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1.发明申请METHODS AND COMPOSITIONS FOR PAPER-BASED AND HYBRID MICROFLUIDIC DEVICES INTEGRATED WITH NUCLEIC ACID AMPLIFICATION FOR DISEASE DIAGNOSIS 审中-公开与用于疾病诊断的核酸扩增相结合的基于纸张和混合微流体装置的方法和组合物公开(公告)号：US20160008809A1
公开(公告)日：2016-01-14
申请号：US14796127
申请日：2015-07-10
申请人： XiuJun Li , Maowei Dou , Delfina Dominguez
发明人： XiuJun Li , Maowei Dou , Delfina Dominguez
CPC分类号： B01L3/50851 , B01L3/5027 , B01L3/502715 , B01L7/52 , B01L2200/0605 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887 , B01L2300/0893 , B01L2300/126 , C12Q1/6865 , C12Q1/6867 , C12Q1/689 , C12Q2563/107 , C12Q2565/601 , C12Q2565/629
摘要： Certain embodiments are directed to paper and its hybrid microfluidic devices integrated with nucleic acid amplification for simple, cost-effective, rapid, and sensitive pathogen detection, especially in low-resource settings.
摘要翻译： 某些实施方案涉及纸和其与核酸扩增集成的杂交微流体装置，用于简单，成本效益，快速和敏感的病原体检测，特别是在低资源设置中。
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公开(公告)号：US20180080067A1
公开(公告)日：2018-03-22
申请号：US15701886
申请日：2017-09-12
申请人： XiuJun Li , Maowei Dou , Delfina C. Dominguez
发明人： XiuJun Li , Maowei Dou , Delfina C. Dominguez
CPC分类号： C12Q1/689 , B01L3/5027 , B01L7/00 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0887 , B01L2300/126 , B01L2300/1827 , B01L2400/0409 , C12Q1/6844 , C12Q2527/101
摘要： Certain embodiments are directed to a point-of-care (POC) microfluidic biochip for rapid, highly sensitive and specific pertussis diagnosis. The POC biochip can be used in various venues such as physician's office, schools, hospitals, and low-resource settings so that rapid prevention and treatment of pertussis can be achieved. The POC biochip based pertussis diagnosis is low-cost and does not rely on any specialized instrument, but offers comparable sensitivity to real-time PCR.
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公开(公告)号：US20170276599A1
公开(公告)日：2017-09-28
申请号：US15468186
申请日：2017-03-24
申请人： XiuJun Li
发明人： XiuJun Li
CPC分类号： C12Q1/6844 , B01L3/502715 , B01L7/52 , G01N21/253 , G01N21/78 , G01N21/82 , G01N2021/6432 , G01N2021/7786 , G01N2201/0221 , G01N2201/0621 , G01N2201/064 , G01N2201/0693 , G01N2201/08 , C12Q2565/60 , C12Q2565/629
摘要： Certain embodiments are directed to a low-cost battery-powered spectrophotometric system (BASS) coupled with a microfluidic chip for POC analysis, as well as methods of using the same.
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4.发明申请公开(公告)号：US20170088875A1
公开(公告)日：2017-03-30
申请号：US15276408
申请日：2016-09-26
申请人： XiuJun Li , Gilberto Henao-Pabon
发明人： XiuJun Li , Gilberto Henao-Pabon
CPC分类号： C12Q1/006 , C12Q1/003 , G01N33/723
摘要： Certain embodiments are directed to sensors that enable the use of optimized biocompatible materials such as pre-anodized paper printed electrode transducer to detect binding of a target agent, wherein the surface is modified or functionalized through zero length cross-linker so that it interacts with or specifically binds a target such as sugars (glucose) or glycated proteins (HgbA1c).
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公开(公告)号：US20180155714A1
公开(公告)日：2018-06-07
申请号：US15826072
申请日：2017-11-29
CPC分类号： C12N15/1093 , C12N15/1006 , C12Q1/6837
摘要： Embodiments described herein are related to a one-step surface modification method with 3-aminopropyl trimethoxysilane (APTMS), which was developed and applied for DNA immobilization on a paper-based device via the ionic adsorption.
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6.发明申请公开(公告)号：US20170261504A1
公开(公告)日：2017-09-14
申请号：US15454200
申请日：2017-03-09
申请人： XiuJun Li , Sanjay S. Timilsina
发明人： XiuJun Li , Sanjay S. Timilsina
IPC分类号： G01N33/543 , B01L3/00
CPC分类号： B01L3/5085 , B01L2300/0829 , B01L2300/0858 , G01N33/54353 , G01N33/54366
摘要： Certain embodiments are directed to an ultrasensitive poly(methyl methacrylate) (PMMA) ELISA microfluidic microplate, where the protein is covalently bound to a poly-lysine modified or carboxylated PMMA surface.
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公开(公告)号：US09682856B2
公开(公告)日：2017-06-20
申请号：US13557861
申请日：2012-07-25
申请人： George Whitesides , Xinyu Liu , XiuJun Li , Martin M. Thuo , Michael O'Brien , Yu Sun
发明人： George Whitesides , Xinyu Liu , XiuJun Li , Martin M. Thuo , Michael O'Brien , Yu Sun
CPC分类号： B81B7/02 , B81C1/0015 , G01G3/13 , G01L1/18 , G01P15/0802 , G01P15/123 , G01P15/18 , G01P2015/0862
摘要： MEMS devices fabricated using inexpensive substrate materials such as paper or fabric, are provided. Using paper as a substrate, low cost, simple to prepare, lightweight, disposable piezoresistive sensors, including accelerometers are prepared. Signal-processing circuitry can also be patterned on the substrate material.The sensors can be utilized as two-dimensional sensors, or the paper substrate material can be folded to arrange the sensors in a three dimensional conformation. For example, three sensors can be patterned on a paper substrate and folded into a cube such that the three sensors are orthogonally positioned on the faces of a cube, permitting simultaneous measurement of accelerations along three orthogonal directions (x-y-z). These paper-based sensors can be mass produced by incorporating highly developed technologies for automatic paper cutting, folding, and screen-printing.Also provided are methods of modifying paper for use as a substrate material in MEMS devices.
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8.发明授权公开(公告)号：US10094793B2
公开(公告)日：2018-10-09
申请号：US15269301
申请日：2016-09-19
申请人： XiuJun Li , Guanglei Fu
发明人： XiuJun Li , Guanglei Fu
摘要： Certain embodiments of the invention are directed to a photothermal immunoassay employing a thermometer or colorimetric detection method for sensitive quantitative readout based on the photothermal effect provided by a detection reagent.
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9.发明申请公开(公告)号：US20170131298A1
公开(公告)日：2017-05-11
申请号：US15345005
申请日：2016-11-07
申请人： XiuJun Li
发明人： XiuJun Li
CPC分类号： G01N33/743 , B01L3/502784
摘要： A simple interfacial nano-biosensing strategy for high-sensitivity detection of low-solubility compounds like 17β-estradiol is disclosed. Apparatuses, methods and compositions for detection incorporate a combination of droplet microfluidics with aptamer-functionalized GO nanosensors.
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10.发明申请公开(公告)号：US20170082615A1
公开(公告)日：2017-03-23
申请号：US15269301
申请日：2016-09-19
申请人： XiuJun Li , Guanglei Fu
发明人： XiuJun Li , Guanglei Fu
IPC分类号： G01N33/543 , G01N25/48 , G01N33/553
CPC分类号： G01N25/4813 , G01N33/58 , G01N33/583 , G01N33/587
摘要： Certain embodiments of the invention are directed to a photothermal immunoassay employing a thermometer or colorimetric detection method for sensitive quantitative readout based on the photothermal effect provided by a detection reagent.
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