公开(公告)号：US5880109A

公开(公告)日：1999-03-09

申请号：US811292

申请日：1997-03-04

申请人： Satoshi Nakamura ,  Takeya Yoshioka ,  Shingo Hamada ,  Ikuo Kimura

发明人： Satoshi Nakamura ,  Takeya Yoshioka ,  Shingo Hamada ,  Ikuo Kimura

IPC分类号： A23K1/16 ,  A23L1/305 ,  A23L1/327 ,  A23L1/33 ,  A61K31/715 ,  A61K31/73

CPC分类号： A61K31/715

摘要： A composition for accelerating calcium absorption containing water-soluble chitosan as an active ingredient is disclosed. The composition is useful as an additive for foods, feed, and pharmaceutical preparations.

摘要翻译： 公开了一种用于加速含有水溶性壳聚糖作为活性成分的钙吸收的组合物。 该组合物可用作食品，饲料和药物制剂的添加剂。

公开(公告)号：US10182592B2

公开(公告)日：2019-01-22

申请号：US13618611

申请日：2012-09-14

申请人： Satoshi Nakamura

发明人： Satoshi Nakamura

IPC分类号： B31B1/62 ,  A24D3/02 ,  A24D3/04

摘要： A filter manufacturing machine includes a feed path (7) configured to continuously feed a sheet material containing filter fibers and provided with a first plasticizer addition unit (9); a forming device (3) connected to a terminating end of the feed path (7) and configured to form the sheet material (6) into a hollow rod-shaped continuous filter body (11), the forming device including a tubular forming path for forming the sheet material (6) into the continuous filter body (11), a heat treating section for heating the sheet material, and a second plasticizer addition unit (14) arranged near the inlet of the tubular forming path; and a wrapping device (4) configured to receive the continuous filter body (11) delivered from the forming device (3) and wrap the continuous filter body in a wrapper to form a filter rod (19).

公开(公告)号：US09519660B2

公开(公告)日：2016-12-13

申请号：US14064484

申请日：2013-10-28

申请人： Satoshi Nakamura

发明人： Satoshi Nakamura

IPC分类号： G06F17/30 ,  G06K9/62 ,  G06K9/00

CPC分类号： G06F17/30247 ,  G06F17/3071 ,  G06K9/00684 ,  G06K9/6223 ,  G06K9/6272

摘要： An information processing apparatus, a clustering method, and a clustering program stored on a recording medium, each of which determines an initial value of model parameter of an input data set based on a model parameter of a reference data set that is similar to the input data set and is previously clustered, modifies the initial value so as to match the input data set, and to obtain a clustering result of the input data set using the updated initial value of model parameter.

摘要翻译： 存储在记录介质上的信息处理设备，聚类方法和聚类程序，每个记录介质基于类似于输入的参考数据集的模型参数来确定输入数据集的模型参数的初始值 数据集并且被预先聚类，修改初始值以匹配输入数据集，并且使用更新的模型参数的初始值来获得输入数据集的聚类结果。

公开(公告)号：US09042658B2

公开(公告)日：2015-05-26

申请号：US13976517

申请日：2012-01-11

申请人： Satoshi Nakamura

发明人： Satoshi Nakamura

IPC分类号： G06K9/32 ,  G06T3/40 ,  G06T5/00 ,  H04N1/401 ,  H04N1/409

CPC分类号： G06T3/4007 ,  G06T5/002 ,  H04N1/401 ,  H04N1/4097

摘要： An image processing device that generates a pixel value of a pixel and interpolates the pixel with the pixel value, the image processing device including: a periodicity determining unit that determines whether an area including the pixel is a periodic area; a boundary determining unit that determines whether the pixel belongs to the periodic area or a non-periodic area; a first pixel value generating unit that generates a first pixel value; a second pixel value generating unit that generates a second pixel value; a control unit that determines whether the first pixel value generating unit is to be used or the second pixel value generating unit is to be used, based on determination results of the periodicity determining unit and the boundary determining unit; a pixel value inputting unit that inputs one of the first pixel value and the second pixel value to the pixel.

摘要翻译： 一种图像处理装置，其生成像素的像素值并且以像素值内插所述像素，所述图像处理装置包括：周期性确定单元，其确定包括所述像素的区域是否是周期性区域; 边界确定单元，确定像素是属于周期区域还是非周期区域; 第一像素值生成单元，生成第一像素值; 第二像素值生成单元，生成第二像素值; 基于周期性确定单元和边界确定单元的确定结果，确定要使用第一像素值生成单元还是要使用第二像素值生成单元的控制单元; 像素值输入单元，其将第一像素值和第二像素值中的一个输入到像素。

公开(公告)号：US08893530B2

公开(公告)日：2014-11-25

申请号：US12808631

申请日：2008-11-10

申请人： Satoshi Nakamura ,  Masahiro Naito ,  Yasuhiro Matsusaki

发明人： Satoshi Nakamura ,  Masahiro Naito ,  Yasuhiro Matsusaki

IPC分类号： A47L23/20 ,  D06F35/00 ,  D06F58/02 ,  D06F57/00 ,  D06F37/08 ,  D06F25/00

CPC分类号： A47L23/20 ,  D06F25/00 ,  D06F35/001 ,  D06F37/08 ,  D06F57/00 ,  D06F58/02

摘要： It is an object of the present invention to provide a washing machine capable of advantageously sanitizing a boot with cleaning air. A tubular member (25) of a boot attachment (30) is inserted in the boot (70) with a sufficient clearance, and an upper end portion (43) of the tubular member (25) is exposed from a top (70B) of the boot (70). A second lower vent (34) provided in a lower portion of the tubular member (25) is directed to a toe portion (70C) in the boot (70), and a first intermediate vent (35) and a second intermediate vent (36) are provided in a vertically intermediate portion of the tubular member (25). Cleaning air supplied into a drum (8) of the washing machine is smoothly introduced into the tubular member (25) of the boot attachment (30) by the upper end portion (43) to flow down through the tubular member (25). The cleaning air flows out of the tubular member (25) through the first intermediate vent (35), the second intermediate vent (36) and the second lower vent (34) to spread inside the boot (70). Thus, the inside of the boot (70) is sanitized with the cleaning air.

摘要翻译： 本发明的目的是提供一种能够有效地清洁带有清洁空气的靴子的洗衣机。 靴子附件（30）的管状构件（25）以足够的间隙插入靴子（70）中，并且管状构件（25）的上端部分（43）从顶部（70B）暴露于 靴子（70）。 设置在管状构件（25）的下部的第二下部通气口（34）被引导到护罩（70）中的脚趾部分（70C），并且第一中间通气口（35）和第二中间通气口 ）设置在管状构件（25）的竖直中间部分中。 供应到洗衣机的滚筒（8）中的清洁空气通过上端部分（43）被顺利地引导到靴子附件（30）的管状构件（25）中，以通过管状构件（25）向下流动。 清洁空气通过第一中间通风口（35），第二中间通风口（36）和第二下部通风口（34）从管状构件（25）流出，以在靴子（70）内部扩展。 因此，靴子70的内部用清洁空气消毒。

公开(公告)号：US20140031522A1

公开(公告)日：2014-01-30

申请号：US13997015

申请日：2011-12-21

申请人： Shun-Cheng LI ,  Xing Li ,  Courtney Voss ,  Satoshi Nakamura ,  Tetsuo Fukuta ,  Yusuke Okano ,  Tomonori Shiotani ,  Kouji Tamori ,  Yu Otani

发明人： Shun-Cheng LI ,  Xing Li ,  Courtney Voss ,  Satoshi Nakamura ,  Tetsuo Fukuta ,  Yusuke Okano ,  Tomonori Shiotani ,  Kouji Tamori ,  Yu Otani

IPC分类号： C07K14/31

CPC分类号： C07K14/31 ,  B01D15/3809 ,  B01J20/28057 ,  B01J20/28078 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3219 ,  B01J20/3274 ,  C07K1/22 ,  C07K17/06

摘要： The present invention relates to immunoglobulin (Ig)-binding proteins with alkali-resistance properties. In one embodiment, the present invention provides for a variant of an Ig-binding protein, the variant comprising the Ig-binding protein having at least one asparagine residue substituted with a histidine, a serine, an aspartic acid or a threonine residue. The at least one substitution may confer to the variant Ig-binding protein an increased stability in alkaline solutions when compared to the wild-type Ig-binding. The present invention relates also to matrices for affinity separation of immunoglobulins comprising the Ig-binding proteins of the present invention, and to methods of using the Ig-binding proteins of the present invention to separate immunoglobulins from mixture compositions.

摘要翻译： 本发明涉及具有耐碱特性的免疫球蛋白（Ig）结合蛋白。 在一个实施方案中，本发明提供Ig结合蛋白的变体，所述变体包含具有至少一个被组氨酸取代的天冬酰胺残基，丝氨酸，天冬氨酸或苏氨酸残基的Ig结合蛋白。 当与野生型Ig结合相比时，至少一种取代可赋予变体Ig结合蛋白在碱性溶液中增加的稳定性。 本发明还涉及用于亲和分离包含本发明的Ig结合蛋白的免疫球蛋白的基质，以及使用本发明的Ig结合蛋白质从混合物组合物中分离免疫球蛋白的方法。

公开(公告)号：US20140005357A1

公开(公告)日：2014-01-02

申请号：US13996978

申请日：2011-12-20

申请人： Satoshi Nakamura ,  Tetsuo Fukuta ,  Yusuke Okano ,  Tomonori Shiotani ,  Kouji Tamori ,  Yu Otani ,  Shun-Cheng Li ,  Xing Li ,  Courtney Voss

发明人： Satoshi Nakamura ,  Tetsuo Fukuta ,  Yusuke Okano ,  Tomonori Shiotani ,  Kouji Tamori ,  Yu Otani ,  Shun-Cheng Li ,  Xing Li ,  Courtney Voss

IPC分类号： C07K1/22

CPC分类号： C07K1/22 ,  B01D15/3804 ,  B01J20/28004 ,  B01J20/28057 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/288 ,  B01J20/321 ,  B01J20/3217 ,  B01J20/3274 ,  B01J20/3278 ,  B01J20/3293 ,  C07K16/065 ,  C07K17/08

摘要： Provided are a support for affinity chromatography which has excellent alkali resistance, and a method for isolating immunoglobulin. A support for affinity chromatography, containing an immobilized protein ligand represented by the following formula (1): R—R2  (1) wherein R represents a polypeptide consisting of 4 to 30 amino acid residues that contains an amino acid sequence represented by ATK or ASK; and R2 represents a polypeptide consisting of 50 to 500 amino acid residues containing an immunoglobulin-binding domain consisting of an amino acid sequence represented by SEQ ID NO: 1 or SEQ ID NO: 2, the partial sequence thereof, or an amino acid sequence having 70% or more identity to these sequences; with the proviso that a terminus at which R2 binds to R is C-terminus or N-terminus of the immunoglobulin-binding domain.

摘要翻译： 提供了具有优异的耐碱性的亲和层析的支持物和分离免疫球蛋白的方法。 含有由下式（1）表示的固定化蛋白质配体的亲和层析的载体：R-R2（1）其中R表示由4至30个氨基酸残基组成的多肽，其含有由ATK或ASK表示的氨基酸序列 ; 并且R 2表示由50-500个氨基酸残基组成的多肽，其含有由SEQ ID NO：1或SEQ ID NO：2所示的氨基酸序列组成的免疫球蛋白结合结构域，其部分序列或具有 这些序列具有70％以上的同一性; 条件是R 2与R结合的末端是免疫球蛋白结合结构域的C末端或N末端。

公开(公告)号：US20130316892A1

公开(公告)日：2013-11-28

申请号：US13994495

申请日：2011-12-14

申请人： Satoshi Nakamura ,  Tetsuo Fukuta ,  Kazuhiro Ikkyu ,  Yu Otani ,  Hiroshi Kawai

发明人： Satoshi Nakamura ,  Tetsuo Fukuta ,  Kazuhiro Ikkyu ,  Yu Otani ,  Hiroshi Kawai

IPC分类号： B01J20/281

CPC分类号： B01J20/281 ,  B01J20/267 ,  B01J20/285 ,  C08B1/003 ,  C08B15/10 ,  C08B37/0018 ,  C08B37/0021 ,  C08B37/003 ,  C08B37/0039 ,  C08J3/16 ,  C08J3/24 ,  C08J2301/02 ,  C08K5/0025 ,  C08L1/02 ,  C08L1/28 ,  C08L5/00 ,  C08L5/02 ,  C08L5/08 ,  C08L5/12 ,  Y02P20/542

摘要： Provided are polymer particles which can be used at a high flow rate when used as a filler for chromatography, that is, has excellent resistance flow rate appropriate for processing in large quantities, and also has a high binding capacity for target molecules such as proteins when an appropriate ligand is contained in the particles, and a method for producing the polymer particles; specifically, crosslinked polymer particles and a method for producing the crosslinked polymer particles, polysaccharide composite particles and a method for producing the polysaccharide composite particles, a filler for chromatography using the polymer particles, and an adsorbent for antibody purification. Disclosed are: A. a method for producing polysaccharide composite particles, the method including the following steps (1) to (3): (1) a step of preparing a polysaccharide solution, in which two or more kinds of polysaccharides are dissolved in an ionic liquid; (2) a step of preparing a droplet dispersion liquid of the polysaccharide solution, in which liquid droplets of the polysaccharide solution are dispersed in an organic solvent having low compatibility with the ionic liquid; and (3) a coagulation step in which a composite of the polysaccharides are coagulated to obtain the polysaccharide composite particles; and B. a method for producing a crosslinked polymer particle, the method including a step of allowing a polymer dissolved in an ionic liquid, to react with a crosslinking agent while the polymer is subjected to droplet dispersion in an organic solvent having low compatibility with the ionic liquid.

摘要翻译： 提供当用作色谱填料时可以以高流速使用的聚合物颗粒，即具有适合于大量加工的优异的电阻流速，并且还具有对蛋白质等靶分子的高结合力 粒子中含有适当的配体，以及聚合物粒子的制造方法。 特别是交联聚合物颗粒和交联聚合物颗粒的制备方法，多糖复合颗粒和多糖复合颗粒的制备方法，使用该聚合物颗粒的色谱用填料和用于抗体纯化的吸附剂。 本发明涉及A.一种多糖复合粒子的制造方法，其特征在于，包括以下工序（1）〜（3）：（1）制备多糖溶液的工序，其中将2种以上的多糖溶解于 离子液体 （2）将多糖溶液的液滴分散在与离子液体的相容性低的有机溶剂中的多糖溶液的液滴分散液的制备工序; 和（3）将多糖的复合体凝结而得到多糖复合粒子的凝固工序; 和B.一种制备交联聚合物颗粒的方法，该方法包括使溶解在离子液体中的聚合物与交联剂反应的步骤，同时聚合物在与 离子液体。

公开(公告)号：US08593300B2

公开(公告)日：2013-11-26

申请号：US12927742

申请日：2010-11-22

申请人： Hiromitsu Ooshima ,  Satoshi Nakamura

发明人： Hiromitsu Ooshima ,  Satoshi Nakamura

IPC分类号： G08G1/00

CPC分类号： G08G1/096791 ,  G08G1/096716 ,  G08G1/09675 ,  G08G1/162

摘要： A vehicle approach warning system is disclosed. The vehicle approach warning system includes: an in-vehicle communication apparatus to be mounted to a vehicle, the in-vehicle communication apparatus being configured to wirelessly transmit vehicle travel data to surroundings of the vehicle; and a portable warning terminal to be carried by a pedestrian, the portable warning terminal being configured to give, in response to receiving the vehicle travel data wirelessly transmitted from the in-vehicle communication apparatus, a warning about approach of the vehicle to the pedestrian in a way other than auditory stimulation if electric field strength at a time of receiving the vehicle travel data is larger than a threshold.

摘要翻译： 公开了一种车辆接近警告系统。 车辆接近警报系统包括：车载通信装置，其被安装到车辆上，所述车载通信装置被配置为将车辆行驶数据无线地传送到车辆的周围; 以及由行人携带的便携式警告终端，便携式警告终端被配置为响应于接收到从车载通信设备无线发送的车辆旅行数据，给出关于车辆对行人的接近的警告 如果在接收车辆行驶数据时的电场强度大于阈值，则听觉刺激以外的方式。

公开(公告)号：US20130272606A1

公开(公告)日：2013-10-17

申请号：US13860678

申请日：2013-04-11

申请人： Satoshi Nakamura

发明人： Satoshi Nakamura

IPC分类号： G06K9/46 ,  G09G5/02 ,  G06K15/02

CPC分类号： G06K9/4652 ,  G06K15/1878 ,  G06T5/007 ,  G06T7/90 ,  G06T2207/10008 ,  G09G5/02 ,  H04N1/60 ,  H04N1/6055

摘要： An image processing apparatus includes a first image output device and a second image output device outputting first and second output data from original image data, a color space fixing device for determining a color space for color tone conversion, a color space conversion device, a color component mapping device for generating color component mapping data containing correspondences between pixels in the image data, a color tone conversion parameter fixing device for generating color tone conversion parameters from corresponding pixels in the image data, and a color tone conversion device for converting the image data using the conversion parameters.

摘要翻译： 图像处理装置包括第一图像输出装置和从原始图像数据输出第一和第二输出数据的第二图像输出装置，用于确定色调转换的颜色空间的颜色空间定影装置，颜色空间转换装置，颜色 用于生成包含图像数据中的像素之间的对应关系的颜色分量映射数据的分量映射装置，用于从图像数据中的相应像素生成色调转换参数的色调转换参数定影装置，以及用于转换图像数据的色调转换装置 使用转换参数。