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14 条记录 (耗时 0.031 秒)

    Interfacial biomaterials for binding ceramic substrates
    6.
    发明申请
    Interfacial biomaterials for binding ceramic substrates 审中-公开
    用于粘结陶瓷基材的界面生物材料

    公开(公告)号：US20060263831A1

    公开(公告)日：2006-11-23

    申请号：US11346855

    申请日：2006-02-03

    申请人： Mark Grinstaff ,  Daniel Kenan ,  Elisabeth Walsh ,  Crystan Middleton

    发明人： Mark Grinstaff ,  Daniel Kenan ,  Elisabeth Walsh ,  Crystan Middleton

    IPC分类号： G01N33/567 ,  C12M1/34 ,  G01N33/543 ,  G01N33/53

    CPC分类号： G01N33/543 ,  A61L27/227 ,  A61L27/34 ,  C08L89/00

    摘要： An interfacial biomaterial prepared using a plurality of binding agents, each binding agent including a first ligand that specifically binds a non-biological substrate and a second ligand that specifically binds a biological substrate. Also provided Is an interfacial biomaterial prepared using a plurality of binding agents, each binding agent including a ligand that specifically binds a non-biological substrate and a non-binding domain that shows substantially no binding to a biological substrate. Also provided are methods for preparing a binding agent, methods for preparing an interfacial biomaterial, and methods for using interfacial biomaterials.

    摘要翻译： 使用多种结合剂制备的界面生物材料，每种结合剂包括特异性结合非生物底物的第一配体和特异性结合生物底物的第二配体。 还提供了使用多种结合剂制备的界面生物材料，每种结合剂包括特异性结合非生物底物的配体和基本上不与生物底物结合的非结合结构域。 还提供了制备粘合剂的方法，制备界面生物材料的方法以及使用界面生物材料的方法。

    Interfacial biomaterials for binding metal substrates
    8.
    发明申请
    Interfacial biomaterials for binding metal substrates 审中-公开
    用于结合金属底物的界面生物材料

    公开(公告)号：US20060216772A1

    公开(公告)日：2006-09-28

    申请号：US11329292

    申请日：2006-01-10

    申请人： Mark Grinstaff ,  Daniel Kenan ,  Elisabeth Walsh ,  Crystan Middleton

    发明人： Mark Grinstaff ,  Daniel Kenan ,  Elisabeth Walsh ,  Crystan Middleton

    IPC分类号： G01N33/558 ,  C07K7/08 ,  C07K7/06

    CPC分类号： G01N33/543 ,  A61L27/227 ,  A61L27/34 ,  C08L89/00

    摘要： An interfacial biomaterial prepared using a plurality of binding agents, each binding agent including a first ligand that specifically binds a non-biological substrate and a second ligand that specifically binds a biological substrate. Also provided is an interfacial biomaterial prepared using a plurality of binding agents, each binding agent including a ligand that specifically binds a non-biological substrate and a non-binding domain that shows substantially no binding to a biological substrate. Also provided are methods for preparing a binding agent, methods for preparing an interfacial biomaterial, and methods for using interfacial biomaterials.

    摘要翻译： 使用多个结合剂制备的界面生物材料，每个结合剂包括特异性结合非生物底物的第一配体和特异性结合生物底物的第二配体。 还提供了使用多种结合剂制备的界面生物材料，每种结合剂包括特异性结合非生物底物的配体和基本上不与生物底物结合的非结合结构域。 还提供了制备粘合剂的方法，制备界面生物材料的方法以及使用界面生物材料的方法。

    Biofunctional, antimicrobial coatings for medical devices
    9.
    发明授权
    Biofunctional, antimicrobial coatings for medical devices 失效
    用于医疗器械的生物功能性抗菌涂层

    公开(公告)号：US07608581B2

    公开(公告)日：2009-10-27

    申请号：US11638973

    申请日：2006-12-14

    申请人： Paul Hamilton ,  Daniel Kenan ,  Mark Grinstaff

    发明人： Paul Hamilton ,  Daniel Kenan ,  Mark Grinstaff

    IPC分类号： C07K14/00

    CPC分类号： A61L27/227 ,  A61K38/00 ,  A61L27/34 ,  A61L27/54 ,  A61L2300/404 ,  A61L2300/606 ,  C07K7/08 ,  C07K14/001 ,  C08L89/00

    摘要： The present invention provides compositions and methods for an improved coating for medical devices. Provided is an interfacial biomaterial or biofunctional coating composition comprising at least one binding domain that has bind specificity for a surface material of a medical device, and at least one binding domain that has binding specificity for an antimicrobial composition. Methods for coating a surface of a medical device, and for manufacturing of a medical device, comprise contacting the surface to be coated with the biofunctional coating material in an amount effective to form a coating.

    摘要翻译： 本发明提供用于医疗装置的改进涂层的组合物和方法。 本发明提供了一种界面生物材料或生物功能性涂料组合物，其包含至少一个对医疗器械的表面材料具有结合特异性的结合结构域和至少一个对抗微生物组合物具有结合特异性的结合结构域。 用于涂覆医疗装置的表面和用于制造医疗装置的方法包括以有效形成涂层的量使待涂覆的表面与生物功能性涂层接触。

    Crosslinked gels comprising polyalkyleneimines, and their uses as medical devices
    10.
    发明申请
    Crosslinked gels comprising polyalkyleneimines, and their uses as medical devices 有权

    公开(公告)号：US20070196454A1

    公开(公告)日：2007-08-23

    申请号：US11653433

    申请日：2007-01-11

    申请人： Kenneth Stockman ,  Michael Carnahan ,  Keith D'Alessio ,  Mark Grinstaff

    发明人： Kenneth Stockman ,  Michael Carnahan ,  Keith D'Alessio ,  Mark Grinstaff

    IPC分类号： A61K31/785 ,  A61K31/787

    CPC分类号： A61L26/0019 ,  A61B2017/0065 ,  A61B2017/00951 ,  A61K31/785 ,  A61K31/787 ,  A61K51/1279 ,  A61L24/0031 ,  A61L24/0036 ,  A61L24/043 ,  A61L24/046 ,  A61L26/0052 ,  A61L26/008 ,  A61L26/0085 ,  A61L27/18 ,  A61L27/26 ,  A61L27/52 ,  A61L27/56 ,  C08L79/02

    摘要： One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneamine. In a preferred embodiment, the polyalkyleneamine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer. In certain instances, the polyethyleneimine is mixed with a second polymer, such as a polyethylene glycol containing nucleophilic groups. In certain instances, the compositions used to seal the wound or tissue plane are formed by reacting a polyalkyleneamine bearing electrophilic groups with a cross-linking reagent containing nucleophilic groups. In certain instances, the electrophilic groups on the polyalkyleneamine are activated esters, such as N-hydroxy succinimide ester. In certain instances, the compositions used to seal the wound or tissue plane are formed by reacting a polyalkyleneamine bearing photopolymerizable groups with ultraviolet or visibile light. Compositions used to seal the wound which contain PEI or a derivative of PEI are found to adhere tightly to the tissue. Other aspects of the present invention relate to methods of filling a void of a patient or adhering tissue. In certain instances, the methods use a polyalkyleneamine. In a preferred embodiment, the polyalkyleneamine is polyethyleneimine. Another aspect of the present invention relates to a polymeric composition formed by exposing a polyalkyleneamine to an activated polyalkylene glycol. In certain instances, the composition is attached to mammalian tissue.