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    SUSTAINED RELEASE DELIVERY SYSTEMS FOR THE PREVENTION AND TREATMENT OF HEAD AND NECK CANCERS
    2.
    发明申请
    SUSTAINED RELEASE DELIVERY SYSTEMS FOR THE PREVENTION AND TREATMENT OF HEAD AND NECK CANCERS 审中-公开
    用于预防和治疗头颈部癌症的可持续发放系统

    公开(公告)号：US20130018069A1

    公开(公告)日：2013-01-17

    申请号：US13391756

    申请日：2010-08-25

    申请人： Michael Friedman ,  Rakefet Czernimski ,  Silvio Gutkind ,  Doron Steinberg ,  Irith Gati ,  Zakhar Nudelman

    发明人： Michael Friedman ,  Rakefet Czernimski ,  Silvio Gutkind ,  Doron Steinberg ,  Irith Gati ,  Zakhar Nudelman

    IPC分类号： A61K31/436 ,  A61P35/00

    CPC分类号： A61K31/436 ,  A61K9/006 ,  A61K9/2054 ,  A61K9/7015

    摘要： The present invention discloses a method of treating a head and neck cancer or preventing the development of pre-malignant lesions to this cancer, by administering locally to the oral cavity, a sustained release drug delivery system comprising a drug for the treatment of this cancer or for the prevention of said lesions, and at least one polymer, such that said system is attached to a surface in the oral cavity and remains attached thereto for at least 1 hour, accompanied by release of the drug and maintaining an effective therapeutic concentration thereof in the cavity, for at least 1 hour. Further are disclosed a sustained release drug delivery system and a liquid precursor varnish composition to this system.

    摘要翻译： 本发明公开了一种通过局部给予口腔治疗头颈部癌症或预防恶性肿瘤发展的方法，包括用于治疗该癌症的药物的持续释放药物递送系统，或 用于预防所述损伤，以及至少一种聚合物，使得所述系统附着到口腔中的表面并保持与其连接至少1小时，同时释放药物并将其有效治疗浓度保持在 空腔至少1小时。 还公开了一种缓释药物递送系统和液体前体清漆组合物。

    CHEWING GUM FOR PREVENTING TOOTH DECAY
    8.
    发明申请
    CHEWING GUM FOR PREVENTING TOOTH DECAY 审中-公开
    用于防止牙齿衰老的牙刷

    公开(公告)号：US20090074910A1

    公开(公告)日：2009-03-19

    申请号：US11884791

    申请日：2006-02-22

    申请人： Doron Steinberg ,  Shlomo Magdassi ,  Alexander Kamyshny ,  Haim Zegerman ,  Arie Letzter

    发明人： Doron Steinberg ,  Shlomo Magdassi ,  Alexander Kamyshny ,  Haim Zegerman ,  Arie Letzter

    IPC分类号： A23G4/06

    CPC分类号： A23G4/06

    摘要： Disclosed are chewing gums that are organoleptically acceptable, and have high adherence to plaque bacteria. A chewing gum according to an exemplary embodiment contains a gum base, at least one edible acid, and optionally other ingredients. The invention also provides a method for preparing a chewing gum composition, which includes triturating of coloring agent, and a method for commercially producing and marketing chewing gums, which includes testing the chewing gums for adhesion to bacteria, such as plaque bacteria.

    摘要翻译： 公开了具有感觉上可接受的口香糖，并且对斑块细菌具有高粘附性。 根据示例性实施方案的口香糖包含胶基，至少一种食用酸和任选的其它成分。 本发明还提供了一种制备口香糖组合物的方法，其包括着色剂的研磨，以及用于商业生产和销售口香糖的方法，其包括测试口香糖以粘附细菌如斑块细菌。

    Oxazaborolidines as bacteria effectors
    9.
    发明申请
    Oxazaborolidines as bacteria effectors 审中-公开
    恶唑烷作为细菌效应物

    公开(公告)号：US20070155698A1

    公开(公告)日：2007-07-05

    申请号：US10570207

    申请日：2004-09-02

    申请人： Doron Steinberg ,  Morris Srebnik ,  Adel Jabbour ,  Arik Moussaieff ,  Valery Dembitsky ,  Moshe Bronshteyn

    发明人： Doron Steinberg ,  Morris Srebnik ,  Adel Jabbour ,  Arik Moussaieff ,  Valery Dembitsky ,  Moshe Bronshteyn

    IPC分类号： A61K31/69 ,  C07F5/04

    CPC分类号： C07F5/02 ,  A61K31/69 ,  A61K2300/00

    摘要： The invention relates to a composition for modulation of at least one bacteria-related parameter comprising oxazaborolidine derivative compounds. The invention additionally relates to new oxazaborolidine derivative compounds. The invention further relates to a composition for decreasing bacterial growth, a composition for increasing the susceptibility of bacteria to the cytotoxic effects of other antibacterial agents, and a pharmaceutical composition comprising as an active ingredient an oxazaborolidine derivative compound. Methods for modulating at least one bacteria-related parameter, for preventing, decreasing or eliminating bacterial growth, and for making bacteria more susceptible to other antibacterial compounds are also described.

    摘要翻译： 本发明涉及用于调节包含恶唑硼烷衍生物化合物的至少一种细菌相关参数的组合物。 本发明还涉及新的恶唑硼烷衍生物化合物。 本发明还涉及用于减少细菌生长的组合物，用于增加细菌对其它抗细菌剂的细胞毒性作用的敏感性的组合物，以及包含作为活性成分的恶唑硼烷衍生物化合物的药物组合物。 还描述了用于调节至少一种细菌相关参数，用于预防，减少或消除细菌生长以及使细菌对其它抗菌化合物更敏感的方法。

    Edible compositions capable of removing oral biofilm
    10.
    发明申请
    Edible compositions capable of removing oral biofilm 审中-公开
    能够去除口腔生物膜的食用组合物

    公开(公告)号：US20050058744A1

    公开(公告)日：2005-03-17

    申请号：US10884631

    申请日：2004-07-01

    申请人： Doron Steinberg ,  Alexander Kamyshny ,  Shlomo Magdassi

    发明人： Doron Steinberg ,  Alexander Kamyshny ,  Shlomo Magdassi

    IPC分类号： A23G1/00 ,  A23G1/32 ,  A23G1/40 ,  A23G1/44 ,  A23G3/00 ,  A23G3/36 ,  A23G3/42 ,  A23G3/44 ,  A23G4/00 ,  A23G4/06 ,  A23G4/10 ,  A23G4/14 ,  A23G9/32 ,  A23G9/34 ,  A23G9/38 ,  A61K8/73 ,  A61Q11/00 ,  A23G3/30

    CPC分类号： A23G1/44 ,  A23G1/325 ,  A23G1/40 ,  A23G3/362 ,  A23G3/42 ,  A23G3/44 ,  A23G4/064 ,  A23G4/10 ,  A23G4/14 ,  A23G9/325 ,  A23G9/34 ,  A23G9/38 ,  A61K8/73 ,  A61K8/731 ,  A61K8/732 ,  A61K8/733 ,  A61K8/736 ,  A61K2800/5424 ,  A61Q11/00

    摘要： An edible and/or chewable article of manufacture containing at least one food grade substance having adsorption affinity towards at least one dental plaque (biofilm) constituent and capable of reducing and/or removing the oral biofilm while present in the mouth. Particular articles of manufacture are chewing gums, sweets, candies, candy, and other nutritional bars, ice creams, chocolates, confectionery and bakery/pastry products, honey, dairy products and beverages, and oral hygiene products such as tooth pastes, oral gels and mouthwashes. A chewing gum having a conventional gum base and at least one food grade active substance having adsorption affinity towards at least one dental plaque (biofilm) constituent (bacteria and proteins and bacterial cell-free enzymes) and capable of reducing and/or removing the oral biofilm while present in the mouth. Active substances include polysaccharides and non-toxic salts thereof, such as alginates, chitosan, carboxymethylcellulose, agar and carrageenan, inorganic substances such as silica, hydroxyapatite and calcium carbonate and proteins, particularly gelatin and lectin. The article of manufacture removes and/or for prevents or reduces dental plaque (biofilm), and controlling oral, dental and periodontal diseases.

    摘要翻译： 包含至少一种对至少一种牙菌斑（生物膜）成分具有吸附亲和力的食品级物质，并且能够在口腔中同时还原和/或除去口腔生物膜的食用和/或咀嚼制品。 特殊的制品是口香糖，糖果，糖果，糖果和其他营养棒，冰淇淋，巧克力，糖果和面包/糕点产品，蜂蜜，乳制品和饮料，以及口腔卫生产品如牙膏，口腔凝胶和 漱口水 一种口香糖，其具有常规胶基和至少一种对至少一种牙菌斑（生物膜）组分（细菌和蛋白质和细菌无细胞酶）具有吸附亲和力并能够减少和/或去除口腔的食品级活性物质 生物膜同时存在于口中。 活性物质包括多糖及其无毒盐如藻酸盐，壳聚糖，羧甲基纤维素，琼脂和角叉菜胶，无机物质如二氧化硅，羟基磷灰石和碳酸钙以及蛋白质，特别是明胶和凝集素。 该制品移除和/或防止或减少牙菌斑（生物膜），以及控制口腔，牙齿和牙周病。