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    SYSTEM AND METHOD FOR USE WITH AN IMPLANTABLE MEDICAL DEVICE FOR DETECTING STROKE BASED ON PHYSIOLOGICAL AND ELECTROCARDIAC INDICES
    1.
    发明申请
    SYSTEM AND METHOD FOR USE WITH AN IMPLANTABLE MEDICAL DEVICE FOR DETECTING STROKE BASED ON PHYSIOLOGICAL AND ELECTROCARDIAC INDICES 审中-公开
    用于基于生理和电学指标检测STR WITH的可植入医疗装置的系统和方法

    公开(公告)号：US20110066055A1

    公开(公告)日：2011-03-17

    申请号：US12558385

    申请日：2009-09-11

    申请人： Rupinder Bharmi ,  Taraneh G. Farazi

    发明人： Rupinder Bharmi ,  Taraneh G. Farazi

    IPC分类号： A61B5/0452

    CPC分类号： A61B5/0452 ,  A61B5/0006 ,  A61B5/0031 ,  A61B5/02028 ,  A61B5/0205 ,  A61B5/024 ,  A61B5/02405 ,  A61B5/0456 ,  A61B5/0472 ,  A61B5/4076 ,  A61B5/6846 ,  A61M5/1723 ,  A61M2205/054 ,  A61M2210/125 ,  A61N1/36114 ,  A61N1/36585

    摘要： Techniques are provided for detecting stroke within a patient using an implantable medical device. In one example, various electrocardiac and physiological signals are sensed within the patient by the implantable device. The device derives a set of indices from the sensed signals based on parameters affected by stroke. Stroke is then detected within the patient based on an examination of the set of indices. Warnings can then be generated, neurostimulation delivered, pacing therapy adjusted, medications dispensed, etc., in response to the stroke. In one particular example, the set of indices includes: a heart rate variability index; a heart rate turbulence index; a baroreflex index; a QT index; a respiration index; and a circadian variability index, from which a composite stroke index is derived. Time delta indices may also be generated for each individual index, which are exploited in generating the composite stroke index.

    摘要翻译： 提供了使用可植入医疗装置来检测患者中的卒中的技术。 在一个示例中，通过可植入装置在患者体内检测各种心电信号和生理信号。 该设备根据受冲击影响的参数从感测到的信号中导出一组索引。 然后根据对该组指标的检查在患者体内检测中风。 然后可以产生警告，响应于中风，递送神经刺激，调节起搏治疗，药​​物分配等。 在一个特定示例中，该组索引包括：心率变异性指数; 心率湍流指数; 压力指标; QT指数; 呼吸指数 和昼夜变异指数，从中得出复合笔画指数。 也可以为每个单独的索引生成时间增量指数，这些索引在生成复合笔画索引时被利用。

    SYSTEMS AND METHODS FOR INCREASED SPECIFICITY IN DIAGNOSTICS
    3.
    发明申请
    SYSTEMS AND METHODS FOR INCREASED SPECIFICITY IN DIAGNOSTICS 有权
    诊断中提高特异性的系统和方法

    公开(公告)号：US20120184867A1

    公开(公告)日：2012-07-19

    申请号：US13432923

    申请日：2012-03-28

    申请人： Taraneh Ghaffari Farazi ,  Rupinder Bharmi ,  Brian Jeffrey Wenzel

    发明人： Taraneh Ghaffari Farazi ,  Rupinder Bharmi ,  Brian Jeffrey Wenzel

    IPC分类号： A61B5/0452 ,  A61B5/0432

    CPC分类号： A61B5/0452 ,  A61B5/4842 ,  A61B5/686 ,  A61N1/365

    摘要： Specific embodiments provided herein relate to diagnosing, with improved specificity, occurrences of episodes relating to disorders that are known to affect T-wave morphology. One or more propensity metric is obtained, each of which is indicative of a patient's propensity for a specific disorder that is known to affect T-wave morphology. T-wave variability is monitored. Additionally, there is monitoring for a specific change in T-wave morphology that is known to be indicative of episodes relating to a disorder. When the specific change in T-wave morphology is detected, a diagnosis is determined for detecting the specific change in T-wave morphology, taking into account the propensity metric(s) and the T-wave variability.

    摘要翻译： 本文提供的具体实施方案涉及具有改善的特异性诊断与已知影响T波形态的病症相关的发作的发生。 获得一个或多个倾向度量，每个倾向度量指示患者对已知影响T波形态的特定病症的倾向。 监测T波变化。 另外，监测T波形态的具体变化已知是指示与病症相关的发作。 当检测到T波形态的具体变化时，考虑到倾向度量和T波变异性，确定检测T波形态的具体变化的诊断。

    ELECTROLYTE MONITORING USING IMPLANTED CARDIAC RHYTHM MANAGEMENT DEVICE
    4.
    发明申请
    ELECTROLYTE MONITORING USING IMPLANTED CARDIAC RHYTHM MANAGEMENT DEVICE 审中-公开
    使用植入式牙科管理装置进行电解质监测

    公开(公告)号：US20100298670A1

    公开(公告)日：2010-11-25

    申请号：US12469564

    申请日：2009-05-20

    申请人： Rupinder Bharmi ,  Gene A. Bornzin

    发明人： Rupinder Bharmi ,  Gene A. Bornzin

    IPC分类号： A61B5/145

    CPC分类号： A61B5/0452 ,  A61B5/0031 ,  A61B5/042 ,  A61B5/14546 ,  A61N1/36557 ,  A61N1/368 ,  A61N1/37211

    摘要： A method for diagnosing an electrolyte level with a cardiac rhythm management device includes recording intra-cardiac electrograms from multiple sites. The method determines the electrolyte level based upon a comparative analysis of intra-cardiac electrograms recorded from at least two of the sites. The electrolyte level can be quantified based upon a general model, or a patient specific model.

    摘要翻译： 用心律管理装置诊断电解质水平的方法包括记录多个部位的心脏内电图。 该方法基于从至少两个位点记录的心脏内电图的比较分析来确定电解质水平。 可以基于一般模型或患者特异性模型量化电解质水平。

    Neurostimulation Based On Glycemic Condition
    5.
    发明申请
    Neurostimulation Based On Glycemic Condition 审中-公开
    基于血糖条件的神经刺激

    公开(公告)号：US20100057158A1

    公开(公告)日：2010-03-04

    申请号：US12198791

    申请日：2008-08-26

    申请人： Rodolfo Rodriguez ,  Brian Jeffrey Wenzel ,  Fujian Qu ,  Rupinder Bharmi ,  Karin Jarverud ,  Taraneh Ghaffari Farazi

    发明人： Rodolfo Rodriguez ,  Brian Jeffrey Wenzel ,  Fujian Qu ,  Rupinder Bharmi ,  Karin Jarverud ,  Taraneh Ghaffari Farazi

    IPC分类号： A61N1/365 ,  A61N1/36

    CPC分类号： A61N1/36114 ,  A61N1/365

    摘要： A glycemic condition is indicated based on variance of a feature derived from cardiac electrogram data. Neurostimulation is then used to counteract a cardiac-related autonomic response to the glycemic condition. For example, stimulation of parasympathetic innervation may be used to counteract an autonomic sympathetic response that is associated with hypoglycemia or hyperglycemia. In addition, stimulation of sympathetic innervation may be used to counteract an autonomic parasympathetic response that is associated with hypoglycemia or hyperglycemia.

    摘要翻译： 根据心脏电图数据得出的特征的方差来指示血糖状况。 然后使用神经刺激来抵消对血糖状况的心脏相关的自主反应。 例如，可以使用副交感神经支配的刺激来抵消与低血糖或高血糖相关的自主交感神经反应。 此外，交感神经支配的刺激可用于抵消与低血糖或高血糖相关的自主神经副交感神经反应。

    System and method for detecting hypoglycemia based on a paced depolarization integral using an implantable medical device
    7.
    发明申请
    System and method for detecting hypoglycemia based on a paced depolarization integral using an implantable medical device 有权

    公开(公告)号：US20060247685A1

    公开(公告)日：2006-11-02

    申请号：US11117624

    申请日：2005-04-27

    申请人： Rupinder Bharmi

    发明人： Rupinder Bharmi

    IPC分类号： A61N1/36

    CPC分类号： A61N1/3925 ,  A61B5/0031 ,  A61B5/0452 ,  A61B5/076 ,  A61B5/14532 ,  A61B5/7275 ,  A61M5/14276 ,  A61M2205/3523 ,  A61N1/36557 ,  A61N1/371

    摘要： Techniques are provided for use with an implantable medical device such as a pacemaker or implantable cardioverter/defibrillator (ICD) for predicting and detecting hypoglycemia. In one example, the device tracks changes in a paced depolarization integral (PDI). A significant increase in PDI over a relatively short period of time indicates the onset of hypoglycemia (this can also be confirmed with QT changes). Upon detection of hypoglycemia, appropriate warning signals are generated to alert the patient. Certain therapies automatically provided by the implantable device may also be controlled in response to hypoglycemia. For example, if the patient is an insulin-dependent diabetic and the implantable device is equipped with an insulin pump capable of delivering insulin directly into the bloodstream, insulin delivery is automatically suspended until blood glucose levels return to acceptable levels. If the device is an ICD, it may be controlled to begin charging defibrillation capacitors upon detection of hypoglycemia so as to permit prompt delivery of a defibrillation shock, which may be needed if hypoglycemia triggers ventricular fibrillation. The detection techniques may be used in conjunction with other hypoglycemia detection techniques to improve detection specificity.

    Two-dimensional refractory period
    9.
    发明授权
    Two-dimensional refractory period 有权
    二维不应期

    公开(公告)号：US08600490B1

    公开(公告)日：2013-12-03

    申请号：US11943825

    申请日：2007-11-21

    申请人： Rupinder Bharmi ,  Jeffery D. Snell

    发明人： Rupinder Bharmi ,  Jeffery D. Snell

    IPC分类号： A61B5/04

    CPC分类号： A61B5/0452 ,  A61B5/0456 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0472 ,  A61N1/0563 ,  A61N1/365 ,  A61N1/368

    摘要： A two-dimensional refractory period is defined in conjunction with the detection of cardiac events. Detection parameters associated with the two-dimensional refractory period may define a period of time during which a sensed cardiac signal is blanked or may define a period of time during which a given sensing threshold applies. The two-dimensional refractory period may be employed in atrial sensing to selectively blank far-field T-waves while enabling P-wave detection. The two-dimensional refractory period may be employed in ventricular sensing to selectively blank near-field T-waves while enabling detection of the QRS complex. The detection parameters associated with the two-dimensional refractory period may be adapted based on characteristics of previously detected cardiac signals.

    摘要翻译： 结合心脏事件的检测来定义二维不应期。 与二维不应期相关联的检测参数可以定义感测心脏信号被消隐的时间段，或者可以限定适用给定感测阈值的时间段。 二维不应期可用于心房感应，以选择性地空白远场T波，同时实现P波检测。 二维不应期可用于心室感应以选择性地空白近场T波，同时能够检测QRS波群。 可以基于先前检测的心脏信号的特征来适应与二维不应期相关的检测参数。