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1.发明授权Replikin-based compounds for prevention and treatment of influenza and methods of differentiating infectivity and lethality in influenza 有权用于预防和治疗流感的基于复制素的化合物和分化流感中的感染性和致死性的方法公开(公告)号：US09233148B2
公开(公告)日：2016-01-12
申请号：US12581112
申请日：2009-10-16
IPC分类号： A61K39/145 , C07K14/00 , C07H21/00 , A61K39/00 , C07K14/005 , C07K14/44 , C07K14/72
CPC分类号： C07K16/1018 , A61K39/00 , A61K39/0011 , A61K2039/542 , A61K2039/552 , C07K7/06 , C07K7/08 , C07K14/005 , C07K14/11 , C07K14/44 , C07K14/72 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2770/24122 , C12N2770/32022
摘要： The present invention provides methods of differentiating the infectivity and lethality of isolates of influenza virus and provides compounds for diagnosing, preventing, and treating outbreaks of influenza virus including compounds for diagnosing, preventing, and treating across different strains of influenza virus.
摘要翻译： 本发明提供了区分流感病毒分离物的感染性和致死性的方法，并提供用于诊断，预防和治疗流感病毒爆发的化合物，包括用于诊断，预防和治疗不同流感病毒株的化合物。
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2.发明申请PEPTIDES SHARED AMONG LETHAL CANCERS AND THERAPEUTIC COMPOSITIONS COMPRISING SAID PEPTIDES 审中-公开肝癌组合物和包含上皮细胞的治疗组合物公开(公告)号：US20130084303A1
公开(公告)日：2013-04-04
申请号：US13553137
申请日：2012-07-19
CPC分类号： A61K39/0011 , C07K7/06 , C07K7/08 , C07K14/4748 , C07K16/30
摘要： The present invention provides cancer peptides related to rapid replication and shared among different histological cancer types. The peptides are provided in compositions for interfering with replication in cancer, in preventive and therapeutic vaccines, and in diagnostic applications. The compositions for interfering with replication in cancer are useful for preventing and treating different histological types of cancer including ectodermic, endodermic, and mesodermic cancers as well as cancers arising in association with HIV.
摘要翻译： 本发明提供了与快速复制相关的癌症肽，并且在不同的组织学癌症类型之间共享。 在用于干扰癌症，预防和治疗疫苗以及诊断应用中的复制的组合物中提供了肽。 用于干扰癌症复制的组合物可用于预防和治疗不同组织学类型的癌症，包括外胚层，内胚层和中胚层癌以及与HIV相关的癌症。
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3.发明授权Synthetic replikin peptides against pathogenic infection of invertebrates in aquaculture 有权针对水产养殖中无脊椎动物感染的合成复制素肽公开(公告)号：US09408902B2
公开(公告)日：2016-08-09
申请号：US12108458
申请日：2008-04-23
IPC分类号： A61K39/12 , A61K39/125 , C07K14/72 , C07K14/005 , A61K39/00
CPC分类号： A61K39/125 , A61K38/08 , A61K38/10 , A61K38/162 , A61K39/00 , A61K39/12 , A61K2039/542 , A61K2039/552 , C07K7/06 , C07K7/08 , C07K14/005 , C07K14/72 , C12N2710/18022 , C12N2760/16022 , C12N2770/22022 , C12N2770/24122 , C12N2770/32022 , C12N2770/32034
摘要： The present invention provides isolated or synthesized peptides of about 7 to about 50 amino acids identified in the genome of pathogens in invertebrates in aquaculture for prevention and treatment of outbreaks of these pathogens in aquaculture and methods of preventing and treating pathogenic outbreaks using the identified peptides.
摘要翻译： 本发明提供在水产养殖中无脊椎动物病原体基因组中鉴定的约7至约50个氨基酸的分离或合成的肽，用于预防和治疗水产养殖中这些病原体的爆发以及使用鉴定的肽预防和治疗致病性爆发的方法。
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公开(公告)号：US20080260764A1
公开(公告)日：2008-10-23
申请号：US11755597
申请日：2007-05-30
IPC分类号： A61K39/145 , C07K14/11 , C07K16/08 , C12Q1/70 , C07H21/00
CPC分类号： C07K14/005 , A61K39/00 , C12N2760/16022 , C12N2770/20022 , G01N2333/11
摘要： The present invention provides isolated influenza peptides and nucleic acid sequences and methods of identifying said influenza peptides and nucleic acid sequences having a pattern of substitution of amino acids or nucleic acids in highly conserved Replikin and Replikin Scaffold sequences that is predictive of rapid replication and virulence. Methods of predicting virulence in emerging influenza strains are provided comprising identifying peptides and nucleic acid sequences having the predictive pattern of substitution.
摘要翻译： 本发明提供分离的流感肽和核酸序列以及鉴定预测快速复制和毒力的高度保守的Replikin和Replikin Scaffold序列中具有氨基酸或核酸取代模式的所述流感肽和核酸序列的方法。 提供了在新出现的流感病毒株中预测毒力的方法，包括鉴定具有预测取代模式的肽和核酸序列。
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5.发明授权Peptides shared among lethal cancers and therapeutic compositions comprising said peptides 有权在致死癌症中共享的肽和包含所述肽的治疗组合物公开(公告)号：US09320784B2
公开(公告)日：2016-04-26
申请号：US13553137
申请日：2012-07-19
CPC分类号： A61K39/0011 , C07K7/06 , C07K7/08 , C07K14/4748 , C07K16/30
摘要： The present invention provides cancer peptides related to rapid replication and shared among different histological cancer types. The peptides are provided in compositions for interfering with replication in cancer, in preventive and therapeutic vaccines, and in diagnostic applications. The compositions for interfering with replication in cancer are useful for preventing and treating different histological types of cancer including ectodermic, endodermic, and mesodermic cancers as well as cancers arising in association with HIV.
摘要翻译： 本发明提供了与快速复制相关的癌症肽，并且在不同的组织学癌症类型之间共享。 在用于干扰癌症，预防和治疗疫苗以及诊断应用中的复制的组合物中提供了肽。 用于干扰癌症复制的组合物可用于预防和治疗不同组织学类型的癌症，包括外胚层，内胚层和中胚层癌以及与HIV相关的癌症。
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6.发明授权公开(公告)号：US09254315B2
公开(公告)日：2016-02-09
申请号：US12699340
申请日：2010-02-03
IPC分类号： A61K39/00 , A61K39/42 , A61K47/00 , A61K39/015 , A61K39/145 , A61K39/215 , C07K14/005 , G01N33/569 , A61K39/12 , G06F19/22
CPC分类号： A61K39/015 , A61K39/12 , A61K39/145 , A61K39/215 , A61K2039/6081 , C07K14/005 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234 , C12N2770/20034 , G01N33/56983 , G01N2333/11 , G01N2469/10 , G06F19/22
摘要： The present invention provides a new class of peptides related to rapid replication and high human mortality, and their use in diagnosing, preventing and treating disease including vaccines and therapeutics for emerging viral diseases and methods of identifying the new class of peptides and related structures.
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7.发明授权Systems and methods for identifying replikin scaffolds and uses of said replikin scaffolds 失效用于鉴定复制素支架的系统和方法以及所述复制素支架的用途公开(公告)号：US08494781B2
公开(公告)日：2013-07-23
申请号：US12965365
申请日：2010-12-10
IPC分类号： G01N33/50
CPC分类号： C07K16/1018 , A61K39/015 , A61K39/12 , A61K39/145 , A61K39/215 , A61K39/42 , A61K2039/6081 , C07K14/005 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234 , C12N2770/20034 , G01N33/56983 , G01N2333/11 , G01N2469/10 , G06F19/22
摘要： The present invention provides a new class of peptides related to rapid replication and high human mortality, and their use in diagnosing, preventing and treating disease including vaccines and therapeutics for emerging viral diseases and methods of identifying the new class of peptides and related structures.
摘要翻译： 本发明提供了与快速复制和高人死亡率相关的新一类肽，以及它们在诊断，预防和治疗疾病中的用途，包括用于新出现的病毒疾病的疫苗和治疗剂以及鉴定新类型肽和相关结构的方法。
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8.发明授权Method of predicting influenza outbreaks by correlating an increase in replikin count in shrimp white spot syndrome virus and/or taura syndrome virus 有权通过将虾白斑综合征病毒和/或牛磺综合征病毒的复制素计数增加相关联来预测流感疫情的方法公开(公告)号：US08050871B2
公开(公告)日：2011-11-01
申请号：US11923559
申请日：2007-10-24
CPC分类号： C12Q1/701
摘要： The present invention provides a method of predicting outbreaks in influenza virus comprising monitoring concentrations of small peptides having defined structure in influenza viruses, and in particular viral pathogens of shrimp.
摘要翻译： 本发明提供一种预测流感病毒爆发的方法，包括监测流感病毒中具有确定结构的小肽，特别是虾的病毒病原体的浓度。
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9.发明申请Methods of determining lethality of pathogens and malignancies involving replikin peak genes 审中-公开确定病原体和涉及复制蛋白峰基因的恶性肿瘤的致死率的方法公开(公告)号：US20090017052A1
公开(公告)日：2009-01-15
申请号：US12010027
申请日：2008-01-18
IPC分类号： A61K39/00 , C12Q1/70 , C12Q1/68 , C07H21/04 , G06G7/50 , A61P31/00 , C07K7/00 , C12Q1/02 , C07H1/00 , A61K31/7088
CPC分类号： C12Q1/701 , Y02A50/394 , Y02A50/412 , Y02A50/58 , Y02A90/26
摘要： The present invention provides methods of identifying lethal, virulent and rapidly replicating viruses, organisms, and malignancies comprising comparing Replikin concentrations among different viruses, organisms, or malignancies. The present invention further provides isolated Replikin Peak Genes associated with increased lethality, virulence and rapid replication, for diagnostic, therapeutic and predictive purposes.
摘要翻译： 本发明提供鉴定致死，有毒和快速复制的病毒，生物和恶性肿瘤的方法，其包括比较不同病毒，生物体或恶性肿瘤之间的复制素浓度。 本发明进一步提供了与诊断，治疗和预测目的相关的增强的致死率，毒力和快速复制相关的分离的Replikin峰基因。
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公开(公告)号：US08417462B2
公开(公告)日：2013-04-09
申请号：US12349955
申请日：2009-01-07
IPC分类号： G01N33/50
CPC分类号： G06F19/16 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/005 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/405 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N2710/24122 , C12N2760/16022 , C12N2760/16122 , C40B30/02 , G06F19/22
摘要： A method and system are disclosed for identifying and/or locating complex patterns in an amino acid sequence stored in a computer file or database. According to an aspect of the present invention, techniques are provided to facilitate queries of protein databases. For protein descriptions received in response to the queries, embodiments of the present invention may scan the received protein descriptions to identify and locate Replikin patterns. A Replikin pattern is defined to be a sequence of 7 to about 50 amino acids that include the following three (3) characteristics, each of which may be recognized by an embodiment of the present invention: (1) the sequence has at least one lysine residue located six to ten amino acid residues from a second lysine residue; (2) the sequence has at least one histidine residue; and (3) at least 6% of the amino acids in the sequence are lysine residues.
摘要翻译： 公开了用于识别和/或定位存储在计算机文件或数据库中的氨基酸序列中的复杂模式的方法和系统。 根据本发明的一个方面，提供了用于促进蛋白质数据库查询的技术。 对于响应于查询而接收到的蛋白质描述，本发明的实施例可以扫描接收到的蛋白质描述以识别和定位Replikin模式。 复制素模式被定义为7至约50个氨基酸的序列，其包括以下三（3）个特征，每个特征可以被本发明的实施方案识别：（1）序列具有至少一个赖氨酸 残基位于第二赖氨酸残基6至10个氨基酸残基; （2）该序列具有至少一个组氨酸残基; 和（3）序列中至少6％的氨基酸是赖氨酸残基。
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