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公开(公告)号:US06224728B1
公开(公告)日:2001-05-01
申请号:US09373872
申请日:1999-08-13
申请人: Michael C. Oborny , Phillip H. Paul , Kenneth R. Hencken , Gregory C. Frye-Mason , Ronald P. Manginell
发明人: Michael C. Oborny , Phillip H. Paul , Kenneth R. Hencken , Gregory C. Frye-Mason , Ronald P. Manginell
IPC分类号: C12Q168
CPC分类号: F04B19/006
摘要: A valve for controlling fluid flows. This valve, which includes both an actuation device and a valve body provides: the ability to incorporate both the actuation device and valve into a unitary structure that can be placed onto a microchip, the ability to generate higher actuation pressures and thus control higher fluid pressures than conventional microvalves, and a device that draws only microwatts of power. An electrokinetic pump that converts electric potential to hydraulic force is used to operate, or actuate, the valve.
摘要翻译: 用于控制流体流动的阀。 该阀包括致动装置和阀体,其提供:将致动装置和阀两者结合成可放置在微芯片上的整体结构的能力,产生更高的致动压力并因此控制较高流体压力的能力 比传统的微型阀,以及只能获得微瓦功率的装置。 将电势转换为液压力的电动泵用于操作或致动阀。
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公开(公告)号:US06277257B1
公开(公告)日:2001-08-21
申请号:US09271687
申请日:1999-03-18
申请人: Phillip H. Paul , David J. Rakestraw , Don W. Arnold , Kenneth R. Hencken , Joseph S. Schoeniger , David W. Neyer
发明人: Phillip H. Paul , David J. Rakestraw , Don W. Arnold , Kenneth R. Hencken , Joseph S. Schoeniger , David W. Neyer
IPC分类号: B01D6144
CPC分类号: G01N30/32 , F04B19/006 , G01N2030/285 , G01N2030/326
摘要: An electrokinetic high pressure hydraulic pump for manipulating fluids in capillary-based systems. The pump uses electro-osmotic flow to provide a high pressure hydraulic system, having no moving mechanical parts, for pumping and/or compressing fluids, for providing valve means and means for opening and closing valves, for controlling fluid flow rate, and manipulating fluid flow generally and in capillary-based systems (Microsystems), in particular. The compact nature of the inventive high pressure hydraulic pump provides the ability to construct a micro-scale or capillary-based HPLC system that fulfills the desire for small sample quantity, low solvent consumption, improved efficiency, the ability to run samples in parallel, and field portability. Control of pressure and solvent flow rate is achieved by controlling the voltage applied to an electrokinetic pump.
摘要翻译: 一种电动高压液压泵,用于在毛细管系统中操纵流体。 泵使用电渗流提供高压液压系统,没有移动的机械部件,用于泵送和/或压缩流体,用于提供阀装置和用于打开和关闭阀门的装置,用于控制流体流速和操纵流体 特别是在毛细管系统(Microsystems)中通常流动。 本发明的高压液压泵的紧凑特性提供构建基于微量或基于毛细管的HPLC系统的能力,其满足对小样品量,低溶剂消耗,提高的效率,并行运行样品的能力的需求,以及 现场可携带性。 通过控制施加到电动泵的电压来实现压力和溶剂流速的控制。
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公开(公告)号:US06572749B1
公开(公告)日:2003-06-03
申请号:US09912154
申请日:2001-07-23
申请人: Phillip H. Paul , David J. Rakestraw , Don W. Arnold , Kenneth R. Hencken , Joseph S. Schoeniger , David W. Neyer
发明人: Phillip H. Paul , David J. Rakestraw , Don W. Arnold , Kenneth R. Hencken , Joseph S. Schoeniger , David W. Neyer
IPC分类号: B05B500
CPC分类号: G01N30/32 , F04B19/006 , G01N2030/285 , G01N2030/326
摘要: An electrokinetic high pressure hydraulic pump for manipulating fluids in capillary-based system. The pump uses electro-osmotic flow to provide a high pressure hydraulic system, having no moving mechanical parts, for pumping and/or compressing fluids, for providing valve means and means for opening and closing valves, for controlling fluid flow rate, and manipulating fluid flow generally and in capillary-based systems (microsystems), in particular. The compact nature of the inventive high pressure hydraulic pump provides the ability to construct a micro-scale or capillary-based HPLC system that fulfills the desire for small sample quantity, low solvent consumption, improved efficiency, the ability to run samples in parallel, and field portability. Control of pressure and solvent flow rate is achieved by controlling the voltage applied to an electrokinetic pump.
摘要翻译: 一种电动高压液压泵,用于在毛细管系统中操纵流体。 泵使用电渗流提供高压液压系统,没有移动的机械部件,用于泵送和/或压缩流体,用于提供阀装置和用于打开和关闭阀门的装置,用于控制流体流速和操纵流体 特别是在毛细管系统(微系统)中流动。 本发明的高压液压泵的紧凑特性提供构建基于微量或基于毛细管的HPLC系统的能力,其满足对小样品量,低溶剂消耗,提高的效率,并行运行样品的能力的需求,以及 现场可携带性。 通过控制施加到电动泵的电压来实现压力和溶剂流速的控制。
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公开(公告)号:US08795493B2
公开(公告)日:2014-08-05
申请号:US12567482
申请日:2009-09-25
IPC分类号: G05D7/06
CPC分类号: G01N30/32 , B01D61/56 , G01N2030/324 , G01N2030/326 , G05D7/0694 , G05D11/132 , Y10T137/85978 , Y10T137/85986 , Y10T137/86027 , G01N30/34 , G01N2030/285
摘要: A flow controller which uses a combination of hydrostatic pressure and electroosmotic flow to control the flow of a fluid. A driving fluid (1204) whose flow rate is dependent on both hydrostatic pressures and electroosmotic flow can be used (a) directly as a working fluid in an operable device, for example a chromatograph, or (b) to displace a working fluid (1203) from a storage container (625) into an operable device (1301), or both (a) and (b). The driving fluid (1204) can be composed of one or more fluids. Part or all the driving fluid (1204) is passed through an electroosmotic device (100) so as to increase or decrease the flow rate induced by hydrostatic pressure.
摘要翻译: 流量控制器,其使用静水压力和电渗流量的组合来控制流体的流动。 其流量取决于流体静力压力和电渗流量的驱动流体(1204)可以(a)直接用作可操作装置(例如色谱仪)中的工作流体,或(b)将工作流体(1203) )从存储容器(625)移动到可操作装置(1301)或(a)和(b)中。 驱动流体(1204)可以由一种或多种流体组成。 部分或全部驱动流体(1204)通过电渗装置(100),以增加或减少由静水压力引起的流速。
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公开(公告)号:US07521140B2
公开(公告)日:2009-04-21
申请号:US10827788
申请日:2004-04-19
申请人: Don W. Arnold , Phillip H. Paul , Deon S. Anex
发明人: Don W. Arnold , Phillip H. Paul , Deon S. Anex
CPC分类号: H01M8/04589 , H01M8/04007 , H01M8/04186 , H01M8/0432 , H01M8/04447 , H01M8/04753 , H01M8/0612
摘要: A fuel cell system having a fuel cell, the fuel cell having a membrane-electrode assembly; a fuel reservoir containing a liquid fuel; a conduit coupling the fuel reservoir to the fuel cell; and an electrokinetic fuel pump coupled to the conduit, the electrokinetic fuel pump having a plurality of electrodes; wherein the electrokinetic fuel pump moves fuel from the fuel reservoir through the conduit to the fuel cell; and wherein the electrokinetic fuel pump electrodes do not deleteriously affect the performance of the membrane-electrode assembly.
摘要翻译: 一种具有燃料电池的燃料电池系统,所述燃料电池具有膜 - 电极组件; 包含液体燃料的燃料储存器; 将燃料储存器联接到燃料电池的导管; 以及耦合到所述导管的电动燃料泵,所述电动燃料泵具有多个电极; 其中所述电动燃料泵将燃料从所述燃料储存器通过所述导管移动到所述燃料电池; 并且其中所述电动燃料泵电极不会有害地影响所述膜 - 电极组件的性能。
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公开(公告)号:US07429317B2
公开(公告)日:2008-09-30
申请号:US11019917
申请日:2004-12-20
申请人: Phillip H. Paul
发明人: Phillip H. Paul
IPC分类号: F16K7/17
CPC分类号: G01N27/44747 , B01L3/50273 , B01L3/502738 , B01L2300/0816 , B01L2400/0418 , B01L2400/0487 , B01L2400/0633 , F16K99/0001 , F16K99/0015 , F16K99/0042 , F16K99/0059
摘要: A non-Newtonian fluid is used in an electrokinetic device to produce electroosmotic flow therethrough. The nonlinear viscosity of the non-Newtonian fluid allows the electrokinetic device to behave differently under different operating conditions, such as externally applied pressures and electric potentials. Electrokinetic devices can be used with a non-Newtonian fluid in a number of applications, including but not limited to electrokinetic pumps, flow controllers, diaphragm valves, and displacement systems.
摘要翻译: 在动电装置中使用非牛顿流体以产生穿过其中的电渗流。 非牛顿流体的非线性粘度允许电动装置在不同的操作条件下,例如外部施加的压力和电势下,表现不同。 电动装置可以在许多应用中与非牛顿流体一起使用,包括但不限于电动泵,流量控制器,隔膜阀和排量系统。
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公开(公告)号:US07364647B2
公开(公告)日:2008-04-29
申请号:US10198223
申请日:2002-07-17
申请人: Phillip H. Paul , David W. Neyer , Jason E. Rehm
发明人: Phillip H. Paul , David W. Neyer , Jason E. Rehm
CPC分类号: B01F13/0076 , B01D61/18 , B01F5/0682 , B01F5/0692 , B01F15/0201 , B01F15/0232 , B01L3/5023 , B01L3/502707 , B01L3/502753 , B01L2300/0645 , B01L2300/0654 , B01L2300/0681 , B01L2300/0877 , B01L2300/0887 , B01L2400/0418 , F04B19/006 , F04B43/043 , F04B43/06 , F16K99/0001 , F16K99/0025 , F16K99/0049 , G01N27/44791 , G01N30/461 , G01N30/6065 , G01N30/6095 , G01N2030/027 , G01N2030/285 , G01N2030/326 , G01N2030/347 , G01N2030/525 , G01N2030/528 , Y10T156/1046
摘要: A laminated flow device comprises a porous material encapsulated within bonding material. The porous material forms a flow path and the bonding material forms an enclosure surrounding the flow path. Micro-components, such as capillaries, electrodes, reservoirs, bridges, electrokinetic elements, and detectors, can be encapsulated within the device.
摘要翻译: 层压流动装置包括封装在粘合材料内的多孔材料。 多孔材料形成流动路径,并且结合材料形成围绕流动路径的外壳。 诸如毛细管,电极,储存器,桥,电动元件和检测器的微组件可以封装在装置内。
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公开(公告)号:US07175810B2
公开(公告)日:2007-02-13
申请号:US10849715
申请日:2004-05-19
IPC分类号: G01N33/48
CPC分类号: G01N21/05 , G01N15/1404 , G01N15/1459 , G01N21/64 , G01N27/447 , G01N33/54313 , G01N2015/1497 , G01N2021/0346 , G01N2035/00564 , Y10T436/2575
摘要: Particles dispersed in a liquid are assembled in a configuration in which all the particles lie in the same plane, and the assembled particles are processed while in that configuration. The assembled particles can for example be simultaneously exposed to electromagnetic radiation which elicits from the particles a response which provides information about the particles. The particles can for example be cells, cell fragments, or analyte-bearing beads of the type conventionally analyzed in a cytometer.
摘要翻译: 分散在液体中的颗粒以其中所有颗粒位于相同平面中的构型组装,并且组装的颗粒在该构造中被处理。 组装的颗粒可以例如同时暴露于从颗粒引起的电磁辐射,该响应提供关于颗粒的信息。 颗粒可以例如是在细胞计数器中常规分析的类型的细胞,细胞碎片或分析物携带珠。
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公开(公告)号:US06833068B2
公开(公告)日:2004-12-21
申请号:US10341870
申请日:2003-01-13
申请人: Phillip H. Paul , Don W. Arnold , David W. Neyer
发明人: Phillip H. Paul , Don W. Arnold , David W. Neyer
IPC分类号: B01D1508
CPC分类号: B01J20/283 , B01J20/285 , B01L3/502746 , B01L2200/0605 , B01L2300/0816 , B01L2300/0864 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , G01N30/10 , G01N30/16 , G01N30/466 , G01N30/6095 , G01N2030/162 , G01N2030/285 , G01N2030/324
摘要: Apparatus for eliminating siphoning, “dead” regions, and fluid concentration gradients in microscale analytical devices. In its most basic embodiment, the present invention affords passive injection control for both electric field-driven and pressure-driven systems by providing additional fluid flow channels or auxiliary channels disposed on either side of a sample separation column. The auxiliary channels are sized such that volumetric fluid flow rate through these channels, while sufficient to move the sample away from the sample injection region in a timely fashion, is less than that through the sample separation channel or chromatograph.
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公开(公告)号:US20110114492A1
公开(公告)日:2011-05-19
申请号:US13013484
申请日:2011-01-25
申请人: Deon S. Anex , Phillip H. Paul , David W. Neyer
发明人: Deon S. Anex , Phillip H. Paul , David W. Neyer
IPC分类号: F04F99/00
CPC分类号: F04B19/006 , F04B17/00 , F04B19/00 , F04B43/043
摘要: An electrokinetic pump achieves high and low flow rates without producing significant gaseous byproducts and without significant evolution of the pump fluid. A first feature of the pump is that the electrodes in the pump are capacitive with a capacitance of at least 10−4 Farads/cm2. A second feature of the pump is that it is configured to maximize the potential across the porous dielectric material. The pump can have either or both features.
摘要翻译: 电动泵实现高和低流速,而不产生显着的气体副产物并且没有泵流体的显着演变。 泵的第一个特征是泵中的电极是容性为至少10-4法拉/ cm2的电容。 泵的第二个特征是其被配置为使跨越多孔介电材料的电势最大化。 泵可以具有两个或两个特征。
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