公开(公告)号：US06843263B2

公开(公告)日：2005-01-18

申请号：US10177122

申请日：2002-06-24

申请人： Yuan-Fong Kuo ,  Nan-Kuang Yao ,  Jhy-Wen Wu ,  Tim Shia ,  Shaw-Hwa Parng

发明人： Yuan-Fong Kuo ,  Nan-Kuang Yao ,  Jhy-Wen Wu ,  Tim Shia ,  Shaw-Hwa Parng

IPC分类号： B01L3/00 ,  F04B43/02 ,  F04B43/04 ,  F17D1/18 ,  F15C1/04

CPC分类号： F04B43/02 ,  B01L3/5027 ,  F04B43/043 ,  Y10T137/0396 ,  Y10T137/2213 ,  Y10T137/2224

摘要： This specification disclosed a partially closed microfluidic system and a fluid driving method. The microfluidic system is comprised of a substrate with microfluidic elements and a thin film. A feature of this structure is that the thin film is elastic and deformable. It has a single opening corresponding to a vent hole on the substrate, thus forming a partially closed microfluidic system. The substrate is designed to have several positions for micro fluid elements and deformable chambers and uses micro channels to form a complete network. Since the thin film is elastic and deformable, one is able to impose a pressure on the thin film above the deformable chambers in this partially closed microfluidic system to drive the fluid into motion. Once the pressure is released, the fluid flows back to its original configuration.

摘要翻译： 本说明书公开了部分封闭的微流体系统和流体驱动方法。 微流体系统由具有微流体元件的基底和薄膜组成。 该结构的特征在于薄膜是弹性的和可变形的。 它具有对应于衬底上的通气孔的单个开口，从而形成部分闭合的微流体系统。 基板被设计为具有用于微流体元件和可变形室的多个位置，并且使用微通道形成完整的网络。 由于薄膜是弹性和可变形的，因此能够在该部分封闭的微流体系统中的可变形室上方的薄膜上施加压力，以驱动流体运动。 一旦压力释放，流体就会流回原来的状态。

公开(公告)号：US06945285B2

公开(公告)日：2005-09-20

申请号：US10437073

申请日：2003-05-14

申请人： Jhy-Wen Wu ,  Nan-Kuang Yao ,  Yuan-Fong Kao ,  Tim-Kuei Shia ,  Shaw-Hwa Parng

发明人： Jhy-Wen Wu ,  Nan-Kuang Yao ,  Yuan-Fong Kao ,  Tim-Kuei Shia ,  Shaw-Hwa Parng

IPC分类号： G01N1/18 ,  G01N30/84 ,  G01N35/10 ,  B67C3/00

CPC分类号： G01N1/18 ,  G01N30/84 ,  G01N2030/8411 ,  G01N2035/1037

摘要： An apparatus and a method for collecting fluid fractions. The present apparatus includes an inlet, a channel, a plurality of collectors, and an outlet. The inlet communicates with the collectors and the outlet through the channel. The collectors are disposed between the inlet and the outlet. The method for collecting the fluid fractions comprises two steps. First step, injecting the fluid in to the inlet for guiding the fluid to the outlet along the channel, wherein the fluid fills the collectors one by one due to the capillary attraction when passing through the collectors, and flows to the outlet after the collectors having been filled. Second step, injecting pressurized gas into the channel to drain the fluid fractions from fill the collectors respectively to a plurality of corresponding containers.

摘要翻译： 用于收集流体分数的装置和方法。 本装置包括入口，通道，多个收集器和出口。 入口通过通道与收集器和出口连通。 收集器设置在入口和出口之间。 收集流体馏分的方法包括两个步骤。 第一步，将流体注入到入口中，以将流体沿着通道引导到出口，其中当流体通过收集器时，流体由于毛细管吸引而逐个填充收集器，并且在收集器具有 已经填满 第二步骤，将加压气体注入通道以将流体部分从收集器填充到多个对应的容器中。

公开(公告)号：US06725882B1

公开(公告)日：2004-04-27

申请号：US10335945

申请日：2003-01-03

申请人： Tim K. Shia ,  Jhy-Wen Wu ,  Nan-Kuang Yao ,  Yuan-Fong Kuo ,  Shaw-Hwa Pang

发明人： Tim K. Shia ,  Jhy-Wen Wu ,  Nan-Kuang Yao ,  Yuan-Fong Kuo ,  Shaw-Hwa Pang

IPC分类号： F15C104

CPC分类号： F16K99/0001 ,  F15C5/00 ,  F16K99/0019 ,  F16K99/0028 ,  F16K99/0034 ,  F16K99/0059 ,  F16K2099/008 ,  Y10T137/2082 ,  Y10T137/2191 ,  Y10T137/2196 ,  Y10T137/2224

摘要： Disclosed is a micro flowguide device comprising: a micro channel comprising at least one bubble trap to retard bubbles positioned in said bubble trap; an electrolytic bubble generating device to generate bubbles in said fluid by an electrolytic reaction; and a pressure source to supply a suited pressure to said fluid to pass through said micro channel; wherein said electrolytic bubble generating device causes bubbles to be generated at areas adjacent to said at least one bubble trap. Electrolytic bubbles are generated through a, localized electrolytic reaction enabled by the exposure of a set of DC-source-connected electrodes inside a conduit branch. Accumulated bubbles will be trapped and kept at several traps of the invented flowguide. When the backward pressure of trapped bubbles is rising to the level of forward pressure head, flow speed reduces to zero and channel branch is shut down.

摘要翻译： 公开了一种微流导装置，包括：微通道，其包括至少一个气泡阱以阻止位于所述气泡阱中的气泡; 电解气泡产生装置，通过电解反应在所述流体中产生气泡; 以及压力源，以向所述流体提供适当的压力以通过所述微通道; 其中所述电解气泡产生装置在与所述至少一个气泡阱相邻的区域处产生气泡。电解气泡通过局部电解反应产生，通过一组直流源连接的电极在管道分支内暴露 。 累积的气泡将被捕获并保持在本发明的导流管的几个陷阱处。 当捕获的气泡的向后压力上升到正向压力头的水平时，流速降低到零，并且通道分支被关闭。

公开(公告)号：US08303555B2

公开(公告)日：2012-11-06

申请号：US12872990

申请日：2010-08-31

申请人： Luo-Hwa Miau ,  Jhy-Wen Wu ,  Jen-Chien Chien ,  Li-Ling Li ,  Nan-Kuang Yao

发明人： Luo-Hwa Miau ,  Jhy-Wen Wu ,  Jen-Chien Chien ,  Li-Ling Li ,  Nan-Kuang Yao

IPC分类号： A61M1/00

CPC分类号： A61M1/0019 ,  A61M1/0088 ,  A61M1/0094 ,  A61M2205/702 ,  A61M2205/7536

摘要： A collector for a negative pressure wound therapy system has a soft collecting bag with a gas-permeable unit and a liquid absorber. The collecting bag is connected to a wound-dressing unit via an inlet connecting set and is connected to a sensor assembly via a detecting connecting set. With the soft collecting bag, the collector occupies less volume. By the gas-permeable unit and the liquid absorber, the liquid and gas entering into the collecting bag quickly isolate. Moreover, multiple collectors connect in series to form a collector combination to reduce the frequency to replace the collector combination so that a longer usage time of the collector combination is available.

摘要翻译： 用于负压伤口治疗系统的收集器具有带有透气单元和液体吸收器的软收集袋。 收集袋通过入口连接组连接到伤口修整单元，并通过检测连接组连接到传感器组件。 使用软收集袋，收集器占用的体积较小。 通过透气单元和液体吸收器，进入收集袋的液体和气体快速隔离。 此外，多个收集器串联连接以形成收集器组合以减少频率以替换收集器组合，使得收集器组合的更长的使用时间可用。

公开(公告)号：US08173078B2

公开(公告)日：2012-05-08

申请号：US10835101

申请日：2004-04-28

申请人： Nan-Kuang Yao ,  Jhy-Wen Wu

发明人： Nan-Kuang Yao ,  Jhy-Wen Wu

IPC分类号： B01L3/00

CPC分类号： F04B19/006

摘要： A microfluidic chip with a built-in gravity-driven micropump is provided. The gravity-driven micropump comprises a winding channel, an inert fluidic material placed inside the winding channel, and a suction channel that links the winding channel to the microfluidic chip. The winding channel is for the inert fluidic material to flow in. A fixed volume of high density, inert fluidic material is placed in the winding channel to act as a micropump in the bio chip. When the microfluidic chip is placed in a declining or standing position, the inert fluidic material flows along the winding channel due to the gravity. The invention provides a simple, convenient, and robust microfluid pumping source. With the built-in micropump, this invention is free-of-pollution and saves the manufacturing cost for the pipe link between the bio chip and peripheral devices.

摘要翻译： 提供具有内置重力驱动微型泵的微流控芯片。 重力驱动的微型泵包括绕组通道，放置在绕组通道内部的惰性流体材料以及将绕组通道连接到微流体芯片的抽吸通道。 卷绕通道用于惰性流体材料流入。固定体积的高密度惰性流体材料被放置在绕组通道中以用作生物芯片中的微型泵。 当微流体芯片处于下降或静止位置时，惰性流体材料由于重力而沿着缠绕通道流动。 本发明提供了一种简单，方便，可靠的微流体泵浦源。 利用内置的微型泵，本发明无污染，节省了生物芯片与外围设备之间管路连接的制造成本。

公开(公告)号：US20090053106A1

公开(公告)日：2009-02-26

申请号：US12007931

申请日：2008-01-17

申请人： Jhy-Wen Wu ,  Hung-Jen Yang ,  Nan-Kuang Yao

发明人： Jhy-Wen Wu ,  Hung-Jen Yang ,  Nan-Kuang Yao

IPC分类号： G01N33/00

CPC分类号： B01L3/502746 ,  B01L3/502738 ,  B01L2200/0621 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0457 ,  B01L2400/0688 ,  B01L2400/084

摘要： The present invention relates to an autonomous microfluidic apparatus. The autonomous microfluidic apparatus is substantially a substrate having a microchannel structure arranged thereon. As a microfluid is being filled in a loading well situated upstream of the microchannel structure, the microfluid is affected by interactions between gravity, adhesive force and surface tension and thus driven to flow downstream in the microchannel structure while filling a plurality of manifolds formed in a area situated downstream of the microchannel structure, so that accurate and autonomous quantification and separation of the microfluid using the plural manifolds, each having a specific length, can be achieved and provided for biomedical inspection and analysis.

摘要翻译： 本发明涉及自主微流体装置。 自主微流体装置基本上是其上布置有微通道结构的基板。 当微流体填充在位于微通道结构上游的装载井中时，微流体受到重力，粘附力和表面张力之间的相互作用的影响，因此被驱动在微通道结构的下游流动，同时填充形成在微通道结构中的多个歧管 位于微通道结构下游的区域，从而可以实现使用多个歧管（每个具有特定长度）的微流体的精确和自主的定量和分离，并提供用于生物医学检查和分析。

公开(公告)号：US07097811B2

公开(公告)日：2006-08-29

申请号：US11253981

申请日：2005-10-19

申请人： Nan-Kuang Yao ,  Jhy-Wen Wu

发明人： Nan-Kuang Yao ,  Jhy-Wen Wu

IPC分类号： B01L3/00

CPC分类号： B01L3/50273 ,  B01L3/502746 ,  B01L2200/0621 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0457 ,  B01L2400/0694 ,  B01L2400/084 ,  Y10T436/2575

摘要： A gravity-driven apparatus and method control the flow order of reactants in microfluidic devices which are employed in a microfluidic chip. The gravity-driven apparatus flow order control mainly comprises a plurality of reactant chambers arranged at different heights, a plurality of flow-control microchannels, and a reaction chamber having a winding collection microchannel. Each reactant chamber has an air-in vent. Each pair of neighboring flow-control microchannels has a U-shaped structure connecting the pair of neighboring flow-control microchannels. To activate the microfluidic device, the device is placed in an inclining or standing position and the air-in vents are unsealed. This method enhances the reliability of flow order control for multiple reactants. It can be built in a microfluidic chip, and does not use any actuating power or element. Therefore, it is low in energy-consumption, low in manufacturing cost and free of pollution.

摘要翻译： 重力驱动装置和方法控制在微流体芯片中使用的微流体装置中的反应物的流动顺序。 重力驱动装置流程顺序控制主要包括布置在不同高度的多个反应物室，多个流量控制微通道和具有卷绕收集微通道的反应室。 每个反应物室都有一个进气口。 每对相邻的流量控制微通道具有连接该对相邻的流量控制微通道的U形结构。 为了激活微流体装置，将装置置于倾斜或站立位置，并且将通风口开封。 这种方法提高了多种反应物流顺序控制的可靠性。 它可以内置在微流控芯片中，不使用任何驱动电源或元件。 因此，能源消耗低，制造成本低，无污染。

公开(公告)号：US20130274718A1

公开(公告)日：2013-10-17

申请号：US13445987

申请日：2012-04-13

申请人： Nan-Kuang Yao ,  Jhy-Wen Wu ,  Luo-Hwa Miau ,  Jen-Chien Chien ,  Shi-Fu Chen ,  Li-Ling Li

发明人： Nan-Kuang Yao ,  Jhy-Wen Wu ,  Luo-Hwa Miau ,  Jen-Chien Chien ,  Shi-Fu Chen ,  Li-Ling Li

IPC分类号： A61M27/00

CPC分类号： A61M1/0001 ,  A61M1/0025 ,  A61M1/0031 ,  A61M1/0088 ,  A61M2205/18 ,  A61M2205/3334 ,  A61M2205/3382

摘要： A fluid collector has a container, a T-tube, a first screw unit and a second screw unit. The T-tube is connected to the container and has a main pipe and a branch pipe. The first screw unit is mounted in an outlet end of the main pipe. The second screw unit is mounted in a connecting end of the branch pipe, which is connected to the main pipe. The branch pipe has a detecting opening far from the connecting end and connects to a detecting device. By changing the length of the first and second screw units, different detecting values of the pressure are adjusted according to containers with different capacities. Moreover, with the flowing resistance resulting from the first and second screw units, different pressure variations are performed when liquid or air passes through the T-tube. Therefore, massive hemorrhage is clearly identified to keep the patient safe.

摘要翻译： 流体收集器具有容器，T形管，第一螺丝单元和第二螺钉单元。 T型管与容器连接，并具有主管和分支管。 第一螺杆单元安装在主管的出口端。 第二螺钉单元安装在分支管的连接端上，该分支管连接到主管。 分支管具有远离连接端的检测开口并连接到检测装置。 通过改变第一和第二螺杆单元的长度，根据具有不同容量的容器来调节不同的压力检测值。 此外，由于由第一和第二螺杆单元产生的流动阻力，当液体或空气通过T形管时，执行不同的压力变化。 因此，清楚地确定大量出血以保持患者的安全。

公开(公告)号：US20070297949A1

公开(公告)日：2007-12-27

申请号：US11524372

申请日：2006-09-21

申请人： Jhy-Wen Wu ,  Hung-Jen Yang ,  Nan-Kuang Yao

发明人： Jhy-Wen Wu ,  Hung-Jen Yang ,  Nan-Kuang Yao

IPC分类号： B01L11/00

CPC分类号： B01L3/502753 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0457 ,  B01L2400/0487 ,  B01L2400/049

摘要： The present invention relates to a gravity-driven fraction separator and method thereof. The gravity-driven fraction separator is substantially a substrate having a microchannel structure arranged thereon, in which the microchannel structure is extending longitudinally on the substrate while sloping with respect to the level of the substrate by a specific angle. As a micro fluidics is being filled in a loading well situated upstream of the microchannel structure, the micro fluidics is driven by gravity to flow downstream in the microchannel structure while filling a plurality of manifolds formed in a area situated downstream of the microchannel structure, so that accurate quantification and separation of the micro fluidics using the plural manifolds, each having a specific length, can be achieved and provided for posterior inspection and analysis.

摘要翻译： 本发明涉及一种重力驱动级分分离器及其方法。 重力驱动级分分离器基本上是其上布置有微通道结构的基板，其中微通道结构在基板上纵向延伸，同时相对于基板的高度以特定角度倾斜。 由于微流体被填充在位于微通道结构上游的装载井中，微流体通过重力驱动以在微通道结构的下游流动，同时填充形成在位于微通道结构下游的区域中的多个歧管，因此 可以实现使用具有特定长度的多个歧管的微流体学的精确定量和分离，并提供用于后验检查和分析。

公开(公告)号：US20050255004A1

公开(公告)日：2005-11-17

申请号：US10836011

申请日：2004-04-29

申请人： Nan-Kuang Yao ,  Jhy-Wen Wu

发明人： Nan-Kuang Yao ,  Jhy-Wen Wu

IPC分类号： G01N35/08 ,  B01J19/00 ,  B01L3/00 ,  B81B1/00 ,  G01N37/00

CPC分类号： B01L3/50273 ,  B01L3/502746 ,  B01L2200/0621 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0457 ,  B01L2400/0694 ,  B01L2400/084 ,  Y10T436/2575

摘要： A gravity-driven apparatus and method for controlling the flow order of reactants in microfluidic devices are provided, which are employed in a microfluidic chip. The gravity-driven apparatus flow order control mainly comprises a plurality of reactant chambers arranged in a stepwise pattern, a plurality of separate microchannels, and a reaction chamber having a winding converged microchannel. Each said reactant chamber has an air vent channel. Each pair of neighboring separate microchannels has a U-shaped structure connecting the pair of neighboring separate microchannels. To activate the microfluidic chip, the microfluidic chip is placed in a declining or standing position and the air vents are unsealed. This invention enhances the reliability of flow order control for multiple reactants. It can be built in a microfluidic chip, and needs not use any activate power or element. Therefore, it is low in energy-consumption, low in manufacturing cost and free-of-pollution.

摘要翻译： 提供了一种用于控制微流体装置中的反应物的流顺序的重力驱动装置和方法，其用于微流体芯片。 重力驱动装置流程顺序控制主要包括以逐步模式布置的多个反应物室，多个单独的微通道，以及具有卷绕收敛微通道的反应室。 每个所述反应物室具有排气通道。 每对相邻的单独微通道具有连接该对相邻的单独微通道的U形结构。 为了激活微流体芯片，微流控芯片被放置在下降或站立的位置，并且通气口是非密封的。 本发明提高了多种反应物流动顺序控制的可靠性。 它可以内置在微流控芯片中，不需要使用任何激活电源或元件。 因此，能源消耗低，制造成本低，污染自由。