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公开(公告)号：US20090158686A1
公开(公告)日：2009-06-25
申请号：US11992286
申请日：2007-05-30
CPC分类号： E04B1/3205 , B21D47/02 , E04B1/19 , E04B1/1903 , E04B1/3211 , E04B2001/1927 , E04B2001/1933 , E04B2001/1984 , E04C2003/0486
摘要： There is provided a truss element in which space truss diagonal members can be easily integrally formed by being drawn in a predetermined direction. This truss element is formed in a corrugated shape with mountain portions 1a and valley portions 2 in left and right directions alternately and cut portions 4a, each which is perpendicular to a ridge line 3 of the mountain portion 1 and leaves a bottom of the valley portion uncut, and cut portions 4b, each which is perpendicular to a bottom line 5 of the valley and leaves a peak of the mountain portion uncut, are formed alternately with spaces in a front and back directions.
摘要翻译： 提供了一种桁架元件，其中空间桁架对角构件可以通过沿预定方向被拉伸而容易地一体地形成。 该桁架元件形成为具有左右方向上的山部1a和谷部2的波纹形状，以及与山部1的脊线3垂直的山形部分的底部的切口部4a， 未切割的切口部分4b和垂直于谷底线5并且留下未切割的山部分的顶点的切割部分4b以前后方向交替地形成空间。
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公开(公告)号：US08996097B2
公开(公告)日：2015-03-31
申请号：US11434657
申请日：2006-05-15
CPC分类号： A61B3/101 , A61B3/10 , A61B3/14 , A61B5/0071 , A61B2576/02 , A61M2210/0612 , G06T7/0014 , G06T2207/30041
摘要： In an ophthalmic measuring method, a traceable marker in particulate form is administered to the lachrymal fluid of a subject's eye, and the lachrymal fluid is irradiated with illuminating light. Images of the illuminated lachrymal fluid are electronically captured respectively at different times. Two images from among the captured images are selected, with each of the two selected images displaying the traceable marker. A characteristic point of each of the two selected images is specified. A movement speed of the traceable marker is measured based on positions thereof in the two selected images and on a time difference from specifying the characteristic point of one of the two selected images to specifying the characteristic point of the other of the two selected images. The measured movement speed of the traceable marker is outputted as the movement speed of the lachrymal fluid of the subject's eye.
摘要翻译： 在眼科测定方法中，向受试者眼睛的泪液施用颗粒状的可追踪标记物，并用照射光照射泪液。 照射的泪液的图像分别在不同时间被电子捕获。 选择拍摄图像中的两个图像，其中两个所选图像中的每一个显示可追踪标记。 指定两个所选图像中的每一个的特征点。 可追踪标记的运动速度是根据两个所选图像中的位置以及与指定两个所选图像之一的特征点的指定时间差来确定两个所选图像中的另一个的特征点来测量的。 可追踪标记的测量移动速度作为受试者眼睛的泪液的移动速度输出。
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3.发明授权Methods for corneal endothelial proliferation using bFGF sustained-release gelatin hydrogel particles 有权使用bFGF缓释明胶水凝胶颗粒进行角膜内皮增殖的方法公开(公告)号：US08895508B2
公开(公告)日：2014-11-25
申请号：US13386844
申请日：2009-07-24
申请人： Yasuhiko Tabata , Shigeru Kinoshita , Noriko Koizumi , Yuji Sakamoto , Naoki Okumura , Hiroaki Takahashi
发明人： Yasuhiko Tabata , Shigeru Kinoshita , Noriko Koizumi , Yuji Sakamoto , Naoki Okumura , Hiroaki Takahashi
CPC分类号： A61K38/1825 , A61K9/0048 , A61K9/06 , A61K47/42
摘要： The present invention aims to provide a corneal endothelium cell proliferation accelerator and a therapeutic agent for a disease relating to corneal endothelium damage, which are administered into the anterior chamber. bFGF is released in a sustained manner by forming bFGF sustained-release gelatin hydrogel particles wherein bFGF is carried on gelatin hydrogel. Therefore, the proliferation of corneal endothelium cells can be accelerated persistently by administration of a preparation containing the bFGF sustained-release gelatin hydrogel particles into the anterior chamber, and diseases relating to corneal endothelium damage can be treated.
摘要翻译： 本发明的目的在于提供角膜内皮细胞增殖促进剂和与角膜内皮损伤相关的疾病的治疗剂，其被施用于前房。 通过形成bFGF缓释明胶水凝胶颗粒，其中bFGF携带在明胶水凝胶上，以持续的方式释放bFGF。 因此，可以通过将含有bFGF缓释明胶水凝胶颗粒的制剂给予前房来持续加速角膜内皮细胞的增殖，并且可以治疗与角膜内皮损伤有关的疾病。
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公开(公告)号：US20140220102A1
公开(公告)日：2014-08-07
申请号：US14175369
申请日：2014-02-07
IPC分类号： A61L27/36
CPC分类号： A61L27/3604 , A61L27/3641 , A61L27/3666 , A61L27/3683 , A61L27/3813 , A61L27/3839 , A61L2430/16
摘要： It is intended to provide a transplantation material applicable to ocular surface diseases with a need for ectocornea transplantation (i.e., an ectocornea-like sheet). Oral mucosal epithelial cells are inoculated onto an amnion and then cultured in the coexistence of supporter cells. When a layered structure of the oral mucosal epithelial cells is formed, the outermost layer is brought into contact with air, thereby inducing differentiation. Thus, an ectocornea-like sheet having an oral mucosal epithelial cell layer on the amnion is obtained.
摘要翻译： 旨在提供适用于需要外耳道移植的眼表疾病的移植材料（即外胚层样片材）。 将口腔粘膜上皮细胞接种到羊膜上，然后在支持细胞共存下培养。 当形成口腔粘膜上皮细胞的分层结构时，最外层与空气接触，从而诱导分化。 因此，获得了在羊膜上具有口腔粘膜上皮细胞层的异齿角膜状片。
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5.发明授权公开(公告)号：US08592885B2
公开(公告)日：2013-11-26
申请号：US13365470
申请日：2012-02-03
IPC分类号： H01L29/78 , H01L21/336
CPC分类号： H01L21/28273 , H01L29/42336 , H01L29/66825
摘要： According to one embodiment, a nonvolatile semiconductor memory device includes a substrate, a tunneling insulating film, a floating gate, a leak suppression unit, an inter-gate insulating film, and a control gate. The substrate includes silicon. The tunneling insulating film is provided on the substrate. The floating gate is provided on the tunneling insulating film. The leak suppression unit is provided on the floating gate. The inter-gate insulating film is provided on the leak suppression unit. The control gate is provided on the inter-gate insulating film. The dielectric constant of the leak suppression unit is higher than a dielectric constant of the inter-gate insulating film.
摘要翻译： 根据一个实施例，非易失性半导体存储器件包括衬底，隧道绝缘膜，浮动栅极，泄漏抑制单元，栅极间绝缘膜和控制栅极。 衬底包括硅。 隧道绝缘膜设置在基板上。 浮动栅极设置在隧道绝缘膜上。 泄漏抑制单元设置在浮动栅极上。 栅极间绝缘膜设置在泄漏抑制单元上。 控制栅极设置在栅极间绝缘膜上。 泄漏抑制单元的介电常数高于栅极间绝缘膜的介电常数。
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公开(公告)号：US08231908B2
公开(公告)日：2012-07-31
申请号：US11989296
申请日：2006-07-19
IPC分类号： A61K35/54
CPC分类号： A61L27/3604 , A01N1/0226 , A61L27/3683 , A61L27/3813 , A61L27/50
摘要： A sheet-shaped composition is provided which has an improved preservability and handling readiness, as well as a high flexibility in use. Amnion with trehalose added thereto is utilized. Addition of trehalose improves the flexibility of the amnion, and prevents basal membrane and stratum compactum from being damaged during lyophilization process.
摘要翻译： 提供了具有改进的保存性和处理准备性以及使用高度灵活性的片状组合物。 利用添加了海藻糖的羊膜。 加入海藻糖可以改善羊膜的柔韧性，并防止在冻干过程中基底膜和地层受到损伤。
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公开(公告)号：US20110284671A1
公开(公告)日：2011-11-24
申请号：US12995010
申请日：2009-05-11
申请人： Seiichi Yamamoto , Takuo Shigehisa , Satoru Sugita , Yuko Sugita , Yutaka Mitou , Shigeru Kinoshita
发明人： Seiichi Yamamoto , Takuo Shigehisa , Satoru Sugita , Yuko Sugita , Yutaka Mitou , Shigeru Kinoshita
摘要： A method of upgrading coal which comprises: pulverizing low-grade coal; mixing the pulverized low-grade coal with an oil to form a slurry; heating the slurry to or above the boiling point of water to vaporize the water contained in the low-grade coal and dehydrate the coal; compressing a vapor mixture of the steam resulting from the slurry heating and that part of the oil which has vaporized simultaneously and thereby elevating the temperature and pressure of the vapor mixture; and supplying the vapor mixture increased in temperature and pressure by the compression and utilizing this vapor mixture as a high-temperature heat source to heat the slurry. In the method, the vapor mixture before being compressed is brought into contact with an oil in a liquid state. This method is a process in which low-grade coal containing water in a large proportion and hence having a low calorific value is dewatered in an oil to thereby upgrade the coal to a high-calorie fuel for thermal power generation, wherein the vapor mixture to be supplied to a compressor can be purified.
摘要翻译： 一种提炼煤的方法，包括：粉碎低档煤; 将粉碎的低品位煤与油混合以形成浆料; 将浆料加热至或高于水的沸点，蒸发低级煤中所含的水分，使煤脱水; 压缩由浆料加热产生的蒸汽的蒸汽混合物和同时蒸发的部分油，从而提高蒸汽混合物的温度和压力; 并通过压缩将蒸汽混合物的温度和压力提高，并利用该蒸气混合物作为高温热源来加热浆料。 在该方法中，压缩前的蒸气混合物与液态的油接触。 这种方法是一种方法，其中大部分含量低，因此具有低热值的低含量煤在油中脱水，从而将煤升级为用于热发电的高热量燃料，其中蒸汽混合物 供应给压缩机可以净化。
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公开(公告)号：US20110207122A1
公开(公告)日：2011-08-25
申请号：US12596462
申请日：2008-04-17
申请人： Shigeru Kinoshita , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
发明人： Shigeru Kinoshita , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/156
摘要： A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 752 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 752 (step B). According to the method of the present invention, the level of a progressive risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention in the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.
摘要翻译： 一种确定青光眼风险的存在或不存在的方法，包括以下步骤：在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型， 其中所述碱基序列是选自SEQ ID NO：203至752所示的碱基序列或其互补序列的至少一种碱基序列（步骤A），并比较检测到的等位基因和/或基因型 在SEQ ID NO：203〜752（步骤B）所示的碱基序列中具有含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。 根据本发明的方法，可以通过分析样品中本发明的单核苷酸多态性的等位基因或基因型来确定样品供体中青光眼进行性风险的水平，使得样品供体可以 采取预防措施的青光眼，或者可以根据这种风险接受适当的治疗。
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9.发明申请METHOD FOR DESIGNING AND MANUFACTURING SEMICONDUCTOR DEVICE AND SOFTWARE THEREFOR 审中-公开用于设计和制造半导体器件及其软件的方法公开(公告)号：US20080244481A1
公开(公告)日：2008-10-02
申请号：US11859162
申请日：2007-09-21
IPC分类号： G06F17/50
CPC分类号： G06F17/5036 , G06F17/5045
摘要： A method for designing a semiconductor device including a semiconductor substrate and an interconnect on the semiconductor substrate, with X-direction being one direction parallel to the semiconductor substrate, Y-direction being a direction parallel to the semiconductor substrate and perpendicular to the X-direction, and Z-direction being perpendicular to the semiconductor substrate, the method includes: determining a cross-sectional configuration in the X-Z direction; three-dimensionalizing the cross-sectional configuration with a range in the Y-direction being specified; and using the three-dimensionalized configuration as a model.
摘要翻译： 一种用于设计包括半导体衬底和半导体衬底上的互连的半导体器件的方法，其中X方向是与半导体衬底平行的一个方向，Y方向是与半导体衬底平行的方向并垂直于X方向 并且Z方向垂直于所述半导体衬底，所述方法包括：确定XZ方向上的横截面构造; 在规定Y方向的范围内对截面结构进行三维化; 并使用三维化配置作为模型。
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10.发明申请Method of culturing embryonic stem cells with the use of amniotic membrane-origin factor 失效使用羊膜来源因子培养胚胎干细胞的方法公开(公告)号：US20070178587A1
公开(公告)日：2007-08-02
申请号：US11569414
申请日：2005-05-27
申请人： Yoshiki Sasai , Morio Ueno , Shigeru Kinoshita
发明人： Yoshiki Sasai , Morio Ueno , Shigeru Kinoshita
CPC分类号： G01N33/5073 , C12N5/0606 , C12N5/0619 , C12N2506/02 , G01N33/5008 , G01N33/502 , G01N33/5058
摘要： The present invention provides a clinically applicable method of inducing differentiation of the embryonic stem cells. Specifically, the present invention provides a method of culturing embryonic stem cells, which comprises culturing embryonic stem cells in the presence of an amnion-derived factor, a cell culture obtained by the culture method, and a culture agent/culture kit of embryonic stem cells comprising an amnion-derived factor. The present invention also provides a method of screening an amnion-derived factor having an activity useful for culturing embryonic stem cells with the activity as an index, and an amniocyte-derived factor obtained by the screening method. Furthermore, the present invention provides a method of preparing amniocytes useful for culturing embryonic stem cells, amniocytes obtained by the preparation method, and the like.
摘要翻译： 本发明提供诱导胚胎干细胞分化的临床适用方法。 具体地，本发明提供培养胚胎干细胞的方法，其包括在羊膜来源的因子存在下培养胚胎干细胞，通过培养方法获得的细胞培养物和胚胎干细胞的培养试剂/培养试剂盒 包括羊膜衍生因子。 本发明还提供一种筛选具有活性作为指标培养胚胎干细胞的活性的羊膜衍生因子和通过筛选方法得到的羊膜细胞衍生因子的方法。 此外，本发明提供了制备用于培养胚胎干细胞的羊膜细胞的方法，通过制备方法获得的羊膜细胞等。
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