公开(公告)号：US20110236911A1

公开(公告)日：2011-09-29

申请号：US13052001

申请日：2011-03-18

申请人： Sae Hyun Choo ,  Weilei Ma ,  Jing Wei

发明人： Sae Hyun Choo ,  Weilei Ma ,  Jing Wei

IPC分类号： G01N33/53 ,  C12M1/34

CPC分类号： G01N33/54373 ,  G01N21/7703 ,  G01N33/53 ,  G01N2021/772

摘要： Improved apparatus, compositions, and methods for carrying out interferometry-based assays for detecting analytes in a sample through the use of a precipitating substrate to enhance an interferometry binding signal, and kits useful for carrying out these assays. Methods comprise providing an optical assembly comprising an optical element with a transparent material and adapted for coupling to a light source via a fiber, a first reflective surface and a second reflecting surface having a first analyte-binding molecule and separated from said first surface by a distance, d, exposing said optical element to a sample comprising said analyte, a second analyte binding molecule, and a precipitating substrate; and detecting a change in thickness at said first reflective surface thereby detecting said analyte in said sample. Kits include reagents for derivatizing assay components along with packaging and instructions for use.

摘要翻译： 改进的用于进行基于干涉测定的测定法的装置，组合物和方法，用于通过使用沉淀底物来增强干涉测量结合信号来检测样品中的分析物，以及可用于进行这些测定的试剂盒。 方法包括提供光学组件，其包括具有透明材料的光学元件，并且适于经由光纤耦合到光源，第一反射表面和具有第一分析物结合分子的第二反射表面，并且从所述第一表面与所述第一表面分离 距离d，将所述光学元件暴露于包含所述分析物的样品，第二分析物结合分子和沉淀基底; 并检测所述第一反射表面的厚度变化，从而检测所述样品中的所述分析物。 试剂盒包括用于衍生测定组分的试剂以及包装和使用说明书。

公开(公告)号：USD971821S1

公开(公告)日：2022-12-06

申请号：US29805523

申请日：2021-08-27

申请人： Jing Wei

设计人： Jing Wei

公开(公告)号：US07166436B2

公开(公告)日：2007-01-23

申请号：US10212628

申请日：2002-08-01

申请人： Paul Haynes ,  Jing Wei ,  John Yates ,  Nancy Andon

发明人： Paul Haynes ,  Jing Wei ,  John Yates ,  Nancy Andon

IPC分类号： G01N33/53 ,  C12P13/12 ,  C07K17/00 ,  C07K5/00 ,  C07K16/00 ,  C07K7/00

CPC分类号： G01N33/6803 ,  C07K1/13 ,  C07K14/395 ,  G01N33/6815 ,  G01N33/6842 ,  G01N33/6848 ,  G01N2458/15 ,  G01N2550/00

摘要： The present invention relates to a method of simultaneously identifying and determining the levels of expression of cysteine-containing proteins in normal and perturbed cells, a method for proteomic analysis, a process for preparing fusion proteins, and compounds and reagents related thereto.

摘要翻译： 本发明涉及同时鉴定和确定正常和扰动细胞中含半胱氨酸的蛋白质的表达水平，蛋白质组分析方法，制备融合蛋白的方法以及与其相关的化合物和试剂的方法。

公开(公告)号：US20050124010A1

公开(公告)日：2005-06-09

申请号：US10398271

申请日：2001-10-01

申请人： Jay Short ,  Pengcheng Fu ,  Jing Wei ,  Michael Levin ,  Martin Latterich

发明人： Jay Short ,  Pengcheng Fu ,  Jing Wei ,  Michael Levin ,  Martin Latterich

IPC分类号： A01H1/00 ,  A01K67/027 ,  C12N20060101 ,  C12N15/00 ,  C12N15/09 ,  C12N15/10 ,  C12N15/82 ,  C12Q1/02 ,  C12Q1/68 ,  G01N27/447 ,  G01N27/62 ,  G01N30/88 ,  G01N33/483 ,  G01N33/53 ,  G01N33/534 ,  G01N33/566 ,  G01N33/58 ,  G01N33/68 ,  G01N37/00 ,  G01N33/574 ,  G01N33/48 ,  G01N33/50 ,  G06F19/00

CPC分类号： C12N15/102 ,  C12N15/1027 ,  C12N15/1058 ,  C12N15/8241 ,  G01N33/534 ,  G01N33/6848 ,  G01N2800/52

摘要： This invention relates to the field of cellular and whole organism engineering. Specifically, this invention relates to a cellular transformation, directed evolution, and screening method for creating novel transgenic organisms having desirable properties. Thus in one aspect, this invention relates to a method of generating a transgenic organism, such as a microbe or a plant, having a plurality of traits that are diffenentially activatable.

摘要翻译： 本发明涉及细胞和整体生物工程领域。 具体地，本发明涉及用于产生具有期望性质的新型转基因生物的细胞转化，定向进化和筛选方法。 因此，在一个方面，本发明涉及产生具有多个难以发生活性的性状的转基因生物体如微生物或植物的方法。

公开(公告)号：US20130137569A1

公开(公告)日：2013-05-30

申请号：US13814645

申请日：2011-11-28

申请人： Zhongtao Zhang ,  Yi Cheng ,  Xuli Zhai ,  Yong Jin ,  Jianzhong Li ,  Guizhi Wang ,  Zhixiang Zhang ,  Huiming Yuan ,  Fengrong Wang ,  Xianming Xu ,  Shubao Wan ,  Fangwei Li ,  Fengbo Ma ,  Jing Wei ,  Jina Zhao ,  Lijun Liu ,  Dawei Zhang

发明人： Zhongtao Zhang ,  Yi Cheng ,  Xuli Zhai ,  Yong Jin ,  Jianzhong Li ,  Guizhi Wang ,  Zhixiang Zhang ,  Huiming Yuan ,  Fengrong Wang ,  Xianming Xu ,  Shubao Wan ,  Fangwei Li ,  Fengbo Ma ,  Jing Wei ,  Jina Zhao ,  Lijun Liu ,  Dawei Zhang

IPC分类号： B01J37/08

CPC分类号： B01J37/08 ,  B01J21/04 ,  B01J23/464 ,  B01J23/755 ,  B01J35/0013 ,  B01J37/0045 ,  B01J37/0217 ,  B01J37/0225 ,  B01J37/023 ,  B01J37/349 ,  C01B3/40 ,  C01B2203/0233 ,  C01B2203/1058 ,  C01B2203/1064 ,  C01B2203/1082 ,  C01B2203/1241 ,  Y02P20/52

摘要： A method for preparing catalyst coating on a metal base plate comprising: thermal-spraying a layer of a-aluminum oxide nano-particles on a metal base plate using a high temperature flame powder spray gun, at a temperature of 2500-3500° C. and a pressure of 0.2-1.2 MPa; coating an aluminum sol, the weight concentration of the aluminum sol aqueous solution being 2-30%, at a pH of 0.5-4, the drying temperature being 50-150° C., the drying time being 0.5-24 hours, the calcination temperature being 200-1200° C., and the calcination time being 0.5-24 hours; immersing in an active component, the immersing temperature being 20-120° C., the duration being 0.5-24 hours, the drying temperature being 50-150° C., the drying time being 0.5-24 hours, the calcination temperature being 200-1200° C., and the calcination time being 0.5-24 hours. The method is suitable for the preparation of various catalyst coatings with active components.

摘要翻译： 一种在金属基板上制备催化剂涂层的方法，包括：使用高温火焰粉末喷枪在2500-3500℃的温度下在金属基板上热喷涂一层氧化铝纳米颗粒。 压力为0.2-1.2MPa; 涂覆铝溶胶，铝溶胶水溶液的重量浓度为2-30％，pH为0.5-4，干燥温度为50-150℃，干燥时间为0.5-24小时，煅烧 温度为200-1200℃，煅烧时间为0.5-24小时; 浸入活性成分中，浸渍温度为20-120℃，持续时间为0.5-24小时，干燥温度为50-150℃，干燥时间为0.5-24小时，煅烧温度为200℃ -1200℃，煅烧时间为0.5-24小时。 该方法适用于制备具有活性组分的各种催化剂涂料。

公开(公告)号：US20080081781A1

公开(公告)日：2008-04-03

申请号：US11784294

申请日：2007-04-06

申请人： Arnold Lippa ,  Jian-Dong Jiang ,  Jing Wei ,  Wei-Jia Kong ,  Li-Xun Zhao ,  Dan-Qing Song

发明人： Arnold Lippa ,  Jian-Dong Jiang ,  Jing Wei ,  Wei-Jia Kong ,  Li-Xun Zhao ,  Dan-Qing Song

IPC分类号： A61K31/4355 ,  A61K31/555 ,  A61K38/28 ,  A61P3/00

CPC分类号： A61K31/4375

摘要： Methods and compositions containing a berberine compound or berberine related or proto-berberine or derivative compound are provided for the prevention and treatment of metabolic and cardiovascular disorders including metabolic syndrome, hyperlipidemia, obesity, diabetes, insulin resistance, hyperglycemia, hypertension and elevated cholesterol in mammalian subjects. The methods and compositions of the invention are effective for prevention and treatment of metabolic syndrome, hyperlipidemia, obesity, diabetes, insulin resistance, hyperglycemia, hypertension and elevated cholesterol. Additional compositions and methods are provided which employ a berberine compound or berberine related or derivative compound in combination with a second anti-therapeutic agent to yield more effective treatment tools against metabolic disorders, and/or dual activity therapeutic methods and formulations useful to prevent or reduce hyperlipidemia and/or hyperglycemia and one or more causal or related symptoms or conditions associated with hyperlipidemia and/or hyperglycemia in mammalian subjects.

摘要翻译： 提供含有小檗碱化合物或小檗碱相关或原小​​檗碱或衍生化合物的方法和组合物用于预防和治疗哺乳动物代谢和心血管疾病，包括代谢综合征，高脂血症，肥胖，糖尿病，胰岛素抵抗，高血糖，高血压和升高的胆固醇 科目。 本发明的方法和组合物可有效预防和治疗代谢综合征，高脂血症，肥胖症，糖尿病，胰岛素抵抗，高血糖症，高血压和升高的胆固醇。 提供了额外的组合物和方法，其使用小檗碱化合物或小檗碱相关或衍生化合物与第二抗治疗剂组合以产生针对代谢紊乱的更有效的治疗工具，和/或可用于预防或减少的双重活性治疗方法和制剂 高脂血症和/或高血糖症和哺乳动物受试者中与高脂血症和/或高血糖相关的一个或多个因果或相关症状或病症。

公开(公告)号：US20190390220A1

公开(公告)日：2019-12-26

申请号：US16269199

申请日：2019-02-06

申请人： Georg Jander ,  Jing Wei

发明人： Georg Jander ,  Jing Wei

IPC分类号： C12N15/82 ,  G01N33/50

摘要： The present invention relates to isolated resistance genes encoding polypeptides that confers resistance to aphid infestation, and methods of transforming plant and cells with the disclosed resistance genes. The invention also relates to transgenic plants and cells having resistance to aphids, particularly Aphis glycines.

公开(公告)号：US20140008291A1

公开(公告)日：2014-01-09

申请号：US13981876

申请日：2012-01-25

申请人： Chuyang Tang ,  Changquan Qiu ,  Jing Wei ,  Rong Wang ,  Anthony G. Fane

发明人： Chuyang Tang ,  Changquan Qiu ,  Jing Wei ,  Rong Wang ,  Anthony G. Fane

IPC分类号： B01D67/00 ,  B01D61/00

CPC分类号： B01D67/0016 ,  B01D61/002 ,  B01D67/0009 ,  B01D69/10 ,  B01D69/125 ,  B01D2323/18 ,  B01D2323/22 ,  B01D2325/026 ,  B01D2325/20

摘要： A method of forming a forward osmosis membrane having a porous substrate and a rejection layer is provided. The method comprises a) forming a thin film of a polymer solution on a suitable substrate, wherein the polymer solution contains at least one polymer and optionally one or more additives in a suitable solvent, b) immersing the thin film in a coagulant bath to form the porous substrate; and c) forming a rejection layer on the porous substrate. A forward osmosis membrane is also provided.

摘要翻译： 提供了形成具有多孔基材和拒绝层的正向渗透膜的方法。 该方法包括：a）在合适的基底上形成聚合物溶液的薄膜，其中聚合物溶液在合适的溶剂中含有至少一种聚合物和任选的一种或多种添加剂，b）将薄膜浸入凝结浴中形成 多孔基材; 和c）在所述多孔基材上形成拒绝层。 还提供了正向渗透膜。

公开(公告)号：US20110158932A1

公开(公告)日：2011-06-30

申请号：US12330447

申请日：2008-12-08

申请人： Jian-Dong Jiang ,  Jing Wei ,  Wei-Jia Kong ,  Li-Xun Zhao ,  Dan-Qing Song

发明人： Jian-Dong Jiang ,  Jing Wei ,  Wei-Jia Kong ,  Li-Xun Zhao ,  Dan-Qing Song

IPC分类号： A61K31/4745 ,  A61K31/575 ,  A61K31/397 ,  A61K31/785 ,  A61K31/721 ,  A61K31/714 ,  A61K38/22 ,  A61P9/00 ,  A61K38/28 ,  A61K31/505 ,  A61K36/00 ,  A61K36/328 ,  A61K36/8962 ,  A61K36/48 ,  A61K35/60 ,  A61K36/82 ,  A61K38/43 ,  A61K36/87 ,  A61K35/64 ,  A61K36/899 ,  A61P3/06 ,  A61P9/10 ,  A61P9/12 ,  C12N5/071

CPC分类号： A61K31/4375

摘要： Methods and compositions containing a berberine compound or berberine related or derivative compound are provided for the prevention and treatment of hyperlipidemia, elevated cholesterol, and/or cardiovascular disease in mammalian subjects. The methods and compositions of the invention are effective for prevention and treatment of atherosclerosis, coronary artery disease, angina pectoris, carotid artery disease, stroke, cerebral arteriosclerosis, high blood pressure, myocardial infarction, cerebral infarction, restenosis following balloon angioplasty, intermittent claudication, dyslipidemia post-prandial lipidemia or xanthoma. Additional compositions and methods are provided which employ a berberine compound or berberine related or derivative compound in combination with a second anti-hyperlipidemia agent, or a different therapeutic agent to yield more effective treatment tools against hyperlipidemia and/or cardiovascular disease, and/or dual activity therapeutic methods and formulations useful to prevent or reduce hyperlipidemia and one or more causal or related symptoms or conditions associated with hyperlipidemia in mammalian subjects.

摘要翻译： 提供含有小檗碱化合物或小檗碱相关或衍生化合物的方法和组合物用于预防和治疗哺乳动物受试者中的高脂血症，升高的胆固醇和/或心血管疾病。 本发明的方法和组合物可有效预防和治疗动脉粥样硬化，冠状动脉疾病，心绞痛，颈动脉疾病，中风，脑动脉硬化，高血压，心肌梗塞，脑梗塞，球囊血管成形术后的再狭窄，间歇性跛行， 餐后血脂异常或血清白血病。 提供了额外的组合物和方法，其使用小檗碱化合物或小檗碱相关或衍生化合物与第二抗高脂血症药物或不同治疗剂组合以产生更有效的治疗工具来抵抗高脂血症和/或心血管疾病和/或双重 用于预防或减少高脂血症的活性治疗方法和制剂以及与哺乳动物受试者中的高脂血症相关的一个或多个因果或相关症状或病症。

公开(公告)号：US20060223838A1

公开(公告)日：2006-10-05

申请号：US11229339

申请日：2005-09-16

申请人： Jian-Dong Jiang ,  Jing Wei ,  Wei-Jia Kong ,  Li-Xun Zhao ,  Dan-Qing Song

发明人： Jian-Dong Jiang ,  Jing Wei ,  Wei-Jia Kong ,  Li-Xun Zhao ,  Dan-Qing Song

IPC分类号： A61K31/4745

CPC分类号： A61K31/4375

摘要： Methods and compositions containing a berberine compound or berberine related or derivative compound are provided for the prevention and treatment of hyperlipidemia, elevated cholesterol, and/or cardiovascular disease in mammalian subjects. The methods and compositions of the invention are effective for prevention and treatment of atherosclerosis, coronary artery disease, angina pectoris, carotid artery disease, stroke, cerebral arteriosclerosis, high blood pressure, myocardial infarction, cerebral infarction, restenosis following balloon angioplasty, intermittent claudication, dyslipidemia post-prandial lipidemia or xanthoma. Additional compositions and methods are provided which employ a berberine compound or berberine related or derivative compound in combination with a second anti-hyperlipidemia agent, or a different therapeutic agent to yield more effective treatment tools against hyperlipidemia and/or cardiovascular disease, and/or dual activity therapeutic methods and formulations useful to prevent or reduce hyperlipidemia and one or more causal or related symptoms or conditions associated with hyperlipidemia in mammalian subjects.

摘要翻译： 提供含有小檗碱化合物或小檗碱相关或衍生化合物的方法和组合物用于预防和治疗哺乳动物受试者中的高脂血症，升高的胆固醇和/或心血管疾病。 本发明的方法和组合物可有效预防和治疗动脉粥样硬化，冠状动脉疾病，心绞痛，颈动脉疾病，中风，脑动脉硬化，高血压，心肌梗塞，脑梗塞，球囊血管成形术后的再狭窄，间歇性跛行， 餐后血脂异常或血清白血病。 提供了额外的组合物和方法，其使用小檗碱化合物或小檗碱相关或衍生化合物与第二抗高脂血症药物或不同治疗剂组合以产生更有效的治疗工具来抵抗高脂血症和/或心血管疾病和/或双重 用于预防或减少高脂血症的活性治疗方法和制剂以及与哺乳动物受试者中的高脂血症相关的一个或多个因果或相关症状或病症。