公开(公告)号：US20090304643A1

公开(公告)日：2009-12-10

申请号：US12162523

申请日：2007-01-30

申请人： Moshe Khurgel ,  Adam J. Katz

发明人： Moshe Khurgel ,  Adam J. Katz

IPC分类号： A61K35/12 ,  C12N5/06 ,  C12N5/08

CPC分类号： C12N5/0667 ,  A61K47/6901 ,  C12N2500/25 ,  C12N2500/36 ,  C12N2500/42 ,  C12N2501/10 ,  C12N2501/11 ,  C12N2501/135 ,  C12N2501/15 ,  C12N2501/23 ,  C12N2501/39 ,  C12N2501/392

摘要： The invention provides compositions and methods for preparing and characterizing multipotential mesenchymal stem cell aggregates. The invention further provides methods for using stem cell aggregates of the invention.

摘要翻译： 本发明提供了用于制备和表征多潜能间充质干细胞聚集体的组合物和方法。 本发明还提供了使用本发明的干细胞聚集体的方法。

公开(公告)号：US08592209B2

公开(公告)日：2013-11-26

申请号：US12162523

申请日：2007-01-30

申请人： Moshe Khurgel ,  Adam J. Katz

发明人： Moshe Khurgel ,  Adam J. Katz

IPC分类号： C12N5/02

CPC分类号： C12N5/0667 ,  A61K47/6901 ,  C12N2500/25 ,  C12N2500/36 ,  C12N2500/42 ,  C12N2501/10 ,  C12N2501/11 ,  C12N2501/135 ,  C12N2501/15 ,  C12N2501/23 ,  C12N2501/39 ,  C12N2501/392

摘要： The invention provides compositions and methods for preparing and characterizing multipotential mesenchymal stem cell aggregates. The invention further provides methods for using stem cell aggregates of the invention.

摘要翻译： 本发明提供了用于制备和表征多潜能间充质干细胞聚集体的组合物和方法。 本发明还提供了使用本发明的干细胞聚集体的方法。

公开(公告)号：US20130224858A1

公开(公告)日：2013-08-29

申请号：US13852463

申请日：2013-03-28

申请人： Adam J. Katz ,  Ramon Llull ,  J. William Futrell ,  Marc H. Hedrick ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu

发明人： Adam J. Katz ,  Ramon Llull ,  J. William Futrell ,  Marc H. Hedrick ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu

IPC分类号： C12N5/07

CPC分类号： C12N5/0667 ,  A61K35/12 ,  A61K48/00 ,  C12N5/0068 ,  C12N5/06 ,  C12N5/0647 ,  C12N5/0654 ,  C12N5/0655 ,  C12N5/0658 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2500/42 ,  C12N2501/01 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2502/1305 ,  C12N2506/1384 ,  C12N2510/00 ,  C12N2533/90

摘要： The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The cells can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the cells can be expanded and cultured to produce hormones and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a lipo-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.

公开(公告)号：US20130217118A1

公开(公告)日：2013-08-22

申请号：US13712546

申请日：2012-12-12

申请人： Adam J. Katz ,  Ramon Llull ,  J. William Futrell ,  Marc H. Hedrick ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu ,  Patricia Zuk

发明人： Adam J. Katz ,  Ramon Llull ,  J. William Futrell ,  Marc H. Hedrick ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu ,  Patricia Zuk

IPC分类号： C12N5/071

CPC分类号： C12N5/0653 ,  A61K35/12 ,  A61K48/00 ,  C12N5/0068 ,  C12N5/0607 ,  C12N5/0647 ,  C12N5/0654 ,  C12N5/0655 ,  C12N5/0658 ,  C12N5/0667 ,  C12N9/1276 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2500/42 ,  C12N2501/01 ,  C12N2501/15 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2510/00 ,  C12N2533/90 ,  C12Y207/07049

摘要： The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.

公开(公告)号：US20120208274A1

公开(公告)日：2012-08-16

申请号：US13408840

申请日：2012-02-29

申请人： Adam J. Katz ,  Ramon Llull ,  J. William Futrell ,  Marc H. Hedrick ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu ,  Patricia Zuk ,  Peter H. Ashjian

发明人： Adam J. Katz ,  Ramon Llull ,  J. William Futrell ,  Marc H. Hedrick ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu ,  Patricia Zuk ,  Peter H. Ashjian

IPC分类号： C12N5/0775

CPC分类号： C12N5/0653 ,  A61K35/12 ,  A61K48/00 ,  C12N5/0068 ,  C12N5/0607 ,  C12N5/0647 ,  C12N5/0654 ,  C12N5/0655 ,  C12N5/0658 ,  C12N5/0667 ,  C12N9/1276 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2500/42 ,  C12N2501/01 ,  C12N2501/15 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2510/00 ,  C12N2533/90 ,  C12Y207/07049

摘要： The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.

摘要翻译： 本发明单独提供脂肪来源的干细胞（ADSCs），脂肪来源的干细胞富含级分（ADSC-EF）和脂肪衍生的格子，并与本发明的ADSC组合。 一方面，本发明提供了基本上不含结缔组织干细胞的脂肪细胞和红细胞和克隆群体的ADSC。 ADSC可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。 另外，可以扩增和培养ADSC以产生分子如激素，并提供条件培养基以支持其它细胞群的生长和扩增。 另一方面，本发明提供了一种基本上不含细胞的脂肪衍生的晶格，其包括来自脂肪组织的细胞外基质材料。 晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。

公开(公告)号：US20150376572A1

公开(公告)日：2015-12-31

申请号：US14581956

申请日：2014-12-23

申请人： Adam J. Katz ,  Ramon Llull ,  J. William Futrell ,  Marc H. Hedrick ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu ,  Patricia Zuk ,  Peter H. Ashjian

发明人： Adam J. Katz ,  Ramon Llull ,  J. William Futrell ,  Marc H. Hedrick ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu ,  Patricia Zuk ,  Peter H. Ashjian

IPC分类号： C12N5/077 ,  C12N9/12

CPC分类号： C12N5/0653 ,  A61K35/12 ,  A61K48/00 ,  C12N5/0068 ,  C12N5/0607 ,  C12N5/0647 ,  C12N5/0654 ,  C12N5/0655 ,  C12N5/0658 ,  C12N5/0667 ,  C12N9/1276 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2500/42 ,  C12N2501/01 ,  C12N2501/15 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2510/00 ,  C12N2533/90 ,  C12Y207/07049

摘要： The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.

摘要翻译： 本发明单独提供脂肪来源的干细胞（ADSCs），脂肪来源的干细胞富含级分（ADSC-EF）和脂肪衍生的格子，并与本发明的ADSC组合。 一方面，本发明提供了基本上不含结缔组织干细胞的脂肪细胞和红细胞和克隆群体的ADSC。 ADSC可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。 另外，可以扩增和培养ADSC以产生分子如激素，并提供条件培养基以支持其它细胞群的生长和扩增。 另一方面，本发明提供了一种基本上不含细胞的脂肪衍生的晶格，其包括来自脂肪组织的细胞外基质材料。 晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。

公开(公告)号：US07470537B2

公开(公告)日：2008-12-30

申请号：US10740315

申请日：2003-12-17

申请人： Marc H. Hedrick ,  Adam J. Katz ,  Ramón Llull ,  J. William Futrell ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu

发明人： Marc H. Hedrick ,  Adam J. Katz ,  Ramón Llull ,  J. William Futrell ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu

IPC分类号： C12N5/00

CPC分类号： C12N5/0667 ,  A61K35/12 ,  A61K48/00 ,  C12N5/0068 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2500/42 ,  C12N2501/01 ,  C12N2501/15 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2510/00 ,  C12N2533/90

摘要： The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides an adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.

摘要翻译： 本发明单独提供脂肪来源的干细胞（ADSCs），脂肪来源的干细胞富含级分（ADSC-EF）和脂肪衍生的格子，并与本发明的ADSC组合。 一方面，本发明提供了基本上不含结缔组织干细胞的脂肪细胞和红细胞和克隆群体的ADSC。 ADSC可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。 另外，可以扩增和培养ADSC以产生分子如激素，并提供条件培养基以支持其它细胞群的生长和扩增。 另一方面，本发明提供了基本上不含细胞的脂肪衍生的晶格，其包括来自脂肪组织的细胞外基质材料。 晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。

公开(公告)号：US20080213235A1

公开(公告)日：2008-09-04

申请号：US11995408

申请日：2006-07-28

申请人： Adam J. Katz ,  Shayn Peirce Cottler

发明人： Adam J. Katz ,  Shayn Peirce Cottler

IPC分类号： A61K35/12 ,  C12N5/06 ,  A61P9/00

CPC分类号： C12N5/0667 ,  A61K35/12 ,  A61K48/00

摘要： The present invention provides methods for growing and inducing perivascular cell differentiation of adipose tissue-derived stromal cells. The invention further provides methods for administering such adipose tissue-derived cells to a subject. The cells of the invention are useful for treating diseases, disorders, conditions, and injuries requiring new or enhanced angiogenesis, vascular remodeling, drug delivery, and tissue engineering.

摘要翻译： 本发明提供了用于生长和诱导脂肪组织来源的基质细胞的血管周围细胞分化的方法。 本发明还提供了将这种脂肪组织衍生的细胞施用于受试者的方法。 本发明的细胞可用于治疗需要新的或增强的血管发生，血管重塑，药物递送和组织工程的疾病，病症，病症和损伤。

公开(公告)号：US20100183519A1

公开(公告)日：2010-07-22

申请号：US12663583

申请日：2008-06-06

申请人： Adam J. Katz ,  George T. Rodeheaver

发明人： Adam J. Katz ,  George T. Rodeheaver

IPC分类号： A61K49/00 ,  A61K31/08 ,  A61K35/12 ,  A61K35/14 ,  A61K31/616 ,  A61K31/522 ,  A61K31/4365 ,  A61K31/56 ,  A61K38/18 ,  A61K31/635 ,  A61K31/7048 ,  A61K38/12 ,  A61K33/18 ,  A61K33/40 ,  A61P31/12 ,  A61P31/10 ,  A61P31/04 ,  A61P17/02

CPC分类号： A61K31/785 ,  A61K9/0014 ,  A61K31/77 ,  A61K45/06 ,  A61K47/10 ,  A61L15/26 ,  A61L15/44 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/426 ,  A61L2300/43 ,  A61L2300/602 ,  A61L2300/64 ,  C08L71/02 ,  A61K2300/00

摘要： This invention relates to therapeutic compositions comprising a surface active copolymer, such as poloxamer-188, in an amount effective to enhance microvascular blood flow and/or inflammation in injured skin or other tissue, and methods of using the therapeutic compositions of the invention to inhibit decreased blood flow associated with an injury, disease, or disorder.

摘要翻译： 本发明涉及包含有效增强微血管血流量和/或损伤的皮肤或其他组织中的炎症的量的表面活性共聚物如泊洛沙姆-188的治疗组合物，以及使用本发明的治疗组合物抑制 减少与损伤，疾病或病症相关的血流量。

公开(公告)号：US20100111897A1

公开(公告)日：2010-05-06

申请号：US12444412

申请日：2007-10-05

申请人： Adam J. Katz ,  Anna M. Parker

发明人： Adam J. Katz ,  Anna M. Parker

IPC分类号： A61K38/20 ,  A61K35/12 ,  A61P3/10 ,  A61P17/02

CPC分类号： A61K35/28 ,  A61K38/18 ,  A61K38/19 ,  A61K2300/00

摘要： The invention provides compositions and methods useful for treating wounds and enhancing wound healing, particularly for diabetic wound healing.

摘要翻译： 本发明提供了用于治疗伤口并增强伤口愈合的组合物和方法，特别是对于糖尿病伤口愈合。