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公开(公告)号：US20240116972A1
公开(公告)日：2024-04-11
申请号：US18510128
申请日：2023-11-15
申请人： Southern Research Institute , Oregon Health & Science University , Washington University in St. Louis , Board of Regents, The University of Texas System
发明人： Omar Moukha-Chafiq , Ashish Kumar Pathak , Shuklendu D. Karyakarte , Larry D. Bratton , Corinne E. Augelli-Szafran , Michael Diamond , Pei Yong Shi , Alec Jay Hirsch , Jessica Lee Smith , Daniel Streblow , Nicole Haese , Baoling Ying
摘要： The present disclosure is concerned with 6-aza-nucleoside prodrugs that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, yellow fever virus, tick-borne encephalitis virus, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), Middle East Respiratory Syndromes (MERS), Severe Acute Respiratory Syndrome (SARS), and coronavirus disease 2019 (COVID-19), using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US11858956B2
公开(公告)日：2024-01-02
申请号：US17554979
申请日：2021-12-17
申请人： Southern Research Institute , Oregon Health & Science University , Washington University in St. Louis , Board of Regents, The University of Texas System
发明人： Omar Moukha-Chafiq , Ashish Kumar Pathak , Shuklendu D. Karyakarte , Larry D. Bratton , Corinne E. Augelli-Szafran , Michael Diamond , Pei Yong Shi , Alec Jay Hirsch , Jessica Lee Smith , Daniel Streblow , Nicole Haese , Baoling Ying
摘要： The present disclosure is concerned with 6-aza-nucleoside prodrugs that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, yellow fever virus, tick-borne encephalitis virus, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), Middle East Respiratory Syndromes (MERS), Severe Acute Respiratory Syndrome (SARS), and coronavirus disease 2019 (COVID-19), using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20240343707A1
公开(公告)日：2024-10-17
申请号：US18631992
申请日：2024-04-10
发明人： Syed Kaleem Ahmed , Shilpa Dutta , Daniel N. Streblow , Corinne E. Augelli-Szafran , Omar Moukha-Chafiq , Ali Nakhi , Ashish Kumar Pathak
IPC分类号： C07D401/12 , A61K31/505 , A61K31/506 , A61K31/55 , A61K31/675 , A61P31/14 , C07D239/26 , C07D403/12 , C07D405/12 , C07D513/12 , C07F9/6512
CPC分类号： C07D401/12 , A61K31/505 , A61K31/506 , A61K31/55 , A61K31/675 , A61P31/14 , C07D239/26 , C07D403/12 , C07D405/12 , C07D513/12 , C07F9/6512
摘要： The present disclosure is concerned with substituted phenyl ethynyl pyrimidine compounds that are capable of inhibiting a viral infection and methods of treating alphavirus viral infections such as, for example, chikungunya, Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), and Venezuelan equine encephalitis using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20220204545A1
公开(公告)日：2022-06-30
申请号：US17554979
申请日：2021-12-17
申请人： Southern Research Institute , Oregon Health & Science University , Washington University in St. Louis , Board of Regents of the University of Texas System and Its Component Institution University of Texas
发明人： Omar Moukha-Chafiq , Ashish Kumar Pathak , Shuklendu D. Karyakarte , Larry D. Bratton , Corinne E. Augelli-Szafran , Michael Diamond , Pei Yong Shi , Alec Jay Hirsch , Jessica Lee Smith , Daniel Streblow , Nicole Haese , Baoling Ying
摘要： The present disclosure is concerned with 6-aza-nucleoside prodrugs that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, yellow fever virus, tick-borne encephalitis virus, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), Middle East Respiratory Syndromes (MERS), Severe Acute Respiratory Syndrome (SARS), and coronavirus disease 2019 (COVID-19), using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20240182450A1
公开(公告)日：2024-06-06
申请号：US18545749
申请日：2023-12-19
发明人： Ashish Kumar Pathak , Corinne E. Augelli-Szafran , Atefeh Garzan , Daniel Steblow , Nicole Haese
IPC分类号： C07D403/04 , C07D213/69 , C07D213/70 , C07D213/74 , C07D491/052 , C07D498/08
CPC分类号： C07D403/04 , C07D213/69 , C07D213/70 , C07D213/74 , C07D491/052 , C07D498/08
摘要： The present disclosure is concerned with 2-pyrimidone compounds that are capable of inhibiting a viral infection and methods of treating alphavirus viral infections such as, for example, chikungunya, Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), and Venezuelan equine encephalitis using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20230219958A1
公开(公告)日：2023-07-13
申请号：US18095429
申请日：2023-01-10
申请人： Southern Research Institute , UAB Research Foundation , The United States Government as represented by the Department of Veterans Affairs
发明人： Mark J. Suto , Bini Mathew , Corinne E. Augelli-Szafran , Marina Fosso Yatchang , Mohammad Athar , Anupam Agarwal , Ritesh Kumar Srivastava , Suhail Muzaffar , Jasim Khan
IPC分类号： C07D473/32 , A61P39/02
CPC分类号： C07D473/32 , A61P39/02
摘要： The present disclosure is concerned with purine diamine compounds for the treatment of conditions associated with BRD4, RIP3K, and/or IL6 signaling dysfunction such as, for example, cancer (e.g., lung cancer, skin cancer, bladder cancer, kidney cancer, liver cancer), arsenicosis, arsenic poisoning, inflammation, skin lesions, dysfunction of systemic organs, and skin blisters. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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7.发明公开公开(公告)号：US20230192733A1
公开(公告)日：2023-06-22
申请号：US18086445
申请日：2022-12-21
申请人： Southern Research Institute , The University of North Carolina at Chapel Hill , Vanderbilt University
发明人： Syed Kaleem Ahmed , Shilpa Dutta , John Phillip Tillotson , Corinne E. Augelli-Szafran , Ashish Kumar Pathak , Omar Moukha-Chafiq , Timothy Patrick Sheahan , Ralph S. Baric , Amy Catherine Sims , Mark R. Denison
IPC分类号： C07F9/58 , C07D213/56 , C07D413/12 , C07D401/12 , C07D417/12
CPC分类号： C07F9/58 , C07D213/56 , C07D413/12 , C07D401/12 , C07D417/12
摘要： The present disclosure is concerned with substituted phenyl ethynyl pyridine carboxamide compounds, pharmaceutical compositions comprising the compounds, and methods of treating viral infections due to a Coronavirus such as, for example, Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and severe acute respiratory syndrome coronavirus disease 2019 (SARS-CoV-2), using the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20230002331A1
公开(公告)日：2023-01-05
申请号：US17893091
申请日：2022-08-22
IPC分类号： C07D263/48 , C07D413/04
摘要： The present disclosure is concerned with 2-aminoaryl-5-aryloxazole compounds that are capable of activating NF-κB signaling. The present disclosure is also concerned with methods of using these compounds for the treatment of neurological disorders such as, for example, amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, spinal muscular atrophy, traumatic brain injury, vascular dementia, Huntington's disease, mental retardation, and attention deficit and hyperactivity disorder (ADHD), and neuromuscular disorders such as, for example, Duchenne muscular dystrophy (DMD). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US10450263B2
公开(公告)日：2019-10-22
申请号：US15892302
申请日：2018-02-08
IPC分类号： C07C233/64 , C07C233/67 , C07C233/75 , C07D231/12 , C07D233/58 , C07D261/08 , C07D277/22 , C07D333/10 , C07D307/36 , C07D213/16 , C07D223/04 , C07D241/12 , C07D271/12 , C07D233/90 , C07D277/56 , C07D261/18 , C07D307/68 , C07D333/38 , C07D241/24 , C07D239/28 , C07C255/41 , C07D213/56 , C07D213/81 , C07D307/85 , C07D309/08 , C07D213/30 , C07D209/46 , C07D223/16 , A61P31/12 , C07D231/14 , C07C255/58 , C07C311/21 , C07C233/29 , C07C233/60 , C07C233/65 , C07C235/48 , C07C255/33
摘要： The present disclosure is concerned with benzo annulene compounds that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, chikungunya, Venezuelan equine encephalitis, dengue, influenza, and zika, using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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10.发明授权公开(公告)号：US10023579B2
公开(公告)日：2018-07-17
申请号：US15382213
申请日：2016-12-16
发明人： Corinne E. Augelli-Szafran , Mark Suto , Robert Galemmo , Omar Moukha-Chafiq , Vandana Gupta , Subramaniam Ananthan
IPC分类号： C07D487/14
摘要： The present disclosure is concerned with certain pyrrolopyrimidine compounds that are capable of inhibiting certain protein kinases, and especially the leucine-rich repeat kinase 2 (LRRK2) protein. Compounds of the present disclosure can be used to treat a number of disorders caused by or associated with abnormal LRRK2 kinase activity. Compounds of the present disclosure can be used to treat disorders including neurodegenerative diseases such as Parkinson's disease; precancerous conditions and cancer; autoimmune disorders such as Crohn's disease, rheumatoid arthritis and psoriasis; and leprosy (Hansen's disease). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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