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    Microchip reservoir devices and facilitated corrosion of electrodes
    1.
    发明授权
    Microchip reservoir devices and facilitated corrosion of electrodes 有权
    Microchip储存器件和电极易腐蚀

    公开(公告)号：US06773429B2

    公开(公告)日：2004-08-10

    申请号：US09975786

    申请日：2001-10-11

    申请人： Norman F. Sheppard, Jr. ,  Christina M. Feakes ,  John T. Santini, Jr.

    发明人： Norman F. Sheppard, Jr. ,  Christina M. Feakes ,  John T. Santini, Jr.

    IPC分类号： A61K922

    CPC分类号： A61K9/0024 ,  A61K9/0009 ,  A61K9/0097 ,  A61M5/14276 ,  A61M2205/0244

    摘要： Methods and devices are provided for enhancing corrosion of an electrode in a biocompatible fluid. The method comprises (1) placing a primary electrode and a counter electrode in an electroconductive biocompatible fluid to form an electrochemical cell; and (2) applying a time-varying potential, through the electrochemical cell, to the primary electrode. In a preferred embodiment, the primary electrode is metal and comprises a reservoir cap of a microchip device for the release of molecules or exposure of device reservoir contents. The potential preferably is characterized by a waveform having a maximum potential effectively anodic to meet or exceed the corrosion potential of the primary electrode. Also, the minimum potential preferably is effectively cathodic to be below the value where re-deposition of metal ions on the metal electrode can substantially occur, thereby corroding the metal electrode.

    摘要翻译： 提供了用于增强生物相容性流体中的电极的腐蚀的方法和装置。 该方法包括（1）将主电极和对电极放置在导电生物相容性流体中以形成电化学电池; 和（2）通过电化学电池将时变电位施加到初级电极。 在优选实施例中，主电极是金属并且包括用于释放分子的微芯片装置的储存器盖或装置储存器内容物的暴露。 该电位优选的特征在于具有有效地阳极以满足或超过初级电极的腐蚀电位的最大电位的波形。 此外，最小电位优选有效地为阴极，低于金属电极上的金属离子的重新沉积基本上可以发生的值，从而腐蚀金属电极。

    Microchip reservoir devices using wireless transmission of power and data
    10.
    发明授权
    Microchip reservoir devices using wireless transmission of power and data 有权
    Microchip库设备使用无线传输电源和数据

    公开(公告)号：US07226442B2

    公开(公告)日：2007-06-05

    申请号：US09975672

    申请日：2001-10-10

    申请人： Norman F. Sheppard, Jr. ,  John T. Santini, Jr. ,  Stephen J. Herman ,  Michael J. Cima ,  Robert S. Langer ,  Dennis Ausiello

    发明人： Norman F. Sheppard, Jr. ,  John T. Santini, Jr. ,  Stephen J. Herman ,  Michael J. Cima ,  Robert S. Langer ,  Dennis Ausiello

    IPC分类号： A61K9/22

    CPC分类号： A61B1/041 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/14539 ,  A61K9/0009 ,  A61K9/0051 ,  A61K9/0097 ,  A61M5/14 ,  A61M5/14276 ,  A61M2205/0244 ,  A61M2205/3523 ,  A61M2210/0612 ,  A61M2210/1042 ,  G06F19/00

    摘要： Devices, systems, and methods are provided for wirelessly powering and/or communicating with microchip devices used for the controlled exposure and release of reservoir contents, such as drugs, reagents, and sensors. In one embodiment, the system includes (1) a microchip device comprising a substrate having a plurality of reservoirs containing reservoir contents for release or exposure; and (2) a rechargeable or on-demand power source comprising a local component which can wirelessly receive power from a remote transmitter wherein the received power can be used, directly or following transduction, to activate said release or exposure of the reservoir contents. In another embodiment, the system comprises (1) a microchip device comprising a substrate a plurality of reservoirs containing reservoir contents for release or exposure; and (2) a telemetry system for the wireless transfer of data between the microchip device and a remote controller.

    摘要翻译： 提供了设备，系统和方法，用于与用于受控地暴露和释放储存器内容物（例如药物，试剂和传感器）的微芯片装置的无线供电和/或通信。 在一个实施例中，系统包括（1）微芯片装置，其包括具有多个储存器的基板，所述储存器包含用于释放或曝光的储存器内容物; 和（2）可充电或点播电源，其包括本地组件，其可以从远程发射器无线地接收电力，其中可以直接或继续使用所接收的功率来激活所述储存器内容物的释放或暴露。 在另一个实施例中，系统包括（1）微芯片装置，其包括基板，多个储存器包含用于释放或曝光的储存器内容物; 和（2）用于在微芯片设备和遥控器之间无线传输数据的遥测系统。