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    CENTRIFUGAL FORCE BASED MICROFLUIDIC DEVICE FOR DILUTION AND MICROFLUIDIC SYSTEM INCLUDING THE SAME
    2.
    发明申请
    CENTRIFUGAL FORCE BASED MICROFLUIDIC DEVICE FOR DILUTION AND MICROFLUIDIC SYSTEM INCLUDING THE SAME 失效
    基于离散力的微流体装置，包括它们的渗透和微流体系统

    公开(公告)号：US20080193336A1

    公开(公告)日：2008-08-14

    申请号：US12029480

    申请日：2008-02-12

    申请人： Yoon-kyoung CHO ,  Jeong-gun Lee ,  Beom-seok Lee ,  Jong-myeon Park ,  Young-sun Lee

    发明人： Yoon-kyoung CHO ,  Jeong-gun Lee ,  Beom-seok Lee ,  Jong-myeon Park ,  Young-sun Lee

    IPC分类号： B01L11/00

    CPC分类号： B01L3/502738 ,  B01L3/50273 ,  B01L3/502792 ,  B01L2200/0605 ,  B01L2200/0647 ,  B01L2200/16 ,  B01L2300/0806 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/1861 ,  B01L2400/0409 ,  B01L2400/0677

    摘要： Provided are a centrifugal force based microfluidic device which can automatically perform a dilution operation and a microfluidic system including the same. The centrifugal force based microfluidic device for dilution includes a rotatable disk type platform, a mixing chamber disposed on the platform; a buffer solution storage disposed on a portion of the platform which is closer to a center of the platform than the mixing chamber, connected to the mixing chamber through a channel to supply a predetermined amount of buffer solution to the mixing chamber at least one time, and a plurality of diluted solution chambers which are disposed on a portion of the platform which is farther from the center of the platform than the mixing chamber, are each connected to the mixing chamber through flow paths extended from a middle exit corresponding to a predetermined water level, and sequentially receiving a solution which is serially diluted in the mixing chamber at least one time.

    摘要翻译： 提供了一种能够自动执行稀释操作的离心力微流体装置和包括其的微流体系统。 用于稀释的基于离心力的微流体装置包括可旋转盘式平台，设置在平台上的混合室; 缓冲溶液储存器，其设置在所述平台的比混合室更靠近所述平台的中心的部分上，所述缓冲溶液存储器经由通道至少一次向所述混合室提供预定量的缓冲溶液，所述通道连接到所述混合室， 并且多个稀释溶液室通过从对应于预定水的中间出口延伸的流路连接到平台的比混合室更远离平台中心的部分上的稀释溶液室 至少一次连续地接收在混合室中连续稀释的溶液。

    Centrifugal force-based microfluidic device for protein detection and microfluidic system including the same
    6.
    发明授权
    Centrifugal force-based microfluidic device for protein detection and microfluidic system including the same 有权
    用于蛋白质检测和微流体系统的基于离心力的微流体装置包括相同的

    公开(公告)号：US07776267B2

    公开(公告)日：2010-08-17

    申请号：US11850129

    申请日：2007-09-05

    申请人： Beom-seok Lee ,  Yoon-kyoung Cho ,  Jeong-gun Lee ,  Jong-myeon Park

    发明人： Beom-seok Lee ,  Yoon-kyoung Cho ,  Jeong-gun Lee ,  Jong-myeon Park

    IPC分类号： G01N9/30

    CPC分类号： G01N33/54326 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0806 ,  B01L2300/0867 ,  B01L2300/1861 ,  B01L2400/0409 ,  B01L2400/0633 ,  B01L2400/0677 ,  B01L2400/0688 ,  G01N33/54366 ,  Y10T436/25375

    摘要： A centrifugal force-based microfluidic device for the detection of a target biomolecule and a microfluidic system including the same are provided. The device includes a body of revolution; a microfluidic structure disposed in the body of revolution including chambers, channels connecting the chambers, and valves disposed in the channels to control fluid flow, the microfluidic structures transmitting fluid using centrifugal force due to rotation of the body of revolution; and beads disposed in the microfluidic structures, the beads having capture probes on the surfaces thereof which are selectively bonded with target protein; and a detection probe disposed in the microfluidic structures and selectively bonded to the target protein, and which includes a material required to express an optical signal, wherein the microfluidic structure mixes the beads, biological samples, and the detection probe to react and washes and separates the beads after the reaction.

    摘要翻译： 提供了用于检测靶生物分子的离心力微流体装置和包括其的微流体系统。 该装置包括一个革命体; 设置在旋转体中的微流体结构，包括腔室，连接腔室的通道，以及设置在通道中的阀，以控制流体流动，微流体结构由于旋转体旋转而使用离心力传送流体; 和珠子，其设置在微流体结构中，珠粒在其表面上具有与靶蛋白质选择性结合的捕获探针; 以及设置在微流体结构中并选择性地结合到靶蛋白上并且包括表达光信号所需的材料的检测探针，其中微流体结构混合珠，生物样品和检测探针以反应和洗涤和分离 反应后的珠子。

    Microfluidic device using microfluidic chip and microfluidic device using biomolecule microarray chip
    10.
    发明授权
    Microfluidic device using microfluidic chip and microfluidic device using biomolecule microarray chip 有权
    使用微流控芯片和微流控器件的微流控器件使用生物分子微阵列芯片

    公开(公告)号：US08333935B2

    公开(公告)日：2012-12-18

    申请号：US13168298

    申请日：2011-06-24

    申请人： Beom-seok Lee ,  Jeong-gun Lee ,  Jong-myeon Park ,  Yoon-kyoung Cho

    发明人： Beom-seok Lee ,  Jeong-gun Lee ,  Jong-myeon Park ,  Yoon-kyoung Cho

    IPC分类号： C40B40/00

    CPC分类号： B01L3/502738 ,  B01L3/502707 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/0621 ,  B01L2200/16 ,  B01L2300/04 ,  B01L2300/0636 ,  B01L2300/0806 ,  B01L2400/0409 ,  B01L2400/0677 ,  Y10T436/15

    摘要： Disclosed is a microfluidic device including a microfluidic structure formed in a platform in which various examinations, such as an immune serum examination, can be automatically performed using the biomolecule microarray chip. The biomolecule microarray chip-type microfluidic device using a biomolecule microarray chip comprises: a platform which is rotatable; a microfluidic structure disposed in the platform, comprising: a plurality of chambers; a plurality of channels connecting the chambers each other; and a plurality of valves controlling flow of fluids through the channels, wherein the microfluidic structure controls flow of a fluid sample using rotation of the platform and the valves; and a biomolecule microarray chip mounted in the platform such that biomolecule capture probes bound to the biomolecule microarray chip contact the fluid sample in the microfluidic structure.

    摘要翻译： 公开了一种微流体装置，其包括在平台中形成的微流体结构，其中可以使用生物分子微阵列芯片自动执行各种检查，例如免疫血清检查。 使用生物分子微阵列芯片的生物分子微阵列芯片型微流器件包括：可旋转的平台; 设置在平台中的微流体结构，包括：多个室; 连接所述室的多个通道; 以及多个阀，其控制通过所述通道的流体流动，其中所述微流体结构通过所述平台和所述阀的旋转来控制流体样品的流动; 以及安装在平台中的生物分子微阵列芯片，使得与生物分子微阵列芯片结合的生物分子捕获探针与微流体结构中的流体样品接触。