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1.发明申请公开(公告)号：US20070254332A1
公开(公告)日：2007-11-01
申请号：US10582799
申请日：2004-12-14
IPC分类号： C12Q1/04
CPC分类号： C12Q1/04
摘要： A method for determining whether a test bacterium is a class C beta-lactamase-producing bacterium. Spots of a class C beta-lactamase inhibitor and a beta-lactam drug are applied at an interval on the surface of a solid medium that has been coated with the test bacterium, the solid medium is cultured, and following culturing, determining whether or not the inhibitory zone formed around the beta-lactam drug has extended toward the class C beta-lactamase inhibitor. A mixture of class C beta-lactamase inhibitor and beta-lactam drug and a beta-lactam drug in spots are applied at an interval on the surface of a solid medium that has been coated with the test bacterium, the solid medium is cultured, and following culturing, observing the difference between the inhibitory zone formed around the mixture and the inhibitory zone formed around the beta-lactam drug. A kit for determining class C beta-lactamase-producing bacteria, in which a disk containing a class C beta-lactamase inhibitor and a disk containing a beta-lactam drug are arranged on a striplike base. A kit for determining class C beta-lactamase-producing bacteria, in which a disk containing both a class C beta-lactamase inhibitor and a beta-lactam drug and a disk containing a beta-lactam drug are arranged on a striplike base. Provided are a method for readily detecting class C beta-lactamas-producing bacterium and kits performing the method.
摘要翻译： 用于确定测试细菌是否是产生C类β-内酰胺酶的细菌的方法。 一段C型β-内酰胺酶抑制剂和β-内酰胺药物的斑点以一定间隔施加在已经被试验细菌包被的固体培养基的表面上，培养固体培养基，培养后，确定是否 在β-内酰胺类药物周围形成的抑制区已延伸至C类β-内酰胺酶类抑制剂。 在已经涂覆有测试细菌的固体培养基的表面上间隔地施加C类β-内酰胺酶抑制剂和β-内酰胺药物和β-内酰胺药物的斑点混合物，培养固体培养基， 在培养后，观察混合物周围形成的抑制区与β-内酰胺类药物周围形成的抑制区之间的差异。 用于测定产生C类β-内酰胺酶的细菌的试剂盒，其中包含C类β-内酰胺酶抑制剂的盘和含有β-内酰胺类药物的盘布置在带状基底上。 用于测定产生C类β-内酰胺酶的细菌的试剂盒，其中包含C类β-内酰胺酶抑制剂和β-内酰胺药物的盘和含有β-内酰胺类药物的盘布置在带状基底上。 提供了容易检测产生C类β-内酰胺的细菌和进行该方法的试剂盒的方法。
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公开(公告)号：US20060051363A1
公开(公告)日：2006-03-09
申请号：US10516264
申请日：2003-05-29
IPC分类号： A61K39/02 , C07H21/04 , C12N15/74 , C07K14/195
CPC分类号： C07K14/195 , A61K39/00 , C07K14/4747 , C12N9/104 , C12Y203/02002
摘要： The present invention identifies the apoptosis-inducing protein of Helicobacter pylori, analyzes the structure and provides the amino acid sequence of the protein and the nucleotide sequence encoding the amino acid sequence. Furthermore, the present invention provides inhibiting agents of an apoptosis-inducing activity of the bacterium for the treatment of disease ascribed to the bacterium and a vaccine to prevent the infection of the bacterium. The present invention revealed that the apoptosis-inducing protein of Helicobacter pylon is a protein complex composed by association of two kinds of proteins, which comprise a part of the amino acid sequence encoded by γ-glutamyl transferase gene (HP1118). The present invention is said protein and a vaccine comprising said protein.
摘要翻译： 本发明鉴定幽门螺杆菌的细胞凋亡诱导蛋白，分析结构并提供蛋白质的氨基酸序列和编码氨基酸序列的核苷酸序列。 此外，本发明提供了用于治疗归因于该细菌的疾病的细菌的细胞凋亡诱导活性的抑制剂和防止细菌感染的疫苗。
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公开(公告)号：US4926711A
公开(公告)日：1990-05-22
申请号：US273609
申请日：1988-11-21
申请人： Yoshichika Arakawa
发明人： Yoshichika Arakawa
CPC分类号： F16H48/29
摘要： A worm gear type differential mechanism has a bias ratio equalization mechanism disposed between the casing and the worm gears. The bias ratio equalization mechanism includes frictional members disposed between axially opposite transverse faces of the casing and each of the worm gears, and each of the frictional materials has frictional faces which create the same friction force per unit of thrust force applied thereagainst. The frictional materials fix the worm gear axially to the casing.
摘要翻译： 蜗轮式差速机构具有设置在壳体与蜗轮之间的偏置平衡机构。 偏置比均衡机构包括设置在壳体的轴向相对的横向面和每个蜗轮之间的摩擦构件，并且每个摩擦材料具有摩擦面，其在施加于其上的每单位推力产生相同的摩擦力。 摩擦材料将蜗轮轴向固定在外壳上。
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公开(公告)号：US09539209B2
公开(公告)日：2017-01-10
申请号：US13376009
申请日：2010-06-04
申请人： Kazuhiro Matsuda , Koji Ichiyama , Sachie Matsuda , Yuko Sasaki , Yoshichika Arakawa , Ryo Harasawa , Yoshihiro Nishida , Norio Katayama , Yasuo Endo , Nobuo Nomura
发明人： Kazuhiro Matsuda , Koji Ichiyama , Sachie Matsuda , Yuko Sasaki , Yoshichika Arakawa , Ryo Harasawa , Yoshihiro Nishida , Norio Katayama , Yasuo Endo , Nobuo Nomura
CPC分类号： A61K39/0241 , A61K9/127 , A61K9/1272 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/55555 , A61K2039/55594 , Y02A50/403
摘要： Disclosed is a vaccine which has a high therapeutic effect on mycoplasma infection and is highly safe. For the purpose of developing effective therapeutic methods for mycoplasma infection, mycoplasma-mimic particles which are effective as a vaccine for mycoplasma infection are provided, and also provided are bacterium-mimic particles including common bacteria. Bacterium-mimic particles such as mycoplasma-mimic particles can be provided by producing liposome particles in which a lipid antigen specific to a pathogenic bacterium such as mycoplasma is contained as a liposome-constituting lipid component. The administration of the mycoplasma-mimic particles enables the induction of a potent immunological activity in living bodies. The mycoplasma-mimic particles can be used as an excellent vaccine for the prevention or treatment of mycoplasma infection.
摘要翻译： 公开了对支原体感染具有高治疗效果的疫苗，并且是高度安全的。 为了开发有效的支原体感染治疗方法，提供了作为支原体感染疫苗有效的支原体模拟颗粒，并且还提供了包括常见细菌的细菌模拟颗粒。 可以通过生产脂质体颗粒来提供细菌模拟颗粒，例如支原体模拟颗粒，其中作为构成脂质体的脂质组分含有诸如支原体的致病菌特异性的脂质抗原。 支原体模拟颗粒的施用使得能够诱导活体中有效的免疫活性。 支原体模拟颗粒可用作预防或治疗支原体感染的优良疫苗。
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公开(公告)号：US20120135067A1
公开(公告)日：2012-05-31
申请号：US13376009
申请日：2010-06-04
申请人： Kazuhiro Matsuda , Koji Ichiyama , Sachie Matsuda , Yuko Sasaki , Yoshichika Arakawa , Ryo Harasawa , Yoshihiro Nishida , Norio Katayama , Yasuo Endo , Nobuo Nomura
发明人： Kazuhiro Matsuda , Koji Ichiyama , Sachie Matsuda , Yuko Sasaki , Yoshichika Arakawa , Ryo Harasawa , Yoshihiro Nishida , Norio Katayama , Yasuo Endo , Nobuo Nomura
IPC分类号： A61K9/127 , A61P37/04 , A61K39/02 , A61K39/09 , A61P31/16 , A61P31/00 , A61P11/06 , A61P19/02 , A61P11/00 , A61K9/00 , A61K39/145
CPC分类号： A61K39/0241 , A61K9/127 , A61K9/1272 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/55555 , A61K2039/55594 , Y02A50/403
摘要： Disclosed is a vaccine which has a high therapeutic effect on mycoplasma infection and is highly safe. For the purpose of developing effective therapeutic methods for mycoplasma infection, mycoplasma-mimic particles which are effective as a vaccine for mycoplasma infection are provided, and also provided are bacterium-mimic particles including common bacteria. Bacterium-mimic particles such as mycoplasma-mimic particles can be provided by producing liposome particles in which a lipid antigen specific to a pathogenic bacterium such as mycoplasma is contained as a liposome-constituting lipid component. The administration of the mycoplasma-mimic particles enables the induction of a potent immunological activity in living bodies. The mycoplasma-mimic particles can be used as an excellent vaccine for the prevention or treatment of mycoplasma infection.
摘要翻译： 公开了对支原体感染具有高治疗效果的疫苗，并且是高度安全的。 为了开发有效的支原体感染治疗方法，提供了作为支原体感染疫苗有效的支原体模拟颗粒，并且还提供了包括常见细菌的细菌模拟颗粒。 可以通过生产脂质体颗粒来提供细菌模拟颗粒，例如支原体模拟颗粒，其中作为构成脂质体的脂质组分含有诸如支原体的致病菌特异性的脂质抗原。 支原体模拟颗粒的施用使得能够诱导活体中有效的免疫活性。 支原体模拟颗粒可用作预防或治疗支原体感染的优良疫苗。
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6.发明授权System for controlling automatic transmission having communication control valve means 失效用于控制具有连通控制阀装置的自动变速器的系统
公开(公告)号：US4633739A
公开(公告)日：1987-01-06
申请号：US594291
申请日：1984-03-28
CPC分类号： F16H63/3003 , F16H61/068 , Y10T477/693754 , Y10T477/693762
摘要： The transmission of the invention is capable of attaining a plurality of shift ranges by locking and releasing one or more elements of a gear mechanism to a casing of the transmission or by connecting and releasing the elements with the input shaft, the output shaft or into and out of engagement with each other. The control system for controlling the action of the elements of the gear set is a hydraulic control system having friction elements which achieve a higher speed range and a lower speed range of the transmission upon actuation by servo valves. An additional servo valve is included to work in opposition to one of the other servo valves and communicates with another of the servo valves. A communication control valve is disposed in a hydraulic line which communicates with another of the servo valves and with the servo valve acting in opposition so as to control the communication between these valves in response to a signal pressure developed by a signal pressure valve.
摘要翻译： 本发明的变速器能够通过将齿轮机构的一个或多个元件锁定和释放到变速器的壳体上或者通过使用输入轴，输出轴连接和释放元件来实现多个换档范围， 彼此之间脱离接触。 用于控制齿轮组件的作用的控制系统是具有摩擦元件的液压控制系统，其通过伺服阀致动时实现变速器的较高速度范围和较低速度范围。 包括一个附加的伺服阀，以与其他伺服阀之一相对工作，并与另一个伺服阀连通。 通信控制阀设置在与另一个伺服阀连通的液压管路中，并且伺服阀作用相反，以响应于由信号压力阀产生的信号压力来控制这些阀之间的连通。
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公开(公告)号：US4618038A
公开(公告)日：1986-10-21
申请号：US585127
申请日：1984-03-01
CPC分类号： F16H61/143
摘要： A control apparatus in an automatic transmission includes first and second shift valves which are independently actuable to define four distinct states corresponding to four speed ranges of the transmission. In the first state, neither valve participates in achieving the first range. In the second state, only the first valve participates in achieving the second range. In the third state, only the second valve participates in achieving the third range. In the fourth state, both valves participate in locking a lock-up clutch by being fluidly interconnected by an interconnecting passage so as to define a signal pressure passage which conducts a signal pressure to a lock-up relay valve to implement a locking of the lock-up clutch.
摘要翻译： 自动变速器中的控制装置包括第一和第二换档阀，其独立地可致动以限定对应于变速器的四个速度范围的四个不同状态。 在第一个状态下，两个阀都不参与实现第一个范围。 在第二状态下，只有第一阀参与实现第二范围。 在第三个状态下，只有第二个阀门参与到第三个范围。 在第四状态下，两个阀通过互连通道流体互连而参与锁定锁止离合器，以便限定信号压力通道，其将信号压力传导到锁定继电阀以实现锁定 -up离合器。
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公开(公告)号：US4616531A
公开(公告)日：1986-10-14
申请号：US589476
申请日：1984-03-14
CPC分类号： F16H61/0246 , F16H61/08 , F16H2061/0485 , F16H61/0206 , Y10T477/689 , Y10T477/6895
摘要： A control system for an automatic transmission equipped with a plurality of friction engaging devices for attaining a plurality of shift ranges by locking the elements of a gear mechanism, which is disposed between an input shaft and an output shaft, to a case, by bringing the elements into and out of engagement with the input shaft or output shaft, or into and out of engagement with each other, said friction engaging devices including a first friction engaging device (C2) which takes part in achieving a reverse shift, and a second friction engaging device (B2) which participates in achieving parking and reverse the control system includes an electronic control circuit means which controls the timing of the actuation of the first and second friction engaging devices upon shifting from parking to reverse range so as to mitigating shock upon gear shifting.
摘要翻译： 一种用于自动变速器的控制系统，其配备有多个摩擦接合装置，用于通过将设置在输入轴和输出轴之间的齿轮机构的元件锁定到壳体上来实现多个换档范围， 元件进入和离开与输入轴或输出轴的接合，或彼此进入和离开接合，所述摩擦接合装置包括参与实现反向换档的第一摩擦接合装置（C2）和第二摩擦 参与实现停车和倒转控制系统的接合装置（B2）包括电子控制电路装置，该控制电路装置控制第一和第二摩擦接合装置在从停车到反向范围的转动时的致动定时，以便减轻对齿轮的冲击 转移
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