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    AEROSOL DELIVERY SYSTEM WITH TEMPERATURE-BASED AEROSOL DETECTOR
    6.
    发明申请
    AEROSOL DELIVERY SYSTEM WITH TEMPERATURE-BASED AEROSOL DETECTOR 审中-公开
    具有基于温度的气溶胶探测器的航空发送系统

    公开(公告)号：US20130186392A1

    公开(公告)日：2013-07-25

    申请号：US13522814

    申请日：2010-12-16

    申请人： Jacob Roger Haartsen ,  Jonathan Stanley Harold Denyer ,  Michael James Robbert Leppard ,  Anthony Dyche ,  Ronald Dekker ,  Bout Marcelis

    发明人： Jacob Roger Haartsen ,  Jonathan Stanley Harold Denyer ,  Michael James Robbert Leppard ,  Anthony Dyche ,  Ronald Dekker ,  Bout Marcelis

    IPC分类号： A61M16/14 ,  A61M15/00 ,  A61M11/04

    CPC分类号： A61M16/14 ,  A61M11/04 ,  A61M15/0065 ,  A61M15/008 ,  A61M15/0085 ,  A61M2205/3368 ,  A61M2205/44 ,  A61M2205/52 ,  A61M2205/581 ,  A61M2205/583

    摘要： An aerosol delivery system (e.g., MDI or nebulizer for delivering aerosolized medication to a patient) includes a temperature sensor (10) in an aerosol output pathway of the system. A controller (600) determines that an aerosol generator of the system has released aerosol when the sensor senses a predetermined temperature change in the pathway. The temperature sensor may also comprise a thermal flow sensor that includes a heater and upstream and downstream temperature sensors. The controller compares the upstream and downstream temperatures to determine the presence, direction, and/or magnitude of fluid flow in the pathway. The controller may use the aerosol detection and/or flow detection to monitor compliance with desired use of the system and/or provide real-time instructions to a user for proper use of the system. The controller may record the aerosolization and flow data for later analysis.

    摘要翻译： 气溶胶递送系统（例如，用于将雾化的药物递送给患者的MDI或雾化器）包括在系统的气溶胶输出路径中的温度传感器（10）。 当传感器感测到路径中的预定温度变化时，控制器（600）确定系统的气溶胶发生器已经释放气溶胶。 温度传感器还可以包括热流传感器，其包括加热器和上游和下游温度传感器。 控制器比较上游和下游温度，以确定通道中流体流动的存在，方向和/或幅度。 控制器可以使用气溶胶检测和/或流量检测来监测系统的期望使用的符合性和/或向用户提供实时指令以正确使用该系统。 控制器可以记录雾化和流数据供以后分析。

    FLOW SENSOR AND AEROSOL DELIVERY DEVICE
    7.
    发明申请
    FLOW SENSOR AND AEROSOL DELIVERY DEVICE 审中-公开
    流量传感器和航空运输装置

    公开(公告)号：US20120291779A1

    公开(公告)日：2012-11-22

    申请号：US13522798

    申请日：2010-12-16

    申请人： Jacob Roger Haartsen ,  Jonathan Stanley Harold Denyer ,  Michael James Robbert Leppard ,  Anthony Dyche ,  Ronald Dekker ,  Bout Marcelis

    发明人： Jacob Roger Haartsen ,  Jonathan Stanley Harold Denyer ,  Michael James Robbert Leppard ,  Anthony Dyche ,  Ronald Dekker ,  Bout Marcelis

    IPC分类号： A61M15/00

    CPC分类号： G01F1/684 ,  A61M15/0065

    摘要： An aerosol delivery system (e.g., MDI or nebulizer for delivering aerosolized medication to a patient) includes a temperature sensor in an aerosol output pathway of the system. A controller determines that an aerosol generator of the system has released aerosol when the sensor senses a predetermined temperature change in the pathway. The temperature sensor may also comprise a thermal flow sensor that includes a heater and upstream and downstream temperature sensors. The controller compares the upstream and downstream temperatures to determine the presence, direction, and/or magnitude of fluid flow in the pathway. The controller may use the aerosol detection and/or flow detection to monitor compliance with desired use of the system and/or provide real-time instructions to a user for proper use of the system. The controller may record the aerosolization and flow data for later analysis.

    摘要翻译： 气雾剂输送系统（例如，用于将雾化的药物递送到患者的MDI或雾化器）包括系统的气溶胶输出路径中的温度传感器。 当传感器感测到路径中的预定温度变化时，控制器确定系统的气溶胶发生器已经释放气溶胶。 温度传感器还可以包括热流传感器，其包括加热器和上游和下游温度传感器。 控制器比较上游和下游温度，以确定通道中流体流动的存在，方向和/或幅度。 控制器可以使用气溶胶检测和/或流量检测来监测系统的期望使用的符合性和/或向用户提供实时指令以正确使用该系统。 控制器可以记录雾化和流数据供以后分析。

    SYSTEM-IN-PACKAGE PLATFORM FOR ELECTRONIC-MICROFLUIDIC DEVICES
    8.
    发明申请
    SYSTEM-IN-PACKAGE PLATFORM FOR ELECTRONIC-MICROFLUIDIC DEVICES 有权
    用于电子微流体装置的系统级封装平台

    公开(公告)号：US20130149215A1

    公开(公告)日：2013-06-13

    申请号：US13755293

    申请日：2013-01-31

    申请人： Ronald Dekker ,  Remco Henricus Wilhelmus Pijnenburg ,  Nicolaas Johannes Anthonius Van Veen

    发明人： Ronald Dekker ,  Remco Henricus Wilhelmus Pijnenburg ,  Nicolaas Johannes Anthonius Van Veen

    IPC分类号： H01L37/00 ,  B01L3/00

    CPC分类号： H01L37/00 ,  B01J2219/00783 ,  B01J2219/0095 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/12 ,  B01L2200/14 ,  B01L2300/0645 ,  B01L2300/1827 ,  B01L2300/1883 ,  B01L2400/0415 ,  B81B2201/058 ,  B81C1/0023 ,  H01L2224/11 ,  Y10T436/11

    摘要： The present invention relates to an integrated electronic-microfluidic device an integrated electronic-microfluidic device, comprising a semiconductor substrate (106) on a first (122) support, an electronic circuit (102, 104) on a first semiconductor-substrate side of the semiconductor substrate, and a signal interface structure to an external device. The signal interface structure is arranged on the first semiconductor-substrate side and configured to receive electrical signals from the electronic circuit. A microfluidic structure (126) is formed in the semiconductor substrate, and is configured to confine a fluid and to allow a flow of the fluid to and from the microfluidic structure only on a second semiconductor-substrate side that is opposite to the first semiconductor-substrate side and faces away form the first support. The electronic-microfluidic device forms a flexible platform for the formation of various System-in-Package applications. It achieves a clear separation between electrical and wet-chemical interfaces. The claimed method for fabricating the device of the invention also allows a simple formation of thermally isolated microfluidic structures.

    摘要翻译： 本发明涉及一种集成电子微流体装置，集成的电子微流体装置，其包括在第一（122）支撑件上的半导体衬底（106），电子电路（102,104）的第一半导体衬底 半导体衬底和与外部设备的信号接口结构。 信号接口结构布置在第一半导体衬底侧并被配置为从电子电路接收电信号。 微流体结构（126）形成在半导体衬底中，并且被配置为限制流体并允许仅在与第一半导体衬底相反的第二半导体衬底侧上流体流过微流体结构， 衬底侧面和背面形成第一支撑件。 电子微流体装置形成用于形成各种系统级封装应用的灵活平台。 它实现了电气和湿化学界面之间的清晰分离。 所要求的制造本发明装置的方法还允许简单地形成热分离的微流体结构。

    CARDIOMYOCYTES-CONTAINING DEVICE AND METHOD FOR MANUFACTURING AND USING THE SAME
    10.
    发明申请
    CARDIOMYOCYTES-CONTAINING DEVICE AND METHOD FOR MANUFACTURING AND USING THE SAME 失效
    含有血小板活性的装置及其制造和使用方法

    公开(公告)号：US20120094323A1

    公开(公告)日：2012-04-19

    申请号：US13147607

    申请日：2010-02-02

    申请人： Ronald Dekker ,  Anja Van De Stolpe

    发明人： Ronald Dekker ,  Anja Van De Stolpe

    IPC分类号： C12Q1/18 ,  H01B13/00 ,  B05D5/00 ,  C12M1/34 ,  B05D1/36

    CPC分类号： G01N1/30 ,  C12N5/0657 ,  C12N2503/02 ,  C12N2535/10 ,  G01N33/5061

    摘要： Disclosed is a device for determining the cardiotoxicity of a chemical compound, comprising a substrate (10) carrying a deformable stack (34), said stack being partially detached from the substrate by a cavity (32) allowing an out-of-plane deformation of the stack, said stack comprising a first deformable layer (16), a second deformable layer (20) and a multi-electrode structure (18) sandwiched between the first and second deformable layers, the second deformable layer carrying a pattern of cardiomyocytes (28) adhered thereto; and a liquid container (26) mounted on the substrate for exposing the cardiomyocytes to the chemical compound. A method of manufacturing such a device is also disclosed. The present invention further relates to the use of the device for drug target discovery and/or drug development and a method for developing a disease model for a disease that is caused by or modified by stretching of cells, in particular a cardiac disease model.

    摘要翻译： 公开了一种用于确定化合物的心脏毒性的装置，包括承载可变形叠层（34）的基底（10），所述叠层通过空腔（32）部分地与基底分离，允许外部变形 所述堆叠包括夹在所述第一和第二可变形层之间的第一可变形层（16），第二可变形层（20）和多电极结构（18），所述第二可变形层承载心肌细胞图案（28 ） 和安装在基板上的用于将心肌细胞暴露于化合物的液体容器（26）。 还公开了制造这种装置的方法。 本发明还涉及该装置用于药物靶发现和/或药物开发的用途，以及用于开发由细胞拉伸，特别是心脏疾病模型引起或改变的疾病的疾病模型的方法。