Threaded fastener for an internal combustion engine, and internal combustion engine incorporating same
    1.
    发明授权
    Threaded fastener for an internal combustion engine, and internal combustion engine incorporating same 失效
    用于内燃机的螺纹紧固件和结合其的内燃机

    公开(公告)号:US06971362B2

    公开(公告)日:2005-12-06

    申请号:US10791672

    申请日:2004-03-02

    摘要: A threaded fastener is configured to reduce stress experienced at a female threaded portion of a hole formed in an engine block, when the threaded fastener is inserted therein, and when an axial load is applied thereto. In a particular application, a crankshaft is supported between a top supporting wall of a crankcase and a bottom supporting wall of a main cap. The inventive bolt includes a hollowed-out male threaded portion, which fits into a hole in the top supporting wall. The male threaded portion includes an elastically deformable low-rigidity portion, in which a cylindrical hole is concentrically formed. The maximum allowable stress of the top supporting wall is less than that of the bolt, due to material considerations. The low-rigidity portion is placed overlapping the female threaded portion in the axial direction, and since it is elastically deformable, it helps alleviate the stress experienced by the female threaded portion.

    摘要翻译: 螺纹紧固件构造成当螺纹紧固件插入其中时以及当向其施加轴向载荷时,减小在形成在发动机缸体中的孔的内螺纹部分处经受的应力。 在具体应用中,曲轴支撑在曲轴箱的顶部支撑壁和主盖的底部支撑壁之间。 本发明的螺栓包括中空的外螺纹部分,该螺纹部分装配在顶部支撑壁中的孔中。 外螺纹部分包括可弹性变形的低刚性部分,其中圆柱形孔同心地形成。 由于材料考虑,顶部支撑壁的最大允许应力小于螺栓的最大允许应力。 低刚性部分沿着轴向方向与母螺纹部分重叠,并且由于其是可弹性变形的,所以有助于减轻内螺纹部分所经受的应力。

    Novel benzylalcohols and pharmaceutical compositions and use thereof
    2.
    发明授权
    Novel benzylalcohols and pharmaceutical compositions and use thereof 失效
    新型苄醇和药物组合物及其用途

    公开(公告)号:US4218479A

    公开(公告)日:1980-08-19

    申请号:US906965

    申请日:1978-05-18

    CPC分类号: A61K31/135

    摘要: Racemic or optically active .alpha.-(2,3,4-trimethoxyphenethylaminomethyl)-2-hydroxybenzylalcohol [I] may be prepared by condensing 2,3,4-trimethoxyphenethylamine with 2-benzyloxyphenylglyoxal or its hydrate, reducing the resultant .alpha.(2,3,4-tri-methoxyphenethylimino)-2-benzyloxyacetophenone to give .alpha.(2,3,4-trimethoxyphenethylaminomethyl)-2-benzyloxybenzylalcohol, if required, resolving the 2-benzyloxybenzylalcohol derivative into each of its optically active enantiomers, and subjecting the racemic modification or optically active enantiomer of said 2-benzyloxybenzylalcohol derivative to catalytic hydrogenation. The compound [I] and pharmaceutically acceptable acid addition salts thereof are useful as anti-diabetic agents. They may be also used in the treatment of thrombosis.

    摘要翻译: 外消旋或光学活性的α-(2,3,4-三甲氧基苯乙氨基甲基)-2-羟基苄醇[I]可以通过将2,3,4-三甲氧基苯乙胺与2-苄氧基苯基乙二醛或其水合物缩合来制备,将所得的α(2,3 ,4-三甲氧基苯乙基亚氨基)-2-苄氧基苯乙酮,得到α(2,3,4-三甲氧基苯乙基氨基甲基)-2-苄氧基苄醇,如果需要,将2-苄氧基苄基衍生物拆分成各自的旋光对映异构体, 或所述2-苄氧基苄基醇衍生物的光学活性对映异构体进行催化氢化。 化合物[I]及其药学上可接受的酸加成盐可用作抗糖尿病药。 它们也可用于治疗血栓形成。