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    Interleukin-1 beta converting enzyme like apoptotic protease 6
    4.
    发明申请
    Interleukin-1 beta converting enzyme like apoptotic protease 6 失效
    白细胞介素-1β转换酶如凋亡蛋白酶6

    公开(公告)号：US20050089984A1

    公开(公告)日：2005-04-28

    申请号：US10961148

    申请日：2004-10-12

    申请人： Vishva Dixit ,  Wei-Wu He ,  Kristine Kikly ,  Steven Ruben

    发明人： Vishva Dixit ,  Wei-Wu He ,  Kristine Kikly ,  Steven Ruben

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/55 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P9/10 ,  A61P25/00 ,  A61P25/28 ,  A61P31/04 ,  A61P43/00 ,  C07K14/47 ,  C07K16/40 ,  C12N5/00 ,  C12N5/10 ,  C12N9/64 ,  C12N9/99 ,  C12N15/12 ,  C12Q1/68 ,  C12R1/91 ,  C07H21/04

    CPC分类号： C12N9/6475 ,  A61K38/00 ,  A61K48/00

    摘要： Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ICE LAP-6 for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility. Antagonists against such ICE LAP-6 and their use as a therapeutic to treat Alzheimer's disease, Parkinson's disease, rheumatoid arthritis, septic shock, sepsis, stroke, chronic inflammation, acute inflammation, CNS inflammation, osteoporosis, ischemia reperfusion injury, cell death associated with cardiovascular disease, polycystic kidney disease, apoptosis of endothelial cells in cardiovascular disease, degenerative liver disease, MS, ALS, cererbellar degeneration, ischemic injury, myocardial infarction, AIDS, myelodysplastic syndromes, aplastic anemia, male pattern baldness, and head injury damage are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the interleukin-1 beta converting enzyme apoptosis proteases and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人ICE LAP-6多肽和编码这种ICE LAP-6的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种ICE LAP-6用于治疗对病毒感染，肿瘤发生的易感性以及控制胚胎发生和组织稳态中的疾病和缺陷的方法，并且上述核酸序列可用于确定 这种敏感性。 对抗这种ICE LAP-6的拮抗剂及其作为治疗性阿尔茨海默病，帕金森病，类风湿性关节炎，败血性休克，败血症，中风，慢性炎症，急性炎症，CNS炎症，骨质疏松症，缺血再灌注损伤，与 心血管疾病，多囊肾病，心血管疾病中的内皮细胞凋亡，退行性肝病，MS，ALS，小脑变性，缺血性损伤，心肌梗塞，艾滋病，骨髓增生异常综合征，再生障碍性贫血，男性型秃发和头部损伤也是 披露 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码白细胞介素-1β转换酶凋亡蛋白酶的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。

    COP1 molecules and uses thereof
    9.
    发明授权
    COP1 molecules and uses thereof 失效
    COP1分子及其用途

    公开(公告)号：US07785815B2

    公开(公告)日：2010-08-31

    申请号：US11786399

    申请日：2007-04-10

    申请人： David Dornan ,  Dorothy French ,  Vishva Dixit

    发明人： David Dornan ,  Dorothy French ,  Vishva Dixit

    IPC分类号： G01N33/53 ,  C12Q1/68

    CPC分类号： G01N33/57496 ,  G01N33/574 ,  G01N2333/9015 ,  G01N2500/02 ,  G01N2800/52

    摘要： The invention provides diagnostic, prognostic, and therapeutic uses for detecting COP1 overexpression in a variety of cancers. The methods and uses can further include detecting p53 expression. The invention also provides reagents and kits for use in screening for test compounds that interfere with COP1 and p53 binding.

    摘要翻译： 本发明提供用于检测多种癌症中COP1过表达的诊断，预后和治疗用途。 所述方法和用途还可包括检测p53表达。 本发明还提供用于筛选干扰COP1和p53结合的测试化合物的试剂和试剂盒。