:US20090054463A1
公开(公告)日:2009-02-26
申请号:US12218228
申请日:2008-07-10
申请人: Pierre Deprez , Christopher Fotsch , Paul Harrington , Sarah Lively , Kanaka Pattabiraman , David St. Jean , Taoues Temal-Laib
发明人: Pierre Deprez , Christopher Fotsch , Paul Harrington , Sarah Lively , Kanaka Pattabiraman , David St. Jean , Taoues Temal-Laib
IPC分类号: A61K31/506 , C07D277/82 , C07D277/12 , C07D417/02 , C07D417/12 , C07D401/12 , A61P5/14 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/497
CPC分类号: C07D277/82 , C07D277/46 , C07D417/12 , C07D417/14
摘要: The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders related to the function of the calcium sensing receptor. The invention also relates to processes for making such compounds and to intermediates useful in these processes.
摘要翻译: 本发明一般涉及式I所示的化合物,包含它们的药物组合物以及治疗与钙敏感受体的功能有关的疾病或病症的方法。 本发明还涉及制备这些化合物和在这些方法中有用的中间体的方法。
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公开(公告)号:US08791147B2
公开(公告)日:2014-07-29
申请号:US13123468
申请日:2009-10-07
IPC分类号: A61K31/44 , C07D211/72 , C07D211/84 , C07D213/62 , C07D213/78 , C07D211/70 , C07D211/82 , C07D213/24
CPC分类号: A61K31/44 , A61K31/437 , A61K31/4412
摘要: The present invention relates generally to novel calcimimetic compounds and pharmaceutical compositions comprising them. The invention also relates to methods of treating of diseases or disorders related to the function of the calcium sensing receptor using the compounds represented in Formula (I). Where Cy1 is pyridinonyl, pyridinyl, quinolinyl or 9-ethyl-9H-beta-carbolinyl, each of which optionally substituted and where Cy2 is phenyl naphthyl.
摘要翻译: 本发明一般涉及新型的拟钙化合物和包含它们的药物组合物。 本发明还涉及使用式(I)表示的化合物治疗与钙感受受体的功能有关的疾病或病症的方法。 其中Cy1是吡啶基,吡啶基,喹啉基或9-乙基-9H-咔啉基,其各自任选被取代,Cy2是苯基萘基。
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公开(公告)号:US20050277646A1
公开(公告)日:2005-12-15
申请号:US11195303
申请日:2005-08-01
申请人: Elizabeth Doherty , Jiawang Zhu , Markian Stec , Mark Norman , Vassil Ognyanov , Christopher Fotsch , Ning Chen , Partha Chakrabarti , Liping Pettus , Hui-Ling Wang , Xianghong Wang , Premilla Arasasingham
发明人: Elizabeth Doherty , Jiawang Zhu , Markian Stec , Mark Norman , Vassil Ognyanov , Christopher Fotsch , Ning Chen , Partha Chakrabarti , Liping Pettus , Hui-Ling Wang , Xianghong Wang , Premilla Arasasingham
IPC分类号: A61K31/4709 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/5377 , A61P1/00 , A61P1/04 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/00 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/14 , A61P19/02 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P27/02 , A61P29/00 , A61P37/08 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/64 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/22 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D237/20 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D43/02
CPC分类号: C07D231/40 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/56 , C07D233/38 , C07D237/20 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要: Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
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公开(公告)号:US20050227986A1
公开(公告)日:2005-10-13
申请号:US11100077
申请日:2005-04-05
申请人: Yunxin Bo , Partha Chakrabarti , Ning Chen , Elizabeth Doherty , Christopher Fotsch , Nianhe Han , Michael Kelly , Qingyian Liu , Mark Norman , Vassil Ognyanov , Xianghong Wang , Jiawang Zhu
发明人: Yunxin Bo , Partha Chakrabarti , Ning Chen , Elizabeth Doherty , Christopher Fotsch , Nianhe Han , Michael Kelly , Qingyian Liu , Mark Norman , Vassil Ognyanov , Xianghong Wang , Jiawang Zhu
IPC分类号: C07D249/18 , A61K31/17 , A61K31/18 , A61K31/343 , A61K31/357 , A61K31/36 , A61K31/37 , A61K31/381 , A61K31/4025 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/443 , A61K31/444 , A61K31/453 , A61K31/47 , A61K31/4704 , A61K31/4709 , A61K31/472 , A61K31/496 , A61K31/4965 , A61K31/498 , A61K31/505 , A61K31/517 , A61K31/5375 , A61K31/538 , A61P1/00 , A61P1/04 , A61P1/12 , A61P3/10 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/00 , A61P13/10 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P17/14 , A61P19/02 , A61P25/00 , A61P25/06 , A61P27/02 , A61P29/00 , A61P31/12 , A61P37/08 , A61P43/00 , C07C233/11 , C07C233/15 , C07C233/33 , C07C233/44 , C07C311/13 , C07C311/16 , C07C317/40 , C07C323/35 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/64 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/22 , C07D215/227 , C07D215/32 , C07D215/38 , C07D215/40 , C07D215/42 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D235/08 , C07D235/26 , C07D237/20 , C07D239/42 , C07D239/88 , C07D239/90 , C07D241/20 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D311/16 , C07D319/18 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , A61K31/502 , C07D43/02
CPC分类号: C07D471/04 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D237/20 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要: Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
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公开(公告)号:US20070265248A1
公开(公告)日:2007-11-15
申请号:US11116759
申请日:2005-04-27
申请人: Christopher Fotsch , Premilla Arasasingham , Yunxin Bo , Ning Chen , Martin Goldberg , Nianhe Han , Feng-Yin Hsieh , Michael Kelly , Qingyian Liu , Mark Norman , Duncan Smith , Markian Stec , Nuria Tamayo , Ning Xi , Shimin Xu , Elizabeth Doherty
发明人: Christopher Fotsch , Premilla Arasasingham , Yunxin Bo , Ning Chen , Martin Goldberg , Nianhe Han , Feng-Yin Hsieh , Michael Kelly , Qingyian Liu , Mark Norman , Duncan Smith , Markian Stec , Nuria Tamayo , Ning Xi , Shimin Xu , Elizabeth Doherty
IPC分类号: A61K31/4965 , A61K31/497 , A61K31/551 , A61P3/10 , C07D243/08 , C07D401/00 , C07D403/12 , C07D407/00
CPC分类号: C07D207/08 , A61K38/00 , C07D205/04 , C07D207/09 , C07D209/14 , C07D209/42 , C07D211/26 , C07D211/60 , C07D211/62 , C07D213/38 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/06 , C07D217/14 , C07D217/26 , C07D233/64 , C07D295/185 , C07D317/60 , C07D317/68 , C07D319/18 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D451/02 , C07K5/06026 , C07K5/06139 , C07K5/06147 , C07K5/06191
摘要: Selected substituted piperazine compounds are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving activation of the melanocortin receptor. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 所选的取代哌嗪化合物对于预防和治疗诸如肥胖症等疾病是有效的。 本发明包括新颖的化合物,类似物,前药和药学上可接受的盐,用于预防和治疗涉及黑皮质素受体活化的疾病和其它疾病或病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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