公开(公告)号：US20080197024A1

公开(公告)日：2008-08-21

申请号：US12055078

申请日：2008-03-25

申请人： Peter C. Simpson ,  Apurv Ullas Kamath ,  Jacob S. Leach ,  Mark Brister ,  Vance Swanson ,  Curtis Hanson ,  Jack Pryor ,  Matthew Wightlin ,  Sean Saint ,  John Nolting

发明人： Peter C. Simpson ,  Apurv Ullas Kamath ,  Jacob S. Leach ,  Mark Brister ,  Vance Swanson ,  Curtis Hanson ,  Jack Pryor ,  Matthew Wightlin ,  Sean Saint ,  John Nolting

IPC分类号： G01N33/50

CPC分类号： A61B5/14865 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/1495 ,  A61B5/412 ,  A61B5/6848 ,  A61B5/6849 ,  A61B2560/0223 ,  A61M5/14 ,  A61M5/16804 ,  A61M5/1723 ,  A61M2005/14296 ,  A61M2230/201 ,  C12Q1/001 ,  C12Q1/006 ,  G06F19/3468 ,  G16H40/40 ,  Y02A90/26

摘要： Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.

公开(公告)号：US08364229B2

公开(公告)日：2013-01-29

申请号：US11750907

申请日：2007-05-18

申请人： Peter C. Simpson ,  Robert Boock ,  James R. Petisce ,  Mark Brister ,  Monica A. Rixman ,  Kum Ming Woo ,  Lisa Nguyen ,  Seth R. Brunner ,  Arthur Chee ,  Melissa A. Nicholas ,  Matthew Wightlin ,  Jack Pryor ,  Dubravka Markovic

发明人： Peter C. Simpson ,  Robert Boock ,  James R. Petisce ,  Mark Brister ,  Monica A. Rixman ,  Kum Ming Woo ,  Lisa Nguyen ,  Seth R. Brunner ,  Arthur Chee ,  Melissa A. Nicholas ,  Matthew Wightlin ,  Jack Pryor ,  Dubravka Markovic

IPC分类号： A61B5/00 ,  A61B5/05

CPC分类号： A61B5/00 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/14735 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/6848 ,  A61B5/7203

摘要： Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

摘要翻译： 提供涉及具有基本上不受非恒定噪声影响的信噪比的传感器的系统和方法用于主机中的连续分析物测量。 在一些实施例中，连续分析物测量系统被配置为完全，经皮，血管内或体外植入。

公开(公告)号：US08423114B2

公开(公告)日：2013-04-16

申请号：US11865572

申请日：2007-10-01

申请人： Peter C. Simpson ,  Mark Brister ,  Matthew Wightlin ,  Jack Pryor

发明人： Peter C. Simpson ,  Mark Brister ,  Matthew Wightlin ,  Jack Pryor

IPC分类号： A61B5/00 ,  A61B5/05

CPC分类号： A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/6849 ,  C12Q1/006

摘要： Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.

摘要翻译： 本文公开了用于连续分析物传感器（例如连续葡萄糖传感器）的系统和方法。 一个这样的系统利用第一和第二工作电极来测量附加分析物或非分析物相关信号。 这样的测量可以提供用于处理传感器数据的背景和/或灵敏度测量，并且可以用于触发诸如数据的数字滤波或暂停显示数据的事件。

公开(公告)号：US20080083617A1

公开(公告)日：2008-04-10

申请号：US11865572

申请日：2007-10-01

申请人： Peter C. Simpson ,  Mark Brister ,  Matthew Wightlin ,  Jack Pryor

发明人： Peter C. Simpson ,  Mark Brister ,  Matthew Wightlin ,  Jack Pryor

IPC分类号： C25B13/08 ,  C25B11/00

CPC分类号： A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/6849 ,  C12Q1/006

摘要： Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.

公开(公告)号：US09131885B2

公开(公告)日：2015-09-15

申请号：US12829318

申请日：2010-07-01

申请人： Peter C. Simpson ,  Robert Boock ,  Paul V. Neale ,  Sebastian Bohm ,  Matthew Wightlin ,  Jack Pryor ,  Jason Mitchell ,  Jeff Jackson ,  Kaushik Patel ,  Antonio C. Llevares

发明人： Peter C. Simpson ,  Robert Boock ,  Paul V. Neale ,  Sebastian Bohm ,  Matthew Wightlin ,  Jack Pryor ,  Jason Mitchell ,  Jeff Jackson ,  Kaushik Patel ,  Antonio C. Llevares

IPC分类号： A61B5/05 ,  A61B5/1473 ,  A61B5/145 ,  A61B5/1486 ,  B05C3/10

CPC分类号： A61B5/1473 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B2560/0223 ,  A61B2562/0209 ,  A61B2562/043 ,  A61B2562/125 ,  B05C3/10

摘要： Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.

摘要翻译： 提供分析物传感器及其制造方法，包括包含多轴灵活性的分析物传感器。 例如，提供了包括两个工作电极和至少一个参考/对电极的多电极传感器系统800。 传感器系统800包括第一和第二细长体E1，E2，每个由导电芯或具有沉积在其上的导电层的芯构成，绝缘层810将导电层820与细长主体分隔开;膜层沉积在 通过去除导电层820和绝缘层810的部分而形成的细长体E1，E2和工作电极802'，802“的顶部，从而暴露细长体E1，E2的电活性表面。

公开(公告)号：US10231653B2

公开(公告)日：2019-03-19

申请号：US13247856

申请日：2011-09-28

申请人： Sebastian Bohm ,  Mark Dervaes ,  Eric Johnson ,  Apurv Ullas Kamath ,  Shawn Larvenz ,  Jacob S. Leach ,  Phong Lieu ,  Aarthi Mahalingam ,  Tom Miller ,  Paul V. Neale ,  Jack Pryor ,  Thomas A. Peyser ,  Daiting Rong ,  Kenneth San Vicente ,  Mohammad Ali Shariati ,  Peter C. Simpson ,  Matthew Wightlin

发明人： Sebastian Bohm ,  Mark Dervaes ,  Eric Johnson ,  Apurv Ullas Kamath ,  Shawn Larvenz ,  Jacob S. Leach ,  Phong Lieu ,  Aarthi Mahalingam ,  Tom Miller ,  Paul V. Neale ,  Jack Pryor ,  Thomas A. Peyser ,  Daiting Rong ,  Kenneth San Vicente ,  Mohammad Ali Shariati ,  Peter C. Simpson ,  Matthew Wightlin

IPC分类号： G06F1/32 ,  A61B5/145 ,  G06F1/3203

摘要： Systems and methods for processing, transmitting, and displaying data received from a continuous analyte (e.g., glucose) sensor are provided. A sensor system can comprise a sensor electronics module that includes power saving features, e.g., a low power measurement circuit that can be switched between a measurement mode and a low power mode, wherein charging circuitry continues to apply power to electrodes of a sensor during the low power mode. The sensor electronics module can be switched between a low power storage mode and a higher power operational mode via a switch, e.g., a reed switch or optical switch. A validation routine can be implemented to ensure an interrupt signal sent from the switch is valid. The sensor can be physically connected to the sensor electronics module in direct wireless communication with a plurality of different display devices.

公开(公告)号：US20120078071A1

公开(公告)日：2012-03-29

申请号：US13247856

申请日：2011-09-28

申请人： Sebastian Bohm ,  Mark Dervaes ,  Eric Johnson ,  Apurv Ullas Kamath ,  Shawn Larvenz ,  Jacob S. Leach ,  Phong Lieu ,  Aarthi Mahalingam ,  Tom Miller ,  Paul V. Neale ,  Jack Pryor ,  Thomas A. Peyser ,  Daiting Rong ,  Kenneth San Vicente ,  Mohammad Ali Shariati ,  Peter C. Simpson ,  Matthew Wightlin

发明人： Sebastian Bohm ,  Mark Dervaes ,  Eric Johnson ,  Apurv Ullas Kamath ,  Shawn Larvenz ,  Jacob S. Leach ,  Phong Lieu ,  Aarthi Mahalingam ,  Tom Miller ,  Paul V. Neale ,  Jack Pryor ,  Thomas A. Peyser ,  Daiting Rong ,  Kenneth San Vicente ,  Mohammad Ali Shariati ,  Peter C. Simpson ,  Matthew Wightlin

IPC分类号： A61B5/145

CPC分类号： A61B5/14532 ,  A61B5/14507 ,  A61B5/1451 ,  A61B2560/0209 ,  A61B2560/0214 ,  A61B2562/02 ,  G06F1/3203

摘要： Systems and methods for processing, transmitting, and displaying data received from a continuous analyte (e.g., glucose) sensor are provided. A sensor system can comprise a sensor electronics module that includes power saving features, e.g., a low power measurement circuit that can be switched between a measurement mode and a low power mode, wherein charging circuitry continues to apply power to electrodes of a sensor during the low power mode. The sensor electronics module can be switched between a low power storage mode and a higher power operational mode via a switch, e.g., a reed switch or optical switch. A validation routine can be implemented to ensure an interrupt signal sent from the switch is valid. The sensor can be physically connected to the sensor electronics module in direct wireless communication with a plurality of different display devices.

摘要翻译： 提供了用于处理，传输和显示从连续分析物（例如，葡萄糖）传感器接收的数据的系统和方法。 传感器系统可以包括传感器电子模块，其包括省电功能，例如可以在测量模式和低功率模式之间切换的低功率测量电路，其中充电电路在该期间继续向传感器的电极施加功率 低功耗模式。 传感器电子模块可以通过诸如簧片开关或光开关的开关在低功率存储模式和较高功率操作模式之间切换。 可以实现验证程序，以确保从交换机发送的中断信号有效。 传感器可以与多个不同的显示设备直接无线通信，物理地连接到传感器电子模块。

公开(公告)号：US20070235331A1

公开(公告)日：2007-10-11

申请号：US11750907

申请日：2007-05-18

申请人： Peter Simpson ,  Robert Boock ,  James Petisce ,  Mark Brister ,  Monica Rixman ,  Kum Ming Woo ,  Lisa Nguyen ,  Seth Brunner ,  Arthur Chee ,  Melissa Nicholas ,  Matthew Wightlin ,  Jack Pryor ,  Dubravka Markovic

发明人： Peter Simpson ,  Robert Boock ,  James Petisce ,  Mark Brister ,  Monica Rixman ,  Kum Ming Woo ,  Lisa Nguyen ,  Seth Brunner ,  Arthur Chee ,  Melissa Nicholas ,  Matthew Wightlin ,  Jack Pryor ,  Dubravka Markovic

IPC分类号： G01N27/26

CPC分类号： A61B5/00 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/14735 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/6848 ,  A61B5/7203

摘要： Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

摘要翻译： 提供涉及具有基本上不受非恒定噪声影响的信噪比的传感器的系统和方法用于主机中的连续分析物测量。 在一些实施例中，连续分析物测量系统被配置为完全，经皮，血管内或体外植入。

公开(公告)号：US09237864B2

公开(公告)日：2016-01-19

申请号：US12829306

申请日：2010-07-01

申请人： Peter C. Simpson ,  Robert Boock ,  Paul V. Neale ,  Sebastian Bohm ,  Matthew Wightlin ,  Jack Pryor ,  Jason Mitchell ,  Jeff Jackson ,  Kaushik Patel ,  Antonio C. Llevares

发明人： Peter C. Simpson ,  Robert Boock ,  Paul V. Neale ,  Sebastian Bohm ,  Matthew Wightlin ,  Jack Pryor ,  Jason Mitchell ,  Jeff Jackson ,  Kaushik Patel ,  Antonio C. Llevares

IPC分类号： A61B5/00 ,  A61B5/1473 ,  A61B5/145 ,  A61B5/1486 ,  B05C3/10

CPC分类号： A61B5/1473 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B2560/0223 ,  A61B2562/0209 ,  A61B2562/043 ,  A61B2562/125 ,  B05C3/10

摘要： Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.

公开(公告)号：US08828201B2

公开(公告)日：2014-09-09

申请号：US12829296

申请日：2010-07-01

申请人： Peter C. Simpson ,  Robert Boock ,  Paul V. Neale ,  Sebastian Bohm ,  Matthew Wightlin ,  Jack Pryor ,  Jason Mitchell ,  Jeff Jackson ,  Kaushik Patel ,  Antonio C. Llevares

发明人： Peter C. Simpson ,  Robert Boock ,  Paul V. Neale ,  Sebastian Bohm ,  Matthew Wightlin ,  Jack Pryor ,  Jason Mitchell ,  Jeff Jackson ,  Kaushik Patel ,  Antonio C. Llevares

IPC分类号： G01N33/483 ,  G01N33/50

CPC分类号： A61B5/1473 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B2560/0223 ,  A61B2562/0209 ,  A61B2562/043 ,  A61B2562/125 ,  B05C3/10

摘要： Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.

摘要翻译： 提供分析物传感器及其制造方法，包括包含多轴灵活性的分析物传感器。 例如，提供了包括两个工作电极和至少一个参考/对电极的多电极传感器系统800。 传感器系统800包括第一和第二细长体E1，E2，每个由导电芯或具有沉积在其上的导电层的芯构成，绝缘层810将导电层820与细长主体分隔开;膜层沉积在 通过去除导电层820和绝缘层810的部分而形成的细长体E1，E2和工作电极802'，802“的顶部，从而暴露细长体E1，E2的电活性表面。