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    COMBINATORIAL DESIGN OF HIGHLY EFFICIENT HETEROLOGOUS PATHWAYS
    3.
    发明申请
    COMBINATORIAL DESIGN OF HIGHLY EFFICIENT HETEROLOGOUS PATHWAYS 审中-公开
    高效率异常路径的组合设计

    公开(公告)号：US20130295631A1

    公开(公告)日：2013-11-07

    申请号：US13877144

    申请日：2011-10-03

    申请人： Huimin Zhao ,  Byoungjin Kim ,  Jing Du ,  Yongbo Yuan ,  Dawn Eriksen ,  Tong Si

    发明人： Huimin Zhao ,  Byoungjin Kim ,  Jing Du ,  Yongbo Yuan ,  Dawn Eriksen ,  Tong Si

    IPC分类号： C12P7/06

    CPC分类号： C12P7/06 ,  C07K14/39 ,  C12N9/0006 ,  C12N9/1205 ,  C12N9/2445 ,  C12N15/1093 ,  C12N15/52 ,  C12N15/81 ,  C12P7/10 ,  C12Y101/01009 ,  C12Y101/0101 ,  C12Y101/01307 ,  C12Y207/01017 ,  C12Y302/01021 ,  Y02E50/16 ,  Y02E50/17

    摘要： The present disclosure relates to the production of highly efficient heterologous pathways in host cells by identifying favorable enzyme and/or promoter combinations. In particular the present disclosure provides methods for assembly and selection of multi-step xylose and arabinose/xylose utilization pathways from a library of fungal enzymes. The present disclosure further provides compositions containing favorable enzyme combinations, as well as recombinant yeast expressing such combinations, and methods of use for bioconversion of pentose sugars. Also provided are compositions and methods involving favorable expression patterns identified by utilization of combinations of promoters of varying strengths. Provided herein are methods for assembly and selection of multi-step xylose, arabinose/xylose, and cellobiose utilization pathways from a library of promoters of varying strengths. The present disclosure further provides compositions containing heterologous enzyme-coding polynucleotides under the control of favorable promoters, as well as recombinant yeast expressing such enzymes, and methods of their use for bioconversion of pentose and/or hexose sugars.

    摘要翻译： 本公开涉及通过鉴定有利的酶和/或启动子组合在宿主细胞中产生高效的异源途径。 特别地，本公开提供了从真菌酶文库中组装和选择多步木糖和阿拉伯糖/木糖利用途径的方法。 本公开进一步提供含有有利的酶组合的组合物，以及表达这种组合的重组酵母以及用于戊糖的生物转化的方法。 还提供了包括通过利用不同强度的启动子的组合鉴定的有利的表达模式的组合物和方法。 本文提供了用于从不同强度的启动子文库中组装和选择多步木糖，阿拉伯糖/木糖和纤维二糖利用途径的方法。 本公开进一步提供了含有有利启动子控制的异源酶编码多核苷酸的组合物，以及表达这些酶的重组酵母，以及它们用于戊糖和/或己糖的生物转化的方法。

    Method and Apparatus for Real-time Inter-organizational Probabilistic Simulation
    4.
    发明申请
    Method and Apparatus for Real-time Inter-organizational Probabilistic Simulation 审中-公开
    用于实时组织间概率模拟的方法和装置

    公开(公告)号：US20150006122A1

    公开(公告)日：2015-01-01

    申请号：US13929903

    申请日：2013-06-28

    申请人： Jing Du

    发明人： Jing Du

    IPC分类号： G06F17/50

    CPC分类号： G06F17/5009 ,  G06F2217/10

    摘要： A method enables multiuser and distributed “what you see is what you get” probabilistic simulation. A method projects a problem P into k sub-problem spaces with at least 1 dimension, and executes the sub-simulations for each sub-problem in parallel with user's model initialization and parameterization process. A method utilizes “Simulate As You Operate” (SAYO) and “Batch Generation Batch Computation” (BGBC) techniques to perform data retrieval, random number generation and simulation in parallel with the user's model initialization and parameterization process. An apparatus only repeats the simulation process on the affected part of the model and holds the model inputs/outputs of unaffected part of the model fixed. A communication protocol allows users at different sites or different organizations to perform real-time simulations on the same model. An apparatus enables a process of sharing and benchmarking the model-associated statistics by aggregating and publishing the submitted information by users.

    摘要翻译： 一种方法可以让多用户和分布式“你所看到的是你所得到的”概率模拟。 一种方法将问题P投入到具有至少1维的k个子问题空间中，并且与用户的模型初始化和参数化过程并行执行每个子问题的子模拟。 一种使用“模拟操作”（SAYO）和“批量生成批量计算”（BGBC）技术，与用户的模型初始化和参数化过程并行执行数据检索，随机数生成和仿真。 一个装置只重复对模型的影响部分的模拟过程，并保持模型的不受影响部分的模型输入/输出。 通信协议允许不同站点或不同组织的用户在同一型号上执行实时仿真。 通过聚合和发布用户提交的信息，设备可以实现共享和基准模型相关统计的过程。

    Lighting device having at least one heat sink
    7.
    发明授权
    Lighting device having at least one heat sink 有权
    吡嗪衍生物，其制备方法和用途

    公开(公告)号：US08796281B2

    公开(公告)日：2014-08-05

    申请号：US13254653

    申请日：2011-07-01

    申请人： Yuqiang Wang ,  Yewei Sun ,  Pei Yu ,  Jing Du ,  Gaoxiao Zhang

    发明人： Yuqiang Wang ,  Yewei Sun ,  Pei Yu ,  Jing Du ,  Gaoxiao Zhang

    IPC分类号： A61K31/4965 ,  C07D241/26

    CPC分类号： C07D241/12 ,  C07D241/24 ,  C07D241/42 ,  C07D495/04

    摘要： The present invention provides pyrazine derivatives of formula I and pharmaceutically acceptable salts thereof, wherein the designation of R1, R2, R3 and R4 is provided herein. The invention also provides syntheses for preparation of such compounds. The invention further provides methods of use of these compounds and pharmaceutical compositions containing them for treatment and/or prevention of diseases and for manufacture of medicaments. These compounds and pharmaceutical compositions have antioxidative and thrombolytic effects, and thus can be used for the treatment and/or prevention of cerebral stroke caused by ischemia, and used for manufacture of medicaments for the treatment and/or prevention of nervous system diseases caused by excessive amount of radicals and/or thrombosis, infectious diseases, metabolic system diseases, cardiovascular and cerebrovascular diseases, and age-related degenerative diseases.

    摘要翻译： 本发明提供式I的吡嗪衍生物及其药学上可接受的盐，其中R1，R2，R3和R4的名称在本文中提供。 本发明还提供了用于制备这些化合物的合成。 本发明还提供了使用这些化合物和含有它们的药物组合物用于治疗和/或预防疾病和制备药物的方法。 这些化合物和药物组合物具有抗氧化和溶栓作用，因此可用于治疗和/或预防由局部缺血引起的脑卒中，并用于制备用于治疗和/或预防由过度引起的神经系统疾病的药物 自由基和/或血栓形成的数量，传染病，代谢系统疾病，心血管和脑血管疾病以及年龄相关的退行性疾病。

    Cancer Treatment Equipment
    8.
    发明申请
    Cancer Treatment Equipment 审中-公开
    癌症治疗设备

    公开(公告)号：US20100145398A1

    公开(公告)日：2010-06-10

    申请号：US12514673

    申请日：2007-11-05

    申请人： Fusheng Li ,  An Li ,  Jing Du ,  Xiaomei Yang

    发明人： Fusheng Li ,  An Li ,  Jing Du ,  Xiaomei Yang

    IPC分类号： A61N1/00 ,  A61N1/30

    CPC分类号： A61N7/00 ,  A61B18/18 ,  A61H7/005 ,  A61N1/32 ,  A61N2/002 ,  A61N5/04

    摘要： A cancer treatment equipment includes a case (7), a squeeze-type friction head (1) connected to direct current, a stiction friction head (2) of low-middle frequency current, a friction head (3) with magnetic sheet, a medicated gauze pad fixation clamp (4), a medicated gauze pad (5) and a treatment device of RF, microwave or ultrasonic. The squeeze-type friction head (1) connected to direct current, the stiction friction head (2) of low-middle frequency current and the friction head (3) with magnetic sheet are fixed in the case (7) in parallel. The medicated gauze pad (5) is fixed on the medicated gauze pad fixation clamp (4) on the lower part of the case (7).

    摘要翻译： 癌症治疗设备包括壳体（7），与直流电连接的挤压式摩擦头（1），低中频电流的静摩擦头（2），具有磁性片的摩擦头（3）， 药剂纱布固定夹（4），药用纱布垫（5）和RF，微波或超声波处理装置。 与直流电连接的挤压式摩擦头（1），低中频电流的静摩擦头（2）和磁片的摩擦头（3）平行地固定在壳体（7）中。 药物纱布垫（5）固定在药盒（7）的下部的药物纱布垫固定夹（4）上。