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    Capillary electrophoresis
    1.
    发明授权
    Capillary electrophoresis 失效
    毛细管电泳

    公开(公告)号：US5384024A

    公开(公告)日：1995-01-24

    申请号：US850764

    申请日：1992-03-13

    申请人： Stephen E. Moring ,  Michael S. Albin ,  Reid B. Kowallis ,  Thomas E. Lee ,  Dennis E. Mead ,  John H. Nickel ,  Mark F. Oldham ,  Richard T. Reel ,  Timothy S. Orpin ,  Janice C. Woods

    发明人： Stephen E. Moring ,  Michael S. Albin ,  Reid B. Kowallis ,  Thomas E. Lee ,  Dennis E. Mead ,  John H. Nickel ,  Mark F. Oldham ,  Richard T. Reel ,  Timothy S. Orpin ,  Janice C. Woods

    IPC分类号： G01N27/447 ,  B01D61/46 ,  B01D57/02 ,  G01N27/26

    CPC分类号： G01N27/44782

    摘要： An instrument for capillary electrophoresis has a vertically translatable carrier holding one end of the capillary and an electrode connected to a power supply, and a rotary carousel for presenting containers of sample and buffer solutions to a load position where the end of the capillary and the electrode may be inserted by operating the carrier. The other end of the capillary and a second electrode connected to the power supply are immersed in an outlet buffer reservoir. The instrument has a vacuum supply for providing a relative vacuum over the solution in the outlet buffer reservoir, so simple material may be injected into the capillary either by electromigration or by differential pressure. After injection, the first end of the capillary and the electrode may be immersed in buffer to accomplish electrophoresis. By manipulating the carousel and carrier, multiple samples may be electrophoresed in series. In a preferred embodiment the instrument includes a flexible duck-billed septum for closing containers while permitting easy access for the electrode and the capillary tube. Also in a preferred embodiment the instrument is controlled by a microprocessor-based controller.

    摘要翻译： 用于毛细管电泳的仪器具有保持毛细管的一端和连接到电源的电极的可垂直平移的载体，以及用于将样品和缓冲溶液的容器呈现到毛细管和电极的端部的负载位置的旋转转盘 可以通过操作载体来插入。 毛细管的另一端和连接到电源的第二电极浸入出口缓冲储存器中。 该仪器具有用于在出口缓冲储存器中的溶液上提供相对真空的真空源，因此可以通过电迁移或通过差压将简单的材料注入毛细管。 注射后，将毛细管和电极的第一端浸入缓冲液中以完成电泳。 通过操纵转盘和载体，可以将多个样品串联进行电泳。 在优选实施例中，该仪器包括用于封闭容器的柔性鸭嘴孔隔膜，同时允许容易地接近电极和毛细管。 同样在优选实施例中，仪器由基于微处理器的控制器控制。

    DNA Sequencing System
    2.
    发明申请
    DNA Sequencing System 有权
    DNA测序系统

    公开(公告)号：US20100103416A1

    公开(公告)日：2010-04-29

    申请号：US12630683

    申请日：2009-12-03

    申请人： Mark F. OLDHAM ,  Eric S. Nordman ,  Richard T. Reel ,  Janice S. Shigeura

    发明人： Mark F. OLDHAM ,  Eric S. Nordman ,  Richard T. Reel ,  Janice S. Shigeura

    IPC分类号： G01N21/00

    CPC分类号： G01N27/44721 ,  B82Y10/00 ,  B82Y20/00 ,  G01N2015/149 ,  G01N2015/1497

    摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.

    摘要翻译： 提供了一种用于检测标记珠粒的装置。 该装置可以包括：一个或多个辐射源，被设置用于用辐射照射一个或多个检测区域; 至少一个检测器被设置用于收集对应于已经被辐射激发的一个或多个检测区域中的标记珠子发射的光信号的电荷; 以及耦合到所述至少一个检测器的系统，用于通过在读取至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分。

    System for detecting markers
    3.
    发明授权
    System for detecting markers 有权
    检测标记系统

    公开(公告)号：US07636160B2

    公开(公告)日：2009-12-22

    申请号：US12321781

    申请日：2009-01-26

    申请人： Mark F. Oldham ,  Eric S. Nordman ,  Richard T. Reel ,  John S. Shigeura ,  Janice G. Shigeura, legal representative

    发明人： Mark F. Oldham ,  Eric S. Nordman ,  Richard T. Reel ,  John S. Shigeura

    IPC分类号： G01N21/00

    CPC分类号： G01N27/44721 ,  B82Y10/00 ,  B82Y20/00 ,  G01N2015/149 ,  G01N2015/1497

    摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.

    摘要翻译： 提供了一种用于检测标记珠粒的装置。 该装置可以包括：一个或多个辐射源，被设置用于用辐射照射一个或多个检测区域; 至少一个检测器被设置用于收集对应于已经被辐射激发的一个或多个检测区域中的标记珠子发射的光信号的电荷; 以及耦合到所述至少一个检测器的系统，用于通过在读取至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分。

    Time-delay integration in detection of labeled beads
    5.
    发明申请
    Time-delay integration in detection of labeled beads 有权
    标记珠的检测时延整合

    公开(公告)号：US20090021735A1

    公开(公告)日：2009-01-22

    申请号：US12283957

    申请日：2008-09-17

    申请人： Mark F. Oldham ,  Eric S. Nordman ,  Richard T. Reel ,  John S. Shigeura ,  Janice G. Shigeura

    发明人： Mark F. Oldham ,  Eric S. Nordman ,  Richard T. Reel ,  John S. Shigeura ,  Janice G. Shigeura

    IPC分类号： G01N21/62

    CPC分类号： G01N27/44721 ,  B82Y10/00 ,  B82Y20/00 ,  G01N2015/149 ,  G01N2015/1497

    摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.

    摘要翻译： 提供了一种用于检测标记珠粒的装置。 该装置可以包括：一个或多个辐射源，被设置用于用辐射照射一个或多个检测区域; 至少一个检测器被设置用于收集对应于已经被辐射激发的一个或多个检测区域中的标记珠子发射的光信号的电荷; 以及耦合到所述至少一个检测器的系统，用于通过在读取至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分。

    DNA sequencing system
    8.
    发明授权
    DNA sequencing system 有权
    DNA测序系统

    公开(公告)号：US07978326B2

    公开(公告)日：2011-07-12

    申请号：US12630683

    申请日：2009-12-03

    申请人： Mark F. Oldham ,  Eric S. Nordman ,  Richard T. Reel ,  John S. Shigeura ,  Janice G. Shigeura, legal representative

    发明人： Mark F. Oldham ,  Eric S. Nordman ,  Richard T. Reel ,  John S. Shigeura

    IPC分类号： G01N21/00

    CPC分类号： G01N27/44721 ,  B82Y10/00 ,  B82Y20/00 ,  G01N2015/149 ,  G01N2015/1497

    摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.

    摘要翻译： 提供了一种用于检测标记珠粒的装置。 该装置可以包括：一个或多个辐射源，被设置用于用辐射照射一个或多个检测区域; 至少一个检测器被设置用于收集对应于已经被辐射激发的一个或多个检测区域中的标记珠子发射的光信号的电荷; 以及耦合到所述至少一个检测器的系统，用于通过在读取至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分。