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公开(公告)号：US07247370B2
公开(公告)日：2007-07-24
申请号：US10484059
申请日：2002-07-18
申请人： Ronald F. Childs , Alicja M. Mika , Jijun Ge , Chris McCrory
发明人： Ronald F. Childs , Alicja M. Mika , Jijun Ge , Chris McCrory
IPC分类号： B32B5/14
CPC分类号： B01D67/0088 , B01D67/0006 , B01D67/0009 , B01D69/10 , B01D69/141 , B01D71/38 , B01D71/40 , B01D71/44 , B01D2323/30 , B01D2323/34 , B01D2325/022 , B01D2325/28 , B01D2325/42 , Y10T428/249953 , Y10T428/249961
摘要： The invention provides asymmetric membranes composed of a microporous substrate whose pores contain a crosslinked gel, the density of the crosslinked gel being greater at or adjacent to one major surface of the membrane than the density at the other major surface. The membranes are useful for separating matter from liquids and display good flux and good rejection at low pressure.
摘要翻译： 本发明提供了由微孔基材组成的不对称膜，孔的孔含有交联凝胶，交联凝胶的密度在膜的一个主表面处或与其另一个主表面的密度相比更大。 该膜可用于从液体中分离物质，并在低压下显示良好的通量和良好的排除性。
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公开(公告)号：US08313651B2
公开(公告)日：2012-11-20
申请号：US13169420
申请日：2011-06-27
CPC分类号： B01D69/10 , B01D63/06 , B01D63/061 , B01D63/081 , B01D63/082 , B01D63/10 , B01D67/0006 , B01D67/0079 , B01D67/0088 , B01D2313/14 , B01D2319/025 , B01D2319/06 , B01D2323/30 , B01D2323/40 , B01D2325/02 , B01D2325/28 , B01D2325/36 , B01D2325/38 , B01J20/28033 , B01J20/28035 , B01J20/28047 , B01J20/28052 , B01J20/28085 , B01J20/281 , B01J20/291 , B01L3/50255
摘要： The present invention discloses a membrane stack comprising a first and second membrane layers, and a spacer layer disposed between said first and second membrane layers, said membrane stack configured such that fluid passes through said membrane stack in a direction substantially perpendicular to the plane of said membrane layers and said spacer layer. The application also discloses a module comprising a membrane as described above, said module having a fluid flow path that is substantially perpendicular to the plane of the major surface of the membrane and spacer layers ins aid membrane stack.
摘要翻译： 本发明公开了一种膜堆叠，其包括第一和第二膜层以及设置在所述第一和第二膜层之间的间隔层，所述膜叠层构造成使得流体在基本上垂直于所述第一和第二膜层的平面的方向上穿过所述膜堆叠 膜层和所述间隔层。 本申请还公开了一种包括如上所述的膜的模块，所述模块具有基本上垂直于膜的主表面的平面的流体流动路径，并且间隔层有助于膜堆叠。
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公开(公告)号：US20100044316A1
公开(公告)日：2010-02-25
申请号：US12609689
申请日：2009-10-30
申请人： Ronald F. Childs , Carlos Filipe , Raja Ghosh , Alicja M. Mika , Jinsheng Zhou , Elena N. Komkova , Marcus Y. Kim , Tapan K. Dey
发明人： Ronald F. Childs , Carlos Filipe , Raja Ghosh , Alicja M. Mika , Jinsheng Zhou , Elena N. Komkova , Marcus Y. Kim , Tapan K. Dey
CPC分类号： C07K1/04 , B01D15/327 , B01D15/34 , B01D15/36 , B01D15/361 , B01D15/3804 , B01D67/0006 , B01D69/02 , B01D69/10 , B01D69/141 , B01D71/40 , B01D2323/30 , B01D2323/34 , B01D2325/12 , B01D2325/14 , B01D2325/16 , B01D2325/38 , B01J20/261 , B01J20/262 , B01J20/264 , B01J20/265 , B01J20/267 , B01J20/28004 , B01J20/28011 , B01J20/28023 , B01J20/28033 , B01J20/28047 , B01J20/28069 , B01J20/28078 , B01J20/28085 , B01J20/28097 , B01J20/285 , B01J20/286 , B01J20/291 , B01J20/3064 , B01J20/321 , B01J20/3212 , B01J20/3272 , B01J20/3276 , B01J20/3278 , B01J20/3282 , B01J39/26 , B01J41/20 , B01J47/018 , B01J47/12 , C07K1/20 , C07K1/22 , C07K1/34 , Y10S530/812 , Y10S530/815 , Y10T428/249978 , Y10T428/249994
摘要： This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.
摘要翻译： 本发明涉及一种复合材料，其包括具有延伸穿过支撑构件的多个孔的支撑构件，并且位于支撑构件的孔中并填充支撑构件的孔，大孔交联凝胶。 本发明还涉及一种制备上述复合材料及其用途的方法。 复合材料例如用于分离物质，例如通过过滤或吸附，包括色谱法，用作合成中的载体或用作细胞生长的载体。
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公开(公告)号：US20090029438A1
公开(公告)日：2009-01-29
申请号：US12244940
申请日：2008-10-03
申请人： Ronald F. Childs , Carlos Filipe , Raja Ghosh , Alicja M. Mika , Jinsheng Zhou , Elena N. Komkova , Marcus Y. Kim , Tapan K. Dey
发明人： Ronald F. Childs , Carlos Filipe , Raja Ghosh , Alicja M. Mika , Jinsheng Zhou , Elena N. Komkova , Marcus Y. Kim , Tapan K. Dey
IPC分类号： C12N9/02 , B01D15/26 , C12N7/02 , C12N5/00 , C07K1/14 , C07K14/52 , C12N9/00 , C07K16/00 , C07K14/805 , C07H21/04 , C07H21/02 , C07H21/00 , C07K14/765 , C07K14/77 , C12N9/14
CPC分类号： C07K1/04 , B01D15/327 , B01D15/34 , B01D15/36 , B01D15/361 , B01D15/3804 , B01D67/0006 , B01D69/02 , B01D69/10 , B01D69/141 , B01D71/40 , B01D2323/30 , B01D2323/34 , B01D2325/12 , B01D2325/14 , B01D2325/16 , B01D2325/38 , B01J20/261 , B01J20/262 , B01J20/264 , B01J20/265 , B01J20/267 , B01J20/28004 , B01J20/28011 , B01J20/28023 , B01J20/28033 , B01J20/28047 , B01J20/28069 , B01J20/28078 , B01J20/28085 , B01J20/28097 , B01J20/285 , B01J20/286 , B01J20/291 , B01J20/3064 , B01J20/321 , B01J20/3212 , B01J20/3272 , B01J20/3276 , B01J20/3278 , B01J20/3282 , B01J39/26 , B01J41/20 , B01J47/018 , B01J47/12 , C07K1/20 , C07K1/22 , C07K1/34 , Y10S530/812 , Y10S530/815 , Y10T428/249978 , Y10T428/249994
摘要： This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.
摘要翻译： 本发明涉及一种复合材料，其包括具有延伸穿过支撑构件的多个孔的支撑构件，并且位于支撑构件的孔中并填充支撑构件的孔，大孔交联凝胶。 本发明还涉及一种制备上述复合材料及其用途的方法。 复合材料例如用于分离物质，例如通过过滤或吸附，包括色谱法，用作合成中的载体或用作细胞生长的载体。
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公开(公告)号：US20080314831A1
公开(公告)日：2008-12-25
申请号：US11950562
申请日：2007-12-05
申请人： Ronald F. Childs , Carlos Filipe , Raja Ghosh , Alicja M. Mika , Jinsheng Zhou , Elena N. Komkova , Marcus Y. Kim , Tapan K. Dey
发明人： Ronald F. Childs , Carlos Filipe , Raja Ghosh , Alicja M. Mika , Jinsheng Zhou , Elena N. Komkova , Marcus Y. Kim , Tapan K. Dey
CPC分类号： C07K1/04 , B01D15/327 , B01D15/34 , B01D15/36 , B01D15/361 , B01D15/3804 , B01D67/0006 , B01D69/02 , B01D69/10 , B01D69/141 , B01D71/40 , B01D2323/30 , B01D2323/34 , B01D2325/12 , B01D2325/14 , B01D2325/16 , B01D2325/38 , B01J20/261 , B01J20/262 , B01J20/264 , B01J20/265 , B01J20/267 , B01J20/28004 , B01J20/28011 , B01J20/28023 , B01J20/28033 , B01J20/28047 , B01J20/28069 , B01J20/28078 , B01J20/28085 , B01J20/28097 , B01J20/285 , B01J20/286 , B01J20/291 , B01J20/3064 , B01J20/321 , B01J20/3212 , B01J20/3272 , B01J20/3276 , B01J20/3278 , B01J20/3282 , B01J39/26 , B01J41/20 , B01J47/018 , B01J47/12 , C07K1/20 , C07K1/22 , C07K1/34 , Y10S530/812 , Y10S530/815 , Y10T428/249978 , Y10T428/249994
摘要： This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.
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公开(公告)号：US20080264867A1
公开(公告)日：2008-10-30
申请号：US11628805
申请日：2005-06-06
CPC分类号： B01J20/28047 , B01J20/28033 , B01J20/28078 , B01J20/28085 , B01J20/28097 , B01J20/285 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/327 , B01J20/3272 , B01J20/3278 , B01J20/3282 , C12N5/0068 , C12N2533/30 , Y10S502/526
摘要： This invention relates to a stable composite material comprising a support member that has a plurality of pores extending through the support member, and a macroporous crosslinked gel that is located in, and fills, the pores of the support member, in which crosslinked gel is entrapped a stabilising polymer, which stabilising polymer is neutral, linear or branched, non-crosslinked, and substantially water-insoluble. The presence of the stabilising polymer is such that it allows the composite material to largely retain its porosity and morphology after being dried. The invention also relates to a process for preparing the stable composite material described above, and to its use. The stable composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.
摘要翻译： 本发明涉及一种稳定的复合材料，其包括具有延伸穿过支撑构件的多个孔的支撑构件和位于并填充支撑构件的孔中并且填充有交联凝胶的孔的大孔交联凝胶 稳定聚合物，其稳定聚合物是中性的，直链或支链的，非交联的，基本上不溶于水的。 稳定聚合物的存在使得其允许复合材料在干燥后大大保持其孔隙率和形态。 本发明还涉及制备上述稳定复合材料及其用途的方法。 稳定的复合材料例如用于分离物质，例如通过过滤或吸附，包括色谱法，用作合成中的载体或用作细胞生长的载体。
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公开(公告)号：US08652849B2
公开(公告)日：2014-02-18
申请号：US12250861
申请日：2008-10-14
申请人： Ronald F. Childs , Carlos Filipe , Raja Ghosh , Alicja M. Mika , Jinsheng Zhou , Elena N. Komkova , Marcus Y. Kim , Tapan K. Dey
发明人： Ronald F. Childs , Carlos Filipe , Raja Ghosh , Alicja M. Mika , Jinsheng Zhou , Elena N. Komkova , Marcus Y. Kim , Tapan K. Dey
IPC分类号： G01N33/20 , G01N33/544 , G01N33/545 , C12N9/00 , C12N11/02 , C12N11/08 , C07K1/14 , C07K1/22 , C07K17/02 , C07K17/08
CPC分类号： C07K1/04 , B01D15/327 , B01D15/34 , B01D15/36 , B01D15/361 , B01D15/3804 , B01D67/0006 , B01D69/02 , B01D69/10 , B01D69/141 , B01D71/40 , B01D2323/30 , B01D2323/34 , B01D2325/12 , B01D2325/14 , B01D2325/16 , B01D2325/38 , B01J20/261 , B01J20/262 , B01J20/264 , B01J20/265 , B01J20/267 , B01J20/28004 , B01J20/28011 , B01J20/28023 , B01J20/28033 , B01J20/28047 , B01J20/28069 , B01J20/28078 , B01J20/28085 , B01J20/28097 , B01J20/285 , B01J20/286 , B01J20/291 , B01J20/3064 , B01J20/321 , B01J20/3212 , B01J20/3272 , B01J20/3276 , B01J20/3278 , B01J20/3282 , B01J39/26 , B01J41/20 , B01J47/018 , B01J47/12 , C07K1/20 , C07K1/22 , C07K1/34 , Y10S530/812 , Y10S530/815 , Y10T428/249978 , Y10T428/249994
摘要： This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.
摘要翻译： 本发明涉及一种复合材料，其包括具有延伸穿过支撑构件的多个孔的支撑构件，并且位于支撑构件的孔中并填充支撑构件的孔，大孔交联凝胶。 本发明还涉及一种制备上述复合材料及其用途的方法。 复合材料例如用于分离物质，例如通过过滤或吸附，包括色谱法，用作合成中的载体或用作细胞生长的载体。
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8.发明授权Separating substances with supported porous gels containing metal-affinity ligands complexed with metal ions 有权分离物质与负载的多孔凝胶含有与金属离子络合的金属亲和配体公开(公告)号：US08192971B2
公开(公告)日：2012-06-05
申请号：US12211618
申请日：2008-09-16
申请人： Ronald F. Childs , Carlos Filipe , Raja Ghosh , Alicja M. Mika , Jinsheng Zhou , Elena N. Komkova , Marcus Y. Kim , Tapan K. Dey
发明人： Ronald F. Childs , Carlos Filipe , Raja Ghosh , Alicja M. Mika , Jinsheng Zhou , Elena N. Komkova , Marcus Y. Kim , Tapan K. Dey
IPC分类号： C12N9/00 , C12N11/02 , C12N11/08 , C12N9/14 , C12N9/76 , G01N33/544 , G01N33/545 , C07K1/14 , C07K1/22 , C07K17/02 , C07K17/08
CPC分类号： C07K1/04 , B01D15/327 , B01D15/34 , B01D15/36 , B01D15/361 , B01D15/3804 , B01D67/0006 , B01D69/02 , B01D69/10 , B01D69/141 , B01D71/40 , B01D2323/30 , B01D2323/34 , B01D2325/12 , B01D2325/14 , B01D2325/16 , B01D2325/38 , B01J20/261 , B01J20/262 , B01J20/264 , B01J20/265 , B01J20/267 , B01J20/28004 , B01J20/28011 , B01J20/28023 , B01J20/28033 , B01J20/28047 , B01J20/28069 , B01J20/28078 , B01J20/28085 , B01J20/28097 , B01J20/285 , B01J20/286 , B01J20/291 , B01J20/3064 , B01J20/321 , B01J20/3212 , B01J20/3272 , B01J20/3276 , B01J20/3278 , B01J20/3282 , B01J39/26 , B01J41/20 , B01J47/018 , B01J47/12 , C07K1/20 , C07K1/22 , C07K1/34 , Y10S530/812 , Y10S530/815 , Y10T428/249978 , Y10T428/249994
摘要： This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.
摘要翻译： 本发明涉及一种复合材料，其包括具有延伸穿过支撑构件的多个孔的支撑构件，并且位于支撑构件的孔中并填充支撑构件的孔，大孔交联凝胶。 本发明还涉及一种制备上述复合材料及其用途的方法。 复合材料例如用于分离物质，例如通过过滤或吸附，包括色谱法，用作合成中的载体或用作细胞生长的载体。
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公开(公告)号：US20090032463A1
公开(公告)日：2009-02-05
申请号：US12250861
申请日：2008-10-14
申请人： Ronald F. Childs , Carlos Felipe , Raja Ghosh , Alicja M. Mika , Jinsheng Zhou , Elena N. Komkova , Marcus Y. Kim , Tapan K. Dey
发明人： Ronald F. Childs , Carlos Felipe , Raja Ghosh , Alicja M. Mika , Jinsheng Zhou , Elena N. Komkova , Marcus Y. Kim , Tapan K. Dey
CPC分类号： C07K1/04 , B01D15/327 , B01D15/34 , B01D15/36 , B01D15/361 , B01D15/3804 , B01D67/0006 , B01D69/02 , B01D69/10 , B01D69/141 , B01D71/40 , B01D2323/30 , B01D2323/34 , B01D2325/12 , B01D2325/14 , B01D2325/16 , B01D2325/38 , B01J20/261 , B01J20/262 , B01J20/264 , B01J20/265 , B01J20/267 , B01J20/28004 , B01J20/28011 , B01J20/28023 , B01J20/28033 , B01J20/28047 , B01J20/28069 , B01J20/28078 , B01J20/28085 , B01J20/28097 , B01J20/285 , B01J20/286 , B01J20/291 , B01J20/3064 , B01J20/321 , B01J20/3212 , B01J20/3272 , B01J20/3276 , B01J20/3278 , B01J20/3282 , B01J39/26 , B01J41/20 , B01J47/018 , B01J47/12 , C07K1/20 , C07K1/22 , C07K1/34 , Y10S530/812 , Y10S530/815 , Y10T428/249978 , Y10T428/249994
摘要： This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.
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10.发明授权公开(公告)号：US08211682B2
公开(公告)日：2012-07-03
申请号：US12244940
申请日：2008-10-03
申请人： Ronald F. Childs , Carlos Filipe , Raja Ghosh , Alicja M. Mika , Jinsheng Zhou , Elena N. Komkova , Marcus Y. Kim , Tapan K. Dey
发明人： Ronald F. Childs , Carlos Filipe , Raja Ghosh , Alicja M. Mika , Jinsheng Zhou , Elena N. Komkova , Marcus Y. Kim , Tapan K. Dey
IPC分类号： C12N9/00 , C12N11/02 , C12N11/08 , C12N9/04 , C12N9/14 , C12N9/76 , G01N33/544 , G01N33/545 , C07K1/14 , C07K1/22 , C07K17/02 , C07K17/08
CPC分类号： C07K1/04 , B01D15/327 , B01D15/34 , B01D15/36 , B01D15/361 , B01D15/3804 , B01D67/0006 , B01D69/02 , B01D69/10 , B01D69/141 , B01D71/40 , B01D2323/30 , B01D2323/34 , B01D2325/12 , B01D2325/14 , B01D2325/16 , B01D2325/38 , B01J20/261 , B01J20/262 , B01J20/264 , B01J20/265 , B01J20/267 , B01J20/28004 , B01J20/28011 , B01J20/28023 , B01J20/28033 , B01J20/28047 , B01J20/28069 , B01J20/28078 , B01J20/28085 , B01J20/28097 , B01J20/285 , B01J20/286 , B01J20/291 , B01J20/3064 , B01J20/321 , B01J20/3212 , B01J20/3272 , B01J20/3276 , B01J20/3278 , B01J20/3282 , B01J39/26 , B01J41/20 , B01J47/018 , B01J47/12 , C07K1/20 , C07K1/22 , C07K1/34 , Y10S530/812 , Y10S530/815 , Y10T428/249978 , Y10T428/249994
摘要： This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.
摘要翻译： 本发明涉及一种复合材料，其包括具有延伸穿过支撑构件的多个孔的支撑构件，并且位于支撑构件的孔中并填充支撑构件的孔，大孔交联凝胶。 本发明还涉及一种制备上述复合材料及其用途的方法。 复合材料例如用于分离物质，例如通过过滤或吸附，包括色谱法，用作合成中的载体或用作细胞生长的载体。
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