公开(公告)号：US20050208514A1

公开(公告)日：2005-09-22

申请号：US10980659

申请日：2004-11-03

申请人： John Alsobrook ,  Ferenc Boldog ,  Michael Jeffers ,  William LaRochelle ,  Denise Lepley ,  Henri Lichenstein ,  Richard Shimkets ,  Meijia Yang ,  Marie Ruiz-Martinez ,  Galina Chernaya ,  Muralidhara Padigaru ,  Sudhirdas Prayaga ,  Mei Zhong

发明人： John Alsobrook ,  Ferenc Boldog ,  Michael Jeffers ,  William LaRochelle ,  Denise Lepley ,  Henri Lichenstein ,  Richard Shimkets ,  Meijia Yang ,  Marie Ruiz-Martinez ,  Galina Chernaya ,  Muralidhara Padigaru ,  Sudhirdas Prayaga ,  Mei Zhong

IPC分类号： A61K38/00 ,  A61K38/18 ,  C07K14/50 ,  C12Q1/68

CPC分类号： C07K14/50 ,  A61K38/00

摘要： The present invention generally relates to nucleic acids, proteins, and antibodies. The invention relates more particularly to nucleic acid molecules, proteins, and antibodies of Fibroblast Growth Factor-20 (FGF-20), or its fragments, derivatives, variants, homologs, analogs, or a combination thereof.

摘要翻译： 本发明一般涉及核酸，蛋白质和抗体。 本发明更具体涉及成纤维细胞生长因子-20（FGF-20）或其片段，衍生物，变体，同系物，类似物或其组合的核酸分子，蛋白质和抗体。

公开(公告)号：US20050063971A1

公开(公告)日：2005-03-24

申请号：US10948588

申请日：2004-09-23

申请人： Michael Jeffers ,  Richard Shimkets ,  Sudhirdas Prayaga ,  Ferenc Boldog ,  Meijia Yang ,  Catherine Burgess ,  Elma Fernandes ,  John Herrmann ,  William LaRochelle ,  Henri Lichenstein

发明人： Michael Jeffers ,  Richard Shimkets ,  Sudhirdas Prayaga ,  Ferenc Boldog ,  Meijia Yang ,  Catherine Burgess ,  Elma Fernandes ,  John Herrmann ,  William LaRochelle ,  Henri Lichenstein

IPC分类号： A01K67/027 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P1/04 ,  A61P7/06 ,  A61P9/00 ,  A61P17/02 ,  A61P17/14 ,  A61P35/00 ,  A61P43/00 ,  C07K14/50 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/566 ,  C07K16/28

CPC分类号： C07K14/50 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505

摘要： The present invention provides FGF-CX, a novel isolated polypeptide, as well as a polynucleotide encoding FGF-CX and antibodies that immunospecifically bind to FGF-CX or any derivative, variant, mutant, or fragment of the FGF-CX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FGF-CX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as other uses.

摘要翻译： 本发明提供了FGF-CX，一种新的分离的多肽，以及编码FGF-CX的多核苷酸和免疫特异性结合FGF-CX或FGF-CX多肽的任何衍生物，变体，突变体或片段的多核苷酸或 抗体。 本发明另外提供了FGF-CX多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。

公开(公告)号：US20050287564A1

公开(公告)日：2005-12-29

申请号：US11126427

申请日：2005-05-10

申请人： Linda Gorman ,  Richard Shimkets ,  Carol Pena ,  Valerie Gerlach ,  Kumud Majumder ,  Sudhirdas Prayaga ,  Catherine Burgess

发明人： Linda Gorman ,  Richard Shimkets ,  Carol Pena ,  Valerie Gerlach ,  Kumud Majumder ,  Sudhirdas Prayaga ,  Catherine Burgess

IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C12N15/12 ,  C12Q1/68 ,  A61K38/17 ,  C07H21/04 ,  C07K16/18

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/705

摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

摘要翻译： 本文公开了编码G偶联蛋白 - 受体相关多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：US20060094647A1

公开(公告)日：2006-05-04

申请号：US09992840

申请日：2001-11-06

申请人： Michael Jeffers ,  Richard Shimkets ,  Sudhirdas Prayaga ,  Ferenc Boldog ,  Meijia Yang ,  Catherine Burgess ,  Elma Fernandes ,  Beth Rittman ,  Juliette Shimkets ,  William LaRochelle ,  Henri Lichenstein

发明人： Michael Jeffers ,  Richard Shimkets ,  Sudhirdas Prayaga ,  Ferenc Boldog ,  Meijia Yang ,  Catherine Burgess ,  Elma Fernandes ,  Beth Rittman ,  Juliette Shimkets ,  William LaRochelle ,  Henri Lichenstein

IPC分类号： A61K38/17

CPC分类号： A61K38/1825 ,  C07K14/49 ,  C07K14/50 ,  C07K14/51 ,  C07K14/52

摘要： The present invention is based upon methods of treating inflammatory conditions in the intestinal tract of mammals using growth factor related polypeptides. Methods of using fibroblast growth factor-CX (FGF-CX) polynucleotide sequences and the FGF-CX polypeptides encoded by such nucleic acid sequences, or variants, fragments and homologs thereof, are claimed in the invention. Similarly, methods of using FCTRX polynucleotide sequences and the FCTRX polypeptides encoded by such nucleic acid sequences, or variants, fragments and homologs thereof, alone or in combination, are also claimed in the invention. FCTRX collectively refers to any of six variant FCTRX sequences, variously designated FCTR1, FCTR2, FCTR3, FCTR4, FCTR5 and FCTR6.

摘要翻译： 本发明是基于使用生长因子相关多肽治疗哺乳动物肠道炎症状况的方法。 在本发明中要求使用成纤维细胞生长因子CX（FGF-CX）多核苷酸序列和由这种核酸序列编码的FGF-CX多肽或其变体，片段和同系物的方法。 类似地，在本发明中还要求保护使用FCTRX多核苷酸序列和由此类核酸序列编码的FCTRX多肽，或其变体，片段和同源物单独或组合使用的方法。 FCTRX统称为六种变体FCTRX序列中的任何一种，分别为FCTR1，FCTR2，FCTR3，FCTR4，FCTR5和FCTR6。

公开(公告)号：US20050208540A1

公开(公告)日：2005-09-22

申请号：US11027948

申请日：2004-12-30

申请人： Richard Shimkets ,  Sudhirdas Prayaga

发明人： Richard Shimkets ,  Sudhirdas Prayaga

IPC分类号： A61K39/395 ,  C07H21/04 ,  C07K14/50 ,  C07K16/22 ,  C12N15/09 ,  C12Q1/68

CPC分类号： C07K14/50

摘要： The present invention provides FGF-CX, a novel isolated polypeptide, as well as a polynucleotide encoding FGF-CX and antibodies that immunospecifically bind to FGF-CX or any derivative, variant, mutant, or fragment of the FGF-CX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FGF-CX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states,as well as to other uses.

摘要翻译： 本发明提供了FGF-CX，一种新的分离的多肽，以及编码FGF-CX的多核苷酸和免疫特异性结合FGF-CX或FGF-CX多肽的任何衍生物，变体，突变体或片段的多核苷酸或 抗体。 本发明还提供了FGF-CX多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。

公开(公告)号：US20060014153A1

公开(公告)日：2006-01-19

申请号：US10877346

申请日：2004-06-25

申请人： Valerie Gerlach ,  John MacDougall ,  Glennda Smithson ,  Isabelle Millet ,  David Stone ,  Erik Gunther ,  Karen Ellerman ,  William Grosse ,  John Alsobrook ,  Denise Lepley ,  Catherine Burgess ,  Muralidhara Padigaru ,  Ramesha Kekuda ,  Kimberly Spytek ,  Martin Leach ,  Richard Shimkets

发明人： Valerie Gerlach ,  John MacDougall ,  Glennda Smithson ,  Isabelle Millet ,  David Stone ,  Erik Gunther ,  Karen Ellerman ,  William Grosse ,  John Alsobrook ,  Denise Lepley ,  Catherine Burgess ,  Muralidhara Padigaru ,  Ramesha Kekuda ,  Kimberly Spytek ,  Martin Leach ,  Richard Shimkets

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/00

CPC分类号： C07K14/47 ,  A61K38/00

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：US20050032073A1

公开(公告)日：2005-02-10

申请号：US10644349

申请日：2003-08-20

申请人： Richard Shimkets

发明人： Richard Shimkets

IPC分类号： A61K38/18 ,  C12Q1/68 ,  G01N33/74 ,  G01N33/53 ,  G01N33/567

CPC分类号： G01N33/6872 ,  A61K38/1825 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N33/74 ,  G01N2333/50 ,  G01N2800/04 ,  G01N2800/52

摘要： The present invention describes novel methods for diagnosis and treatment of conditions that alter phosphate transport in mammals. The fibroblast growth factor proteins and nucleotides that may be useful as a therapeutic or in the diagnosis of such conditions are also described.

公开(公告)号：US20070166756A1

公开(公告)日：2007-07-19

申请号：US11724656

申请日：2007-03-15

申请人： Richard Shimkets ,  Elma Fernandes

发明人： Richard Shimkets ,  Elma Fernandes

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/47 ,  C07K16/18

CPC分类号： C07K14/4703 ,  A61K38/00 ,  C07K14/47 ,  C07K14/515 ,  C07K14/575 ,  C07K14/705

摘要： The invention provides polypeptides, designated herein as SECP polypeptides, as well as polynucleotides encoding SECP polypeptides, and antibodies that immunospecifically-bind to SECP polypeptide or polynucleotide, or derivatives, variants, mutants, or fragments thereof. The invention additionally provides methods in which the SECP polypeptide, polynucleotide, and antibody are used in the detection, prevention, and treatment of a broad range of pathological states.

摘要翻译： 本发明提供了本文中称为SECP多肽的多肽，以及编码SECP多肽的多核苷酸，以及免疫特异性结合SECP多肽或多核苷酸或其衍生物，变体，突变体或其片段的抗体。 本发明另外提供了在广泛的病理状态的检测，预防和治疗中使用SECP多肽，多核苷酸和抗体的方法。

公开(公告)号：US20060084054A1

公开(公告)日：2006-04-20

申请号：US10455772

申请日：2003-06-04

申请人： John Alsobrook ,  David Anderson ,  Jason Baumgartner ,  Constance Berghs ,  Ferenc Boldog ,  Catherine Burgess ,  Stacie Casman ,  Elina Catterton ,  Mohanraj Dhanabal ,  Shlomit Edinger ,  Karen Ellerman ,  Seth Ettenberg ,  Esha Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  William Grosse ,  Erik Gunther ,  Xiaojia Guo ,  Vladimir Gusev ,  John Herrmann ,  Weizhen Ji ,  Ramesh Kekuda ,  Nikolai Khramtsov ,  William LaRochelle ,  Li Li ,  Hongping Liang ,  Kenneth Low ,  John MacDougall ,  Timothy Maclachlan ,  Uriel Malyankar ,  Kelly McQueeney ,  Amanda Mezick ,  Charles Miller ,  Isabelle Millet ,  Muralidhara Padigaru ,  Meera Patturajan ,  John Peyman ,  Xiaozhong Qian ,  Luca Rastelli ,  Daniel Rieger ,  Mark Rothenberg ,  Suresh Shenoy ,  Richard Shimkets ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Sujatha Sukumaran ,  Edward Szekeres ,  Corine Vernet ,  Edward Voss ,  Adam Wolenc ,  Mei Zhong ,  Haihong Zhong

发明人： John Alsobrook ,  David Anderson ,  Jason Baumgartner ,  Constance Berghs ,  Ferenc Boldog ,  Catherine Burgess ,  Stacie Casman ,  Elina Catterton ,  Mohanraj Dhanabal ,  Shlomit Edinger ,  Karen Ellerman ,  Seth Ettenberg ,  Esha Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  William Grosse ,  Erik Gunther ,  Xiaojia Guo ,  Vladimir Gusev ,  John Herrmann ,  Weizhen Ji ,  Ramesh Kekuda ,  Nikolai Khramtsov ,  William LaRochelle ,  Li Li ,  Hongping Liang ,  Kenneth Low ,  John MacDougall ,  Timothy Maclachlan ,  Uriel Malyankar ,  Kelly McQueeney ,  Amanda Mezick ,  Charles Miller ,  Isabelle Millet ,  Muralidhara Padigaru ,  Meera Patturajan ,  John Peyman ,  Xiaozhong Qian ,  Luca Rastelli ,  Daniel Rieger ,  Mark Rothenberg ,  Suresh Shenoy ,  Richard Shimkets ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Sujatha Sukumaran ,  Edward Szekeres ,  Corine Vernet ,  Edward Voss ,  Adam Wolenc ,  Mei Zhong ,  Haihong Zhong

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12N9/00

CPC分类号： C07K16/40 ,  C07K14/47

摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

摘要翻译： 本发明提供由多核苷酸编码的新型分离的多核苷酸和小分子靶向多肽。 公开了免疫特异性结合该多肽，多核苷酸或抗体的新型小分子靶多肽或任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和 治疗广泛的病理状态。 更具体地，本发明公开了在各种筛选方法中使用重组表达和/或内源表达的蛋白质用于鉴定与疾病相关的治疗性抗体和治疗性小分子的方法。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：US20060013813A1

公开(公告)日：2006-01-19

申请号：US11054281

申请日：2005-02-08

申请人： Peter Mezes ,  Luca Rastelli ,  John Herrmann ,  John MacDougall ,  Haihong Zhong ,  Stacie Casman ,  Frenc Boldog ,  Richard Shimkets ,  Linda Gorman ,  Andrew Eisen ,  Steven Spaderna ,  Corine Vernet ,  Constance Berghs ,  Kimberly Spytek ,  Vincent DiPippo ,  Bryan Zerhusen ,  John Peyman ,  Karen Ellerman ,  David Stone ,  William Grosse ,  John Alsobrook ,  Denise Lepley ,  Daniel Rieger ,  Catherine Burgess ,  Sholmit Edinger ,  Edward Voss ,  Charles Miller

发明人： Peter Mezes ,  Luca Rastelli ,  John Herrmann ,  John MacDougall ,  Haihong Zhong ,  Stacie Casman ,  Frenc Boldog ,  Richard Shimkets ,  Linda Gorman ,  Andrew Eisen ,  Steven Spaderna ,  Corine Vernet ,  Constance Berghs ,  Kimberly Spytek ,  Vincent DiPippo ,  Bryan Zerhusen ,  John Peyman ,  Karen Ellerman ,  David Stone ,  William Grosse ,  John Alsobrook ,  Denise Lepley ,  Daniel Rieger ,  Catherine Burgess ,  Sholmit Edinger ,  Edward Voss ,  Charles Miller

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  A61K39/395 ,  C07K14/705 ,  C07K16/18

CPC分类号： C12N9/2462 ,  A61K38/00 ,  A61K47/6829 ,  A61K47/6851 ,  A61K47/6869 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  G01N33/6893

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.