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公开(公告)号：US4406792A
公开(公告)日：1983-09-27
申请号：US321692
申请日：1981-11-16
申请人： Magnus J. Glad , Sten A. Ohlson , Lennart H. Hansson , Mats-Olle Mansson , Per-Olof Larsson , Klaus H. Mosbach
发明人： Magnus J. Glad , Sten A. Ohlson , Lennart H. Hansson , Mats-Olle Mansson , Per-Olof Larsson , Klaus H. Mosbach
CPC分类号： B01D15/08 , B01J20/10 , B01J20/286 , B01J20/3092 , B01J20/3204 , B01J20/3246 , B01J20/3259 , B01J20/3261 , B01J20/3263 , B01J2220/54 , B01J2220/58
摘要： A chromatographic separation agent composed of a water unsoluble solid substance showing dihydroxyboryl groups. Said solid substance is structurally composed of a water unsoluble silica or silicate material as basic structure and, via a linkage to silicon atoms in the silica or silicate material, covalently bound dihydroxyboryl groups in acid, salt or complex form
摘要翻译： 一个
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公开(公告)号：US4246346A
公开(公告)日：1981-01-20
申请号：US939117
申请日：1978-09-05
摘要： A method for activating immobilized living microorganisms applied to transformations of steroids, antibiotics and other compounds characterized by the addition of peptone, glucose or a mixture of peptone and glucose to the reaction mixture.
摘要翻译： 用于激活固定化的活微生物的方法，其用于类固醇，抗生素和其它化合物的转化，其特征在于向反应混合物中加入蛋白胨，葡萄糖或蛋白胨和葡萄糖的混合物。
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3.发明授权Method and apparatus for measuring temperature changes generated by enzyme activity 失效用于测量由酶活性产生的温度变化的方法和装置
公开(公告)号：US4021307A
公开(公告)日：1977-05-03
申请号：US584595
申请日：1975-06-06
申请人： Klaus H. Mosbach
发明人： Klaus H. Mosbach
CPC分类号： G01N25/4873
摘要： A method and apparatus for measuring temperature changes generated by enzyme activity consists in conducting a matrixbound enzyme through a flowpath formed by a helical coil and sensing the temperature in the immediate vicinity of the flowpath.
摘要翻译： 用于测量由酶活性产生的温度变化的方法和装置在于通过由螺旋线圈形成的流动路径进行基质结合的酶，并感测在流动路径附近的温度。
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公开(公告)号：US5015576A
公开(公告)日：1991-05-14
申请号：US114421
申请日：1987-10-28
申请人： Kjell Nilsson , Klaus H. Mosbach
发明人： Kjell Nilsson , Klaus H. Mosbach
CPC分类号： B01J20/28004 , B01J20/26 , B01J20/28016 , B01J20/28078 , B01J20/28097 , C08J3/12 , C08J9/28 , C12M25/16 , C08J2201/0546 , Y10S435/803
摘要： Particles which enclose cavities can be produced by adding a water-insoluble solid, liquid or gaseous cavity generating compound to an aqueous solution of matrix material. Subsequent to forming particles by dispersion in a water-insoluble dispersion medium, the matrix is rendered insoluble in water by cooling, by covalent cross-linking or by polymerization. The cavity generating compound is washed out, whereafter the particles can be used as ion exchangers in gel filtration processes, in hydrophobic chromatography or in affinity chromatography, optionally subsequent to derivatizing the particles. The particles can also be used to advantage as microcarriers in the cultivation of anchorage-dependent cells.
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公开(公告)号：US4524137A
公开(公告)日：1985-06-18
申请号：US261220
申请日：1981-04-13
摘要： A catalyst is disclosed, which can be used for carrying out, in a continuous manner simultaneously and in one and the same reaction space, two or more stages of a biochemical conversion reaction which is of the kind requiring, for certain reaction stages, the presence of an enzyme, and for other reaction stages the presence of a microorganism. The catalyst comprises solid bodies of one or more polymers of which at least one is a cross-linked polymer. At least one enzyme is bound to the polymer material of the solid bodies by covalent bonds, and at least one microorganism is physically entrapped in the three-dimensional structure of the cross-linked polymer of the solid bodies.
摘要翻译： PCT No.PCT / SE80 / 00216 Sec。 371日期：1981年4月13日 102（e）日期1981年4月13日PCT申请日1980年8月22日PCT公布。 公开号WO81 / 00576 1981年3月5日公开了一种催化剂，其可以以连续的方式同时和在同一反应空间中进行生化转化反应的两个或多个阶段进行， 对于某些反应阶段，酶的存在，以及其它反应阶段存在微生物。 该催化剂包含其中至少一个是交联聚合物的一种或多种聚合物的固体。 至少一种酶通过共价键与固体的聚合物材料结合，并且至少一种微生物物理地截留在固体的交联聚合物的三维结构中。
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公开(公告)号：US4935365A
公开(公告)日：1990-06-19
申请号：US919325
申请日：1986-10-15
CPC分类号： B01J20/28004 , B01J20/26 , B01J20/28016 , B01J20/28078 , B01J20/28097 , C08J3/12 , C08J9/28 , C12M25/16 , C08J2201/0546 , Y10S435/803
摘要： Particles which enclose cavities can be produced by adding a water-insoluble solid, liquid or gaseous cavity generating compound to an aqueous solution of a matrix material. Subsequent to forming particles by dispersion in a water-insoluble dispersion medium, the matrix is rendered insoluble in water by cooling, by covalent cross-linking or by polymerization. The cavity generating compound is washed out, whereafter the particles can be used as ion exchangers in gel filtration processes, in hydrophobic chromatography or in affinity chromatography, optionally subsequent to derivatizing the particles. The particles can also be used to advantage as microcarriers in the cultivation of anchorage dependent cells.
摘要翻译： 包围空腔的颗粒可以通过向基质材料的水溶液中加入水不溶性固体，液体或气体产生化合物来制备。 在通过分散在水不溶性分散介质中形成颗粒后，通过冷却，共价交联或通过聚合使基质变得不溶于水。 洗出空腔产生化合物，此后，可以在凝胶过滤方法，疏水色谱法或亲和层析中任选地将颗粒衍生化使用颗粒作为离子交换剂。 这些颗粒也可用作培养依赖于锚定细胞的微载体。
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7.发明授权Method of covalently binding biologically active organic substances to polymeric substances 失效将生物活性有机物质共价结合到聚合物质的方法
公开(公告)号：US4415665A
公开(公告)日：1983-11-15
申请号：US326332
申请日：1981-12-01
IPC分类号： A61K47/48 , B01J20/32 , C12N11/08 , C12N11/10 , C12N11/12 , G01N33/531 , G01N33/548
CPC分类号： G01N33/531 , A61K47/48369 , A61K47/48715 , B01J20/262 , B01J20/267 , B01J20/28047 , B01J20/286 , B01J20/291 , B01J20/3071 , B01J20/3092 , B01J20/3204 , B01J20/3212 , B01J20/3217 , B01J20/3219 , B01J20/3246 , B01J20/3248 , B01J20/3251 , B01J20/3253 , B01J20/3274 , B01J20/3425 , B01J20/345 , B01J20/3475 , C12N11/08 , C12N11/10 , C12N11/12 , G01N33/548 , B01J2220/54 , B01J2220/58
摘要： The invention relates to a method of coupling organic ligands to a polymeric carrier. The organic ligand contains at least one primary or secondary amino group, at least one thiol group and/or at least one aromatic hydroxy group, and the polymeric carrier contains at least one hydroxy group. According to the invention the coupling is performed by forming a reactive derivative of the polymeric carrier by treatment with a sulfonyl halogenid, and reacting the formed reactive derivative with the organic ligand, which is thereby bonded directly to a carbon atom in the polymeric carrier. The polymeric carrier can, for example, be a possibly cross-linked polysaccharide, and the organic ligand is preferably a biological material such as a protein. The coupling product can, for example, be used for immunologic determinations, for affinity chromatography, etc. The coupling method can be performed under mild conditions not damaging sensitive organic ligands.
摘要翻译： 本发明涉及将有机配体偶联到聚合物载体上的方法。 有机配体含有至少一个伯氨基或仲氨基，至少一个硫醇基和/或至少一个芳族羟基，聚合物载体含有至少一个羟基。 根据本发明，通过用磺酰卤处理形成聚合物载体的活性衍生物，并使所形成的反应性衍生物与有机配体反应，由此直接键合到聚合物载体中的碳原子上来进行偶联。 聚合物载体可以是例如可能是交联的多糖，并且有机配体优选是诸如蛋白质的生物材料。 偶联产物可以例如用于免疫测定，亲和层析等。偶联方法可以在不损害敏感有机配体的温和条件下进行。
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公开(公告)号：US4335094A
公开(公告)日：1982-06-15
申请号：US21603
申请日：1979-01-26
申请人： Klaus H. Mosbach
发明人： Klaus H. Mosbach
IPC分类号： A61K9/50 , C12N11/02 , C12N11/14 , G01N33/543 , G01N33/56
CPC分类号： C12N11/14 , A61K9/5094 , C12N11/02 , G01N33/5434 , G01N2400/32 , G01N2446/10
摘要： This invention relates to magnetic polymer particles as carriers of biologically, preferably pharmaceutically, active substances, the utilization of the magnetic polymer particles, the method of retaining a biologically active substance, preferably a pharmaceutically active substance within a restricted area, and the method of treating diseased tissue with the use of the magnetic polymer particles.
摘要翻译： PCT No.PCT / SE78 / 00001 Sec。 371日期1979年2月2日 102（e）日期1979年1月26日PCT Filed 1978年6月1日PCT公布。 No.W078 / 00005 PCT出版物 本发明涉及磁性聚合物颗粒作为生物学优选药学活性物质的载体，磁性聚合物颗粒的利用，将生物活性物质，优选药物活性物质保留在限制性物质内的方法 面积和使用磁性聚合物颗粒治疗患病组织的方法。
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