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公开(公告)号：US6157030A
公开(公告)日：2000-12-05
申请号：US143398
申请日：1998-08-28
申请人： Minoru Sakairi , Tadao Mimura , Toshihiro Ishizuka , Masaru Tomioka , Yasuaki Takada , Takayuki Nabeshima
发明人： Minoru Sakairi , Tadao Mimura , Toshihiro Ishizuka , Masaru Tomioka , Yasuaki Takada , Takayuki Nabeshima
IPC分类号： H01J49/42
CPC分类号： H01J49/424
摘要： Disclosed is an ion trap mass spectrometer improved to obtain a high sensitivity without the lowering of resolution. By fitting a mesh electrode to an aperture (an ion sampling aperture or an ion extracting aperture) made in endcap electrodes constituting an ion trap mass analysis region, a radio frequency electric field in the mass analysis region is not disturbed even if the diameter of the aperture is set to a large value to heighten ion transmission efficiency. By fitting a shield electrode for preventing collision of ions with an insulated ring constituting an outer wall of the mass analysis region, charging up of the insulated ring is prevented to improve stability of detection signals. Furthermore, by arranging a shield member for shielding stray charged particles detouring through the circumference of the mass analysis region to approach an ion detector, generation of noises based on these stray charged particles is prevented.
摘要翻译： 公开了一种改进的离子阱质谱仪，可以在不降低分辨率的情况下获得高灵敏度。 通过将网状电极装配到构成离子阱质量分析区域的端盖电极中的孔（离子取样孔或离子提取孔）上，即使直径为 孔径被设定为大的值以提高离子传输效率。 通过安装用于防止离子与构成质量分析区域的外壁的绝缘环碰撞的屏蔽电极，防止了绝缘环的充电以提高检测信号的稳定性。 此外，通过设置用于屏蔽通过质量分析区域的圆周去除杂散带电粒子的屏蔽构件以接近离子检测器，防止了基于这些杂散带电粒子的噪声的产生。
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公开(公告)号：US5663560A
公开(公告)日：1997-09-02
申请号：US555192
申请日：1995-11-08
CPC分类号： H01J49/044 , H01J49/061
摘要： A method in which cutting of small droplets, neutral particles or photons through to a slit provided between a differential pumping portion and a mass analysis portion is combined with slight deflection of ions just before introduction of the ions into the mass analysis portion so that noises are greatly reduced without reduction of signals to thereby improve the signal-to-noise ratio which is an index of detecting sensitivity or lower limit.
摘要翻译： 将小液滴，中性粒子或光子穿过到设置在差分泵送部分和质量分析部分之间的狭缝的切割与在将离子引入质量分析部分之前的离子的轻微偏转相结合，使得噪声为 大大降低了信号的降低，从而提高作为检测灵敏度或下限的指标的信噪比。
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3.发明授权Method and apparatus for ionizing a sample under atmospheric pressure and selectively introducing ions into a mass analysis region 失效用于在大气压下电离样品并选择性地将离子引入质量分析区域的方法和装置
公开(公告)号：US6005245A
公开(公告)日：1999-12-21
申请号：US919785
申请日：1997-08-29
CPC分类号： H01J49/061 , H01J49/044
摘要： A method in which cutting of small droplets, neutral particles or photons through to a slit provided between a differential pumping portion and a mass analysis portion is combined with slight deflection of ions just before introduction of the ions into the mass analysis portion so that noises are greatly reduced without reduction of signals to thereby improve the signal-to-noise ratio which is an index of detecting sensitivity or lower limit.
摘要翻译： 将小液滴，中性粒子或光子穿过到设置在差分泵送部分和质量分析部分之间的狭缝的切割与在将离子引入质量分析部分之前的离子的轻微偏转相结合，使得噪声为 大大降低了信号的降低，从而提高作为检测灵敏度或下限的指标的信噪比。
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公开(公告)号：US06437327B2
公开(公告)日：2002-08-20
申请号：US09859508
申请日：2001-05-18
IPC分类号： H01J4910
CPC分类号： H01J49/165 , G01N30/7266 , H01J49/168
摘要： A mass spectrometer including a sprayer for spraying a sample solution, a needle electrode for ionizing the sample contained in the sample solution, an aperture for introducing the ions of the sample into a lower pressure region having a pressure lower than the pressure of a region in which the needle electrode is disposed, and a mass spectrometric apparatus for analyzing the ions introduced from the aperture. A direction of a spray caused by the sprayer is almost perpendicular to or at an angle with respect to a center axis of the aperture, and a tip of the needle is disposed facing to an electrode having the aperture.
摘要翻译： 一种质谱仪，包括用于喷射样品溶液的喷雾器，用于使包含在样品溶液中的样品电离的针状电极，用于将样品的离子引入低于区域压力的低压区域的孔 设置针状电极的质谱仪和用于分析从孔径引入的离子的质谱仪。 由喷雾器引起的喷雾方向几乎与孔的中心轴垂直或成一定角度，并且针的尖端面向具有孔的电极。
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5.发明授权Mass spectrometer and mass spectrometry method for analyzing compounds contained in a solution 有权用于分析溶液中所含化合物的质谱仪和质谱法
公开(公告)号：US6114693A
公开(公告)日：2000-09-05
申请号：US299638
申请日：1999-04-27
申请人： Atsumu Hirabayashi , Yukiko Hirabayashi , Minoru Sakairi , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
发明人： Atsumu Hirabayashi , Yukiko Hirabayashi , Minoru Sakairi , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
IPC分类号： G01N27/62 , G01N27/447 , G01N30/72 , H01J49/04 , H01J49/10
CPC分类号： G01N30/7266 , H01J49/0468 , H01J49/167
摘要： A mass spectrometer comprising a passage through which a sample solution flows, the passage including a capillary having an open tip, the sample solution flowing through the capillary out of the open tip of the capillary, a gas passage which forms a gas flow around the open tip of the capillary, the gas flow spraying the sample solution flowing out of the open tip of the capillary, a first electrode which contacts the sample solution flowing in the passage and applies an electric potential to the sample solution flowing in the passage, a second electrode disposed around the capillary near the open tip of the capillary, the second electrode being downstream from the first electrode with respect to a direction in which the sample solution flows in the passage, there being no gap extending downstream from the open tip of the capillary to the second electrode in a direction in which the sample solution flows out of the open tip of the capillary, the second electrode being electrically isolated from the sample solution flowing in the capillary and applying an electric field to the sample solution flowing in the capillary, and an analyzer which analyzes a mass of gaseous ions formed from the sample solution sprayed by the gas flow.
摘要翻译： 一种质谱仪，包括样品溶液流过的通道，所述通道包括具有开口尖端的毛细管，所述样品溶液从毛细管的开口尖端流过毛细管，气体通道围绕开口形成气流 毛细管的尖端，气流喷射从毛细管的开口尖端流出的样品溶液，第一电极，其接触在通道中流动的样品溶液，并向在通道中流动的样品溶液施加电位，第二电极 设置在毛细管附近的毛细管周围的电极，第二电极相对于样品溶液在通道中流动的方向从第一电极下游，在毛细管的开口尖端的下游没有间隙 在样品溶液从毛细管的开口尖端流出的方向到第二电极，第二电极是电隔离的 从在毛细管中流动的样品溶液流出并向在毛细管中流动的样品溶液施加电场，以及分析器，其分析由气流喷射的样品溶液形成的气态离子的质量。
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公开(公告)号：US6075243A
公开(公告)日：2000-06-13
申请号：US827184
申请日：1997-03-27
CPC分类号： H01J49/424 , H01J49/044 , H01J49/4255
摘要： A mass spectrometer in which, in order to reduce noise due to other particles (large charge droplets, neutral particles, photons, or the like), the orbit of ions and the orbit of other particles are separated from each other in the inside of a mass analysis region so as to make it possible to prevent the other particles from reaching an ion detection region without using any deflector.
摘要翻译： 一种质谱仪，其中为了减少由于其它颗粒（大电荷液滴，中性粒子，光子等）引起的噪声，离子的轨道和其它颗粒的轨道在一个 质量分析区域，使得可以防止其他颗粒在不使用任何偏转器的情况下到达离子检测区域。
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公开(公告)号：US6060706A
公开(公告)日：2000-05-09
申请号：US23461
申请日：1998-02-13
CPC分类号： H01J49/424 , H01J49/061
摘要： In an analytical apparatus, an ion trap mass spectrometer and a detector for detecting ions separated in the mass spectrometer are installed in different chambers. Ions generated from an ion source and passing through two differential pumping chambers into a third chamber containing the detector are deflected from their initial trajectory into the mass spectrometer in a fourth chamber for separation. In a first embodiment, the separated ions are returned along the same path into the detector in the third chamber. According to a second embodiment, the detector is located along the path of ion travel beyond the mass spectrometer, and the separated ions pass through a second orifice in the mass spectrometer and into the detector in the third chamber.
摘要翻译： 在分析装置中，离子阱质谱仪和用于检测在质谱仪中分离的离子的检测器安装在不同的室中。 从离子源产生并且通过两个差分泵送室的包含检测器的第三室中的离子从第一个进入第四室的初始轨迹偏转到质谱仪中进行分离。 在第一实施例中，分离的离子沿相同的路径返回到第三室中的检测器中。 根据第二实施例，检测器沿着离子行进的路径位于质谱仪之外，并且分离的离子通过质谱仪中的第二孔并进入第三室中的检测器。
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公开(公告)号：US06465779B2
公开(公告)日：2002-10-15
申请号：US09968928
申请日：2001-10-03
IPC分类号： H01J4942
CPC分类号： H01J49/067 , H01J49/04
摘要： A mass spectrometer comprising an ionization means for ionizing sample compounds to be analyzed mass spectroscopically in an atmospheric pressure, a sample solution supply means for supplying a solution containing the sample compounds to the ionization means, means for feeding the ions formed by the ionization means through an aperture disposed in an electrode into a vacuum region, and an ion trap type mass spectroscopic means for mass spectroscopically analyzing ions entered through the aperture into the vacuum region, in which an ion decelerating electric field forming means is disposed between the electrode disposed with the aperture and an electrode disposed with an ion entrance opening for entering the ions into the ion trap type mass spectroscopic means for forming an electric field for decelerating the ions, and the ions injected to the ion trap mass spectroscopic means is lowered. This facilitates accumulation ions in the ion trap mass spectralyzing means even if a high drift voltage is used thereby enabling high sensitivity analysis for polar compounds such as peptides.
摘要翻译： 一种质谱仪，其特征在于，包括：离子化装置，用于在大气压下对质谱进行质谱分析的样品化合物进行离子化;将含有所述样品化合物的溶液供给到所述电离装置的样品溶液供给装置，将由所述电离装置形成的离子供给 将设置在电极中的孔设置在真空区域中，以及离子阱型质谱分析装置，用于对通过孔进入真空区域的离子进行质谱分析，其中离子减速电场形成装置设置在 孔和设置有离子入口的电极，用于将离子进入离子阱型质谱分析装置，用于形成用于使离子减速的电场，并且注入离子阱质谱分析装置的离子降低。 即使使用高漂移电压，这也有助于离子阱质谱分析手段中的积聚离子，从而能够对极性化合物如肽进行高灵敏度分析。
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公开(公告)号：US06316769B2
公开(公告)日：2001-11-13
申请号：US09739217
申请日：2000-12-19
IPC分类号： H01J4942
CPC分类号： H01J49/067 , H01J49/04
摘要： A mass spectrometer comprising an ionization means for ionizing sample compounds to be analyzed mass spectro-scopically in an atmospheric pressure, a sample solution supply means for supplying a solution containing the sample compounds to the ionization means, means for feeding the ions formed by the ionization means through an aperture disposed in an electrode into a vacuum region and a ion trap type mass spectroscopic means for mass spectroscopically analyzing ions entered through the aperture into the vacuum region, in which an ion decelerating electric field forming means is disposed between the electrode disposed with the aperture and an electrode disposed with an ion entrance opening for entering the ions into the ion trap type mass spectroscopic means for forming an electric field for decelerating the ions, and the ions injected to the ion trap mass spectroscopic means is lowered. This facilitates accumulation ions in the ion trap mass spectralyzing means even if a high drift voltage is used thereby enabling high sensitivity analysis for polar compounds such as peptides.
摘要翻译： 一种质谱仪，其特征在于，包括：离子化装置，用于将大气压力分散分析的样品化合物离子化;将含有样品化合物的溶液供给到电离装置的样品溶液供给装置， 意味着通过设置在电极中的孔进入真空区域和离子阱型质谱分析装置，用于质谱分析通过孔进入真空区域的离子，其中离子减速电场形成装置设置在设置有 所述孔和电极设置有离子入口，用于将离子进入离子阱型质谱分析装置，用于形成用于使离子减速的电场，以及注入离子阱质谱分析装置的离子。 即使使用高漂移电压，这也有助于离子阱质谱分析手段中的积聚离子，从而能够对极性化合物如肽进行高灵敏度分析。
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公开(公告)号：US06252225B1
公开(公告)日：2001-06-26
申请号：US09492352
申请日：2000-01-27
IPC分类号： H01J4910
CPC分类号： H01J49/165 , G01N30/7266 , H01J49/168
摘要： A mass spectrometer including a sprayer for spraying a sample solution, a needle electrode for ionizing the sample contained in the sample solution, an aperture for introducing the ions of the sample into a lower pressure region having a pressure lower than the pressure of a region in which the needle electrode is disposed, and a mass spectrometric apparatus for analyzing the ions introduced from the aperture. A direction of a spray caused by the sprayer is almost perpendicular to a center axis of the aperture and a tip of the needle is disposed facing to an electrode having the aperture.
摘要翻译： 一种质谱仪，包括用于喷射样品溶液的喷雾器，用于使包含在样品溶液中的样品电离的针状电极，用于将样品的离子引入低于区域压力的低压区域的孔 设置针状电极的质谱仪和用于分析从孔径引入的离子的质谱仪。 由喷雾器引起的喷雾方向几乎垂直于孔的中心轴线，并且针的尖端面向具有孔的电极设置。
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