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    METHOD FOR CONFIGURING A DHCP SERVER USING DHCP OPTION 82
    1.
    发明申请
    METHOD FOR CONFIGURING A DHCP SERVER USING DHCP OPTION 82 审中-公开
    使用DHCP选项配置DHCP服务器的方法82

    公开(公告)号：US20090279454A1

    公开(公告)日：2009-11-12

    申请号：US12177292

    申请日：2008-07-22

    申请人： Michael Wacker ,  Markus Rentschler ,  Dirk Mohl ,  Oliver Kleineberg

    发明人： Michael Wacker ,  Markus Rentschler ,  Dirk Mohl ,  Oliver Kleineberg

    IPC分类号： H04L12/28

    CPC分类号： H04L41/0806 ,  G05B19/41855 ,  H04L29/12283 ,  H04L29/1282 ,  H04L61/2015 ,  H04L61/2061 ,  H04L61/6013 ,  Y02P90/185

    摘要： The invention relates to a method for creating a DHCP network device configuration, wherein the parameter allocation by a DHCP server is performed using Option 82, and the assignment for the IP address to be allocated to a network device is determined on the basis of the topological information. The topological information is provided to the DHCP server by the requesting device and a DHCP relay agent, and the relay agent acts on each DHCP message sent by a device in the network by means of an additional DHCP Option 82 and sends the messages via unicast to the DHCP server, whereas the standard DHCP message is forwarded. According to the invention, a network device sends, in addition to the regular DHCP discovers via MAC broadcast, DHCP messages via MAC multicast to a MAC multicast address, and from this MAC multicast sends unique information via unicast to the DHCP server by means of a DHCP relay agent, since the associated network device filters the multicast. The creation of a DHCP server configuration is automated by use of a software component for the network management.

    摘要翻译： 本发明涉及一种用于创建DHCP网络设备配置的方法，其中使用Option 82执行DHCP服务器的参数分配，并且基于拓扑结构来确定要分配给网络设备的IP地址的分配 信息。 拓扑信息由请求设备和DHCP中继提供给DHCP服务器，并且中继代理通过附加DHCP选项82对由网络中的设备发送的每个DHCP消息进行操作，并通过单播将消息发送到 DHCP服务器，而标准的DHCP消息被转发。 根据本发明，网络设备除了经由MAC广播的常规DHCP发现之外，还经由MAC组播向MAC组播地址发送DHCP消息，并且从该MAC组播通过单播向US服务器发送唯一信息，借助于 DHCP中继，因为相关网络设备过滤组播。 通过使用网络管理的软件组件自动创建DHCP服务器配置。

    Capsular gram-positive bacteria bioconjugate vaccines
    2.
    发明授权
    Capsular gram-positive bacteria bioconjugate vaccines 有权
    荚膜革兰氏阳性菌生物共轭疫苗

    公开(公告)号：US08871491B2

    公开(公告)日：2014-10-28

    申请号：US13100603

    申请日：2011-05-04

    申请人： Michael Wacker ,  Michael Kowarik ,  Michael Wetter

    发明人： Michael Wacker ,  Michael Kowarik ,  Michael Wetter

    IPC分类号： C12N1/20 ,  A61K39/085 ,  A61K39/00

    CPC分类号： A61K39/085 ,  A61K2039/505 ,  A61K2039/575 ,  A61K2039/6037 ,  A61K2039/6087 ,  A61K2039/64 ,  A61K2039/70 ,  C07K14/21 ,  C07K16/1271 ,  C07K2317/734 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/034 ,  C07K2319/21 ,  C12N9/1029 ,  C12N9/1048 ,  C12N15/70 ,  C12N15/74 ,  Y02A50/47

    摘要： The present invention encompasses a novel S. aureus bioconjugate vaccine. More generally, the invention is directed to Gram-positive and other bioconjugate vaccines containing a protein carrier, at least one polysaccharide such as a capsular Gram-positive polysaccharide, and, optionally, an adjuvant or pharmaceutically acceptable carrier. The instant invention also includes methods of producing Gram-positive and other bioconjugate vaccines. An N-glycosylated protein is also provided that contains one or more polysaccharides such as Gram-positive polysaccharides. The invention is additionally directed to engineered prokaryotic organisms comprising nucleotide sequences encoding a glycosyltransferase of a first prokaryotic organism and a glycosyltransferase of a second prokaryotic organism. The invention further includes plasmids and prokaryotic cells transformed with plasmids encoding polysaccharides and enzymes which produce an N-glycosylated protein and/or bioconjugate vaccine. Further, the invention is directed to methods of inducing an immune response in a mammal comprising administering said bioconjugate vaccines.

    摘要翻译： 本发明包括一种新型金黄色葡萄球菌生物缀合物疫苗。 更一般地，本发明涉及含有蛋白质载体，至少一种多糖例如荚膜革兰氏阳性多糖和任选的佐剂或药学上可接受的载体的革兰氏阳性和其他生物缀合物疫苗。 本发明还包括生产革兰氏阳性和其他生物缀合疫苗的方法。 还提供了含有一种或多种多糖如革兰氏阳性多糖的N-糖基化蛋白质。 本发明还涉及包含编码第一原核生物的糖基转移酶和第二原核生物的糖基转移酶的核苷酸序列的工程化原核生物。 本发明还包括用编码多糖的质粒和产生N-糖基化蛋白质和/或生物缀合物疫苗的酶转化的质粒和原核细胞。 此外，本发明涉及在哺乳动物中诱导免疫应答的方法，包括施用所述生物缀合物疫苗。

    System and method for the production of recombinant glycosylated proteins in a prokaryotic host
    3.
    发明授权
    System and method for the production of recombinant glycosylated proteins in a prokaryotic host 有权
    用于在原核宿主中生产重组糖基化蛋白质的系统和方法

    公开(公告)号：US08703471B2

    公开(公告)日：2014-04-22

    申请号：US12219383

    申请日：2008-07-21

    申请人： Markus Aebi ,  Michael Wacker

    发明人： Markus Aebi ,  Michael Wacker

    IPC分类号： C12N1/20 ,  C12N15/00 ,  C12N9/10 ,  C12P21/06 ,  C12P21/04 ,  C07H21/04 ,  C07H21/02 ,  C07K1/00 ,  A61K38/00

    CPC分类号： C12P21/005 ,  A61K39/02 ,  A61K47/549 ,  C07K16/121 ,  C07K2317/92 ,  C12N9/1048

    摘要： A system and a method for the production of recombinant N-glycosylated target proteins. The system comprises a prokaryotic organism (e.g. Escherichia coli) into which is introduced a genetic information encoding for a metabolic apparatus capable of carrying out the requested N-glycosylation of the target protein. Said prokaryotic organism also contains the genetic information required for the expression of one or more recombinant target proteins. The metabolic apparatus preferably comprises specific glycosyltransferases for the assembly of the oligosaccharide on a lipid carrier and an OTase that covalently links this oligosaccharide to specific residues of the desired protein.

    摘要翻译： 用于生产重组N-糖基化靶蛋白的体系和方法。 该系统包含原核生物（例如大肠杆菌），其中引入了编码能够进行靶蛋白所要求的N-糖基化的代谢装置的遗传信息。 所述原核生物体还含有表达一种或多种重组靶蛋白所需的遗传信息。 代谢装置优选包含用于在脂质载体上装配寡糖的特异性糖基转移酶和共价连接该寡糖与所需蛋白质的特定残基的OTase。

    CAPSULAR GRAM-POSITIVE BACTERIA BIOCONJUGATE VACCINES
    4.
    发明申请
    CAPSULAR GRAM-POSITIVE BACTERIA BIOCONJUGATE VACCINES 有权

    公开(公告)号：US20110274720A1

    公开(公告)日：2011-11-10

    申请号：US13100603

    申请日：2011-05-04

    申请人： Michael Wacker ,  Michael Kowarik ,  Michael Wetter

    发明人： Michael Wacker ,  Michael Kowarik ,  Michael Wetter

    IPC分类号： A61K39/085 ,  A61P37/02 ,  A61P31/04 ,  A61K39/116 ,  C07K14/00

    CPC分类号： A61K39/085 ,  A61K2039/505 ,  A61K2039/575 ,  A61K2039/6037 ,  A61K2039/6087 ,  A61K2039/64 ,  A61K2039/70 ,  C07K14/21 ,  C07K16/1271 ,  C07K2317/734 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/034 ,  C07K2319/21 ,  C12N9/1029 ,  C12N9/1048 ,  C12N15/70 ,  C12N15/74 ,  Y02A50/47

    摘要： The present invention encompasses a novel S. aureus bioconjugate vaccine. More generally, the invention is directed to Gram-positive and other bioconjugate vaccines containing a protein carrier, at least one polysaccharide such as a capsular Gram-positive polysaccharide, and, optionally, an adjuvant or pharmaceutically acceptable carrier. The instant invention also includes methods of producing Gram-positive and other bioconjugate vaccines. An N-glycosylated protein is also provided that contains one or more polysaccharides such as Gram-positive polysaccharides. The invention is additionally directed to engineered prokaryotic organisms comprising nucleotide sequences encoding a glycosyltransferase of a first prokaryotic organism and a glycosyltransferase of a second prokaryotic organism. The invention further includes plasmids and prokaryotic cells transformed with plasmids encoding polysaccharides and enzymes which produce an N-glycosylated protein and/or bioconjugate vaccine. Further, the invention is directed to methods of inducing an immune response in a mammal comprising administering said bioconjugate vaccines.

    摘要翻译： 本发明包括一种新型金黄色葡萄球菌生物缀合物疫苗。 更一般地，本发明涉及含有蛋白质载体，至少一种多糖例如荚膜革兰氏阳性多糖和任选的佐剂或药学上可接受的载体的革兰氏阳性和其他生物缀合物疫苗。 本发明还包括生产革兰氏阳性和其他生物缀合疫苗的方法。 还提供了含有一种或多种多糖如革兰氏阳性多糖的N-糖基化蛋白质。 本发明还涉及包含编码第一原核生物的糖基转移酶和第二原核生物的糖基转移酶的核苷酸序列的工程化原核生物。 本发明还包括用编码多糖的质粒和产生N-糖基化蛋白质和/或生物缀合物疫苗的酶转化的质粒和原核细胞。 此外，本发明涉及在哺乳动物中诱导免疫应答的方法，包括施用所述生物缀合物疫苗。

    Biosynthetic system that produces immunogenic polysaccharides in prokaryotic cells
    5.
    发明授权
    Biosynthetic system that produces immunogenic polysaccharides in prokaryotic cells 有权
    在原核细胞中产生免疫原性多糖的生物合成系统

    公开(公告)号：US08846342B2

    公开(公告)日：2014-09-30

    申请号：US13510859

    申请日：2010-11-16

    申请人： Michael Wacker ,  Charles Waechter

    发明人： Michael Wacker ,  Charles Waechter

    IPC分类号： A61K39/00 ,  C07K14/21 ,  A61K39/385 ,  A61K39/112

    CPC分类号： A61K39/0258 ,  A61K39/0283 ,  A61K39/385 ,  A61K47/646 ,  A61K2039/6068 ,  Y02A50/47 ,  Y02A50/476

    摘要： The invention is directed to bioconjugate vaccines comprising N-glycosylated proteins. Further, the present invention is directed to a recombinant prokaryotic biosynthetic system comprising nucleic acids encoding an epimerase that synthesizes an oligo- or polysaccharide having N-acetylgalactosamine at the reducing terminus. The invention is further directed to N-glycosylated proteins containing an oligo- or polysaccharide having N-acetylgalactosamine at the reducing terminus and an expression system and methods for producing such N-glycosylated proteins.

    摘要翻译： 本发明涉及包含N-糖基化蛋白质的生物缀合疫苗。 此外，本发明涉及包含在还原末端合成具有N-乙酰半乳糖胺的寡糖或多糖的差向异构酶的核酸的重组原核生物合成系统。 本发明进一步涉及含有在还原末端具有N-乙酰半乳糖胺的寡糖或多糖的N-糖基化蛋白质和表达系统以及用于制备这种N-糖基化蛋白质的方法。

    System and method for the production of recombinant glycosylated proteins in a prokaryotic host
    8.
    发明申请
    System and method for the production of recombinant glycosylated proteins in a prokaryotic host 审中-公开
    用于在原核宿主中生产重组糖基化蛋白质的系统和方法

    公开(公告)号：US20050287628A1

    公开(公告)日：2005-12-29

    申请号：US10506917

    申请日：2003-03-05

    申请人： Markus Aebi ,  Michael Wacker

    发明人： Markus Aebi ,  Michael Wacker

    IPC分类号： A23L1/305 ,  A61K8/64 ,  A61K8/96 ,  A61K38/00 ,  A61K38/16 ,  A61K39/00 ,  A61K47/48 ,  C07H21/04 ,  C07K16/12 ,  C12N9/10 ,  C12N15/09 ,  C12P21/00 ,  C12P21/02 ,  C12P21/06

    CPC分类号： C12P21/005 ,  A61K39/02 ,  A61K47/549 ,  C07K16/121 ,  C07K2317/92 ,  C12N9/1048

    摘要： A system and a method for the production of recombinant N-glycosylated target proteins. The system comprises a prokaryotic organism (e.g. Escherichia coli) into which is introduced a genetic information encoding for a metabolic apparatus capable of carrying out the requested N-glycosylation of the target protein. Said prokaryotic organism also contains the genetic information required for the expression of one or more recombinant target proteins. The metabolic apparatus preferably comprises specific glycosyltransferases for the assembly of the oligosaccharide on a lipid carrier and an OTase that covalently links this oligosaccharide to specific residues of the desired protein.

    摘要翻译： 用于生产重组N-糖基化靶蛋白的体系和方法。 该系统包含原核生物（例如大肠杆菌），其中引入了编码能够进行靶蛋白所要求的N-糖基化的代谢装置的遗传信息。 所述原核生物体还含有表达一种或多种重组靶蛋白所需的遗传信息。 代谢装置优选包含用于在脂质载体上装配寡糖的特异性糖基转移酶和共价连接该寡糖与所需蛋白质的特定残基的OTase。

    System and method for the production of recombinant glycosylated proteins in a prokaryotic host
    10.
    发明申请
    System and method for the production of recombinant glycosylated proteins in a prokaryotic host 有权
    用于在原核宿主中生产重组糖基化蛋白质的系统和方法

    公开(公告)号：US20090074798A1

    公开(公告)日：2009-03-19

    申请号：US12219383

    申请日：2008-07-21

    申请人： Markus Aebi ,  Michael Wacker

    发明人： Markus Aebi ,  Michael Wacker

    IPC分类号： A61K39/00 ,  C12N1/21 ,  C12N9/00 ,  A61P31/00 ,  C12P21/04

    CPC分类号： C12P21/005 ,  A61K39/02 ,  A61K47/549 ,  C07K16/121 ,  C07K2317/92 ,  C12N9/1048

    摘要： A system and a method for the production of recombinant N-glycosylated target proteins. The system comprises a prokaryotic organism (e.g. Escherichia coli) into which is introduced a genetic information encoding for a metabolic apparatus capable of carrying out the requested N-glycosylation of the target protein. Said prokaryotic organism also contains the genetic information required for the expression of one or more recombinant target proteins. The metabolic apparatus preferably comprises specific glycosyltransferases for the assembly of the oligosaccharide on a lipid carrier and an OTase that covalently links this oligosaccharide to specific residues of the desired protein.

    摘要翻译： 用于生产重组N-糖基化靶蛋白的体系和方法。 该系统包含原核生物（例如大肠杆菌），其中引入了编码能够进行靶蛋白所要求的N-糖基化的代谢装置的遗传信息。 所述原核生物体还含有表达一种或多种重组靶蛋白所需的遗传信息。 代谢装置优选包含用于在脂质载体上装配寡糖的特异性糖基转移酶和共价连接该寡糖与所需蛋白质的特定残基的OTase。