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    SUSTAINED RELEASE DELIVERY SYSTEMS FOR THE PREVENTION AND TREATMENT OF HEAD AND NECK CANCERS
    1.
    发明申请
    SUSTAINED RELEASE DELIVERY SYSTEMS FOR THE PREVENTION AND TREATMENT OF HEAD AND NECK CANCERS 审中-公开
    用于预防和治疗头颈部癌症的可持续发放系统

    公开(公告)号：US20130018069A1

    公开(公告)日：2013-01-17

    申请号：US13391756

    申请日：2010-08-25

    申请人： Michael Friedman ,  Rakefet Czernimski ,  Silvio Gutkind ,  Doron Steinberg ,  Irith Gati ,  Zakhar Nudelman

    发明人： Michael Friedman ,  Rakefet Czernimski ,  Silvio Gutkind ,  Doron Steinberg ,  Irith Gati ,  Zakhar Nudelman

    IPC分类号： A61K31/436 ,  A61P35/00

    CPC分类号： A61K31/436 ,  A61K9/006 ,  A61K9/2054 ,  A61K9/7015

    摘要： The present invention discloses a method of treating a head and neck cancer or preventing the development of pre-malignant lesions to this cancer, by administering locally to the oral cavity, a sustained release drug delivery system comprising a drug for the treatment of this cancer or for the prevention of said lesions, and at least one polymer, such that said system is attached to a surface in the oral cavity and remains attached thereto for at least 1 hour, accompanied by release of the drug and maintaining an effective therapeutic concentration thereof in the cavity, for at least 1 hour. Further are disclosed a sustained release drug delivery system and a liquid precursor varnish composition to this system.

    摘要翻译： 本发明公开了一种通过局部给予口腔治疗头颈部癌症或预防恶性肿瘤发展的方法，包括用于治疗该癌症的药物的持续释放药物递送系统，或 用于预防所述损伤，以及至少一种聚合物，使得所述系统附着到口腔中的表面并保持与其连接至少1小时，同时释放药物并将其有效治疗浓度保持在 空腔至少1小时。 还公开了一种缓释药物递送系统和液体前体清漆组合物。

    SUSTAINED-RELEASE INJECTABLE FORMULATION
    8.
    发明申请
    SUSTAINED-RELEASE INJECTABLE FORMULATION 审中-公开
    持续发布注册制

    公开(公告)号：US20140018323A1

    公开(公告)日：2014-01-16

    申请号：US14007331

    申请日：2012-03-28

    申请人： Michael Friedman ,  Amnon Hoffman ,  Eran Lavy

    发明人： Michael Friedman ,  Amnon Hoffman ,  Eran Lavy

    IPC分类号： A61K47/10 ,  A61K9/06

    CPC分类号： A61K9/06 ,  A61K9/0024 ,  A61K9/10 ,  A61K31/43 ,  A61K31/496 ,  A61K31/546 ,  A61K31/65 ,  A61K47/10

    摘要： A composition which comprises a biologically active agent and a polymer that exhibits a reverse thermal gelation at a physiological temperature, in a carrier, and in which the active agent is in an undissolved form is disclosed herein. Further disclosed herein are methods utilizing the compositions for treating subjects, including non-human subjects, as well as kits for preparing and using a composition. The composition is preferably a sustained release formulation, and is particularly useful for treating animals, where single-dose treatment is desired.

    摘要翻译： 本文公开了一种组合物，其包含生物活性剂和在生理温度下，在载体中表现出反向热凝胶化，并且其中活性剂为未溶解形式的聚合物。 本文进一步公开的是利用组合物治疗受试者，包括非人受试者的方法，以及制备和使用组合物的试剂盒。 组合物优选为持续释放制剂，并且特别可用于治疗需要单剂量治疗的动物。