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15 条记录 (耗时 0.018 秒)

    Peptide
    1.
    发明授权
    Peptide 失效
    肽

    公开(公告)号：US4889917A

    公开(公告)日：1989-12-26

    申请号：US265550

    申请日：1988-11-01

    申请人： Masao Tanihara ,  Kiichiro Oka ,  Hideaki Yamada ,  Akira Kobayashi ,  Toshihide Nakashima ,  Yoshiaki Omura ,  Koichi Takakura

    发明人： Masao Tanihara ,  Kiichiro Oka ,  Hideaki Yamada ,  Akira Kobayashi ,  Toshihide Nakashima ,  Yoshiaki Omura ,  Koichi Takakura

    IPC分类号： A61K38/00 ,  A61M1/36 ,  A61P43/00 ,  C07K7/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/705 ,  G01N33/564 ,  G01N33/566

    CPC分类号： C07K14/705 ,  A61M1/3679 ,  Y02P20/55

    摘要： A peptide is disclosed which is represented by the formula:H-X-Gly-Trp-Lys-His-Trp-Val-Tyr-Tyr-Thr-Cys-Cys-Pro-Asp-Thr-Pro-Tyr-Leu-Asp-Y -Zwherein one of X and Y stands for a single bond, an amino acid residue selected from the class consisting of Asp, Glu, Lys and a divalent group represented by the formula, ##STR1## (wherein n stands for an integer in the range of 1 to 17), or a peptide residue formed by peptide linkage of two to ten amino acid residues of at least one species selected from the class mentioned above, the other of X and Y stands for an amino acid residue selected from the class consisting of Asp, Glu, Lys and a divalent group represented by the formula, ##STR2## (wherein n stands for an integer in the range of 1 to 17), or a peptide residue formed by peptide linkage of two to ten amino acid residues of at least one species selected from the class mentioned above and Z stands for a hydroxyl group or an amino group, and two cysteinyl mercapto groups in the Cys-Cys moiety may be interlinked to each other to form a disulfide bond.

    摘要翻译： 公开了由下式表示的肽：HX-Gly-Trp-Lys-His-Trp-Val-Tyr-Tyr-Thr-Cys-Cys-Pro-Asp-Thr-Pro-Tyr-Le-Asp- Y -Z其中X和Y中的一个代表单键，选自Asp，Glu，Lys和由下式表示的二价基团的氨基酸残基：其中n表示 1至17的范围）或通过选自上述类别的至少一种的2至10个氨基酸残基的肽键形成的肽残基，X和Y中的另一个表示选自以下的氨基酸残基： 由Asp，Glu，Lys和由式表示的二价基团，其中n表示1〜17的整数，或由2〜10个氨基酸的肽键形成的肽残基 选自上述类别中的至少一种的残基和Z表示羟基或氨基，并且Cys-Cys moie中的两个半胱氨酰巯基 ty可以彼此互连以形成二硫键。

    Adsorbent, method for production thereof, and method for use thereof
    3.
    发明授权
    Adsorbent, method for production thereof, and method for use thereof 失效
    吸附剂，其制造方法及其使用方法

    公开(公告)号：US5132402A

    公开(公告)日：1992-07-21

    申请号：US265540

    申请日：1988-11-01

    申请人： Masao Tanihara ,  Kiichiro Oka ,  Hideaki Yamada ,  Akira Kobayashi ,  Toshihide Nakashima ,  Yoshiaki Omura ,  Koichi Takakura

    发明人： Masao Tanihara ,  Kiichiro Oka ,  Hideaki Yamada ,  Akira Kobayashi ,  Toshihide Nakashima ,  Yoshiaki Omura ,  Koichi Takakura

    IPC分类号： A61M1/36 ,  C07K14/705

    CPC分类号： C07K14/705 ,  A61M1/3679

    摘要： There is disclosed an adsorbent, comprising a carrier on which is immobilized a peptide possessing an ability to bind to the human antibody to the nicotinic acetylcholine receptor and represented by the formula:H--X--A--Y--Zwherein A stands for a peptide residue, one of X and Y stands for a single bond, an amino acid residue selected from the class consisting of Asp, Glu, Lys and a divalent group represented by the formula, ##STR1## (wherein n stands for an integer in the range of 1 to 17), or a peptide residue formed by peptide linkage of two to ten amino acid residues of at least one species selected from the class mentioned above and the other of X and Y stands for an amino acid residue selected from the class consisting of Asp, Glu, Lys and a divalent group represented by the formula, ##STR2## (wherein n stands for an integer in the range of 1 to 17), or a peptide residue formed by peptide linkage of two to ten amino acid residues of at least one species selected from the class mentioned above and Z stands for a hydroxyl group or an amino group. A method for the production of the adsorbent and a method for the use of the adsorbent are also disclosed.

    摘要翻译： 公开了一种吸附剂，其包含载体，其上固定有具有与烟碱乙酰胆碱受体的人抗体结合的能力并由下式表示的肽：HXAYZ其中A代表肽残基，X和Y之一 对于单键，选自Asp，Glu，Lys和由下式表示的二价基团的氨基酸残基（其中n表示1至17的整数）或 通过选自上述类别的至少一种的2至10个氨基酸残基和X和Y中的另一个的肽键形成的肽残基代表选自Asp，Glu，Lys和 由下式表示的二价基团（其中n表示1〜17的整数），或由选自所述类别的至少一种的2〜10个氨基酸残基通过肽键形成的肽残基 提到 Z代表羟基或氨基。 还公开了制备吸附剂的方法和吸附剂的使用方法。

    Human IgG.sub.1 monoclonal antibody specific for the nicotinic acetylcholine receptor and hybridoma producing the antibody
    6.
    发明授权
    Human IgG.sub.1 monoclonal antibody specific for the nicotinic acetylcholine receptor and hybridoma producing the antibody 失效
    特异于烟碱乙酰胆碱受体的人IgG1单克隆抗体和产生抗体的杂交瘤

    公开(公告)号：US5192684A

    公开(公告)日：1993-03-09

    申请号：US175304

    申请日：1988-03-30

    申请人： Masao Tanihara ,  Hideaki Yamada ,  Toshihide Nakashima ,  Yoshiaki Omura ,  Koichi Takakura

    发明人： Masao Tanihara ,  Hideaki Yamada ,  Toshihide Nakashima ,  Yoshiaki Omura ,  Koichi Takakura

    IPC分类号： A61B10/00 ,  A61K39/395 ,  A61P21/00 ,  C07K16/28 ,  C12N5/10 ,  C12N5/24 ,  C12N15/02 ,  C12P21/00 ,  C12P21/08 ,  C12R1/91 ,  G01N33/566 ,  G01N33/577

    CPC分类号： C07K16/286

    摘要： A human IgG.sub.1 type monoclonal antibody which possesses a molecular weight in the range of 180,000.+-.20,000 as measured by the method of polyacrylamide gel electrophoresis performed in the presence of sodium dodecyl sulfate and is specific to nicotinic acetylcholine receptor. The human IgG.sub.1 type monoclonal antibody mentioned above is produced by a method which comprises fusing human cells capable of producing an antibody against nicotinic acetylcholine receptor with propagable human cells thereby giving rise to a hybridoma capable of producing the aforementioned human IgG.sub.1 type monoclonal antibody, selecting the hybridoma from the production of the fusion, culturing the hybridoma thereby giving rise to the aforementioned human IgG.sub.1 type monoclonal antibody, and selecting the antibody from the cultured medium. The hybridoma mentioned above is also identified.

    摘要翻译： 通过在十二烷基硫酸钠存在下进行的聚丙烯酰胺凝胶电泳测定，其具有180,000 +/- 20,000范围内的分子量的人IgG1型单克隆抗体，并且对烟碱乙酰胆碱受体是特异性的。 上述人IgG1型单克隆抗体是通过将能够产生抗烟碱型乙酰胆碱受体抗体的人细胞与可扩增人细胞融合从而产生能产生上述人IgG1型单克隆抗体的杂交瘤的方法制备的， 从产生融合物中获得杂交瘤，培养杂交瘤，从而产生上述人IgG1型单克隆抗体，并从培养基中选择抗体。 也鉴定了上述杂交瘤。

    Wound covering material
    8.
    发明授权
    Wound covering material 失效
    伤口覆盖材料

    公开(公告)号：US4287177A

    公开(公告)日：1981-09-01

    申请号：US66699

    申请日：1979-08-15

    申请人： Toshihide Nakashima ,  Osamu Nakaji ,  Koichi Takakura ,  Takayoshi Suzuki

    发明人： Toshihide Nakashima ,  Osamu Nakaji ,  Koichi Takakura ,  Takayoshi Suzuki

    IPC分类号： C08L33/00 ,  A61K9/06 ,  A61K9/70 ,  A61L26/00 ,  C08L33/02 ,  C08L33/04 ,  A61K31/78

    CPC分类号： A61L26/008 ,  A61L26/0014 ,  A61L26/0071 ,  A61L26/0076 ,  Y10S424/13

    摘要： The present invention provides a covering material consisting essentially of a hydrophilic, water insoluble polymer (component A), a high boiling plasticizer and/or organic solvent (component B) for said component A, and an aqueous liquid (component C). Said covering material is useful as a protective covering material for forming a film or coat on the skin and/or wound surface in the treatment of burn. The material is characterized in that film or coat formation on the skin and/or wound surface can be realized in a short time.

    摘要翻译： 本发明提供了一种基本上由用于所述组分A的亲水性，水不溶性聚合物（组分A），高沸点增塑剂和/或有机溶剂（组分B）和水性液体（组分C）组成的覆盖材料。 所述覆盖材料可用作在烧伤治疗中在皮肤和/或伤口表面上形成膜或涂层的保护性覆盖材料。 该材料的特征在于可以在短时间内实现皮肤和/或伤口表面上的膜或涂层形成。