公开(公告)号：US20110143199A1

公开(公告)日：2011-06-16

申请号：US13057610

申请日：2009-07-14

申请人： Yoshiyuki Muraoka ,  Yasushi Hirakawa ,  Miho Tanaka

发明人： Yoshiyuki Muraoka ,  Yasushi Hirakawa ,  Miho Tanaka

IPC分类号： H01M4/62 ,  H01M4/139 ,  H01M10/058

CPC分类号： H01M4/70 ,  H01M4/13 ,  H01M4/139 ,  H01M4/1391 ,  H01M4/621 ,  H01M4/623 ,  H01M4/661 ,  H01M4/662 ,  H01M4/666 ,  H01M10/0587 ,  H01M2004/028 ,  Y10T29/49108 ,  Y10T29/49115

摘要： A nonaqueous electrolyte secondary battery includes: a positive electrode 4 including a positive electrode current collector and a positive electrode material mixture layer containing a positive electrode active material and a binder and provided on the positive electrode current collector; a negative electrode 5; a porous insulating layer 6 interposed between the positive electrode 4 and the negative electrode 5; and a nonaqueous electrolyte. The positive electrode 4 has a tensile extension percentage of 3.0% or more. The binder is made of polyvinylidene fluoride. The positive electrode current collector has a softening temperature lower than a crystalline melting point of the binder.

摘要翻译： 非水电解质二次电池包括：具有正极集电体的正极4和含有正极活性物质和粘合剂的正极合剂层，设置在正极集电体上; 负极5; 夹在正极4和负极5之间的多孔绝缘层6; 和非水电解质。 正极4的拉伸伸长率为3.0％以上。 粘合剂由聚偏二氟乙烯制成。 正极集电体的软化温度低于粘结剂的结晶熔点。

公开(公告)号：US20110136010A1

公开(公告)日：2011-06-09

申请号：US13058126

申请日：2009-07-15

申请人： Yoshiyuki Muraoka ,  Miho Tanaka ,  Kazunori Kubota

发明人： Yoshiyuki Muraoka ,  Miho Tanaka ,  Kazunori Kubota

IPC分类号： H01M4/13 ,  H01M4/62 ,  H01M4/64 ,  H01M10/05

CPC分类号： H01M4/13 ,  H01M4/623 ,  H01M4/661 ,  H01M4/662 ,  H01M4/666 ,  H01M4/70 ,  H01M10/0587 ,  H01M2004/028 ,  Y10T29/49108 ,  Y10T29/49115

摘要： A nonaqueous electrolyte secondary battery includes: a positive electrode 4 including a positive electrode current collector and a positive electrode material mixture layer containing a positive electrode active material and a binder and provided on the positive electrode current collector; a negative electrode 5; a porous insulating layer 6 interposed between the positive electrode 4 and the negative electrode 5; and a nonaqueous electrolyte. The positive electrode 4 has a tensile extension percentage of 3.0% or more. The binder is made of copolymer containing vinylidene fluoride and hexafluoropropylene.

摘要翻译： 非水电解质二次电池包括：具有正极集电体的正极4和含有正极活性物质和粘合剂的正极合剂层，设置在正极集电体上; 负极5; 夹在正极4和负极5之间的多孔绝缘层6; 和非水电解质。 正极4的拉伸伸长率为3.0％以上。 粘合剂由含有偏二氟乙烯和六氟丙烯的共聚物制成。

公开(公告)号：US06573084B1

公开(公告)日：2003-06-03

申请号：US09656417

申请日：2000-09-06

申请人： Satoshi Ueda ,  Miho Tanaka ,  Masami Ezaki ,  Kazutoshi Sakamoto ,  Seiji Hashimoto ,  Nobutaka Oohata ,  Masaru Tsuboi ,  Michio Yamashita

发明人： Satoshi Ueda ,  Miho Tanaka ,  Masami Ezaki ,  Kazutoshi Sakamoto ,  Seiji Hashimoto ,  Nobutaka Oohata ,  Masaru Tsuboi ,  Michio Yamashita

IPC分类号： C12N120

CPC分类号： C12R1/465 ,  C07K7/56 ,  C12N9/80

摘要： There is provided a cyclic lipopeptide acylase which is capable of deacylating the acyl side chain of a cyclic lipopeptide compound, e.g. Substance FR901379 or its analog, of the following general formula [I] with effectiveness as well a method of producing a cyclic peptide compound which comprises using the acylase. [wherein R1 is acyl; R2 is hydroxy or acyloxy; R3 is hydrogen or hydroxy; R4 is hydrogen or hydroxy; R5 is hydrogen or hydroxysulfonyloxy; and R6 is hydrogen or carbamoyl.]

摘要翻译： 提供了能够使环状脂肽化合物的酰基侧链脱酰化的环状脂肽酰基酶。 物质FR901379或其类似物，具有以下通式[I]，其有效性以及包含使用酰基转移酶的环肽化合物的制备方法。[其中R 1为酰基; R 2为羟基或酰氧基; R 3为氢或羟基; R4是氢或羟基; R5是氢或羟基磺酰氧基; 和R6是氢或氨基甲酰基。]

公开(公告)号：US06825003B2

公开(公告)日：2004-11-30

申请号：US10050150

申请日：2002-01-18

申请人： Satoshi Ueda ,  Miho Tanaka ,  Masami Ezaki ,  Kazutoshi Sakamoto ,  Seiji Hashimoto ,  Nobutaka Oohata ,  Masaru Tsuboi ,  Michio Yamashita

发明人： Satoshi Ueda ,  Miho Tanaka ,  Masami Ezaki ,  Kazutoshi Sakamoto ,  Seiji Hashimoto ,  Nobutaka Oohata ,  Masaru Tsuboi ,  Michio Yamashita

IPC分类号： C12N120

CPC分类号： C12P21/02 ,  A61K38/00 ,  C07K7/56 ,  C12N9/80

摘要： The present invention provides a cyclic lipopeptide acylase which may effectively deacylate the acyl side chain of a cyclic lipopeptide compound, specifically FR901379 Substance or its analog thereof shown by the following general formula [I], and a process for production of a cyclic peptide compound which comprises the use of said acylase. [wherein R1 is acyl; R2 is hydroxy or acyloxy; R3 is hydrogen or hydroxy; R4 is hydrogen or hydroxy; R5 is hydrogen or hydroxysulfonyloxy; and R6 is hydrogen or carbamoyl]

摘要翻译： 本发明提供一种环状脂肽酰基转移酶，其可以有效地使酰基侧链环化脂肽化合物脱酰化，特别是FR901379由下列通式[I]表示的物质或其类似物，以及环肽化合物的制备方法 包括使用所述酰基转移酶[其中R 1是酰基; R 2是羟基或酰氧基; R 3是氢或羟基; R 4是氢或羟基; R 5是氢或 羟基磺酰氧基 和R 6是氢或氨基甲酰基]

公开(公告)号：US06372474B1

公开(公告)日：2002-04-16

申请号：US09659335

申请日：2000-09-12

申请人： Satoshi Ueda ,  Miho Tanaka ,  Masami Ezaki ,  Kazutoshi Sakamoto ,  Seiji Hashimoto ,  Nobutaka Oohata ,  Masaru Tsuboi ,  Michio Yamashita

发明人： Satoshi Ueda ,  Miho Tanaka ,  Masami Ezaki ,  Kazutoshi Sakamoto ,  Seiji Hashimoto ,  Nobutaka Oohata ,  Masaru Tsuboi ,  Michio Yamashita

IPC分类号： C12N950

CPC分类号： C12P21/02 ,  A61K38/00 ,  C07K7/56 ,  C12N9/80

摘要： The present invention provides a cyclic lipopeptide acrylase which may effectively deacylate the acyl side chain of a cyclic lipopeptide compound, specifically FR901379 Substance or its analog thereof shown by the following general formula [I], and a process for production of a cyclic peptide compound which comprises the use of said acylase. [wherein R1 is acyl; R2 is hydroxy or acyloxy; R3 is hydrogen or hydroxy; R4 is hydrogen or hydroxy; R5 is hydrogen or hydroxysulfonyloxy; and R6 is hydrogen or carbamoyl]

摘要翻译： 本发明提供一种环状脂肽丙烯酸酯，其可以有效地脱酰基环状脂肽化合物的酰基侧链，特别是由以下通式[I]表示的FR901379物质或其类似物，以及环肽化合物的制备方法 包括使用所述酰基转移酶[其中R1是酰基; R2是羟基或酰氧基; R3是氢或羟基; R4是氢或羟基; R5是氢或羟基磺酰氧基; 和R6是氢或氨基甲酰基]

公开(公告)号：US06207434B1

公开(公告)日：2001-03-27

申请号：US09142045

申请日：1998-09-03

申请人： Satoshi Ueda ,  Miho Tanaka ,  Masami Ezaki ,  Kazutoshi Sakamoto ,  Seiji Hashimoto ,  Nobutaka Oohata ,  Masaru Tsuboi ,  Michio Yamashita

发明人： Satoshi Ueda ,  Miho Tanaka ,  Masami Ezaki ,  Kazutoshi Sakamoto ,  Seiji Hashimoto ,  Nobutaka Oohata ,  Masaru Tsuboi ,  Michio Yamashita

IPC分类号： C12N914

CPC分类号： C12R1/465 ,  C07K7/56 ,  C12N9/80

摘要： There is provided a cyclic lipopeptide acylase which is capable of deacylating the acyl side chain of a cyclic lipopeptide compound, e.g. Substance FR901379 or its analog, of the general formula [I] with effectiveness as well a method of producing a cyclic peptide compound which comprises using the acylase.

摘要翻译： 提供了能够使环状脂肽化合物的酰基侧链脱酰化的环状脂肽酰基酶。 物质FR901379或其具有通式[I]的类似物，其有效性以及包含使用酰基转移酶的环肽化合物的制备方法。

公开(公告)号：US5255116A

公开(公告)日：1993-10-19

申请号：US835341

申请日：1992-02-14

申请人： Keisuke Araki ,  Kazuo Fujibayashi ,  Miho Tanaka

发明人： Keisuke Araki ,  Kazuo Fujibayashi ,  Miho Tanaka

IPC分类号： G02B26/10 ,  G02B26/08

CPC分类号： G02B26/10

摘要： The present invention provides an original scanning apparatus comprising, an original support plate on which an original is rested, a fixed point light source having a width smaller than that of the original support plate, a shiftable reflection member for reflecting light beams emitted from the light source toward the original support plate, and a first deflector member for deflecting the light beams emitted from the light source in a slit widthwise direction and a second deflector member for deflecting the light beams in a slit longitudinal direction, the first and second deflector members being formed discretely.

摘要翻译： 本发明提供了一种原始扫描装置，包括原始支撑板，原件搁置在原始支撑板上，具有比原始支撑板的宽度小的固定点光源;可移动反射构件，用于反射从光发射的光束 源极朝向原始支撑板，以及第一偏转构件，用于使狭缝宽度方向上的光源发射的光束偏转，以及用于使光束沿狭缝纵向方向偏转的第二偏转器构件，第一和第二偏转构件为 离散地形成。

公开(公告)号：US20090203538A1

公开(公告)日：2009-08-13

申请号：US12318829

申请日：2009-01-09

申请人： Atsushi Sugioka ,  Mototaka Sugiura ,  Yasushi Akahori ,  Nobuhiro Hayashi ,  Akihiko Takasaki ,  Miwa Morita ,  Gene Kurosawa ,  Mariko Sumitomo ,  Susumu Tsutsumi ,  Keiko Ogawa ,  Kazuki Matsuda ,  Chiho Muramatsu ,  Noriko Satou ,  Masachika Azuma ,  Yoshinori Ukai ,  Kazuhiro Suzuki ,  Yoshikazu Kurosawa ,  Miho Tanaka ,  Mamoru Shiraishi

发明人： Atsushi Sugioka ,  Mototaka Sugiura ,  Yasushi Akahori ,  Nobuhiro Hayashi ,  Akihiko Takasaki ,  Miwa Morita ,  Gene Kurosawa ,  Mariko Sumitomo ,  Susumu Tsutsumi ,  Keiko Ogawa ,  Kazuki Matsuda ,  Chiho Muramatsu ,  Noriko Satou ,  Masachika Azuma ,  Yoshinori Ukai ,  Kazuhiro Suzuki ,  Yoshikazu Kurosawa ,  Miho Tanaka ,  Mamoru Shiraishi

IPC分类号： C40B30/04 ,  G01N33/567 ,  G01N33/574 ,  C07K16/00 ,  C40B40/10 ,  C40B60/10

CPC分类号： C07K16/30 ,  C07K16/005 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/2863 ,  C07K16/2896 ,  C07K16/303 ,  C07K16/32 ,  C07K16/40 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C12N15/1138 ,  C12N2310/14 ,  G01N33/57492 ,  G01N33/6854

摘要： It is intended to provide a method whereby a plural number of antibodies against cell surface antigens are quickly classified and to provide a method whereby antigens of the thus classified antibodies are quickly identified. Further, it is intended to provide a method of promoting the utilization of the useful data obtained by the above methods. Furthermore, it is intended to provide an antibody which is effective in treating or diagnosing cancer. Namely, a method of classifying antibodies which comprises: (1) the step of preparing a plural number of antibodies respectively recognizing cell surface antigens; (2) the step of bringing each of these antibodies into contact with a cell of the same species; (3) the step of analyzing each of the cells having been treated in the step (2) by flow cytometry and thus obtaining data indicating the reactivity of each antibody with its cell surface antigen; and (4) the step of comparing the thus obtained data and classifying the individual antibodies depending on the similarity. A method of identifying antigens which further comprises: (5) the step of selecting one to several antibodies from each antibody group formed in the step (4) and identifying antigens thereof; and (6) on the assumption that antigens of the antibodies belonging to a single antibody group are the same or highly related to one another, making relations between the antigens having been identified in the step (5) and the antibody groups to thereby identify the antigens. An antibody against HER1, an antibody against HER2, an antibody against CD46, an antibody against ITGA3, an antibody against ICAM1, an antibody against ALCAM, an antibody against CD147, an antibody against C1qR, an antibody against CD44, an antibody against CD73, an antibody against EpCAM and an antibody against HGFR, each obtained by using the above methods.

公开(公告)号：US06537789B1

公开(公告)日：2003-03-25

申请号：US09656420

申请日：2000-09-06

申请人： Satoshi Ueda ,  Miho Tanaka ,  Masami Ezaki ,  Kazutoshi Sakamoto ,  Seiji Hashimoto ,  Nobutaka Oohata ,  Masaru Tsuboi ,  Michio Yamashita

发明人： Satoshi Ueda ,  Miho Tanaka ,  Masami Ezaki ,  Kazutoshi Sakamoto ,  Seiji Hashimoto ,  Nobutaka Oohata ,  Masaru Tsuboi ,  Michio Yamashita

IPC分类号： C12N914

CPC分类号： C12R1/465 ,  C07K7/56 ,  C12N9/80

摘要： There is provided a cyclic lipopeptide acylase which is capable of deacylating the acyl side chain of a cyclic lipopeptide compound, e.g. Substance FR901379 or its analog, of the following general formula [I] with effectiveness as well a method of producing a cyclic peptide compound which comprises using the acylase. [wherein R1 is acyl; R2 is hydroxy or acyloxy; R3 is hydrogen or hydroxy; R4 is hydrogen or hydroxy; R5 is hydrogen or hydroxysulfonyloxy; and R6 is hydrogen or carbamoyl.]

摘要翻译： 提供了能够使环状脂肽化合物的酰基侧链脱酰化的环状脂肽酰基酶。 物质FR901379或其类似物，具有以下通式[I]，其有效性以及包括使用酰基转移酶的环肽化合物的制备方法[其中R1为酰基; R2为羟基或酰氧基; R3为氢或羟基; R4 是氢或羟基; R 5是氢或羟基磺酰氧基; 和R6是氢或氨基甲酰基。]

公开(公告)号：US08694453B2

公开(公告)日：2014-04-08

申请号：US13145516

申请日：2009-12-15

申请人： Mihoko Kitamura ,  Toshiki Murata ,  Tatsuya Sukehiro ,  Sayori Shimohata ,  Ikuo Orihara ,  Atsushi Ikeno ,  Shigehiro Kato ,  Miho Tanaka

发明人： Mihoko Kitamura ,  Toshiki Murata ,  Tatsuya Sukehiro ,  Sayori Shimohata ,  Ikuo Orihara ,  Atsushi Ikeno ,  Shigehiro Kato ,  Miho Tanaka

IPC分类号： G06F17/00

CPC分类号： G06F17/30734 ,  G06F17/30654

摘要： A dialogue control system that uses an ontology that systematically expresses domain knowledge representing concepts and relationships between concepts to determine questions for a user and implements the questions, and implements a dialogue in accordance with received user answers. One or more dimension-classified ontologies and a basic ontology are stored, a concept from a user response is specified as a condition, and one or a plural number of the dimension-classified ontologies that meet the specified condition are fetched. The content of the fetched dimension-classified ontology/ies is overwritten on the basic ontology, in order according to dimension priorities from the dimension-classified ontology with the lowest dimension priority, and a multidimensional ontology is generated. The dialogue control system uses this multidimensional ontology to control the dialogue.

摘要翻译： 一种对话控制系统，其使用系统地表达代表概念和概念之间的关系的领域知识的本体，以确定用户的问题并实现问题，并且根据接收到的用户答案来实现对话。 存储一个或多个维度分类本体和基本本体，将来自用户响应的概念指定为条件，并且获取满足指定条件的一个或多个维度分类本体。 获取的维度分类本体的内容被覆盖在基本本体上，以便根据维度优先级的维度优先级，并且生成多维本体。 对话控制系统使用这种多维本体来控制对话。