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    Determining cancer-linked genes and therapeutic targets using molecular cytogenetic methods
    8.
    发明申请
    Determining cancer-linked genes and therapeutic targets using molecular cytogenetic methods 审中-公开
    使用分子细胞遗传学方法确定癌症相关基因和治疗靶点

    公开(公告)号：US20070059697A1

    公开(公告)日：2007-03-15

    申请号：US10553098

    申请日：2004-04-15

    申请人： Jeffrey Strovel ,  Colyn Cain ,  Stephen Horrigan ,  Meena Augustus

    发明人： Jeffrey Strovel ,  Colyn Cain ,  Stephen Horrigan ,  Meena Augustus

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16

    摘要： Methods for identifying potential therapeutic agents, such as anti-tumor agents, based on their modulation of the expression of specified genes, especially genes mapping to specific chromosomal regions, are disclosed. Also described are methods for diagnosing cancerous, or potentially cancerous, conditions as a result of the expression, or patterns of expression, of such genes, including detecting changes in levels of gene copy number and/or level of amplification of the said gene, or sets of genes, to detect and/or diagnose the cancer. Methods for detecting or determining functionally related genes, as well as methods for treating cancer based on targeting expression products of such genes, determining genes involved in the cancerous process and the success and/or response rates and survival statistics for cancer patients on treatment are encompassed by the invention. Also encompassed are methods involving determining the modulated expression of the genes in these regions of interest (ROIs) as pharmacodynamic/pharmacogenetic /surrogate markers and/or for patient profiling prior to accrual for clinical trials/treatments based on the identification of these genes as validated gene/drug targets in various cancer tissue types.

    摘要翻译： 公开了基于其对特定基因的表达调控，特别是映射到特定染色体区域的基因的潜在治疗剂如抗肿瘤剂的方法。 还描述了作为这些基因的表达或表达模式的癌症或潜在癌症病症的诊断方法，包括检测所述基因的基因拷贝数和/或扩增水平的变化，或 一组基因，以检测和/或诊断癌症。 包括用于检测或确定功能相关基因的方法，以及基于这些基因的靶向表达产物治疗癌症的方法，确定参与癌症过程的基因以及癌症患者治疗的成功和/或应答率和存活统计数据。 通过本发明。 还包括涉及将这些感兴趣区域（ROI）中的基因的调节表达作为药效学/药物代谢/替代标记物确定的方法和/或基于鉴定这些被验证的临床试验/治疗之前的患者分析 基因/药物靶标在各种癌组织类型。

    Amplified cancer target genes useful in diagnosis and thereapeutic screening
    9.
    发明申请
    Amplified cancer target genes useful in diagnosis and thereapeutic screening 审中-公开
    扩增的癌症靶基因可用于诊断和治疗筛选

    公开(公告)号：US20060134622A1

    公开(公告)日：2006-06-22

    申请号：US10540311

    申请日：2003-12-19

    申请人： Meena Augustus ,  Stephen Horrigan ,  Colyn Cain ,  Jeffrey Strovel

    发明人： Meena Augustus ,  Stephen Horrigan ,  Colyn Cain ,  Jeffrey Strovel

    IPC分类号： C12Q1/68

    CPC分类号： G01N33/57484 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5011 ,  G01N33/574 ,  G01N33/57415 ,  G01N33/78 ,  G01N2500/00 ,  G01N2800/52

    摘要： A gene useful as a prognostic indicator of survival of patients afflicted with cancers such as breast cancer is described. Also disclosed are methods for screening potential therapeutic agents, such as antitumor agents, based on their modulation of the expression of a TRIP13 gene, or splice variants thereof, along with methods for diagnosing cancerous, or potentially cancerous, conditions as a result of the expression, or patterns of expression, of such genes, including changes in copy number. Also disclosed are methods for detecting or determining functionally related genes, where disruption of TRIP13 may affect such related-gene expression, as well as methods for treating cancer based on targeting expression products of such genes and determining genes involved in the cancerous process. Methods for identifying, detecting and following patients and others having high levels of amplification/expression of the gene before treatment where differences after treatment serve as markers for indication of success of treatment or for identifying individuals who would benefit from such treatment using this gene marker as a diagnostic and/or prognostic and/or pharmacodynamic or surrogate marker are described.

    摘要翻译： 描述了可用作患有诸如乳腺癌之类的患者的存活的预后指标的基因。 还公开了用于筛选潜在治疗剂，例如抗肿瘤剂的方法，其基于它们对TRIP13基因或其剪接变体的表达的调节，以及作为表达结果诊断癌性或潜在癌性病症的方法 ，或这些基因的表达模式，包括拷贝数的变化。 还公开了用于检测或确定功能相关基因的方法，其中TRIP13的破坏可能影响这种相关基因表达，以及基于这些基因的靶向表达产物和确定参与癌症过程的基因来治疗癌症的方法。 用于鉴定，检测和跟踪患者和其他在治疗前具有高水平的基因的扩增/表达的方法，其中治疗之后的差异用作指示治疗成功的标志物或用于鉴定将使用该基因标记从这种治疗中受益的个体 描述了诊断和/或预后和/或药效学或替代标记。