-
公开(公告)号：US5660178A
公开(公告)日：1997-08-26
申请号：US583406
申请日：1996-01-05
IPC分类号： A61B5/0408 , A61L15/44 , A61L15/58 , A61N1/30 , C09J4/00 , C09J7/02 , C09J171/00 , C09J171/02 , H01B1/12 , H01B1/20 , H01M10/052 , H01M10/0565 , A61B5/04 , A61F13/02 , B32B7/12
CPC分类号： C09J171/02 , C09J171/00 , H01B1/122 , H01B1/20 , H01M10/052 , H01M10/0565 , Y10S428/913 , Y10T428/2839 , Y10T428/2852 , Y10T428/31504
摘要： A hydrophilic, pressure sensitive adhesive of a poly(ethylene oxide) derived network plasticized with an essentially non-volatile, polar plasticizer present in an amount sufficient to form a cohesive, pressure sensitive adhesive. The polymeric network is prepared from an oligomeric precursor comprising difunctional poly(ethylene glycol) moieties which have been end-capped with ethylenically unsaturation. The adhesive is useful as a biomedical adhesive for transmitting or receiving electrical signals as a component of a biomedical electrode. The adhesive is also useful as a drug delivery device to deliver pharmaceuticals or other active ingredients to or through mammalian skin. The adhesive is also useful as a component in a skin covering for protecting mammalian skin or mammalian skin openings with antimicrobial agents. A method of preparation of the adhesive is also disclosed.
摘要翻译： 用基本上不挥发的极性增塑剂增塑的聚（环氧乙烷）衍生网的亲水性压敏粘合剂，其量足以形成粘合的压敏粘合剂。 聚合物网络由包含已被封端具有烯属不饱和键的二官能聚（乙二醇）部分的低聚前体制备。 该粘合剂可用作生物医学粘合剂，用于作为生物医学电极的组分传输或接收电信号。 粘合剂也可用作药物递送装置，以将药物或其它活性成分递送至哺乳动物皮肤或通过哺乳动物皮肤。 粘合剂也可用作皮肤覆盖物中用于用抗微生物剂保护哺乳动物皮肤或哺乳动物皮肤开口的组分。 还公开了制备粘合剂的方法。
-
公开(公告)号：US5489624A
公开(公告)日：1996-02-06
申请号：US983688
申请日：1992-12-01
IPC分类号： A61B5/0408 , A61L15/44 , A61L15/58 , A61N1/30 , C09J4/00 , C09J7/02 , C09J171/00 , C09J171/02 , H01B1/12 , H01B1/20 , H01M10/052 , H01M10/0565 , C08K5/06 , C08K5/05
CPC分类号： C09J171/02 , C09J171/00 , H01B1/122 , H01B1/20 , H01M10/052 , H01M10/0565 , Y10S428/913 , Y10T428/2839 , Y10T428/2852 , Y10T428/31504
摘要： A hydrophilic, pressure sensitive adhesive of a poly(ethylene oxide) derived network plasticized with an essentially non-volatile, polar plasticizer present in an amount sufficient to form a cohesive, pressure sensitive adhesive. The polymeric network is prepared from an oligomeric precursor comprising difunctional poly(ethylene glycol) moieties which have been end-capped with ethylenically unsaturation. The adhesive is useful as a biomedical adhesive for transmitting or receiving electrical signals as a component of a biomedical electrode. The adhesive is also useful as a drug delivery device to deliver pharmaceuticals or other active ingredients to or through mammalian skin. The adhesive is also useful as a component in a skin covering for protecting mammalian skin or mammalian skin openings with antimicrobial agents. A method of preparation of the adhesive is also disclosed.
摘要翻译： 用基本上不挥发的极性增塑剂增塑的聚（环氧乙烷）衍生网的亲水性压敏粘合剂，其量足以形成粘合的压敏粘合剂。 聚合物网络由包含已被封端具有烯属不饱和键的二官能聚（乙二醇）部分的低聚前体制备。 该粘合剂可用作生物医学粘合剂，用于作为生物医学电极的组分传输或接收电信号。 粘合剂也可用作药物递送装置，以将药物或其它活性成分递送至哺乳动物皮肤或通过哺乳动物皮肤。 粘合剂也可用作皮肤覆盖物中用于用抗微生物剂保护哺乳动物皮肤或哺乳动物皮肤开口的组分。 还公开了制备粘合剂的方法。
-
公开(公告)号：US5536768A
公开(公告)日：1996-07-16
申请号：US583456
申请日：1996-01-05
IPC分类号： A61B5/0408 , A61L15/44 , A61L15/58 , A61N1/30 , C09J4/00 , C09J7/02 , C09J171/00 , C09J171/02 , H01B1/12 , H01B1/20 , H01M10/052 , H01M10/0565 , C08K5/06 , B32B7/12
CPC分类号： C09J171/02 , C09J171/00 , H01B1/122 , H01B1/20 , H01M10/052 , H01M10/0565 , Y10S428/913 , Y10T428/2839 , Y10T428/2852 , Y10T428/31504
摘要： A hydrophilic, pressure sensitive adhesive of a poly(ethylene oxide) derived network plasticized with an essentially non-volatile, polar plasticizer present in an amount sufficient to form a cohesive, pressure sensitive adhesive. The polymeric network is prepared from an oligomeric precursor comprising difunctional poly(ethylene glycol) moieties which have been end-capped with ethylenically unsaturation. The adhesive is useful as a biomedical adhesive for transmitting or receiving electrical signals as a component of a biomedical electrode. The adhesive is also useful as a drug delivery device to deliver pharmaceuticals or other active ingredients to or through mammalian skin. The adhesive is also useful as a component in a skin covering for protecting mammalian skin or mammalian skin openings with antimicrobial agents. A method of preparation of the adhesive is also disclosed.
-
4.发明授权Medicinal aerosol compositions with an amide and/or ester containing excipient compound 失效含有酰胺和/或酯的赋形剂化合物的药用气溶胶组合物公开(公告)号：US07186402B2
公开(公告)日：2007-03-06
申请号：US10327198
申请日：2002-12-20
CPC分类号： A61K9/008 , A61K9/145 , A61K47/183 , Y10S514/958
摘要： The invention comprises a medicinal aerosol composition comprising a propellant, an excipient comprising an acid or amine end-group and at least one and no more than two amide and/or ester functional groups, and a drug. The invention also comprises particulate medicinal compositions comprising particles with a mean mass aerodynamic diameter of less than about 10 microns that incorporate an excipient containing an acid or amine end-group and at least one and no more than two amide and/or ester functional groups.
摘要翻译： 本发明包括药物气溶胶组合物，其包含推进剂，包含酸或胺末端基团和至少一个且不多于两个酰胺和/或酯官能团的赋形剂和药物。 本发明还包括颗粒药物组合物，其包含具有小于约10微米的平均质量空气动力学直径的颗粒，其掺入含有酸或胺端基和至少一个且不超过两个酰胺和/或酯官能团的赋形剂。
-
公开(公告)号：US07459146B2
公开(公告)日：2008-12-02
申请号：US10449443
申请日：2003-05-30
CPC分类号： A61K9/008 , A61K47/02 , B01F17/0078 , B01F17/0085 , B01J13/0095 , Y10S514/937
摘要： The invention relates to stabilized dispersions containing nanoparticles of use for the administration of medicaments. The dispersions comprise excipient nanoparticles, a dispersed phase comprising medicament and a continuous phase comprising propellant.
摘要翻译： 本发明涉及包含用于给药药物的纳米颗粒的稳定分散体。 分散体包括赋形剂纳米颗粒，包含药物的分散相和包含推进剂的连续相。
-
6.发明申请STABILIZED PARTICLE DISPERSIONS CONTAINING SURFACE-MODIFIED INORGANIC NANOPARTICLES 审中-公开含有表面改性无机纳米颗粒的稳定颗粒分散体公开(公告)号：US20080268062A1
公开(公告)日：2008-10-30
申请号：US12167714
申请日：2008-07-03
IPC分类号： A61K9/51
CPC分类号： B01F17/0078 , A61K9/10 , A61K47/02 , A61K47/24
摘要： This invention relates to particle-in-liquid dispersions containing surface-modified inorganic nanoparticles.
摘要翻译： 本发明涉及含有表面改性无机纳米粒子的粒子 - 液体分散体。
-
公开(公告)号：US20080267885A1
公开(公告)日：2008-10-30
申请号：US10596836
申请日：2004-12-10
CPC分类号： A61K9/008 , A61K9/08 , A61K9/10 , A61K9/1647 , A61K47/34 , A61K47/593 , C08G63/912
摘要： Methods for the manufacture of medicinal compositions are described. A method for the manufacture of a medicinal composition according to the invention comprises: (a) Providing a biocompatible polymer of the general formula —[O—R1—C(O)]n— wherein: “R1” is a linear, branched, or cyclic organic group, “n” is at least three, (b) Acylating the biocompatible polymer to provide an acylated biocompatible polymer and a mixed anhydride; (c) Reacting the mixed anhydride with a nucleophile to provide an acylated biocompatible polymer with a terminal carboxylic acid derivative capable of being chemically converted to an acid in the absence of water, (d) Converting the terminal carboxylic acid derivative to an acylated biocompatible polymer with a terminal carboxylic acid; and (e) Combining the acylated biocompatible polymer with a drug to provide the medicinal composition.
摘要翻译： 描述了药物组合物的制造方法。 制备根据本发明的药物组合物的方法包括：（a）提供具有通式的生物相容性聚合物 - [OR 1 -C 2 -C（O）] n 其中：“R 1”是直链，支链或环状有机基团，“n”为至少三个，（b）酰化生物相容性聚合物以提供酰化生物相容性聚合物和混合 酐; （c）用亲核试剂反应混合酸酐以提供酰化的生物相容性聚合物，其具有能够在不存在水的情况下化学转化为酸的末端羧酸衍生物; （d）将末端羧酸衍生物与末端羧酸转化成酰化生物相容性聚合物; 和（e）将酰化的生物相容性聚合物与药物组合以提供药物组合物。
-
公开(公告)号：US5510421A
公开(公告)日：1996-04-23
申请号：US249877
申请日：1994-05-26
IPC分类号： C12N11/08 , B01D71/44 , B01D71/62 , B01D71/82 , B01J20/32 , B01J39/20 , C07K1/22 , C08F26/06 , C08J5/18 , C08L1/12 , C08L27/16 , C08L33/04 , C08L39/04 , C08L71/02 , C08L81/06 , C08L101/06 , C08L27/12 , C08L29/12 , C08L33/06
CPC分类号： B01D71/44 , B01D71/62 , B01J20/264 , B01J20/267 , B01J20/28033 , B01J20/28078 , B01J20/285 , B01J20/286 , B01J20/287 , B01J20/321 , B01J20/3212 , B01J20/3217 , B01J20/3274 , B01J20/3276 , B01J20/3278 , B01J20/3282 , C07K1/22 , B01J2220/4831 , B01J2220/54 , B01J2220/64
摘要： Azlactone-functional membranes prepared by solvent phase inversion techniques are disclosed. Adduct membranes prepared by the reaction of azlactone-functional membranes with nucleophilic reagents are also disclosed. Both azlactone-functional copolymers and blends of azlactone-functional homopolymers or copolymers with blending polymers can be used. These azlactone-functional membranes have azlactone functionality throughout all surfaces formed ab initio into any desired shape. Membrane properties can be modified by sacrifice of some azlactone functionality via crosslinking between azlactone moieties or coupling of hydrophilic ligands.
摘要翻译： 公开了通过溶剂相转化技术制备的吖内酯官能膜。 还公开了通过吖内酯官能膜与亲核试剂的反应制备的加合物膜。 可以使用吖内酯功能性共聚物和吖内酯官能的均聚物或共聚物与共混聚合物的共混物。 这些吖内酯官能膜在从头开始形成任何所需形状的所有表面中都具有吖内酯官能团。 可以通过吖内酯部分之间的交联或亲水性配体的偶联牺牲一些吖内酯官能团来修饰膜性质。
-
公开(公告)号：US5508060A
公开(公告)日：1996-04-16
申请号：US193170
申请日：1994-09-19
申请人： Craig A. Perman , Joanne M. Bartkus , Hye-Ok Choi , Manfred E. Riechert , Kelvin J. Witcher , Richard C. Kao , James S. Stefely , John E. Gozum
发明人： Craig A. Perman , Joanne M. Bartkus , Hye-Ok Choi , Manfred E. Riechert , Kelvin J. Witcher , Richard C. Kao , James S. Stefely , John E. Gozum
IPC分类号： A61K9/00 , A61K9/16 , A61K47/32 , A61K47/34 , A61L17/00 , A61L29/16 , A61L31/16 , C08J3/20 , C08J7/06 , D06M23/10 , D06P1/94 , B05D3/12
CPC分类号： D06P1/94 , A61K9/1647 , A61K9/1658 , A61K9/1694 , A61L17/005 , C08J7/065 , D06M23/105 , A61L2300/252 , A61L2300/406 , A61L2300/43 , A61L2300/442 , A61L2300/622 , Y02P20/544
摘要： Methods of impregnating various polymer substrates with an impregnation additive, by simultaneously contacting the polymer substrate with an impregnation additive, carrier liquid, and supercritical fluid are provided. The impregnation additive is substantially insoluble in the supercritical fluid, and the carrier liquid is preferably substantially insoluble in the supercritical fluid.
摘要翻译： PCT No.PCT / US94 / 01557 Sec。 371日期1994年9月19日 102（e）1994年9月19日PCT 1994年2月10日PCT PCT。 出版物WO94 / 18264 日期：1994年8月18日。提供了用浸渍添加剂浸渍各种聚合物基材，同时使聚合物基材与浸渍添加剂，载体液体和超临界流体接触的方法。 浸渍添加剂基本上不溶于超临界流体，载体液体优选基本上不溶于超临界流体。
-
公开(公告)号：US20090123391A1
公开(公告)日：2009-05-14
申请号：US12293205
申请日：2007-03-21
申请人： John T. Capecchi , James S. Stefely
发明人： John T. Capecchi , James S. Stefely
CPC分类号： A61K9/008
摘要： A pharmaceutical aerosol formulation includes a therapeutically effective amount of particulate medicament of formula (I) or a solvate thereof, a propellant selected from the group consisting of 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoro-n-propane or mixtures thereof, and a biocompatible polymer comprising one or more compounds of formula (II)
摘要翻译： 药物气溶胶制剂包括治疗有效量的式（I）的颗粒药物或其溶剂合物，推荐剂选自1,1,1,2-四氟乙烷，1,1,1,2,3， 3,3-七氟正丙烷或其混合物，以及包含一种或多种式（II）化合物的生物相容性聚合物，
-
-
-
-
-
-
-
-
-
搜索结果
26 条记录 (耗时 0.032 秒)