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    Quinazolinone compounds as anticancer agents
    2.
    发明申请
    Quinazolinone compounds as anticancer agents 失效
    喹唑啉酮化合物作为抗癌剂

    公开(公告)号：US20050209254A1

    公开(公告)日：2005-09-22

    申请号：US10996814

    申请日：2004-11-24

    申请人： Weibo Wang ,  Liana Lagniton ,  Ryan Constantine ,  Manoj Desai

    发明人： Weibo Wang ,  Liana Lagniton ,  Ryan Constantine ,  Manoj Desai

    IPC分类号： A61K31/517 ,  C07D239/40 ,  C07D239/90 ,  C07D401/06 ,  C07D43/02

    CPC分类号： C07D401/06 ,  C07D239/90

    摘要： Quinazolinone compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the quinazolinone compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the quinazolinone compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.

    摘要翻译： 喹唑啉酮化合物，其药学上可接受的盐和前药; 包括药学上可接受的载体和一种或多种喹唑啉酮化合物的组合物，单独或与至少一种另外的治疗剂组合。 单独使用喹唑啉酮化合物或与至少一种其它治疗剂组合使用的方法可用于预防或治疗增殖性疾病。

    Anti-proliferative compounds, compositions, and methods of use thereof
    9.
    发明申请
    Anti-proliferative compounds, compositions, and methods of use thereof 有权

    公开(公告)号：US20050222090A1

    公开(公告)日：2005-10-06

    申请号：US11026303

    申请日：2004-12-29

    申请人： Xiaqin Cheng ,  Gary Cook ,  Manoj Desai ,  Edward Doerffler ,  Gong-Xin He ,  Choung Kim ,  William Lee ,  John Rohloff ,  Jianying Wang ,  Zheng-Yu Yang

    发明人： Xiaqin Cheng ,  Gary Cook ,  Manoj Desai ,  Edward Doerffler ,  Gong-Xin He ,  Choung Kim ,  William Lee ,  John Rohloff ,  Jianying Wang ,  Zheng-Yu Yang

    IPC分类号： A61K31/66 ,  A61K31/675 ,  C07F9/44 ,  C07F9/6561

    CPC分类号： C07F9/65616 ,  Y02P20/55

    摘要： Compounds and compositions of Formula I are described, useful as anti-proliferative agents, and in particular anti-HPV, wherein: Y1A and Y1B are independently Y1; RX1 and RX2 are independently RX; Y1 is ═O, —O(RX), ═S, —N(RX), —N(O)(RX), —N(ORX), —N(O)(ORX), or —N(N(RX)(RX)); RX is independently R1, R2, R4, W3, or a protecting group; R1 is independently —H or alkyl of 1 to 18 carbon atoms; R2 is independently R3 or R4 wherein each R4 is independently substituted with 0 to 3 R3 groups or taken together at a carbon atom, two R2 groups form a ring of 3 to 8 carbons and the ring may be substituted with 0 to 3 R3 groups; R3 is R3a, R3b, R3c or R3d, provided that when R3 is bound to a heteroatom, then R3 is R3c or R3d; R3a is —H, —F, —Cl, —Br, —I, —CF3, —CN, N3, —NO2, or —OR4; R3b is ═O, —O(R4), ═S, —N(R4), —N(O)(R4), —N(OR4), —N(O)(OR4), or —N(N(R4)(R4)); R3c is —R4, —N(R4)(R4), —SR4, —S(O)R4, —S(O)2R4, —S(O)(OR4), —S(O)2(OR4), —OC(R3b)R4, —OC(R3b)OR4, —OC(R3b)(N(R4)(R4)), —SC(R3b)R4, —SC(R3b)OR4, —SC(R3b)(N(R4)(R4)), —N(R4)C(R3b)R4, —N(R4)C(R3b)OR4, N(R4)C(R3b)(N(R4)(R4)), W3 or —R5W3; R3d is —C(R3b)R4, —C(R3b)OR4, —C(R3b)W3, —C(R3b)OW3 or —C(R3b)(N(R4)(R4)); R4 is —H, or an alkyl of 1 to 18 carbon atoms, alkenyl of 2 to 18 carbon atoms, or alkynyl of 2 to 18 carbon atoms; R5 is alkylene of 1 to 18 carbon atoms, alkenylene of 2 to 18 carbon atoms, or alkynylene of 2 to 18 carbon atoms; W3 is W4 or W5; W4 is R6, —C(R3b)R6, —C(R3b)W5, —SOM2R6, or —SOM2W5, wherein R6 is R4 wherein each R4 is substituted with 0 to 3 R3 groups; W5 is carbocycle or heterocycle wherein W5 is independently substituted with 0 to 3 R2 groups; and M2 is 0, 1 or 2; and pharmaceutically acceptable salts thereof.