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公开(公告)号:US20170119886A1
公开(公告)日:2017-05-04
申请号:US15341924
申请日:2016-11-02
发明人: Jed JOHNSON , Devan OHST , Jason CHAKROFF
CPC分类号: A61K47/34 , A61K49/0002 , A61K49/0409 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/58 , D01D5/0038 , D01F1/09 , D01F1/10 , C08L67/04
摘要: A fiber may comprise an electrospun polymer and a contrast agent. A method of making an electrospun fiber may comprise configuring a receiving surface to receive a polymer fiber, applying a charge to one or more of the receiving surface, a polymer injection system, and a polymer solution ejected from the polymer injection system, and depositing a polymer solution ejected from the polymer injection system onto the receiving surface. The polymer solution may comprise a polymer and a contrast agent.
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2.
公开(公告)号:US20180161185A1
公开(公告)日:2018-06-14
申请号:US15842228
申请日:2017-12-14
发明人: McKenzie Jacob KRESSLEIN , Brandon Javier BORJA , Jed JOHNSON , Tyler Matthew GROEHL , Devan OHST , Quang Quoc TRAN , Kevin J. NELSON
CPC分类号: A61F2/90 , A61B17/12109 , A61B17/12113 , A61B17/12172 , A61B17/12177 , A61B2017/00004 , A61B2017/00526 , A61F2/06 , A61L31/022 , A61L31/041 , A61L31/08 , A61L31/14 , A61L31/146 , A61L31/148 , A61L2430/36 , D01D5/003 , D01D5/0038 , D01D5/0076 , D01D5/0084
摘要: The instant disclosure is directed to medical devices having a lattice framework. The lattice framework may comprise a plurality of interconnected polymeric electrospun fiber members, or may comprise one or more wires formed into a plurality of interconnected members. The lattice framework may be substantially tubular, or may have a bowtie or cone configuration. The medical devices described herein may find particular uses as stents, flow diverters, and occlusive devices. The instant disclosure is also directed to methods of making such medical devices, using electrospinning and processing techniques.
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公开(公告)号:US20190054036A1
公开(公告)日:2019-02-21
申请号:US16104517
申请日:2018-08-17
发明人: Jed JOHNSON , Katie KAFFENBARGER , Devan OHST , Ross KAYUHA
IPC分类号: A61K9/70 , A61K31/05 , A61K9/00 , A61K47/34 , A61K47/32 , A61K47/44 , A61K47/10 , D01D5/00 , D01F1/10 , D01F6/62 , D01F6/16 , D01F6/66
摘要: A fiber may comprise an electrospun polymer and a pharmaceutical. The pharmaceutical may be dispersed within the electrospun polymer, and may have the form of a crystal, an oil, or a combination thereof. A method of making an electrospun fiber may comprise configuring a receiving surface to receive a polymer fiber, applying a charge to one or more of the receiving surface, a polymer injection system, and a polymer solution ejected from the polymer injection system, and depositing a polymer solution ejected from the polymer injection system onto the receiving surface. The polymer solution may comprise a polymer and a pharmaceutical. A method of treating a disorder in a subject may comprise obtaining such a fiber having an effective amount of a pharmaceutical, applying the fiber to an oral region of the subject, and allowing the fiber to disintegrate, thereby delivering the effective amount of the pharmaceutical to the subject.
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公开(公告)号:US20180221537A1
公开(公告)日:2018-08-09
申请号:US15887301
申请日:2018-02-02
发明人: Jed JOHNSON , Jason CHAKROFF , Devan OHST , Brian COHEN , Anthony ROMEO
CPC分类号: A61L27/18 , A61B17/0401 , A61B2017/00526 , A61B2017/00884 , A61B2017/0406 , A61B2017/0414 , A61B2017/0464 , A61B2017/0495 , A61F2/0811 , A61F2002/0852 , A61F2002/0858 , A61L27/10 , A61L27/12 , A61L27/3662 , A61L27/46 , A61L2300/64 , A61L2430/10 , C08L67/04
摘要: The instant disclosure is directed to methods of improving bone-soft tissue healing using biocompatible electrospun polymer fibers. In one embodiment, a method may include locating a portion of a subject's bone, affixing a tendon or ligament to the bone using a hardware fixture, and placing a patch comprising at least one electrospun polymer fiber in physical communication with both the bone and the tendon or ligament. In some embodiments, the bone may be a humerus, and the tendon or ligament may be a supraspinatus tendon. In certain embodiments, the patch may comprise substantially parallel electrospun polymer fibers, and may be placed such that the fibers are also substantially parallel with the long axis of the tendon or ligament.
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