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公开(公告)号：US07597885B2
公开(公告)日：2009-10-06
申请号：US10810518
申请日：2004-03-26
CPC分类号： A61L27/3847 , A61L27/3852 , A61L27/3869 , A61L27/3886 , A61L27/56 , A61L27/58
摘要： The present invention relates to an improved scaffold which is constructed to mimic the architecture of the native hair follicle. The present invention also relates to the use of specific compositions and methods of manufacture to produce scaffolds that combine biocompatibility with the desired rates of bioabsorption. In another embodiment, the present invention relates to a process for manufacturing a biomimetic hair follicle graft and a method for seeding the graft with cells and implanting the graft into the skin where the growth of a new hair shaft is desired. A further embodiment of the present invention relates to a method for hair multiplication in which cells are multiplied in culture and aliquoted into a multitude of bioabsorbable scaffolds in combination with cultured keratinocytes or other allogenic cells.
摘要翻译： 本发明涉及一种改进的支架，其被构建为模拟本地毛囊的结构。 本发明还涉及特定组合物和制造方法用于生产将生物相容性与所需生物吸收速率相结合的支架的用途。 在另一个实施方案中，本发明涉及生物仿生毛囊移植物的制备方法和用细胞接种移植物并将移植物植入皮肤中的方法，其中需要新发丝的生长。 本发明的另一个实施方案涉及一种用于毛发繁殖的方法，其中将细胞在培养物中倍增并分装成与培养的角质化细胞或其他同种异体细胞组合的许多生物可吸收支架。
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公开(公告)号：US06884427B1
公开(公告)日：2005-04-26
申请号：US09890888
申请日：2000-02-08
申请人： Thomas H. Barrows
发明人： Thomas H. Barrows
CPC分类号： A61L27/3847 , A61F2/10 , A61F2250/0068 , A61L27/3804
摘要： The present invention provides a filamentary structure for the introduction of agents into a living host, comprising a filament comprising a solid core and a porous sheath which coats at least a portion of the solid core. When the filamentary structure is to be permanently implanted into a living host, both the solid core and the porous sheath are bioabsorbable. When the filamentary structure is to be temporarily implanted into the skin of a living host to deliver agents, such as cells, therein, the porous sheath is preferably bioabsorbable but the core need only be biocompatable, not bioabsorabable. The devices and methods of the present invention enable one to regenerate hair follicles, to introduce genetically altered cells or encapsulated cells to a living host transdermally, to regenerate bones, and to deliver drugs transdermally.
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公开(公告)号：US5013315A
公开(公告)日：1991-05-07
申请号：US754870
申请日：1985-01-12
申请人： Thomas H. Barrows
发明人： Thomas H. Barrows
CPC分类号： C08L77/00 , A61B17/80 , A61B17/8028 , A61L31/041 , A61L31/148 , C08L77/02 , A61B2017/00004
摘要： A medical prosthesis for use in bone fracture fixation comprises a bone plate, a bone plate spacer comprising a blend or mixture of a nonabsorbable polymer and a bioabsorbable polymer, and a means for fastening both the bone plate and the bone plate spacer to the bone.
摘要翻译： 用于骨折固定的医疗假体包括骨板，包含不可吸收聚合物和生物可吸收聚合物的共混物或混合物的骨板间隔物，以及用于将骨板和骨板间隔物固定到骨上的装置。
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公开(公告)号：US5856367A
公开(公告)日：1999-01-05
申请号：US574679
申请日：1995-12-19
CPC分类号： A61L27/56 , A61L27/18 , C08L67/04 , Y10S977/795
摘要： A process for forming biocompatible porous matrices of bioabsorbable materials comprising:a) providing a bioabsorbable polymer;b) dissolving the bioabsorbable polymer in a volumetric orientation aid to yield a molten solution;c) solidifying the molten solution to yield an orientation matrix comprising first and second phases, the first phase being the bioabsorbable polymer and the second phase being the volumetric orientation aid; andd) removing the volumetric orientation aid while the solution is solid; to yield a biocompatible matrix of bioabsorbable polymer. Also matrices formed by the process and devices made with such matrices.
摘要翻译： 一种用于形成生物可吸收材料的生物相容多孔基质的方法，包括：a）提供生物可吸收聚合物; b）将生物可吸收聚合物溶解在体积取向助剂中以产生熔融溶液; c）固化熔融溶液以产生包含第一和第二相的取向基质，第一相为生物可吸收聚合物，第二相为体积取向助剂; 和d）当溶液是固体时，去除体积取向助剂; 以产生生物可吸收聚合物的生物相容性基质。 还由通过这些矩阵制造的工艺和器件形成的矩阵。
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公开(公告)号：US4883618A
公开(公告)日：1989-11-28
申请号：US14869
申请日：1987-02-17
申请人： Thomas H. Barrows
发明人： Thomas H. Barrows
CPC分类号： A61B17/1128 , A61B2017/00004 , A61F2002/30062 , A61F2210/0004
摘要： Medical devices for the sutureless repair of lacerated, severed, or grafted nerves comprising longitudinally-openable, porous, rough-surfaced tubes of a body-absorbable polymer are disclosed. The tubular devices of the invention are prepared by sintering or otherwise bonding together granules or fibers, or melt processing suitable polymers in the form of the desired device.
摘要翻译： 公开了用于无缝缝合修复包括可纵向打开的，多孔的，粗糙表面的身体可吸收的聚合物管的撕裂，切断或接枝的神经的医疗装置。 本发明的管状装置通过将颗粒或纤维烧结或以其它方式结合在一起而制成，或以所需装置的形式熔融加工合适的聚合物。
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公开(公告)号：US4360013A
公开(公告)日：1982-11-23
申请号：US142239
申请日：1980-04-21
申请人： Thomas H. Barrows
发明人： Thomas H. Barrows
CPC分类号： A61K9/0036 , Y10S424/14
摘要： A disposable non-woven sponge vaginal contraceptive device is made of alginic acid or related polysaccharides bearing carboxylic acid functionality and a method of making same is disclosed.
摘要翻译： 一次性无纺海绵阴道避孕装置由藻酸或具有羧酸官能团的相关多糖制成，其制备方法公开。
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公开(公告)号：US5583114A
公开(公告)日：1996-12-10
申请号：US281473
申请日：1994-07-27
CPC分类号： A61L24/043 , A61L24/046 , A61L24/10 , A61L24/106 , C09J189/00 , Y10S530/83
摘要： This invention is related to an adhesive composition which may be used to bond or seal tissue in vivo. The adhesive composition is readily formed from a two component mixture which includes a first part of a protein, preferably a serum albumin protein, in an aqueous buffer having a pH in the range of about 8.0-11.0 and a second part of a water-compatible or water-soluble bifunctional crosslinking agent. When the two parts of the mixture are combined, the mixture is initially a liquid which cures in vivo on the surface of tissue in less than about one minute to give a strong, flexible, pliant substantive composition which bonds to the tissue and is absorbed in about four to sixty days. The adhesive composition may be used either to bond tissue, to seal tissue or to prevent tissue adhesions caused by surgery.
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公开(公告)号：US5502092A
公开(公告)日：1996-03-26
申请号：US198906
申请日：1994-02-18
CPC分类号： A61L27/56 , A61L27/18 , C08L67/04 , Y10S977/795
摘要： A process for forming biocompatible porous matrices of bioabsorbable materials comprising:a) providing a bioabsorbable polymer;b) dissolving the bioabsorbable polymer in a volumetric orientation aid to yield a molten solution;c) solidifying the molten solution to yield an orientation matrix comprising first and second phases, the first phase being the bioabsorbable polymer and the second phase being the volumetric orientation aid; andd) removing the volumetric orientation aid while the solution is solid; to yield a biocompatible matrix of bioabsorbable polymer. Also matrices formed by the process and devices made with such matrices.
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公开(公告)号：US5286837A
公开(公告)日：1994-02-15
申请号：US986665
申请日：1992-12-08
IPC分类号： A61L27/00 , A61L17/10 , A61L31/06 , C08G63/685 , C08G69/44 , C08G69/46 , C08G69/48 , C08J3/00 , C08L77/00 , C08L77/12 , C08G73/10 , C08G63/68
摘要： Process for treating poly(esteramides) to improve the heat and storage stability thereof. Polymer is optionally suspended in a liquid medium, treated with an amide group-containing solvent, and then separated from the solvent and liquid medium (if any). Also, poly(esteramides) treated in this process and devices and articles comprising such poly(esteramides).
摘要翻译： 用于处理聚（酯酰胺）以改进其热和储存稳定性的方法。 将聚合物任选地悬浮在液体介质中，用含酰胺基的溶剂处理，然后从溶剂和液体介质（如果有的话）中分离。 此外，在该方法中处理的聚（酯酰胺）和包含这种聚（酯酰胺）的装置和制品。
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公开(公告)号：US4669474A
公开(公告)日：1987-06-02
申请号：US719009
申请日：1985-04-02
申请人： Thomas H. Barrows
发明人： Thomas H. Barrows
CPC分类号： A61L27/50 , A61B17/1128 , A61L27/18 , A61B2017/0417 , A61F2002/30062 , A61F2210/0004 , A61L2430/32
摘要： Medical devices for the sutureless repair of lacerated, severed, or grafted nerves comprising longitudinally-openable, porous, rough-surfaced tubes of a body-absorbable polymer are disclosed. The tubular devices of the invention are prepared by sintering or otherwise bonding together granules or fibers, or melt processing suitable polymers in the form of the desired device.
摘要翻译： 公开了用于无缝缝合修复包括可纵向打开的，多孔的，粗糙表面的身体可吸收的聚合物管的撕裂，切断或接枝的神经的医疗装置。 本发明的管状装置通过将颗粒或纤维烧结或以其它方式结合在一起而制成，或以所需装置的形式熔融加工合适的聚合物。
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