公开(公告)号：US4937209A

公开(公告)日：1990-06-26

申请号：US248437

申请日：1988-09-23

Applicant: Thomas R. Jones ,  Caryl Gould ,  Alan J. Brown ,  Roger James

Inventor： Thomas R. Jones ,  Caryl Gould ,  Alan J. Brown ,  Roger James

IPC: B01J20/16 ,  C04B38/00 ,  C12N11/14 ,  D21H17/68

CPC classification number: C04B38/0051 ,  B01J20/16 ,  C04B38/009 ,  C12N11/14 ,  D21H17/68

Abstract: There is provided a porous cellular material comprising a plurality of cavities each defined by a substantially spherical wall formed of a rigid intermeshing matrix of ceramic needles said wall being pierced by at least one aperture to provide access to the cavity, and the or each aperture having a diameter such that the ratio of the diameter of the aperture to the diameter of the cavity into which the aperture opens is in the range of from 0.1:1 to 1:1.

Abstract translation: 提供了多孔多孔材料，其包括多个空腔，每个空腔由基本上为球形的壁形成，该壁由陶瓷针的刚性啮合基体形成，所述壁被至少一个孔刺穿以提供对腔的通路，并且所述或每个孔具有 使得孔的直径与孔的开口直径的比率在0.1:1至1:1的范围内的直径。

公开(公告)号：US4937210A

公开(公告)日：1990-06-26

申请号：US248422

申请日：1988-09-23

Applicant: Thomas R. Jones ,  Caryl Gould ,  Alan J. Brown ,  Roger James

Inventor： Thomas R. Jones ,  Caryl Gould ,  Alan J. Brown ,  Roger James

IPC: C04B38/00 ,  C12N11/14

CPC classification number: C12N11/14 ,  C04B38/0051 ,  C04B38/009

Abstract: There is disclosed a process for preparing a porous inorganic material. The process comprises preparing a cellular aluminosilicate material by foaming or spray drying an aqueous suspension of the material. The cellular material is calcined, leached with hydroxide to remove silica, dewatered and dried to leave a porous, cellular ceramic material.

公开(公告)号：US5008220A

公开(公告)日：1991-04-16

申请号：US311221

申请日：1989-02-15

Applicant: Alan J. Brown ,  Roger James ,  Nigel P. Glasson

Inventor： Alan J. Brown ,  Roger James ,  Nigel P. Glasson

IPC: C12N11/14 ,  B01J20/16 ,  C04B38/02 ,  C04B38/06 ,  C07K1/16

CPC classification number: B01J20/16 ,  C07K1/16

Abstract: There is disclosed a porous inorganic material suitable for use as a support for immobilizing biological macromolecules and which comprises a 3-dimensional network of defect aluminium-silicon spinel, said network defining an interconnecting array of pores predominantly in the size range of from 100 to 1000 .ANG..A process for preparing the porous inorganic material is also disclosed.

公开(公告)号：US5055429A

公开(公告)日：1991-10-08

申请号：US275429

申请日：1988-11-22

Applicant: Roger James ,  Alan J. Brown

Inventor： Roger James ,  Alan J. Brown

IPC: C04B38/00 ,  C12N11/14

CPC classification number: C04B38/009 ,  C12N11/14

Abstract: There is disclosed a porous inorganic material, suitable for use as a support material for biological macromolecules, comprising substantially spherical particles of an aluminosilicate ceramic material, any internal cavities present in a particle occupying no more than 10% of the volume of the particle, each particle having a diameter in the range of from 5 micrometers to 5 millimeters and consisting predominantly of an open three-dimensional matrix of needles of the ceramic material each of which needles has a length in the range of from 2 to 20 micrometers and a width in the range of from about 0.2 to 2 micrometers, the ceramic needles defining between them interconnecting pores of width of from 0.1 to 5 micrometers. Also disclosed is a method of preparing such a porous inorganic material.

公开(公告)号：US20080207636A1

公开(公告)日：2008-08-28

申请号：US12024561

申请日：2008-02-01

Applicant: Scott Boyd ,  Peter William Rodney Caulkett ,  Rodney Brian Hargreaves ,  Suzanne Saxon Bowker ,  Roger James ,  Clifford David Jones ,  Darren McKerrecher ,  Michael Howard Block ,  Craig Johnstone

Inventor： Scott Boyd ,  Peter William Rodney Caulkett ,  Rodney Brian Hargreaves ,  Suzanne Saxon Bowker ,  Roger James ,  Clifford David Jones ,  Darren McKerrecher ,  Michael Howard Block ,  Craig Johnstone

IPC: A61K31/496 ,  C07D277/20 ,  A61K31/426 ,  A61K31/433 ,  A61P3/10 ,  A61K31/4436 ,  A61K31/415 ,  C07D231/10 ,  C07D213/02 ,  A61P3/04 ,  C07D285/12 ,  C07D295/00

CPC classification number: C07D213/75 ,  A61K31/165 ,  A61K31/195 ,  A61K31/425 ,  A61K31/445 ,  C07D213/82 ,  C07D213/85 ,  C07D231/40 ,  C07D233/48 ,  C07D237/20 ,  C07D237/24 ,  C07D239/42 ,  C07D241/20 ,  C07D241/26 ,  C07D261/14 ,  C07D277/46 ,  C07D277/56 ,  C07D277/82 ,  C07D285/135 ,  C07D307/66 ,  C07D401/04 ,  C07D403/04 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

Abstract: The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).

Abstract translation: 本发明涉及式（I）化合物或其盐，溶剂合物或前体药物的用途，其中R 1，R 2，R 3， N和m如说明书中所述，在制备用于治疗或预防通过葡萄糖激酶（GLK）如2型糖尿病介导的疾病状况的药物中的描述。 本发明还涉及一组新的式（I）化合物和制备式（I）化合物的方法。

公开(公告)号：US6161850A

公开(公告)日：2000-12-19

申请号：US220949

申请日：1998-12-24

Applicant: Cleve James ,  Roger James

Inventor： Cleve James ,  Roger James

IPC: B62B1/20 ,  B62B1/00

CPC classification number: B62B1/208 ,  B62B2202/42

Abstract: A collapsible game gurney system is provided including a base and a wheel assembly mounted on the base. Also included is an arm assembly having a pair of elongated arms each with an inboard end hingably mounted to the base for pivoting between a parallel orientation and an angled orientation. Next provided is a tarp removably mounted to the arm assembly for supporting game thereon.

Abstract translation: 提供了一种可折叠的游戏机，其包括底座和安装在基座上的车轮组件。 还包括具有一对细长臂的臂组件，每个细长臂具有铰接地安装到基座的内侧端部，用于在平行取向和成角度定向之间枢转。 接下来提供一种可拆卸地安装到臂组件上以在其上支撑游戏的篷布。

公开(公告)号：US5668137A

公开(公告)日：1997-09-16

申请号：US667131

申请日：1996-06-20

Applicant: Paul John Phillips ,  Peter Grahame Ballard ,  Robert Hugh Bradbury ,  Roger James

Inventor： Paul John Phillips ,  Peter Grahame Ballard ,  Robert Hugh Bradbury ,  Roger James

IPC: A61K31/41 ,  A61K31/42 ,  A61K31/433 ,  A61K31/495 ,  A61K31/496 ,  A61K31/50 ,  A61K31/505 ,  A61P1/00 ,  A61P1/16 ,  A61P3/06 ,  A61P9/00 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D237/20 ,  C07D239/69 ,  C07D241/22 ,  C07D261/16 ,  C07D285/12 ,  C07D285/135 ,  C07D241/00 ,  A61K31/54

CPC classification number: C07D285/135 ,  C07D237/20 ,  C07D239/69 ,  C07D241/22 ,  C07D261/16

Abstract: The invention concerns pharmaceutically useful compounds of the formula I, in which R.sup.1, R.sup.2, R.sup.3, n, m and Het have any of the meanings defined herein, and their pharmaceutically-acceptable salts, and pharmaceutical compositions containing them. The novel compounds possess endothelin receptor antagonist activity and are useful, for example, in the treatment of diseases or medical conditions in which elevated or abnormal levels of endothelin play a significant causative role. The invention further concerns processess for the manufacture of the novel compounds and the use of the compounds in medical treatment.

Abstract translation: 本发明涉及药学上有用的式I化合物，其中R 1，R 2，R 3，n，m和Het具有本文定义的任何含义及其药学上可接受的盐和含有它们的药物组合物。 新型化合物具有内皮素受体拮抗剂活性，并且可用于例如治疗疾病或医学病症，其中升高或异常水平的内皮素起重要作用。 本发明还涉及用于制备新化合物的方法和该化合物在医疗中的用途。

公开(公告)号：US4452817A

公开(公告)日：1984-06-05

申请号：US834292

申请日：1977-09-19

Applicant: John B. Glen ,  Roger James

Inventor： John B. Glen ,  Roger James

IPC: A61K9/08 ,  A61K9/00 ,  A61K9/107 ,  A61K31/05 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61K47/44

CPC classification number: A61K47/26 ,  A61K31/05 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44 ,  A61K9/0019 ,  A61K9/1075

Abstract: Sterile pharmaceutical compositions for parenteral administration containing the compound 2,6-diisopropylphenol, and a method for producing anaesthesia in a warm-blooded animal by parenteral administration of said compound.

Abstract translation: 含有化合物2,6-二异丙基苯酚的肠胃外给药的无菌药物组合物，以及通过肠胃外给药所述化合物在温血动物中产生麻醉的方法。

公开(公告)号：US20070093535A1

公开(公告)日：2007-04-26

申请号：US11544946

申请日：2006-10-10

Applicant: Barry Hayter ,  Gordon Currie ,  Rodney Hargreaves ,  Peter William Caulkett ,  Roger James

Inventor： Barry Hayter ,  Gordon Currie ,  Rodney Hargreaves ,  Peter William Caulkett ,  Roger James

IPC: A61K31/455 ,  A61K31/426

CPC classification number: C07D213/78 ,  C07D213/80 ,  C07D213/82 ,  C07D239/28 ,  C07D277/56 ,  C07D307/68 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12

Abstract: The invention related to novel compounds of Formula (I) or a salt, solvate or prodrug thereof, wherein A, R1, R2, R3, n and m are as described in the specification, useful in the treatment of a disease or condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to methods for preparing compounds of Formula (I) and their use as medicaments in the treatment of diseases mediated by glucokinase.

Abstract translation: 本发明涉及新的式（I）化合物或其盐，溶剂合物或前体药物，其中A，R 1，R 2，R 3， SUP，n和m如说明书所述，可用于治疗通过葡萄糖激酶（GLK）介导的疾病或病症，例如2型糖尿病。 本发明还涉及制备式（I）化合物及其作为药物用于治疗由葡萄糖激酶介导的疾病的用途的方法。

公开(公告)号：US20050080106A1

公开(公告)日：2005-04-14

申请号：US10486496

申请日：2002-08-15

Applicant: Scott Boyd ,  Peter Caulkett ,  Rodney Hargreaves ,  Suzanne Bowker ,  Roger James ,  Clifford Jones ,  Darren McKerrecher ,  Michael Block ,  Craig Johnstone

Inventor： Scott Boyd ,  Peter Caulkett ,  Rodney Hargreaves ,  Suzanne Bowker ,  Roger James ,  Clifford Jones ,  Darren McKerrecher ,  Michael Block ,  Craig Johnstone

IPC: A61K31/165 ,  A61K31/167 ,  A61K31/192 ,  A61K31/195 ,  A61K31/341 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/42 ,  A61K31/425 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61K31/433 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/445 ,  A61K31/454 ,  A61K31/455 ,  A61K31/496 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/50 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61K31/5377 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P43/00 ,  C07D213/75 ,  C07D213/76 ,  C07D213/82 ,  C07D213/85 ,  C07D231/40 ,  C07D233/48 ,  C07D237/20 ,  C07D237/24 ,  C07D239/42 ,  C07D239/47 ,  C07D241/20 ,  C07D241/26 ,  C07D241/28 ,  C07D261/14 ,  C07D277/20 ,  C07D277/46 ,  C07D277/54 ,  C07D277/56 ,  C07D277/58 ,  C07D277/82 ,  C07D285/12 ,  C07D285/135 ,  C07D307/66 ,  C07D307/68 ,  C07D401/04 ,  C07D403/04 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

CPC classification number: C07D213/75 ,  A61K31/165 ,  A61K31/195 ,  A61K31/425 ,  A61K31/445 ,  C07D213/82 ,  C07D213/85 ,  C07D231/40 ,  C07D233/48 ,  C07D237/20 ,  C07D237/24 ,  C07D239/42 ,  C07D241/20 ,  C07D241/26 ,  C07D261/14 ,  C07D277/46 ,  C07D277/56 ,  C07D277/82 ,  C07D285/135 ,  C07D307/66 ,  C07D401/04 ,  C07D403/04 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

Abstract: The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).

Abstract translation: 本发明涉及式（I）化合物或其盐，溶剂合物或前体药物的用途，其中R 1，R 2，R 3，n和m如说明书中所述，在 制备用于治疗或预防通过葡萄糖激酶（GLK）介导的疾病状况的药物，例如2型糖尿病。 本发明还涉及一组新的式（I）化合物和制备式（I）化合物的方法。