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    CXCR4 MODULATORS
    2.
    发明申请
    CXCR4 MODULATORS 有权
    CXCR4调制器

    公开(公告)号：US20070254915A1

    公开(公告)日：2007-11-01

    申请号：US11694935

    申请日：2007-03-30

    申请人： Manmohan Leleti ,  William Thomas ,  Penglie Zhang ,  Andrew Pennell

    发明人： Manmohan Leleti ,  William Thomas ,  Penglie Zhang ,  Andrew Pennell

    IPC分类号： A61K31/4709 ,  A61K31/454 ,  A61K31/4162 ,  C07D491/02

    CPC分类号： C07D491/052 ,  C07D231/54 ,  C07D471/04 ,  C07D491/04

    摘要： The present invention is directed to novel compounds and pharmaceutical compositions that inhibit the binding of the SDF-1 chemokine to the chemokine receptor CXCR4 and/or the binding of the SDF-1 or I-TAC chemokines to the chemokine receptor CCXCKR2 (CXCR7). These compounds are useful in preventing tumor cell proliferation, tumor formation, metastasis, inflammatory diseases, treatment of HIV infectivity, treatment of stem cell differentiation and mobilization disorders, and ocular disorders.

    摘要翻译： 本发明涉及抑制SDF-1趋化因子与趋化因子受体CXCR4的结合和/或SDF-1或I-TAC趋化因子与趋化因子受体CCXCKR2（CXCR7）的结合的新化合物和药物组合物。 这些化合物可用于预防肿瘤细胞增殖，肿瘤形成，转移，炎性疾病，HIV感染的治疗，治疗干细胞分化和动员障碍以及眼部疾病。

    Punching bag having two sections
    5.
    发明授权
    Punching bag having two sections 有权

    公开(公告)号：US11406886B1

    公开(公告)日：2022-08-09

    申请号：US16995949

    申请日：2020-08-18

    申请人： William Thomas

    发明人： William Thomas

    IPC分类号： A63B69/20 ,  A63B69/24 ,  A63B69/00 ,  A63B69/34 ,  A63B71/14

    摘要： The punching bag having two sections is a physical training apparatus. The punching bag having two sections is adapted for use in training participants in combat sports. The punching bag having two sections presents a plurality of targets that are struck during training activities. The punching bag having two sections incorporates a plurality of punching bags, an internal fastener, and a harness. The internal fastener interconnect the plurality of punching bags. The harness limits the motion of a first punching bag selected from the plurality of punching bags relative to a second punching bag selected from the plurality of punching bags. Each of the plurality of punching bags forms a target selected from the plurality of targets.

    Substance holder with removable insert
    7.
    发明授权
    Substance holder with removable insert 有权
    具有可移除插入物的物质支架

    公开(公告)号：US08250970B2

    公开(公告)日：2012-08-28

    申请号：US11140673

    申请日：2005-05-27

    申请人： William Thomas

    发明人： William Thomas

    IPC分类号： A47J31/24

    CPC分类号： A47J31/0663 ,  A47J31/4467

    摘要： A substance holder and an insert for use in the substance holder. The insert elevates a brewing substance, filter or pod above a floor of the substance holder. The substance holder and insert allow water to infuse the brewing substance and allow beverage to drain through a portion of the insert for draining into a container. The insert is retained in the holder and is selectively removable from the holder to facilitate actions, for example but not limited to cleaning of the holder and insert as well as replacing the insert with other structures which may be used with the holder.

    摘要翻译： 物质支架和用于物质支架的插入物。 插入物将物质支架的地板上的冲泡物质，过滤器或荚提升。 物质保持器和插入物允许水注入冲泡物质并允许饮料通过插入物的一部分排出以排入容器。 插入件被保持在保持器中并且可选择性地从保持器移除，以促进动作，例如但不限于清洁保持器和插入件，以及用可能与保持器一起使用的其它结构来替换插入件。

    Television chat system
    10.
    发明申请
    Television chat system 审中-公开
    电视聊天系统

    公开(公告)号：US20050262542A1

    公开(公告)日：2005-11-24

    申请号：US10918753

    申请日：2004-08-12

    申请人： Toby DeWeese ,  Pamela McKissick ,  William Thomas ,  Michael Ellis

    发明人： Toby DeWeese ,  Pamela McKissick ,  William Thomas ,  Michael Ellis

    IPC分类号： G06F13/00 ,  H04N7/14 ,  H04N7/15 ,  H04N7/16 ,  H04N7/173 ,  G06F9/00

    CPC分类号： H04N21/4788 ,  H04L12/1818 ,  H04N7/147 ,  H04N7/17318 ,  H04N21/2408 ,  H04N21/254 ,  H04N21/2665 ,  H04N21/4223 ,  H04N21/431 ,  H04N21/4316 ,  H04N21/454 ,  H04N21/4622 ,  H04N21/4751 ,  H04N21/4755 ,  H04N21/4756 ,  H04N21/4758 ,  H04N21/4782 ,  H04N21/4786 ,  H04N21/632 ,  H04N21/6581 ,  H04N21/812 ,  H04N21/8173 ,  H04N21/84 ,  H04N21/8545

    摘要： A television chat system is provided that allows television viewers to engage in real-time communications in chat groups with other television viewers while watching television. Users of the television chat system may engage in real-time communications with other users who are currently watching the same television program or channel. The system allows real-time communications in a chat group to be transmitted between users at user television equipment devices via a television distribution facility. The television chat system of the present invention permits users to join chat groups related to television programs, channels, or categories of programs that the user may be interested in. Real-time communications may be textual messages, audio communications, or video communications. The television chat system may also allow users to send chat requests to ask other users to enter a chat group. The system also permits users to establish chat groups that television viewers are permitted to join. The television chat system may be based on an interactive television program guide or set-top box application implemented on a set-top box.

    摘要翻译： 提供电视聊天系统，其允许电视观众在观看电视的同时与其他电视观众进行聊天组中的实时通信。 电视聊天系统的用户可以与正在观看同一电视节目或频道的其他用户进行实时通信。 该系统允许通过电视分配设施在用户电视设备设备的用户之间传输聊天组中的实时通信。 本发明的电视聊天系统允许用户加入与电视节目，频道或用户可能感兴趣的节目类别相关的聊天组。实时通信可以是文本消息，音频通信或视频通信。 电视聊天系统还可以允许用户发送聊天请求以请求其他用户进入聊天组。 该系统还允许用户建立电视观众允许加入的聊天组。 电视聊天系统可以基于在机顶盒上实现的交互式电视节目指南或机顶盒应用程序。