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公开(公告)号：US20060228813A1
公开(公告)日：2006-10-12
申请号：US10549824
申请日：2004-04-06
申请人： Ying Wu , Robby Ruijtenbeek
发明人： Ying Wu , Robby Ruijtenbeek
IPC分类号： C12Q1/68 , C12M1/34 , B32B15/02 , G01N33/551
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00351 , B01J2219/00527 , B01J2219/00529 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00677 , B01J2219/00711 , B01J2219/00722 , C40B40/06 , C40B60/14 , G01N33/54393 , G01N33/553 , Y10T428/2993
摘要： The present invention relates to an improved method for providing biomolecules on a metal oxide substrate. In another aspect, the invention relates to a metal oxide substrate, having a surface that is coated with a polymer, said substrate having biomolecules immobilised thereon, wherein said biomolecules are immobilized on said coated surface of said substrate by covalent binding, by means of electromagnetic irradiation. In another aspect, the invention relates to the use of a metal oxide substrate according to the invention for performing probe-based assays.
摘要翻译： 本发明涉及在金属氧化物基底上提供生物分子的改进方法。 另一方面，本发明涉及金属氧化物基底，其具有被聚合物涂覆的表面，所述基底上固定有生物分子，其中所述生物分子通过共价结合固定在所述基底的所述涂覆表面上，借助电磁 照射。 在另一方面，本发明涉及根据本发明的金属氧化物底物用于进行基于探针的测定法的用途。
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公开(公告)号：US20120115754A1
公开(公告)日：2012-05-10
申请号：US13138850
申请日：2010-04-12
CPC分类号： G01N33/57438 , G01N33/57496 , G01N2800/52 , G01N2800/60
摘要： The present invention relates to a method for diagnosing, typing and/or subtyping renal cell carcinoma as well as predicting the response to medication of patients suffering from renal cell carcinoma. More specifically, the present invention provides methods which measure kinase activity by studying phosphorylation levels and profiles in samples of said patients.
摘要翻译： 本发明涉及一种用于诊断，分型和/或分型肾细胞癌的方法，以及预测患有肾细胞癌的患者对药物的反应。 更具体地，本发明提供了通过研究所述患者的样品中的磷酸化水平和分布来测量激酶活性的方法。
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3.发明申请TREATMENT AND DIAGNOSIS OF METASTATIC PROSTATE CANCER WITH INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) 审中-公开治疗和诊断与EPIDERM生长因子受体（EGFR）的抑制剂分离前列腺癌公开(公告)号：US20100203043A1
公开(公告)日：2010-08-12
申请号：US12450743
申请日：2008-04-11
IPC分类号： A61K39/395 , A61K31/5377 , A61K31/517 , A61K31/4706 , A61K38/09 , A61P35/00 , A61P35/04 , G01N33/53
CPC分类号： A61K31/517 , A61K31/167 , A61K31/4706 , G01N33/57434 , G01N2800/50 , G01N2800/52 , A61K2300/00
摘要： The present invention relates to a method for the treatment, prevention and/or diagnosis of metastatic prostate cancer. More specifically inhibitors of Epidermal Growth Factor Receptor (EGFR) are used in the preparation of a pharmaceutical composition for treating or preventing metastatic prostate cancer. The EGFR inhibitors can for instance be EGFR inhibitors, EGFR signaling inhibitors and/or inhibitors of kinases downstream of EGFR kinases. The EGFR inhibitors can also be used in detection, screening, prediction and treatment monitoring methods for metastatic prostate cancer.
摘要翻译： 本发明涉及一种治疗，预防和/或诊断转移性前列腺癌的方法。 更具体地，表皮生长因子受体（EGFR）的抑制剂用于制备用于治疗或预防转移性前列腺癌的药物组合物。 EGFR抑制剂可以例如是EGFR抑制剂，EGFR信号传导抑制剂和/或EGFR激酶下游的激酶抑制剂。 EGFR抑制剂也可用于转移性前列腺癌的检测，筛选，预测和治疗监测方法。
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4.发明授权Method for predicting the response of non-small cell lung cancer patients to targeted pharmacotherapy 有权预测非小细胞肺癌患者对靶向药物治疗反应的方法公开(公告)号：US08962267B1
公开(公告)日：2015-02-24
申请号：US13138843
申请日：2010-04-12
申请人： Richard De Wijn , Robby Ruijtenbeek , Maria Helena Hilhorst , Michael Maria Van Den Heuvel , Houke Marian Klomp
发明人： Richard De Wijn , Robby Ruijtenbeek , Maria Helena Hilhorst , Michael Maria Van Den Heuvel , Houke Marian Klomp
CPC分类号： G01N33/57423 , C12Q1/485 , G01N2333/91205 , G01N2800/52
摘要： The present invention relates to a method for determining or predicting the response of a patient diagnosed with non small cell lung cancer to targeted pharmacotherapy. The present invention also aims to provide methods and devices for predicting the response of patients diagnosed with non small cell lung cancer to specific medicaments. More specifically, the present invention provides methods which measure kinase activity by studying phosphorylation levels and profiles and inhibitions thereof by drugs in samples of said patients.
摘要翻译： 本发明涉及一种用于确定或预测诊断为非小细胞肺癌的患者对靶向药物治疗的反应的方法。 本发明还旨在提供用于预测诊断为非小细胞肺癌的患者对具体药物的反应的方法和装置。 更具体地，本发明提供了通过研究所述患者样品中的药物的磷酸化水平及其特征和抑制来测量激酶活性的方法。
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5.发明申请METHOD FOR DETERMINING SURIVIVAL PROGNOSIS OF PATIENTS SUFFERING FROM NON-SMALL CELL LUNG CANCER (NSCLC) 有权确定非小细胞肺癌（NSCLC）患者生存预后的方法公开(公告)号：US20130017963A1
公开(公告)日：2013-01-17
申请号：US13138849
申请日：2010-04-12
IPC分类号： C40B30/04
CPC分类号： G01N33/57423 , C12Q1/485
摘要： The present invention relates to a method for determining the survival prognosis of patients suffering from non-small cell lung cancer. More specifically, the present invention provides methods which measure kinase activity by studying phosphorylation levels in response to a kinase inhibitor and profiles in samples obtained from patients diagnosed with non-small cell lung cancer. The present invention also provides methods for predicting the response of a patient diagnosed with non-small cell lung cancer to a medicament.
摘要翻译： 本发明涉及一种确定患有非小细胞肺癌患者的生存预后的方法。 更具体地，本发明提供了通过研究响应于激酶抑制剂的磷酸化水平和从诊断为非小细胞肺癌的患者获得的样品中的分布来测量激酶活性的方法。 本发明还提供了用于预测诊断为非小细胞肺癌的患者对药物的反应的方法。
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6.发明申请公开(公告)号：US20120135888A1
公开(公告)日：2012-05-31
申请号：US13138848
申请日：2010-04-12
申请人： Pieter Jacob Boender , Richard De Wijn , Anne Hansen Ree , Sigurd Folkvord , Kjersti Flatmark , Robby Ruijtenbeek
发明人： Pieter Jacob Boender , Richard De Wijn , Anne Hansen Ree , Sigurd Folkvord , Kjersti Flatmark , Robby Ruijtenbeek
CPC分类号： C12Q1/485 , G01N33/57419
摘要： The present invention relates to a method for determining or predicting the response of a patient diagnosed with locally advanced rectal cancer to chemoradiotherapy. The present invention also aims to provide methods and devices for predicting the response of patients diagnosed with rectal cancer to specific medicaments, radiotherapy and/or chemotherapy. More specifically, the present invention provides methods which measure kinase activity by studying phosphorylation levels and profiles in samples of said patients.
摘要翻译： 本发明涉及一种用于确定或预测诊断为局部晚期直肠癌的患者对放化疗的反应的方法。 本发明还旨在提供用于预测诊断为直肠癌的患者对特定药物，放射治疗和/或化学疗法的反应的方法和装置。 更具体地，本发明提供了通过研究所述患者的样品中的磷酸化水平和分布来测量激酶活性的方法。
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公开(公告)号：US09075061B2
公开(公告)日：2015-07-07
申请号：US13138847
申请日：2010-04-12
申请人： Robby Ruijtenbeek , Maria Helena Hilhorst , Arzu Umar , Johannes Albert Foekens , Johannes Wilhelmus Maria Martens
发明人： Robby Ruijtenbeek , Maria Helena Hilhorst , Arzu Umar , Johannes Albert Foekens , Johannes Wilhelmus Maria Martens
IPC分类号： C12Q1/48 , C40B40/10 , C40B30/08 , G01N33/574 , G01N33/74
CPC分类号： G01N33/57415 , C12Q1/485 , G01N33/74 , G01N2333/723 , G01N2800/52
摘要： The present invention relates to a method for determining the estrogen receptor status of patients suffering from breast cancer. The present invention also aims to provide methods and devices for predicting the response of patients diagnosed with breast cancer to specific medicaments. More specifically, the present invention provides methods which measure kinase activity by studying phosphorylation levels and profiles in samples obtained from patients diagnosed with breast cancer.
摘要翻译： 本发明涉及确定患有乳腺癌的患者的雌激素受体状态的方法。 本发明还旨在提供用于预测诊断为乳腺癌的患者对具体药物的反应的方法和装置。 更具体地，本发明提供了通过研究从诊断为乳腺癌的患者获得的样品中的磷酸化水平和特征来测量激酶活性的方法。
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8.发明申请公开(公告)号：US20120021939A1
公开(公告)日：2012-01-26
申请号：US13138846
申请日：2010-04-12
申请人： Robby Ruijtenbeek
发明人： Robby Ruijtenbeek
IPC分类号： C40B30/04
CPC分类号： C12Q1/485 , G01N2800/52
摘要： The present invention relates to a method for determining the effect of a drug on the kinase activity in a sample or predicting the response of a patient to a drug, wherein the kinase activity of a sample in the presence of a protein kinase inhibitor is measured, said protein kinase inhibitor mimicking the effect of said drug compound on the kinase activity in said sample.
摘要翻译： 本发明涉及一种用于测定药物对样品中激酶活性的影响或预测患者对药物的反应的方法，其中测量在蛋白激酶抑制剂存在下样品的激酶活性， 所述蛋白激酶抑制剂模拟所述药物化合物对所述样品中激酶活性的影响。
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公开(公告)号：US20110111980A1
公开(公告)日：2011-05-12
申请号：US12736468
申请日：2009-04-10
申请人： René Houtman , Robby Ruijtenbeek
发明人： René Houtman , Robby Ruijtenbeek
CPC分类号： C12Q1/485
摘要： The present invention relates to systems and methods for testing kinase inhibition using an array of substrates, in particular protein kinase substrates, preferably immobilized on a porous matrix. More particularly, the method provides kinase inhibition profiles of kinase inhibitors using phosphorylation patterns. The present invention can therefore be used to predict the response of cells, tissues, organs and/or warm-blooded animals to a drug, to determine the clinical outcome of a drug therapy and for diagnostical and prognostical purposes.
摘要翻译： 本发明涉及使用基底阵列，特别是蛋白激酶底物测试激酶抑制的系统和方法，优选固定在多孔基质上。 更具体地，该方法使用磷酸化模式提供激酶抑制剂的激酶抑制曲线。 因此，本发明可用于预测细胞，组织，器官和/或温血动物对药物的反应，以确定药物治疗的临床结果以及用于诊断和预后目的。
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10.发明授权Modified tyrosine amino acids, peptides containing them, and their use for detecting hydrolase enzyme activity 有权修饰的酪氨酸氨基酸，含有它们的肽，以及它们用于检测水解酶活性的用途公开(公告)号：US09448237B2
公开(公告)日：2016-09-20
申请号：US14118920
申请日：2012-05-18
IPC分类号： C07K2/00 , C07K14/00 , G01N33/573 , C07C305/24 , C07F9/12 , C12Q1/42 , C07F9/08
CPC分类号： G01N33/573 , C07C305/24 , C07F9/08 , C07F9/12 , C12Q1/42
摘要： The present invention relates to a method and tools which allow the kinetic monitoring of hydrolase enzyme activity. The present invention also aims to provide synthetic peptides and peptide residues modified such that they can be used in assays for monitoring hydrolase enzyme activity, and preferably phosphatase activity. Also claimed are modified tyrosine amino acid derivatives of formula (IV), wherein Y is chosen from —POy2− with y equal to 2 or 3 and esters thereof, —SOZ− with z equal to 2 or 3 and esters thereof, a carbohydrate or carbohydrate derivatives; and; wherein X1 and/or X2 is selected from —N3, —NO2, —CI, or —CN, —SCN, a C1 to C8 alkyl, or H, wherein either X1 or X2 is not H.
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