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    Raised surface assay plate
    3.
    发明授权
    Raised surface assay plate 失效
    升高的表面测定板

    公开(公告)号：US07763455B2

    公开(公告)日：2010-07-27

    申请号：US10556996

    申请日：2004-05-13

    申请人： Michael Cima ,  Wendy Pryce-Lewis ,  Javier Gonzalez-Zugasti ,  J. Richard Gyory ,  Anthony Lemmo ,  Julie Monagle

    发明人： Michael Cima ,  Wendy Pryce-Lewis ,  Javier Gonzalez-Zugasti ,  J. Richard Gyory ,  Anthony Lemmo ,  Julie Monagle

    IPC分类号： C12M1/20 ,  A61F13/00 ,  A61K9/70

    CPC分类号： B01L3/5085 ,  B01L3/5025 ,  B01L3/5088 ,  B01L2300/0609 ,  B01L2300/0819 ,  B01L2300/0829

    摘要： The assay plate includes a substrate having an substrate surface and at least one raised pad extending from the substrate surface. The raised pad includes a substantially planar sample receiving surface configured for holding a sample thereon for in situ experimentation. The sample receiving surface preferably has at least one sharp edge at the junction between a sidewall coupling the sample receiving surface to the substrate surface. The sample receiving surface is preferably a circle, oval, square, rectangle, triangle, pentagon, hexagon, or octagon shape that is sized to hold a predetermined volume of the sample. A method of using the above described assay plate is also provided. Once a raised pad extending from a substrate is formed, a sample is deposited on the raised pad. Experiments are subsequently performed using the sample on the raised pad.

    摘要翻译： 测定板包括具有基底表面的基底和从基底表面延伸的至少一个凸起垫。 凸起垫包括基本平坦的样品接收表面，其构造成用于将样品保持在其上用于原位实验。 样品接收表面优选在将样品接收表面耦合到衬底表面的侧壁之间的接合处具有至少一个尖锐边缘。 样品接收表面优选为圆形，椭圆形，正方形，矩形，三角形，五边形，六边形或八边形，其尺寸适于保持样品的预定体积。 还提供了使用上述测定板的方法。 一旦形成了从衬底延伸的凸起垫，则将样品沉积在凸起垫上。 随后使用凸起垫上的样品进行实验。

    Raised surface assay plate
    4.
    发明授权
    Raised surface assay plate 失效
    升高的表面测定板

    公开(公告)号：US07449307B2

    公开(公告)日：2008-11-11

    申请号：US10694639

    申请日：2003-10-27

    申请人： Michael Cima ,  Wendy Pryce Lewis ,  Javier Gonzalez-Zugasti ,  J. Richard Gyory ,  Anthony V. Lemmo ,  Julie Monagle

    发明人： Michael Cima ,  Wendy Pryce Lewis ,  Javier Gonzalez-Zugasti ,  J. Richard Gyory ,  Anthony V. Lemmo ,  Julie Monagle

    IPC分类号： A61K9/70 ,  G01N13/04 ,  G01N1/28 ,  C12Q1/24

    CPC分类号： B01L3/5085 ,  B01L3/5025 ,  B01L3/5088 ,  B01L2300/0609 ,  B01L2300/0819 ,  B01L2300/0829

    摘要： The assay plate includes a substrate having an substrate surface and at least one raised pad extending from the substrate surface. The raised pad includes a substantially planar sample receiving surface configured for holding a sample thereon for in situ experimentation. The sample receiving surface preferably has at least one sharp edge at the junction between a sidewall coupling the sample receiving surface to the substrate surface. The sample receiving surface is preferably a circle, oval, square, rectangle, triangle, pentagon, hexagon, or octagon shape that is sized to hold a predetermined volume of the sample. A method of using the above described assay plate is also provided. Once a raised pad extending from a substrate is formed, a sample is deposited on the raised pad. Experiments are subsequently performed using the sample on the raised pad.

    摘要翻译： 测定板包括具有基底表面的基底和从基底表面延伸的至少一个凸起垫。 凸起垫包括基本平坦的样品接收表面，其构造成用于将样品保持在其上用于原位实验。 样品接收表面优选在将样品接收表面耦合到衬底表面的侧壁之间的接合处具有至少一个尖锐边缘。 样品接收表面优选为圆形，椭圆形，正方形，矩形，三角形，五边形，六边形或八边形，其尺寸适于保持样品的预定体积。 还提供了使用上述测定板的方法。 一旦形成了从衬底延伸的凸起垫，则将样品沉积在凸起垫上。 随后使用凸起垫上的样品进行实验。

    ELECTROCHEMICAL ACTUATORS
    5.
    发明申请
    ELECTROCHEMICAL ACTUATORS 有权
    电化学执行器

    公开(公告)号：US20120175998A1

    公开(公告)日：2012-07-12

    申请号：US13328504

    申请日：2011-12-16

    申请人： Yet-Ming Chiang ,  Timothy E. Chin ,  Michael J. Cima ,  J. Richard Gyory

    发明人： Yet-Ming Chiang ,  Timothy E. Chin ,  Michael J. Cima ,  J. Richard Gyory

    IPC分类号： H02N11/00

    CPC分类号： H01M14/00 ,  F03G7/005 ,  H01M4/131 ,  H01M4/134 ,  H01M10/052 ,  H01M10/058

    摘要： Devices and methods for providing electrochemical actuation are described herein. In one embodiment, an actuator device includes an electrochemical cell including a negative electrode and a positive electrode At least a portion of the negative electrode is formed with a material formulated to at least one of intercalate, de-intercalate, alloy with, oxidize, reduce, or plate with a first portion of the positive electrode to an extent different than with a second portion of the positive electrode such that a differential strain is imparted between the first portion and the second portion of the positive electrode and such that at least a portion of the electrochemical cell is displaced. The electrochemical cell includes a portion that is pre-bent along an axis of the electrochemical cell to define a fold axis and the displacement of the at least a portion of the electrochemical cell is maximized along the fold axis.

    摘要翻译： 本文描述了用于提供电化学致动的装置和方法。 在一个实施例中，致动器装置包括包括负极和正极的电化学电池。负极的至少一部分由配制成插层，去插入，合金，氧化，还原的至少一种的材料形成 或者具有与正极的第二部分不同的程度的正极的第一部分的板，使得在正极的第一部分和第二部分之间施加微分应变，使得至少一部分 的电化学电池被移位。 电化学电池包括沿着电化学电池的轴线预弯曲以限定折叠轴线的部分，并且电化学电池的至少一部分的位移沿折叠轴线最大化。

    SYSTEMS AND METHODS FOR DELIVERING A THERAPEUTIC AGENT
    6.
    发明申请
    SYSTEMS AND METHODS FOR DELIVERING A THERAPEUTIC AGENT 有权
    用于递送治疗剂的系统和方法

    公开(公告)号：US20110275997A1

    公开(公告)日：2011-11-10

    申请号：US13101749

    申请日：2011-05-05

    申请人： Glenn R. Booma ,  Alessandro Pizzochero ,  J. Richard Gyory

    发明人： Glenn R. Booma ,  Alessandro Pizzochero ,  J. Richard Gyory

    IPC分类号： A61M37/00

    CPC分类号： A61M5/145 ,  A61M5/14248 ,  A61M31/00 ,  A61M35/00 ,  A61M37/00 ,  A61M2005/14506 ,  A61M2005/14513

    摘要： Devices, methods, and kits for delivering a therapeutic agent to a patient are disclosed herein. In one embodiment, an apparatus comprises a reservoir for containing a fluid, a first actuator, a transfer structure, and a second actuator. The first actuator has a first configuration and a second configuration and is configured to exert a first force on the reservoir when moved from its first configuration to its second configuration such that a first volume of fluid within the reservoir is communicated out of the fluid reservoir. The transfer structure is disposed between the first actuator and the reservoir and has a surface configured to engage the reservoir such that the first force exerted by the first actuator is distributed across a surface of the reservoir engaged by the transfer structure. The second actuator has a first configuration and a second configuration and is configured to exert a second force on the reservoir when the second actuator is moved from its first configuration to its second configuration such that a second volume of fluid within the reservoir is communication out of the fluid reservoir.

    摘要翻译： 本文公开了用于将治疗剂递送至患者的装置，方法和试剂盒。 在一个实施例中，装置包括用于容纳流体的储存器，第一致动器，转印结构和第二致动器。 第一致动器具有第一构造和第二构造，并且构造成当从其第一构型移动到其第二构造时在储存器上施加第一力，使得储存器内的第一体积的流体被连通出流体储存器。 转移结构设置在第一致动器和储存器之间，并且具有构造成与储存器接合的表面，使得由第一致动器施加的第一力分布在由传送结构接合的储存器的表面上。 第二致动器具有第一构造和第二构造，并且构造成当第二致动器从其第一构型移动到其第二构造时在储存器上施加第二力，使得储存器内的第二体积的流体从 流体储存器。

    Iontophoretic drug delivery apparatus
    8.
    发明授权
    Iontophoretic drug delivery apparatus 失效
    离子电渗药物输送装置

    公开(公告)号：US06317629B1

    公开(公告)日：2001-11-13

    申请号：US08351381

    申请日：1994-12-02

    申请人： Ronald P. Haak ,  J. Richard Gyory ,  Robert M. Myers ,  Felix A. Landrau ,  Harold F. Sanders ,  Lothar W. Kleiner ,  Linda M. Hearney

    发明人： Ronald P. Haak ,  J. Richard Gyory ,  Robert M. Myers ,  Felix A. Landrau ,  Harold F. Sanders ,  Lothar W. Kleiner ,  Linda M. Hearney

    IPC分类号： A61N130

    CPC分类号： A61N1/0436 ,  A61N1/0444 ,  A61N1/0448 ,  A61N1/303

    摘要： An iontophoretic delivery device (10) is provided. Device (10) has an electronic circuit (32) having electronic components such as batteries (30) mounted thereon. Device (10) also includes a pair of electrode assemblies (18, 19). The electronic circuit (32) is electrically connected to the electrode assemblies (18, 19) using an electrically conductive adhesive (34). The adhesive can also be used to electrically connect two or more electronic components within circuit (32) or to connect an electronic component to the electronic circuit (32). In one practice of the invention, the electrically conductive adhesive (44) functions as an electrode and electrically connects the circuit (32) to an agent-containing reservoir (24, 25). In a further practice of the invention, the electrically conductive adhesive (93) functions as an agent reservoir and contains the agent to be iontophoretically delivered.

    摘要翻译： 提供了一种离子电渗疗法输送装置（10）。 设备（10）具有电子电路（32），其具有安装在其上的电池（30）等电子部件。 装置（10）还包括一对电极组件（18,19）。 使用导电粘合剂（34）将电子电路（32）电连接到电极组件（18,19）。 粘合剂也可以用于电连接电路（32）内的两个或更多个电子部件或将电子部件连接到电子电路（32）。 在本发明的一个实践中，导电粘合剂（44）用作电极并将电路（32）电连接到含药剂的储存器（24,25）。 在本发明的进一步实践中，导电粘合剂（93）用作试剂储存器并且包含待离子电渗传递的试剂。

    Device and method of iontophoretic drug delivery
    9.
    发明授权
    Device and method of iontophoretic drug delivery 失效
    离子电渗药物递送的装置和方法

    公开(公告)号：US5993435A

    公开(公告)日：1999-11-30

    申请号：US139036

    申请日：1998-08-24

    申请人： Ronald P. Haak ,  J. Richard Gyory ,  Felix Theeuwes

    发明人： Ronald P. Haak ,  J. Richard Gyory ,  Felix Theeuwes

    IPC分类号： A61N1/30

    CPC分类号： A61N1/0444 ,  A61N1/0448 ,  A61N1/0436

    摘要： A selectively permeable membrane (14) is positioned between the agent reservoir (15) and the electrode (11) of a donor electrode assembly (8) in an iontophoretic delivery device (10). Optionally, an electrolyte reservoir (13) is positioned intermediate the electrode (11) and the agent reservoir (15). In certain embodiments, the membrane (14) is permeable to species of less than a predetermined molecular weight and substantially less permeable to species of greater than the predetermined molecular weight. The agent is capable of dissociating into agent ions and counter ions. The size selectivity of the membrane (14), the molecular weight of the agent ions, the molecular weight of the counter ions, and optionally the molecular weight of the electrolyte ions are selected to (A) inhibit agent ions from interacting with the electrode (11), and from permeating into the electrolyte reservoir (13), where they might otherwise be degraded and (B) inhibit electrolyte ions, having a charge similar to that of the agent ions, from permeating into the agent reservoir (15) and competing with the agent ions for iontophoretic delivery into the patient.

    摘要翻译： 选择性渗透膜（14）位于药剂储存器（15）和离子电渗输送装置（10）中的施主电极组件（8）的电极（11）之间。 可选地，电解质储存器（13）位于电极（11）和药剂储存器（15）之间。 在某些实施方案中，膜（14）对于小于预定分子量的物质是可渗透的，并且对于大于预定分子量的物质基本上较不可渗透。 该试剂能够解离成试剂离子和抗衡离子。 选择膜（14）的尺寸选择性，试剂离子的分子量，抗衡离子的分子量和任选的电解质离子的分子量以使（A）抑制剂离子与电极相互作用（ 11），并且从渗透到电解质储存器（13）中，否则可能会降解，并且（B）抑制具有类似于试剂离子的电荷的电解质离子渗透到试剂储存器（15）中并且竞争 用离子电渗疗法输送到患者体内。