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32 条记录 (耗时 0.018 秒)

    Biocompatible and biodegradable nanoparticles designed for proteinaceous drugs absorption and delivery
    6.
    发明授权
    Biocompatible and biodegradable nanoparticles designed for proteinaceous drugs absorption and delivery 失效
    生物相容性和可生物降解的纳米粒子设计用于蛋白质药物的吸收和输送

    公开(公告)号：US5962566A

    公开(公告)日：1999-10-05

    申请号：US973863

    申请日：1998-05-07

    申请人： Christian Grandfils ,  Robert Jerome ,  Nicole Nihant ,  Philippe Teyssie

    发明人： Christian Grandfils ,  Robert Jerome ,  Nicole Nihant ,  Philippe Teyssie

    IPC分类号： A61K9/51

    CPC分类号： A61K9/5153 ,  A61K9/5192 ,  Y10S977/773 ,  Y10S977/801

    摘要： The presently claimed invention comprises a biopolymer nanoparticle for drug delivery wherein the nanoparticle comprises a homogeneous blend of an aliphatic polyester polymer blended with a polyether, a lipophilic or polypeptide drug and a biocompatible cholesterol interacting agent for preserving the activity of the drug administered to the patient while at the same time controlling the release of the drug. Methods for making the homogeneous drug delivery nanoparticles are also disclosed.

    摘要翻译： PCT No.PCT / EP96 / 02878第 371日期1998年5月7日 102（e）日期1998年5月7日PCT PCT 1996年7月2日PCT公布。 出版物WO97 / 0202200 日本1997年1月23日本发明包括用于药物递送的生物聚合物纳米颗粒，其中纳米颗粒包含与聚醚共混的脂族聚酯聚合物，亲脂性或多肽药物和生物相容性胆固醇相互作用剂的均匀共混物，用于保持 同时施用于患者的药物同时控制药物的释放。 还公开了制备均匀药物递送纳米颗粒的方法。

    Process for controlled radical polymerization or copolymerization of (meth)acrylic and vinyl monomers and (co)polymers obtained
    7.
    发明授权
    Process for controlled radical polymerization or copolymerization of (meth)acrylic and vinyl monomers and (co)polymers obtained 失效
    获得的（甲基）丙烯酸和乙烯基单体和（共）聚合物的受控自由基聚合或共聚方法

    公开(公告)号：US5767210A

    公开(公告)日：1998-06-16

    申请号：US827386

    申请日：1997-03-27

    申请人： Philippe Lecomte ,  Philippe Dubois ,  Robert Jerome ,  Philippe Teyssie ,  Thierry Senninger

    发明人： Philippe Lecomte ,  Philippe Dubois ,  Robert Jerome ,  Philippe Teyssie ,  Thierry Senninger

    IPC分类号： C08F2/24 ,  C08F2/02 ,  C08F2/38 ,  C08F4/00 ,  C08F4/04 ,  C08F4/26 ,  C08F4/28 ,  C08F4/72 ,  C08F4/80 ,  C08F20/00 ,  C08F20/14 ,  C08F2/00 ,  C08F20/06

    CPC分类号： C08F4/00 ,  C08F4/80

    摘要： This process is characterized by the fact that at least one of the said monomers is polymerized or copolymerized in bulk, solution, emulsion or suspension, at a temperature that can be as low as 0.degree. C., in the presence of an initiation system including: at least one compound generating radicals, other than bromofluorene, and at least one catalyst consisting of a complex of palladium in the 0 oxidation state, denoted by the following formula (I): Pd(0)L.sup.1 L.sup.2 L.sup.3 L.sup.4 in which each of L.sup.1, L.sup.2, L.sup.3 and L.sup.4, which are identical or different, denotes a ligand which may be a chiral ligand, which is chosen from PRR'R", P(OR)(OR')(OR"), NRR'R", ORR', SRR', SeRR', AsRR'R", SbRR'R", where each of R, R' and R" independently denotes a C.sub.1 -C.sub.14 alkyl group, optionally substituted, or an optionally substituted aromatic group, it being possible for at least two of these ligands to be joined to one another by one or more divalent radicals.

    摘要翻译： 该方法的特征在于，在起始系统存在下，至少一种所述单体在本体，溶液，乳液或悬浮液中在可低至0℃的温度下聚合或共聚，包括 ：除了溴芴之外，至少一种产生自由基的化合物和至少一种由O型氧化态的钯络合物组成的催化剂，由下式（I）表示：Pd（0）L1L2L3L4，其中L1，L2 表示可以是手性配体的配体，其选自PRR'R“，P（OR）（OR'）（OR”）（OR“），NRR'R” ，ORR'，SRR'，SeRR'，AsRR'R“，SbRR'R”，其中R，R'和R“各自独立地表示任选取代的C 1 -C 14烷基或任选取代的芳族 这些配体中的至少两个可能通过一个或多个二价基团彼此连接。

    Process for the controlled polymerization or copolymerization of (meth)acrylic and vinyl monomers and products thus obtained
    9.
    发明授权
    Process for the controlled polymerization or copolymerization of (meth)acrylic and vinyl monomers and products thus obtained 失效
    （甲基）丙烯酸和乙烯基单体和由此获得的产物的受控聚合或共聚方法

    公开(公告)号：US5869583A

    公开(公告)日：1999-02-09

    申请号：US821873

    申请日：1997-03-21

    申请人： Claude Granel ,  Philippe Teyssie ,  Robert Jerome ,  Pascal Nicol

    发明人： Claude Granel ,  Philippe Teyssie ,  Robert Jerome ,  Pascal Nicol

    IPC分类号： C08F4/80 ,  C08F2/00 ,  C08F2/38 ,  C08F4/40 ,  C08F4/42 ,  C08F20/00 ,  C08F293/00 ,  C08F4/00 ,  C08F210/00

    CPC分类号： C08F293/00 ,  C08F4/40

    摘要： The process for the controlled radical (co)polymerization of (meth)acrylic and/or vinyl monomers is characterized in that the bulk, solution, emulsion or suspension polymerization or copolymerization is carried out, at a temperature at which can fall to 0.degree. C., of at least one of the said monomers in the presence of an initiating system comprising a radical-generating compound and at least one catalyst composed of a metal complex containing a ligand of the type�4-R.sup.3 -2,6-(CH.sub.2 NR.sup.1 R.sup.2).sub.2 C.sub.6 H.sub.2 !--(I)in which: R.sup.1 and R.sup.2, which are identical or different, represent a branched or unbranched C.sub.1 -C.sub.4 alkyl group or a phenyl group or alternatively R.sup.1 and R.sup.2 form, with the nitrogen atom to which they are connected, a cyclic amine or alternatively the two R.sup.2 groups, taken together, form a polymethylene bridge and R.sup.3 represents a hydrogen atom, an alkyl or benzyl group or an electron-donating or electron-withdrawing functional group.

    摘要翻译： （甲基）丙烯酸和/或乙烯基单体的受控自由基（共）聚合的方法的特征在于，在可以降至0℃的温度下进行本体，溶液，乳液或悬浮液的聚合或共聚 在包含自由基产生化合物的起始系统存在下的至少一种所述单体，和至少一种由含有[4-R3-2,6-（CH2NR1R2 ）2C 6 H 2] - （I）其中：相同或不同的R 1和R 2表示支链或非支链C 1 -C 4烷基或苯基，或者R 1和R 2与它们连接的氮原子形成 环状胺或两个R2基团一起形成多亚甲基桥，R 3表示氢原子，烷基或苄基或给电子或吸电子官能团。

    Process for the controlled radical (CO) polymerization of (Meth) acrylic vinyl vinylidene and diene monomers in the presence of an Rh Co OR Ir
    10.
    发明授权
    Process for the controlled radical (CO) polymerization of (Meth) acrylic vinyl vinylidene and diene monomers in the presence of an Rh Co OR Ir 失效
    （甲基）丙烯酸乙烯基亚乙烯基和二烯单体在Rh Co OR Ir存在下的受控自由基（CO）聚合方法

    公开(公告)号：US5811500A

    公开(公告)日：1998-09-22

    申请号：US884219

    申请日：1997-06-27

    申请人： Philippe Dubois ,  Georges Moineau ,  Philippe Teyssie ,  Robert Jerome ,  Thierry Senninger

    发明人： Philippe Dubois ,  Georges Moineau ,  Philippe Teyssie ,  Robert Jerome ,  Thierry Senninger

    IPC分类号： C08F2/24 ,  C08F2/38 ,  C08F4/00 ,  C08F4/04 ,  C08F4/28 ,  C08F4/60 ,  C08F4/72 ,  C08F4/80 ,  C08F12/08 ,  C08F14/00 ,  C08F18/08 ,  C08F20/10 ,  C08F20/14 ,  C08F297/06 ,  C08F4/06

    CPC分类号： C08F4/00

    摘要： This process is characterized in that at least one of the said monomers is polymerized or copolymerized in bulk, solution, emulsion or suspension, at a temperature which may be as low as 0.degree. C., in the presence of an initiator system comprising at least one non-peroxy radical-generator compound and at least one catalyst consisting of a metal complex represented by formula Ma.sub.a (L).sub.n in which M represents Rh, Co or Ir; A represents, a halogen or a pseudohalogen; the groups L, which may be identical or different, each represent a ligand which may be a chiral ligand, which is chosen from cyclooctadiene, PRR'R", P(OR) (OR') (OR"), NRR'R", ORR', SRR', SeRR', AsRR'R", SbRR'R", each radical R, R' and R" independently representing an optionally substituted C.sub.1 -C.sub.14 alkyl group or an optionally substituted aromatic group, it being possible for at least two of these ligands to be joined together by one or more divalent radicals; a is an integer such that 1.ltoreq.a.ltoreq.3 ; n is an integer such that 1.ltoreq.n.ltoreq.5, and in the absence of activator.

    摘要翻译： 该方法的特征在于，至少一种所述单体在本体，溶液，乳液或悬浮液中，在可能低至0℃的温度下，在至少包含至少 一种非过氧自由基产生剂化合物和至少一种由式Ma（L）n表示的金属配合物组成的催化剂，其中M表示Rh，Co或Ir; A表示卤素或假卤素; 可以相同或不同的基团L各自表示可以是手性配体的配体，其选自环辛二烯，PRR'R“，P（OR）（OR'）（OR”），NRR' R“，ORR'，SRR'，SeRR'，AsRR'R”，SbRR'R“，每个基团R，R'和R”独立地表示任选取代的C 1 -C 14烷基或任选取代的芳族 这些配体中的至少两个可能通过一个或多个二价基团连接在一起; a是整数，使得1