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    Nasal peptide pharmaceutical formulation
    1.
    发明申请
    Nasal peptide pharmaceutical formulation 审中-公开
    鼻肽药物制剂

    公开(公告)号：US20050158247A1

    公开(公告)日：2005-07-21

    申请号：US10516613

    申请日：2003-06-24

    申请人： Paolo Veronesi ,  Pablo Rodriguez

    发明人： Paolo Veronesi ,  Pablo Rodriguez

    IPC分类号： A61K9/00 ,  A61K38/095 ,  A61K47/18 ,  A61L9/04 ,  A61K38/22

    CPC分类号： A61K9/0043 ,  A61K47/18

    摘要： The invention provides a pharmaceutical formulation comprising: (1) THAM, which is tris(hydroxymethyl)aminomethane, as a selective absorbefacient to enhance through the nasal mucosa-lined epithelium the absorption of substances of peptide nature; and (2) a therapeutically effective amount of active nasal peptide, its pharmaceutically acceptable salt or its peptidic fragment; in a pharmaceutically acceptable, aqueous liquid diluent or carrier, said formulation being in a form suitable for nasal administration.

    摘要翻译： 本发明提供一种药物制剂，其包含：（1）THAM，其是三（羟甲基）氨基甲烷，作为选择性吸收剂，以增强穿过鼻粘膜上皮的吸收肽性质的物质; 和（2）治疗有效量的活性鼻肽，其药学上可接受的盐或其肽片段; 在药学上可接受的水性液体稀释剂或载体中，所述制剂为适合于鼻内给药的形式。

    Apparatus and methods for providing translucent proxies in a communications network
    5.
    发明授权
    Apparatus and methods for providing translucent proxies in a communications network 失效
    在通信网络中提供半透明代理的装置和方法

    公开(公告)号：US07016973B1

    公开(公告)日：2006-03-21

    申请号：US09713214

    申请日：2000-11-16

    申请人： Sandeep Sibal ,  Oliver Spatscheck ,  Pablo Rodriguez

    发明人： Sandeep Sibal ,  Oliver Spatscheck ,  Pablo Rodriguez

    IPC分类号： G06F15/173 ,  G06F15/16 ,  G06F15/177

    CPC分类号： H04L69/16 ,  H04L67/28 ,  H04L67/2871 ,  H04L69/163

    摘要： The Translucent Proxying of TCP (TPOT) device and methods use TCP-OPTIONS and IP tunneling to guarantee that all IP packets belonging to a specific TCP connection will traverse the proxy which intercepts the first packet of data. This guarantee allows the ad-hoc deployment of TPOT devices anywhere within the communication network, and does not restrict the placement of proxy devices at the edge of the network. Furthermore, no extra signaling support is required for the TPOT device to properly function while the addition of TPOT devices to communication networks significantly improves the throughput of intercepted TCP packets of data.

    摘要翻译： TCP（TPOT）设备和方法的半透明代理使用TCP-OPTIONS和IP隧道来保证属于特定TCP连接的所有IP包将遍历拦截第一个数据包的代理。 此保证允许在通信网络内的任何地方临时部署TPOT设备，并且不会限制代理设备在网络边缘的位置。 此外，当TPOT设备添加到通信网络时，TPOT设备不需要额外的信令支持，从而显着提高了所拦截的TCP数据包的吞吐量。

    User specific request redirection in a content delivery network
    6.
    发明申请
    User specific request redirection in a content delivery network 有权
    内容传送网络中的用户特定请求重定向

    公开(公告)号：US20060020684A1

    公开(公告)日：2006-01-26

    申请号：US10894725

    申请日：2004-07-20

    申请人： Sarit Mukherjee ,  Sampath Rangarajan ,  Pablo Rodriguez

    发明人： Sarit Mukherjee ,  Sampath Rangarajan ,  Pablo Rodriguez

    IPC分类号： G06F15/16

    CPC分类号： H04L67/06 ,  H04L67/02 ,  H04L67/2804 ,  H04L67/2814 ,  H04L67/2823 ,  H04L67/2842

    摘要： A method and apparatus for providing user specific request redirection in a content delivery network includes parsing a page having embedded objects intended for redirection to at least one cache server, and transforming the embedded objects into relative uniform resource locators (URLs). A content-base token is inserted into an HTTP response header in response to a user request for the page. In an instance where the content-base token is not supported by the server and/or client devices, a base token is inserted into the page in response to a user request for the page. The content-base token and base token provide identification of a server or URL prefix where the embedded objects in the page are to be retrieved. The requested page is then sent to the user's browser. The browser constructs absolute URLs from the embedded URLs using either the received content-base token or base token, to retrieve embedded objects from the server.

    摘要翻译： 一种用于在内容传递网络中提供用户特定请求重定向的方法和装置包括：将具有用于重定向的嵌入对象的页解析到至少一个缓存服务器，以及将嵌入的对象变换为相对统一的资源定位符（URL）。 响应于用户对该页面的请求，将内容令牌插入HTTP响应头。 在服务器和/或客户端设备不支持内容库令牌的情况下，响应于用户对该页面的请求，将基本标记插入页面。 内容库令牌和基本令牌提供要检索页面中的嵌入对象的服务器或URL前缀的标识。 然后将请求的页面发送到用户的浏览器。 浏览器使用接收到的内容基础令牌或基本令牌从嵌入式URL构建绝对URL，以从服务器检索嵌入的对象。

    Session level technique for improving web browsing performance on low speed links
    9.
    发明授权
    Session level technique for improving web browsing performance on low speed links 有权
    用于提高低速链路网页浏览性能的会话级技术

    公开(公告)号：US08589561B2

    公开(公告)日：2013-11-19

    申请号：US11085849

    申请日：2005-03-22

    申请人： Sarit Mukherjee ,  Sampath Rangarajan ,  Pablo Rodriguez

    发明人： Sarit Mukherjee ,  Sampath Rangarajan ,  Pablo Rodriguez

    IPC分类号： G06F15/16

    CPC分类号： H04L67/2814 ,  G06F17/30902

    摘要： A method and apparatus for retrieving embedded objects of a web page across links. The method and apparatus include receiving, at a gateway, a requested top-level web page having at least one embedded uniform resource locator (URL) from at least one content server in response to a request for the web page from an end-user browser.The at least one embedded URL is modified with an IP address of a caching proxy. The caching proxy may be either co-located or separate from the gateway. The top-level web page and modified embedded URLs are sent to the end-user browser, wherein the caching proxy forwards the at least one embedded URL from the at least one content server to the end-user browser.

    摘要翻译： 一种跨链接检索网页的嵌入对象的方法和装置。 该方法和装置包括响应于来自最终用户浏览器的对网页的请求，在网关处从至少一个内容服务器接收具有至少一个嵌入式统一资源定位符（URL）的所请求的顶级网页 。 至少一个嵌入式URL被缓存代理的IP地址修改。 缓存代理可以与网关共存或分离。 顶级网页和修改的嵌入式URL被发送到最终用户浏览器，其中缓存代理将至少一个嵌入的URL从至少一个内容服务器转发到最终用户浏览器。

    Security for network coding file distribution
    10.
    发明申请
    Security for network coding file distribution 有权
    网络编码文件分发安全

    公开(公告)号：US20060282677A1

    公开(公告)日：2006-12-14

    申请号：US11191761

    申请日：2005-07-28

    申请人： Pablo Rodriguez ,  Christos Gkantsidis ,  Stephane Ubeda

    发明人： Pablo Rodriguez ,  Christos Gkantsidis ,  Stephane Ubeda

    IPC分类号： H04L9/00

    CPC分类号： H04L67/104 ,  H04L9/3236 ,  H04L63/0428 ,  H04L63/12 ,  H04L67/06 ,  H04L67/108 ,  H04L69/329 ,  H04L2209/60

    摘要： A content distribution mechanism that relies on cooperative desktop PCs to distribute content is disclosed. The mechanism distributes content in a robust manner by allowing at least one intermediate network node (i.e., between a source and client) to generate and send packets that contain a linear combination of the portions of content available at the node. Such linear combinations may be created by the source and client using at least a portion of the original content file in either encoded or unencoded form. After the client has received enough linearly independent combinations of packets, the original content may be reconstructed. Further, security for network coding file distribution may be employed to maintain the efficiency and security of the content distribution mechanism. A security server may generate security information using a hashing algorithm including the property of producing security information for each block which survives the process of creating encoded blocks. The security server may generate a unique set of security information for each node participating in the content distribution which each node may then use to verify that the blocks being examined are valid and were created from a linear combination of the original blocks of the file.

    摘要翻译： 披露了依靠合作台式机分发内容的内容分发机制。 该机制通过允许至少一个中间网络节点（即，源和客户端之间）来生成和发送包含节点可用内容的部分的线性组合的分组，以鲁棒的方式分发内容。 这样的线性组合可以由源和客户端使用原始内容文件的至少一部分以编码或非编码形式来创建。 在客户端已经接收到足够的线性独立的分组组合之后，可以重构原始内容。 此外，可以采用网络编码文件分发的安全性来保持内容分发机制的效率和安全性。 安全服务器可以使用散列算法来生成安全信息，散列算法包括为创建编码块的过程中生存的每个块生成安全信息的属性。 安全服务器可以为参与内容分发的每个节点生成一组唯一的安全信息，每个节点可以使用该安全信息来验证被检查的块是有效的，并且是从该文件的原始块的线性组合创建的。