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公开(公告)号：US09587222B2
公开(公告)日：2017-03-07
申请号：US10567728
申请日：2004-02-02
CPC分类号： C12N5/0658 , A61K35/12 , A61K35/34 , A61L27/3804 , A61L27/3834 , A61L27/3839 , A61L27/3895 , A61L2430/20 , C12N5/0068 , C12N5/0657 , C12N2506/02 , C12N2506/1392 , C12N2513/00 , C12N2523/00 , C12N2533/40 , C12N2539/10
摘要： The present invention provides a prosthetic tissue or sheet capable of withstanding implantation operations, which can be used in actual operation and can be produced by culture. The present invention also provides a novel therapy which can substitute for cell therapy. Particularly, the present invention provides a method for producing a prosthetic tissue comprising a cell derived from a part other than myocardium and capable of withstanding implantation operation. The above-described objects of the present invention were partially achieved by finding that by culturing cells under specific culture conditions, the cells are unexpectedly organized into a tissue, and the resultant prosthetic tissue is capable of being detached from culture dishes. The present invention also provides a three-dimensional structure applicable to heart, comprising a cell derived from a part other than the myocardium of an adult.
摘要翻译： 本发明提供能够承受植入操作的假体组织或片材，其可以在实际操作中使用并且可以通过培养产生。 本发明还提供了可代替细胞治疗的新型治疗方法。 特别地，本发明提供了一种用于制造假体组织的方法，所述假体组织包含源于除了心肌之外的部分的细胞并且能够承受植入操作。 通过发现通过在特定培养条件下培养细胞，细胞意外地组织成组织，并且所得到的假体组织能够从培养皿中分离，部分实现了本发明的上述目的。 本发明还提供了适用于心脏的三维结构，其包含源自成人心肌之外的部分的细胞。
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公开(公告)号：US20070244568A1
公开(公告)日：2007-10-18
申请号：US10584740
申请日：2004-12-24
申请人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shigeru Miyagawa , Shigemitau Iwai , Takeyoshi Ota , Jun Miyake , Masayuki Hara , Masakazu Furuta , Eiichiro Uchimura
发明人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shigeru Miyagawa , Shigemitau Iwai , Takeyoshi Ota , Jun Miyake , Masayuki Hara , Masakazu Furuta , Eiichiro Uchimura
IPC分类号： A61F2/02
CPC分类号： A61L27/3683 , A61L27/3604
摘要： Decellularization of tissue by means of an amphipathic solvent a well-established practice. However, situations exist where the provision of enhanced decellularization is preferred. There is a demand for treating methods for coping with such situations. Thus, it is intended to provide a method for enhancing decellularization. The method comprises not only the immersing of a tissue in a solution containing an amphiphilic molecule in non-micellar form (for example, 1,2-epoxide polymer) but also performing a radical reaction (for example, treatment selected from the group consisting of exposure to gamma-ray irradiation, ultraviolet irradiation, a free radical supply source, ultrasonication, electron beam irradiation, and X-ray irradiation).
摘要翻译： 通过两性溶剂去除细胞组织，这是一个很好的做法。 然而，存在提供增强脱细胞化优先的情况。 需要处理这种情况的方法。 因此，旨在提供一种增强脱细胞化的方法。 该方法不仅包括将组织浸入含有非胶束形式的两亲分子（例如1,2-环氧化物聚合物）的溶液中，而且还进行自由基反应（例如，选自由 暴露于γ射线照射，紫外线照射，自由基供应源，超声波处理，电子束照射和X射线照射）。
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公开(公告)号：US20070092492A1
公开(公告)日：2007-04-26
申请号：US10567728
申请日：2004-02-02
CPC分类号： C12N5/0658 , A61K35/12 , A61K35/34 , A61L27/3804 , A61L27/3834 , A61L27/3839 , A61L27/3895 , A61L2430/20 , C12N5/0068 , C12N5/0657 , C12N2506/02 , C12N2506/1392 , C12N2513/00 , C12N2523/00 , C12N2533/40 , C12N2539/10
摘要： The present invention provides a prosthetic tissue or sheet capable of withstanding implantation operations, which can be used in actual operation and can be produced by culture. The present invention also provides a novel therapy which can substitute for cell therapy. Particularly, the present invention provides a method for producing a prosthetic tissue comprising a cell derived from a part other than myocardium and capable of withstanding implantation operation. The above-described objects of the present invention were partially achieved by finding that by culturing cells under specific culture conditions, the cells are unexpectedly organized into a tissue, and the resultant prosthetic tissue is capable of being detached from culture dishes. The present invention also provides a three-dimensional structure applicable to heart, comprising a cell derived from a part other than the myocardium of an adult.
摘要翻译： 本发明提供能够承受植入操作的假体组织或片材，其可以在实际操作中使用并且可以通过培养产生。 本发明还提供了可代替细胞治疗的新型治疗方法。 特别地，本发明提供了一种用于制造假体组织的方法，所述假体组织包含源于除了心肌之外的部分的细胞并且能够承受植入操作。 通过发现通过在特定培养条件下培养细胞，细胞意外地组织成组织，并且所得到的假体组织能够从培养皿中分离，部分实现了本发明的上述目的。 本发明还提供了适用于心脏的三维结构，其包含源自成人心肌之外的部分的细胞。
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4.发明申请公开(公告)号：US20060018941A1
公开(公告)日：2006-01-26
申请号：US10954639
申请日：2004-09-30
申请人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shin Kawamata , Shigeru Miyagawa , Emi Maeno , Yoshiho Toyota , Shinji Ozawa
发明人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shin Kawamata , Shigeru Miyagawa , Emi Maeno , Yoshiho Toyota , Shinji Ozawa
IPC分类号： A61F13/00
CPC分类号： A61M5/1456 , A61M5/14566 , A61M5/14593 , A61M5/482 , A61M5/488 , A61M2005/14513 , C12M35/00
摘要： A method for injecting a liquid drug containing a biological material is provided, which comprises the step of injecting the liquid drug containing the biological material contained in an injector into a subject at a predetermined range of velocity.
摘要翻译： 提供了一种用于注射含有生物材料的液体药物的方法，其包括将包含在注射器中的生物材料的液体药物以预定的速度范围注射到受试者中的步骤。
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5.发明申请公开(公告)号：US20050070874A1
公开(公告)日：2005-03-31
申请号：US10675254
申请日：2003-09-30
申请人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shin Kawamata , Shigeru Miyagawa , Emi Maeno , Yoshiho Toyota , Shinji Ozawa
发明人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shin Kawamata , Shigeru Miyagawa , Emi Maeno , Yoshiho Toyota , Shinji Ozawa
CPC分类号： A61M5/1456 , A61M5/14566 , A61M5/14593 , A61M5/482 , A61M5/488 , A61M2005/14513 , C12M35/00
摘要： A method for injecting a liquid drug containing a biological material is provided, which comprises the step of injecting the liquid drug containing the biological material contained in an injector into a subject at a predetermined range of velocity.
摘要翻译： 提供了一种用于注射含有生物材料的液体药物的方法，其包括将包含在注射器中的生物材料的液体药物以预定的速度范围注射到受试者中的步骤。
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公开(公告)号：US20150032223A1
公开(公告)日：2015-01-29
申请号：US14008769
申请日：2012-04-02
IPC分类号： A61F2/02
摘要： A cell sheet transplantation device having a plane for transplanting a sheet of cultured cells, the device comprising, in the plane in the same direction, (1) a planar surface portion for capturing a cell sheet while maintaining a sheet-shaped form, and (2) suction holes for immobilizing a transplantation site by suction, the suction holes being positioned around the planar surface portion. By using the cell sheet transplantation device, a cultured cell sheet can be detached effectively, and the detached cultured cell sheet can be transplanted in an effective and simple manner.
摘要翻译： 一种具有用于移植培养细胞片的平面的细胞移植装置，所述装置在相同方向的平面中包括（1）用于在保持片状形状的同时捕获细胞片的平面部分，以及（ 2）用于通过抽吸固定移植部位的吸孔，吸孔位于平面部分周围。 通过使用细胞移植装置，可以有效地剥离培养的细胞片，并且可以有效且简单地移植分离的培养细胞片。
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7.发明申请CELL SHEET FOR MYOCARDIAL REGENERATION, METHOD OF PRODUCING THE SAME, AND METHOD OF USING THE SAME 审中-公开用于心肌细胞再生的细胞片及其制备方法及其使用方法公开(公告)号：US20130101659A1
公开(公告)日：2013-04-25
申请号：US13509322
申请日：2010-09-09
申请人： Yoshiki Sawa , Yasuhiro Shudo , Shigeru Miyagawa , Tatsuya Shimizu , Teruo Okano , Akifumi Matsuyama , Atsuhiro Saito
发明人： Yoshiki Sawa , Yasuhiro Shudo , Shigeru Miyagawa , Tatsuya Shimizu , Teruo Okano , Akifumi Matsuyama , Atsuhiro Saito
CPC分类号： A61K35/34 , A61K9/70 , A61K35/12 , A61K35/28 , A61K38/18 , A61K38/19 , A61L27/367 , A61L27/3826 , A61L27/3834 , A61L27/3886 , A61L27/3891 , C12N5/0657 , C12N5/0697 , C12N2502/1329 , C12N2502/1382 , C12N2513/00 , C12N2539/10
摘要： Provided are a cell sheet and a three-dimensional structure thereof that include at least mesenchymal stem cells and myoblasts isolated from a cell culture support and that are to be applied to heart disease. Use of the cell sheet and the three-dimensional structure thereof including mesenchymal stem cells and myoblasts can notably improve cardiac functions compared with a conventional technology, i.e., use of cell sheets composed of myoblasts only or mesenchymal stem cells only. Furthermore, the cell sheet itself has high strength, and the transplantation procedure is also improved.
摘要翻译： 提供一种细胞片及其三维结构，其至少包括间充质干细胞和从细胞培养支持物分离的并且应用于心脏病的成肌细胞。 包括间充质干细胞和成肌细胞在内的细胞片及其三维结构的使用与常规技术相比，可以显着地改善心脏功能，即仅使用由成肌细胞或间充质干细胞构成的细胞片。 此外，细胞片本身具有高强度，并且移植程序也得到改善。
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8.发明申请ADIPOCYTE SHEET, THREE-DIMENSIONAL STRUCTURE THEREOF, AND METHOD FOR PRODUCING THE SAME 审中-公开其特征在于其三维结构及其生产方法公开(公告)号：US20120308533A1
公开(公告)日：2012-12-06
申请号：US13513489
申请日：2010-10-08
申请人： Yukiko Imanishi , Yoshiki Sawa , Iichiro Shimomura , Norikazu Maeda , Shigeru Miyagawa , Hideaki Sakai
发明人： Yukiko Imanishi , Yoshiki Sawa , Iichiro Shimomura , Norikazu Maeda , Shigeru Miyagawa , Hideaki Sakai
CPC分类号： A61L27/3804 , A61K35/35 , A61L27/3683 , A61L27/3691 , A61L27/3695 , A61L27/3839 , A61L27/3891 , A61L2300/64 , A61L2430/20 , C12N5/0653 , C12N2500/38 , C12N2501/33 , C12N2501/39 , C12N2539/10
摘要： The present invention aims to provide an artificial tissue that can efficiently reproduce myocardial tissue function and that can be used in an actual implantation and produced by culturing. The present invention relates to a graft material for treating myocardial disease, the graft material including a cell sheet containing adipocytes.
摘要翻译： 本发明的目的在于提供能够有效地再现心肌组织功能的人造组织，其可以用于实际植入中并通过培养产生。 本发明涉及用于治疗心肌疾病的移植材料，该移植材料包括含有脂肪细胞的细胞片。
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公开(公告)号：US06346433B1
公开(公告)日：2002-02-12
申请号：US09523420
申请日：2000-03-10
申请人： Keiji Maeda , Shigeru Miyagawa
发明人： Keiji Maeda , Shigeru Miyagawa
IPC分类号： H01L2150
CPC分类号： H01L21/565 , H01L2924/0002 , H01L2924/00
摘要： In a method of coating a semiconductor wafer with a resin of the present invention, first, a semiconductor wafer is placed on a bottom surface of a cavity provided in a molding surface of a lower mold of a mold with its surface having a bump facing upward. Thereafter, a required amount of resin material is supplied to cavity, and a film for exposing the bump is applied to a molding surface of the upper one of the molds. In this state, molds are closed together. Resin material is heated to melt in cavity. Then, film is pressed against the bottom surface of cavity by a pressing member provided on the molding surface of the upper mold, so that film is abutted against a leading edge of bump in cavity. A pressure is applied to the resin in cavity through film, and the surface having the bump of semiconductor wafer is coated with resin. According to the method, pressing member is provided on the upper mold, so that melted resin does not enter a sliding portion. Accordingly, productivity of the resin-coated wafer increases and a resin-coated wafer with high quality and reliability is obtained.
摘要翻译： 在利用本发明的树脂涂覆半导体晶片的方法中，首先，将半导体晶片放置在设置在模具的下模具的模制表面中的空腔的底表面上，其表面具有朝上的凸起 。 此后，将所需量的树脂材料供应到空腔中，并且将用于暴露凸块的膜施加到上模具的模制表面。 在这种状态下，模具封闭在一起。 将树脂材料在空腔中加热熔化。 然后，通过设置在上模的模制表面上的按压构件将膜压在空腔的底表面上，使得膜抵住空腔中凸起的前缘。 在空腔通过膜中对树脂施加压力，并且用树脂涂覆具有半导体晶片的凸块的表面。 根据该方法，在上模具上设置按压部件，使熔融树脂不进入滑动部。 因此，树脂涂覆的晶片的生产率增加，并且获得了具有高质量和可靠性的树脂涂覆的晶片。
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