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公开(公告)号：US08535719B2
公开(公告)日：2013-09-17
申请号：US11825540
申请日：2007-07-06
申请人： Stephen F. Badylak , Donald O. Freytes , Thomas W. Gilbert , Jianjun Guan , John Stankus , William R. Wagner
发明人： Stephen F. Badylak , Donald O. Freytes , Thomas W. Gilbert , Jianjun Guan , John Stankus , William R. Wagner
IPC分类号： A61K9/70
CPC分类号： A61L27/56 , A61L27/3633 , A61L27/3804 , A61L27/58
摘要： Provided herein is a biohybrid elastomeric scaffold comprising a synthetic polymeric component and a biological polymeric component. The scaffold can be fabricated to have many different forms, non-limiting examples of which include a non-woven fibrous mesh or in a porous composite. Methods of use of the biohybrid elastomeric scaffolds in wound healing and tissue regeneration are also provided.
摘要翻译： 本文提供了包含合成聚合物组分和生物聚合物组分的生物混合弹性体支架。 支架可以制造成具有许多不同的形式，其非限制性实例包括非织造纤维网或多孔复合材料。 还提供了在伤口愈合和组织再生中使用生物混合弹性体支架的方法。
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公开(公告)号：US20080268019A1
公开(公告)日：2008-10-30
申请号：US11825540
申请日：2007-07-06
申请人： Stephen F. Badylak , Donald O. Freytes , Thomas W. Gilbert , Jianjun Guan , John Stankus , William R. Wagner
发明人： Stephen F. Badylak , Donald O. Freytes , Thomas W. Gilbert , Jianjun Guan , John Stankus , William R. Wagner
CPC分类号： A61L27/56 , A61L27/3633 , A61L27/3804 , A61L27/58
摘要： Provided herein is a biohybrid elastomeric scaffold comprising a synthetic polymeric component and a biological polymeric component. The scaffold can be fabricated to have many different forms, non-limiting examples of which include a non-woven fibrous mesh or in a porous composite. Methods of use of the biohybrid elastomeric scaffolds in wound healing and tissue regeneration are also provided.
摘要翻译： 本文提供了包含合成聚合物组分和生物聚合物组分的生物混合弹性体支架。 支架可以制造成具有许多不同的形式，其非限制性实例包括非织造纤维网或多孔复合材料。 还提供了在伤口愈合和组织再生中使用生物混合弹性体支架的方法。
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公开(公告)号：US08889791B2
公开(公告)日：2014-11-18
申请号：US11869774
申请日：2007-10-10
IPC分类号： A61K47/34 , A61K47/38 , C08G63/46 , C12N5/02 , C08F265/10 , C08F290/06 , A61L27/16 , A61K47/48 , A61L27/38 , C08F265/00 , C08F265/04 , C08L51/00 , A61K9/00
CPC分类号： A61K47/482 , A61K9/0019 , A61K47/34 , A61K47/58 , A61K47/593 , A61K47/6903 , A61L27/16 , A61L27/3873 , C08F265/00 , C08F265/04 , C08F265/10 , C08F290/06 , C08L51/003 , C08L33/26 , C08L2666/02
摘要： Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers and degradation products thereof are non-toxic and typically have an LCST between room temperature and 37° C. so that they are liquid at room temperature and gelled at 37° C. which facilitates their use in humans, for example for wound treatment and as a cellular growth matrix or niche. The copolymer comprises numerous ester linkages in its backbone so that the copolymers are erodeable in situ. Degradation products of the polymer are soluble and non-toxic. The copolymer is amine-reactive so that it can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymer.
摘要翻译： 提供了包含该共聚物的新型生物相容性共聚物和组合物。 其共聚物和降解产物是无毒的，并且通常在室温至37℃之间具有LCST，使得它们在室温下为液体并在37℃下凝胶化，这有助于其在人体中的用途，例如用于伤口处理 并且作为细胞生长矩阵或利基。 共聚物在其主链中包含许多酯键，使得共聚物在原位可侵蚀。 聚合物的降解产物是可溶的和无毒的。 共聚物是胺反应性的，因此它可以与蛋白质如胶原蛋白结合。 活性成分，例如药物，可以并入包含该共聚物的组合物中。
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4.发明授权公开(公告)号：US08673295B2
公开(公告)日：2014-03-18
申请号：US13265067
申请日：2010-04-30
申请人： Kazuro Lee Fujimoto , Zuwei Ma , Jianjun Guan , William R. Wagner
发明人： Kazuro Lee Fujimoto , Zuwei Ma , Jianjun Guan , William R. Wagner
IPC分类号： A01N63/00
CPC分类号： A61K31/56 , A61K9/0024 , A61K38/1825 , A61K38/22 , A61K38/30 , A61K47/32 , A61L27/52 , A61L27/58
摘要： Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers can be used for wound treatment, as a cellular growth matrix or niche and for injection into cardiac tissue to repair and mechanically support damaged tissue. The copolymers comprise numerous ester linkages so that the copolymers are erodeable in situ. Degradation products of the copolymers are soluble and non-toxic. The copolymers can be amine-reactive so that they can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymers.
摘要翻译： 提供了包含该共聚物的新型生物相容性共聚物和组合物。 共聚物是无毒的并且通常具有低于37℃的LCST。包含共聚物的组合物可以用作伤口处理，作为细胞生长基质或小生境，并用于注射到心脏组织中以修复和机械支持受损组织。 共聚物包含许多酯键，使得共聚物原位可侵蚀。 共聚物的降解产物是可溶的和无毒的。 共聚物可以是胺反应性的，使得它们可以与蛋白质例如胶原结合。 活性成分，例如药物，可以并入包含共聚物的组合物中。
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5.发明授权Biodegradable elastomeric patch for treating cardiac or cardiovascular conditions 有权用于治疗心脏或心血管疾病的可生物降解弹性体贴片公开(公告)号：US08974542B2
公开(公告)日：2015-03-10
申请号：US11823359
申请日：2007-06-27
申请人： Kazuro Lee Fujimoto , Kimimasa Tobita , Jianjun Guan , William R. Wagner , Bradley Barth Keller
发明人： Kazuro Lee Fujimoto , Kimimasa Tobita , Jianjun Guan , William R. Wagner , Bradley Barth Keller
CPC分类号： A61L31/06 , A61K9/0024 , A61K9/7007
摘要： Provided herein is a biodegradable elastomeric patch that can be implanted on a heart or other portions of the cardiovascular system to repair tissue deficiencies or tissue damage. The biodegradable elastomeric patch may be engineered to have mechanical properties similar to that of soft tissue and to provide mechanical support to the damaged tissue. The biodegradable elastomeric patch also may comprise therapeutic agents to aid in the healing process. Methods also are provided for using a biodegradable elastomeric patch for treating patients suffering from tissue damage or tissue deficiencies in the cardiac or cardiovascular system.
摘要翻译： 本文提供了可植入心脏或心血管系统的其它部分以修复组织缺陷或组织损伤的可生物降解的弹性体贴片。 可生物降解的弹性体贴片可以被设计成具有类似于软组织的机械性能并且向受损组织提供机械支撑。 可生物降解的弹性体贴片还可以包含治疗剂以帮助愈合过程。 还提供了使用可生物降解的弹性体贴剂来治疗患有组织损伤或心脏或心血管系统中组织缺陷的患者的方法。
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6.发明申请公开(公告)号：US20120156176A1
公开(公告)日：2012-06-21
申请号：US13265067
申请日：2010-04-30
申请人： Kazuro Lee Fujimoto , Zuwei Ma , Jianjun Guan , William R. Wagner
发明人： Kazuro Lee Fujimoto , Zuwei Ma , Jianjun Guan , William R. Wagner
IPC分类号： A61K47/32 , C08F283/02 , C08G81/02 , A61K38/19 , A61K38/02 , A61K31/56 , A61K31/7088 , A61K47/36 , A61K47/42 , A61K38/18 , A61K38/30 , C12N5/071 , A61K35/12 , A61P9/00 , A61P9/10 , A61P31/00 , A61P29/00 , A61P23/00 , A61P7/04 , C08F283/01
CPC分类号： A61K31/56 , A61K9/0024 , A61K38/1825 , A61K38/22 , A61K38/30 , A61K47/32 , A61L27/52 , A61L27/58
摘要： Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers can be used for wound treatment, as a cellular growth matrix or niche and for injection into cardiac tissue to repair and mechanically support damaged tissue. The copolymers comprise numerous ester linkages so that the copolymers are erodeable in situ. Degradation products of the copolymers are soluble and non-toxic. The copolymers can be amine-reactive so that they can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymers.
摘要翻译： 提供了包含该共聚物的新型生物相容性共聚物和组合物。 共聚物是无毒的，并且通常具有低于37℃的LCST。包含共聚物的组合物可以用作伤口处理，作为细胞生长基质或小生境，并用于注射到心脏组织中以修复和机械支撑受损组织。 共聚物包含许多酯键，使得共聚物原位可侵蚀。 共聚物的降解产物是可溶的和无毒的。 共聚物可以是胺反应性的，使得它们可以与蛋白质例如胶原结合。 活性成分，例如药物，可以并入包含共聚物的组合物中。
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公开(公告)号：US20090136553A1
公开(公告)日：2009-05-28
申请号：US12237835
申请日：2008-09-25
申请人： Jorg C. Gerlach , Jianjun Guan , Steven R. Little , Alan J. Russell , Jillian Tengood , William R. Wagner
发明人： Jorg C. Gerlach , Jianjun Guan , Steven R. Little , Alan J. Russell , Jillian Tengood , William R. Wagner
CPC分类号： A61L27/38 , A61L27/50 , A61L27/54 , A61L2300/414 , A61L2300/45 , A61L2300/602 , D01D5/24
摘要： Provided are tubular structures of a biocompatible, triggerably-dissolvable material such as cellulose or a copolymer having an LCST below physiological temperatures. The structures may be embedded within a cell growth scaffold. The tubular structures are useful in growing 3-dimensional tissue structures because nutrients, cytokines or other cell growth and/or differentiation compounds, as well as drugs, such as antibiotics and steroids, can be administered over time, and the tubular structures can be dissolved non-invasively.
摘要翻译： 提供了生物相容性，可触发性可溶解的材料的管状结构，例如在生理温度以下具有LCST的纤维素或共聚物。 结构可以嵌入细胞生长支架内。 管状结构可用于生长三维组织结构，因为营养物质，细胞因子或其它细胞生长和/或分化化合物以及药物如抗生素和类固醇可随时间施用，并且管状结构可溶解 非侵略性
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8.发明申请公开(公告)号：US20080109070A1
公开(公告)日：2008-05-08
申请号：US11837235
申请日：2007-08-10
申请人： William Wagner , John Stankus , Jianjun Guan , Kazuro Fujimoto , Alejandro Nieponice , Lorenzo Soletti , David Vorp , Michael Sacks , Todd Courtney , John Mayer
发明人： William Wagner , John Stankus , Jianjun Guan , Kazuro Fujimoto , Alejandro Nieponice , Lorenzo Soletti , David Vorp , Michael Sacks , Todd Courtney , John Mayer
CPC分类号： A61L27/3843 , A61F2/2415 , A61L27/54 , A61L27/56 , A61L2300/236 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602
摘要： Described herein are elastomeric materials, and in particular porous biodegradable elastomeric materials which optionally may have microintegrated cells. Also described herein are bioprosthetic devices that can be manufactured using the biodegradable elastomeric materials, non-limiting examples of such devices including pulmonary valves, vocal chords, and blood vessels.
摘要翻译： 本文描述的是弹性体材料，特别是多孔可生物降解的弹性体材料，其任选地可以具有微结合的细胞。 本文还描述了可以使用可生物降解的弹性体材料制造的生物假体装置，这种装置的非限制性实例包括肺动脉瓣，声带和血管。
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公开(公告)号：US20120071407A1
公开(公告)日：2012-03-22
申请号：US13163302
申请日：2011-06-17
CPC分类号： A61K38/1709
摘要： A novel method of treating a wound is provided. The method comprises administering a therapeutically effective amount of periostin to the wound.
摘要翻译： 提供了一种治疗伤口的新方法。 该方法包括向伤口施用治疗有效量的骨膜素。
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10.发明申请Biodegradable elastomeric patch for treating cardiac or cardiovascular conditions 有权用于治疗心脏或心血管疾病的可生物降解弹性体贴片公开(公告)号：US20080009830A1
公开(公告)日：2008-01-10
申请号：US11823359
申请日：2007-06-27
IPC分类号： A61M31/00
CPC分类号： A61L31/06 , A61K9/0024 , A61K9/7007
摘要： Provided herein is a biodegradable elastomeric patch that can be implanted on a heart or other portions of the cardiovascular system to repair tissue deficiencies or tissue damage. The biodegradable elastomeric patch may be engineered to have mechanical properties similar to that of soft tissue and to provide mechanical support to the damaged tissue. The biodegradable elastomeric patch also may comprise therapeutic agents to aid in the healing process. Methods also are provided for using a biodegradable elastomeric patch for treating patients suffering from tissue damage or tissue deficiencies in the cardiac or cardiovascular system.
摘要翻译： 本文提供了可植入心脏或心血管系统的其它部分以修复组织缺陷或组织损伤的可生物降解的弹性体贴片。 可生物降解的弹性体贴片可以被设计成具有类似于软组织的机械性能并且向受损组织提供机械支撑。 可生物降解的弹性体贴片还可以包含治疗剂以帮助愈合过程。 还提供了使用可生物降解的弹性体贴剂来治疗患有组织损伤或心脏或心血管系统中组织缺陷的患者的方法。
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