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    ELECTRIC TOMOGRAPHY
    6.
    发明申请
    ELECTRIC TOMOGRAPHY 审中-公开
    电动图

    公开(公告)号：US20080058656A1

    公开(公告)日：2008-03-06

    申请号：US11731786

    申请日：2007-03-30

    申请人： Benedict Costello ,  Timothy Robertson ,  Mark Zdeblick ,  George Savage ,  Olivier Colliou ,  Todd Thompson

    发明人： Benedict Costello ,  Timothy Robertson ,  Mark Zdeblick ,  George Savage ,  Olivier Colliou ,  Todd Thompson

    IPC分类号： A61B5/02

    CPC分类号： A61B5/1107 ,  A61B5/686 ,  A61B8/08 ,  A61B8/488 ,  A61B2562/046 ,  A61N1/3627

    摘要： Methods for evaluating motion of a tissue, such as of a cardiac location, e.g., heart wall, via electrical field tomography are provided. In the subject methods, an sensing element is stably associated with a tissue location of interest. Signals obtained from the sensing element are obtained to evaluate movement of the tissue location. Also provided are systems and devices for practicing the subject methods. In addition, innovative data displays and systems for producing the same are provided. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.

    摘要翻译： 提供了用于通过电场层析成像评估诸如心脏位置（例如心脏壁）的组织运动的方法。 在本方法中，感测元件与感兴趣的组织位置稳定地相关联。 获得从感测元件获得的信号以评估组织位置的移动。 还提供了用于实践主题方法的系统和设备。 此外，还提供了创新的数据显示和用于生产数据的系统。 主题方法和设备可用于各种不同的应用，包括心脏再同步治疗。

    HIGH PHRENIC, LOW CAPTURE THRESHOLD PACING DEVICES AND METHODS
    7.
    发明申请
    HIGH PHRENIC, LOW CAPTURE THRESHOLD PACING DEVICES AND METHODS 审中-公开
    高光，低电压阈值设备和方法

    公开(公告)号：US20080077186A1

    公开(公告)日：2008-03-27

    申请号：US11734617

    申请日：2007-04-12

    申请人： Todd Thompson ,  Mark Zdeblick ,  Olivier Colliou ,  Benedict Costello ,  Marc Jensen ,  George Savage

    发明人： Todd Thompson ,  Mark Zdeblick ,  Olivier Colliou ,  Benedict Costello ,  Marc Jensen ,  George Savage

    IPC分类号： A61N1/00

    CPC分类号： A61N1/3627

    摘要： Methods of highly selective cardiac tissue stimulation and devices for practicing the same, e.g., implantable segmented electrode devices, are provided. The methods and devices provide a previously unavailable high phrenic nerve capture voltage paired with a low pacing capture voltage threshold. The subject methods and devices provide a number of benefits. For example, patients who previously would have been required to have their resynchronization device turned off due to phrenic nerve capture will now be able to reap the benefits of resynchronization therapy.

    摘要翻译： 提供了高选择性心脏组织刺激的方法和用于实施该方法的装置，例如可植入分段的电极装置。 这些方法和装置提供了与低起搏捕获电压阈值配对的先前不可用的高膈神经捕获电压。 主题方法和设备提供了许多好处。 例如，以前由于膈神经捕获而被关闭的再同步装置的患者现在将能够获得再同步治疗的好处。

    DEPLOYABLE EPICARDIAL ELECTRODE AND SENSOR ARRAY
    8.
    发明申请
    DEPLOYABLE EPICARDIAL ELECTRODE AND SENSOR ARRAY 审中-公开
    可配电子电极和传感器阵列

    公开(公告)号：US20090299447A1

    公开(公告)日：2009-12-03

    申请号：US11917992

    申请日：2006-06-30

    申请人： Marc Jensen ,  Olivier Colliou ,  Benedict Costello ,  Mark Zdeblick ,  Todd Thompson ,  George Savage ,  Andrew Thompson

    发明人： Marc Jensen ,  Olivier Colliou ,  Benedict Costello ,  Mark Zdeblick ,  Todd Thompson ,  George Savage ,  Andrew Thompson

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0587

    摘要： Minimally invasive deployable epicardial array devices are provided. The devices include deployable platform comprising two or more effectors, such as sensors and actuators, where the devices are configured to be deployed at an epicardial location via a minimally invasive, e.g., sub-xiphoid approach. In embodiments of the present invention, at least one area of the electrode patch is an electrical control area that comprises a series of effectors, e.g., sensors and/or electrodes. Other embodiments provide localized physical constraint and dynamic mechanical stimulation of the heart to effectuate physical and biological responses. Still other embodiments provide both of these functions. Also provided are methods of using the devices, as well as systems and kits that include the devices.

    摘要翻译： 提供微创可部署的心外阵列器件。 这些装置包括包括两个或更多个效应器（诸如传感器和致动器）的可展开平台，其中装置被配置成经由微创例如亚剑突方法部署在心外膜位置。 在本发明的实施例中，电极贴片的至少一个区域是包括一系列效应器例如传感器和/或电极的电控制区域。 其他实施例提供心脏的局部物理约束和动态机械刺激以实现物理和生物反应。 其他实施例提供这两个功能。 还提供了使用这些设备的方法，以及包括设备的系统和套件。

    IMPLANTABLE INTEGRATED CIRCUIT
    9.
    发明申请
    IMPLANTABLE INTEGRATED CIRCUIT 审中-公开
    可嵌入式集成电路

    公开(公告)号：US20100204766A1

    公开(公告)日：2010-08-12

    申请号：US12097959

    申请日：2006-12-22

    申请人： Mark Zdeblick ,  Robert Leichner ,  Behrad Aria ,  Nilay Jani ,  Haifeng Li ,  Todd Thompson ,  Lawrence Arne ,  Timothy Robertson ,  Yafei Bi ,  Vladimier Gelfandbein

    发明人： Mark Zdeblick ,  Robert Leichner ,  Behrad Aria ,  Nilay Jani ,  Haifeng Li ,  Todd Thompson ,  Lawrence Arne ,  Timothy Robertson ,  Yafei Bi ,  Vladimier Gelfandbein

    IPC分类号： A61N1/05

    CPC分类号： A61N1/056 ,  A61B5/0422 ,  A61N1/025 ,  A61N1/362 ,  A61N1/3686 ,  A61N1/372 ,  A61N1/37205 ,  A61N1/37276 ,  A61N1/37288 ,  A61N1/3756

    摘要： Embodiments of the present invention enable robust, reliable control functionality for effectors present on intraluminal, e.g., vascular leads, as well as other types of implantable devices. Embodiments of the invention enable the required functionality for accurate long term control of effectors units, even ones present on multiplex carrier configurations, while provide for low power consumption. Aspects of the invention include implantable integrated circuits that have power extraction; energy storage; communication; and device configuration functional blocks, where these functional blocks are all present in a single integrated circuit on an intraluminal-sized support. Also provided by the invention are effector assemblies that include the integrated circuits, as well as implantable medical devices, e.g., pulse generators that include the same, as well as systems and kits thereof and methods of using the same, e.g., in pacing applications, including cardiac resynchronization therapy (CRT) applications.

    摘要翻译： 本发明的实施例对存在于管腔内（例如血管引线）以及其它类型的可植入装置的效果器提供了鲁棒，可靠的控制功能。 本发明的实施例能够实现对效果器单元的准确的长期控制所需的功能，即使存在于多路载波配置上的单元也能提供低功耗。 本发明的方面包括具有功率提取的可植入集成电路; 储能; 通讯; 以及器件配置功能块，其中这些功能块都存在于腔内尺寸支持体上的单个集成电路中。 本发明还提供了包括集成电路的效应器组件以及可植入的医疗装置，例如包括其的脉冲发生器，以及其系统和套件，以及使用该装置的方法，例如在起搏应用中， 包括心脏再同步治疗（CRT）应用。

    Multiplexed multi-electrode neurostimulation devices
    10.
    发明授权
    Multiplexed multi-electrode neurostimulation devices 有权
    复用多电极神经刺激装置

    公开(公告)号：US08738154B2

    公开(公告)日：2014-05-27

    申请号：US13115031

    申请日：2011-05-24

    申请人： Mark Zdeblick ,  Todd Thompson ,  Marc Jensen ,  Olivier Colliou ,  Angela Strand

    发明人： Mark Zdeblick ,  Todd Thompson ,  Marc Jensen ,  Olivier Colliou ,  Angela Strand

    IPC分类号： A61N1/05

    CPC分类号： A61N1/375 ,  A61N1/025 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/36017 ,  A61N1/36185

    摘要： Implantable stimulation devices are provided. Aspects of the devices include a multiplexed multi-electrode component configured for neural stimulation. The multiplexed multi-electrode component includes two or more individually addressable satellite electrode structures electrically coupled to a common conductor. The satellite structures include a hermetically sealed integrated circuit controller operatively coupled to one or more electrodes. Also provided are systems that include the devices of the invention, as well as methods of using the systems and devices in a variety of different applications.

    摘要翻译： 提供可植入的刺激装置。 器件的方面包括配置用于神经刺激的复用多电极部件。 多路复用多电极部件包括电耦合到公共导体的两个或更多个可单独寻址的卫星电极结构。 卫星结构包括可操作地耦合到一个或多个电极的密封的集成电路控制器。 还提供了包括本发明的装置的系统，以及在各种不同应用中使用系统和装置的方法。