-
公开(公告)号：US5157106A
公开(公告)日：1992-10-20
申请号：US61439
申请日：1987-06-15
申请人： Klaus Schollmeier , Achim Moeller , Wolfgang Koerwer , Thomas Doerper , Heinz Hillen , Lothar Daum , Franz Emling , Gerhard Keilhauer
发明人： Klaus Schollmeier , Achim Moeller , Wolfgang Koerwer , Thomas Doerper , Heinz Hillen , Lothar Daum , Franz Emling , Gerhard Keilhauer
IPC分类号： C07K14/52 , A61K38/00 , A61P35/00 , C07K14/00 , C07K14/525 , C12N15/00 , C12N15/09 , C12P21/02 , C12R1/19
CPC分类号： C07K14/525 , A61K38/00 , Y10S530/82 , Y10S930/143 , Y10S930/144
摘要： Polypeptides which differ from lymphotoxin by the absence of amino acids at the N-terminal end of the lymphotoxin are described. The polypeptides can be prepared by gene manipulation and are suitable, alone or in combination with lymphokines, as pharmaceuticals.
摘要翻译： 描述了通过在淋巴毒素的N-末端不存在氨基酸而与淋巴毒素不同的多肽。 多肽可以通过基因操作制备，并且单独或与淋巴因子组合适合作为药物。
-
2.发明授权Proteins having a TNF action comprising TNF-fibromectin fusion protein 失效具有包含TNF-FIBROMECTIN融合蛋白的TNF作用的蛋白质
公开(公告)号：US5180811A
公开(公告)日：1993-01-19
申请号：US193661
申请日：1988-05-13
申请人： Thomas Doerper , Achim Moeller , Heinz Hillen , Gerhard Keilhauer , Franz Emling , Lothar Daum
发明人： Thomas Doerper , Achim Moeller , Heinz Hillen , Gerhard Keilhauer , Franz Emling , Lothar Daum
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , C07K1/20 , C07K14/00 , C07K14/52 , C07K14/525 , C07K14/78 , C07K19/00 , C12P21/02 , C12R1/19
CPC分类号： C07K14/78 , C07K14/525 , A61K38/00 , C07K2319/00 , C07K2319/33 , C07K2319/75 , Y10S930/144
摘要： Derivatives of a tumor necrosis factor (TNF), which originate from a modification at the amino terminus of the TNF molecule are suitable for controlling diseases.
摘要翻译： 起源于TNF分子氨基末端修饰的肿瘤坏死因子（TNF）的衍生物适用于控制疾病。
-
公开(公告)号：US5344915A
公开(公告)日：1994-09-06
申请号：US768443
申请日：1991-09-26
申请人： Hans-Georg LeMaire , Heinz Hillen , Achim Moeller , Lothar Daum , Thomas Doerper , Thomas Subkowski
发明人： Hans-Georg LeMaire , Heinz Hillen , Achim Moeller , Lothar Daum , Thomas Doerper , Thomas Subkowski
IPC分类号： A61K35/22 , A61K38/00 , A61P7/02 , A61P7/04 , A61P11/00 , A61P19/00 , A61P19/02 , A61P25/00 , A61P29/00 , A61P31/04 , A61P37/02 , A61P37/08 , A61P43/00 , C07K1/18 , C07K1/22 , C07K7/08 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/715 , C07K16/18 , C07K15/06
CPC分类号： C07K16/18 , C07K14/7151 , A61K38/00
摘要： Novel proteins which have a molecular weight of about 42,000 daltons and have at the N terminus the amino acid sequenceXaa Thr Pro Tyr Ala Pro Glu Pro Gly Set Thr Cys Arg Leu Arg Gluwhere X is hydrogen, a phenylalanine residue (Phe) or the amino acid sequences Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe, and which are suitable for the treatment of diseases, are described.
摘要翻译： PCT No.PCT / EP90 / 00719 Sec。 371日期1991年9月26日 102（e）1991年9月26日PCT PCT 1990年5月4日PCT公布。 第WO90 / 13575号公报 日期：1990年11月15日。分子量为约42,000道尔顿且在N末端具有氨基酸序列的新型蛋白质Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Set Thr Cys Arg Leu Arg Glu，其中X为氢， 苯丙氨酸残基（Phe）或氨基酸序列Ala Phe，Val Ala Phe，Gln Val Ala Phe，Ala Gln Val Ala Phe，Pro Ala Gln Val Ala Phe或Leu Pro Ala Gln Val Ala Phe，适用于治疗 的疾病。
-
公开(公告)号：US4966894A
公开(公告)日：1990-10-30
申请号：US288444
申请日：1988-12-22
申请人： Dieter Herr , Thomas Doerper , Lothar Daum , Karl-Heinz Geiss , Achim Moeller
发明人： Dieter Herr , Thomas Doerper , Lothar Daum , Karl-Heinz Geiss , Achim Moeller
IPC分类号： C08B37/10 , A61K20060101 , A61K31/715 , A61P31/12
CPC分类号： A61K31/715
摘要： Polysulfated heparins are used for the preparation of drugs for the prophylaxis and therapy of diseases caused by retroviruses.
摘要翻译： 多硫酸肝素用于制备用于预防和治疗由逆转录病毒引起的疾病的药物。
-
5.发明授权Monoclonal antibodies against human tumor necrosis factor (TNF), and use thereof 失效抗人肿瘤坏死因子（TNF）的单克隆抗体及其用途
公开(公告)号：US5231024A
公开(公告)日：1993-07-27
申请号：US94289
申请日：1987-09-08
申请人： Achim Moeller , Franz Emling
发明人： Achim Moeller , Franz Emling
IPC分类号： G01N33/53 , A61K39/395 , A61P29/00 , A61P31/04 , A61P35/00 , C07H21/04 , C07K14/00 , C07K14/005 , C07K14/195 , C07K14/52 , C07K14/525 , C07K16/00 , C07K16/24 , C12N5/10 , C12N5/20 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/577
CPC分类号： C07K16/241
摘要： New hybridoma cell lines which synthesize highly specific monoclonal antibodies (mAb) against human tumor necrosis factor (TNF), monoclonal antibodies against TNF, a process for the preparation of such hybridoma cell lines and antibodies, and the use of the monoclonal antibodies are described.
摘要翻译： 描述了合成针对人肿瘤坏死因子（TNF）的高度特异性单克隆抗体（mAb），针对TNF的单克隆抗体，制备这种杂交瘤细胞系和抗体的方法以及使用单克隆抗体的新型杂交瘤细胞系。
-
6.发明授权Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof 有权淀粉样蛋白β（1-42）寡聚体，其衍生物和抗体，其制备方法和用途公开(公告)号：US09176150B2
公开(公告)日：2015-11-03
申请号：US13195533
申请日：2011-08-01
CPC分类号： C07K14/4711 , A61K38/1709 , A61K39/0007 , A61K2039/57 , C07K16/005 , C07K16/18 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/6896 , G01N2333/4709
摘要： The invention relates to neuromodulatory oligomers of the amyloid-β(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers as diagnostic and therapeutics agents, for the generation of oligomer-specific antibodies and for the discovery of substances which can interact with the oligomers and in the formation thereof. Corresponding methods for the production of the antibodies and for discovery of the substances are also disclosed as are the antibodies themselves and the use of the antibodies or substances as diagnostic and therapeutic agents. The invention further relates to derivatives of the oligomers and oligomers based on abbreviated forms of the amyloid-β(1-42) proteins, the production and use thereof.
摘要翻译： 本发明涉及淀粉样蛋白（1-42）蛋白的神经调节性低聚物，一种特定的制备方法，通过该方法可以以高产率以可重复的方式获得寡聚体，使用低聚物作为诊断和治疗 用于产生寡聚体特异性抗体以及用于发现可与低聚物相互作用并在其形成中的物质。 还公开了生产抗体和发现物质的相应方法，抗体本身以及抗体或物质作为诊断和治疗剂的用途也是如此。 本发明还涉及基于淀粉样蛋白（1-42）蛋白质的缩写形式的寡聚物和低聚物的衍生物，其生产和用途。
-
7.发明申请AMYLOID BETA(1-42) OLIGOMERS, DERIVATIVES THEREOF AND ANTIBODIES THERETO, METHODS OF PREPARATION THEREOF AND USE THEREOF 有权AMYLOID BETA（1-42）低聚物，其衍生物及其抗体，其制备方法及其用途公开(公告)号：US20120034166A1
公开(公告)日：2012-02-09
申请号：US13195533
申请日：2011-08-01
IPC分类号： A61K49/00 , A61K39/00 , C12P21/06 , C12N5/16 , G01N33/566 , C12P21/00 , C40B50/06 , C07K7/08 , C07K14/00 , C07K16/18 , C07K1/00 , C07H21/04 , A61K39/395 , C40B30/00
CPC分类号： C07K14/4711 , A61K38/1709 , A61K39/0007 , A61K2039/57 , C07K16/005 , C07K16/18 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/6896 , G01N2333/4709
摘要： The invention relates to neuromodulatory oligomers of the amyloid-β(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers as diagnostic and therapeutics agents, for the generation of oligomer-specific antibodies and for the discovery of substances which can interact with the oligomers and in the formation thereof. Corresponding methods for the production of the antibodies and for discovery of the substances are also disclosed as are the antibodies themselves and the use of the antibodies or substances as diagnostic and therapeutic agents. The invention further relates to derivatives of the oligomers and oligomers based on abbreviated forms of the amyloid-β(1-42) proteins, the production and use thereof.
摘要翻译： 本发明涉及淀粉样蛋白（1-42）蛋白的神经调节性低聚物，一种特定的制备方法，通过该方法可以以高产率以可重复的方式获得寡聚体，使用低聚物作为诊断和治疗 用于产生寡聚体特异性抗体以及用于发现可与低聚物相互作用并在其形成中的物质。 还公开了生产抗体和发现物质的相应方法，抗体本身以及抗体或物质作为诊断和治疗剂的用途也是如此。 本发明还涉及基于淀粉样蛋白（1-42）蛋白质的缩写形式的寡聚物和低聚物的衍生物，其生产和用途。
-
8.发明申请AMYLOID BETA(1-42) OLIGOMERS, DERIVATIVES THEREOF AND ANTIBODIES THERETO, METHODS OF PREPARATION THEREOF AND USE THEREOF 审中-公开AMYLOID BETA（1-42）低聚物，其衍生物及其抗体，其制备方法及其用途公开(公告)号：US20100209346A1
公开(公告)日：2010-08-19
申请号：US12559255
申请日：2009-09-14
IPC分类号： A61K49/00 , C07K14/435 , G01N33/68 , G01N33/53 , C12P21/00 , C07K16/00 , C07K14/00 , A61K38/16 , A61K39/00 , A61P25/28
CPC分类号： C07K14/4711 , A61K38/1709 , A61K39/0007 , A61K2039/57 , C07K16/005 , C07K16/18 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/6896 , G01N2333/4709
摘要： The invention relates to neuromodulatory oligomers of the amyloid β(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers and diagnostic and therapeutic agents, for the generation of oligomer-specific antibodies and for the discovery of substances which can interact with the oligomers and in the formation thereof.
摘要翻译： 本发明涉及淀粉样蛋白（1-42）蛋白的神经调节性低聚物，一种特定的制备方法，通过该方法可以以高产率以可重复的方式获得寡聚体，使用寡聚物和诊断和治疗剂 ，用于产生寡聚体特异性抗体以及用于发现可与低聚物相互作用并在其形成中的物质。
-
9.发明申请Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof 有权淀粉样蛋白β（1-42）寡聚体，其衍生物和抗体，其制备方法和用途公开(公告)号：US20070098721A1
公开(公告)日：2007-05-03
申请号：US10543841
申请日：2004-02-02
IPC分类号： A01K67/00 , G01N33/567 , C12P21/06 , C12P21/04 , A61K39/395 , C07K16/18
CPC分类号： C07K14/4711 , A61K38/1709 , A61K39/0007 , A61K2039/57 , C07K16/005 , C07K16/18 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/6896 , G01N2333/4709
摘要： The invention relates to neuromodulatory oligomers of the amyloid-β(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers as diagnostic and therapeutics agents, for the generation of oligomer-specific antibodies and for the discovery of substances which can interact with the oligomers and in the formation thereof. Corresponding methods for the production of the antibodies and for discovery of the substances are also disclosed as are the antibodies themselves and the use of the antibodies or substances as diagnostic and therapeutic agents. The invention further relates to derivatives of the oligomers and oligomers based on abbreviated forms of the amyloid-β(1-42) proteins, the production and use thereof.
摘要翻译： 本发明涉及淀粉样蛋白-β（1-42）蛋白的神经调节性低聚物，一种特定的制备方法，通过该方法可以以高产率以可重复的方式获得寡聚体，使用低聚物作为诊断和治疗剂 ，用于产生寡聚体特异性抗体以及用于发现可与低聚物相互作用并在其形成中的物质。 还公开了生产抗体和发现物质的相应方法，抗体本身以及抗体或物质作为诊断和治疗剂的用途也是如此。 本发明还涉及基于淀粉样蛋白-β（1-42）蛋白的缩写形式的寡聚物和寡聚体的衍生物，其生产和用途。
-
公开(公告)号：US08877194B2
公开(公告)日：2014-11-04
申请号：US13314878
申请日：2011-12-08
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/241 , A61K39/3955 , A61K45/06 , A61K47/48546 , A61K47/6845 , A61K49/0058 , A61K51/1021 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/14 , C07K2317/20 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/6863
摘要： TNF-α binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind TNF-α are provided. Binding proteins have high affinity for TNF-α and neutralize TNF-α activity. A binding protein can be a full-length antibody or a TNF-α-binding portion thereof. Methods of making and methods of using the binding proteins are also described. The TNF-α binding proteins are useful for detecting TNF-α and for inhibiting TNF-α activity, including in a human subject suffering from a disease or disorder in which TNF-α activity is detrimental.
摘要翻译： 提供TNF-α结合蛋白，包括结合TNF-α的嵌合，CDR移植和人源化抗体。 结合蛋白对TNF-α具有高亲和力，并中和TNF-α活性。 结合蛋白可以是全长抗体或其TNF-α结合部分。 还描述了制备方法和使用结合蛋白的方法。 TNF-α结合蛋白可用于检测TNF-α和抑制TNF-α活性，包括在患有TNF-α活性有害的疾病或病症的人类受试者中。
-
-
-
-
-
-
-
-
-
搜索结果
35 条记录 (耗时 0.035 秒)
