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    Microfluidic separation system
    3.
    发明授权
    Microfluidic separation system 有权
    微流控分离系统

    公开(公告)号：US08268177B2

    公开(公告)日：2012-09-18

    申请号：US12673160

    申请日：2008-08-13

    申请人： Jackie Y. Ying ,  Guolin Xu ,  Yoke San Daniel Lee

    发明人： Jackie Y. Ying ,  Guolin Xu ,  Yoke San Daniel Lee

    IPC分类号： B03C1/035 ,  B81B1/00

    CPC分类号： B03C1/32 ,  B03C1/002 ,  B03C1/01 ,  B03C1/0332 ,  B03C1/0335 ,  B03C1/035 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/22 ,  B03C2201/26 ,  G01N35/0098

    摘要： A microfluidic separation system, which comprises a magnetic separator, which itself comprises a magnetic energy source; first and second magnetically conductive members leading from the magnetic energy source and having respective terminal ends that are separated by a gap over which a magnetic field is applied due to the magnetic energy source. The separation system further comprises a microfluidic chip for insertion into the gap, which comprises a body defining channels on respective faces of the body; and an exterior lining that seals the plurality of channels to allow separate test sample volumes to circulate in at least two of the channels. Upon insertion of the chip into the gap, a first test sample volume is confined to circulating closer to the terminal end of the first member and a second test sample volume is confined to circulating closer to the terminal end of the second member.

    摘要翻译： 微流体分离系统，其包括磁分离器，其本身包括磁能源; 第一和第二导电构件，其从磁能源引出并且具有由由于磁能源而施加磁场的间隙分开的相应末端。 分离系统还包括用于插入到间隙中的微流体芯片，其包括在主体的相应面上限定通道的主体; 以及密封多个通道以允许单独的测试样品体积在至少两个通道中循环的外部衬里。 当将芯片插入到间隙中时，第一测试样本体积被限制为更靠近第一构件的终端循环，并且第二测试样本体积被限制为更靠近第二构件的终端循环。

    Multi-phase linear motor having an integrated coil assembly and method for forming the integrated coil assemblly
    4.
    发明授权
    Multi-phase linear motor having an integrated coil assembly and method for forming the integrated coil assemblly 失效

    公开(公告)号：US06573622B2

    公开(公告)日：2003-06-03

    申请号：US09804204

    申请日：2001-03-12

    申请人： Howe Yuen Lim ,  Chai Meng Goh ,  Guolin Xu

    发明人： Howe Yuen Lim ,  Chai Meng Goh ,  Guolin Xu

    IPC分类号： H02K4100

    CPC分类号： H02K41/02 ,  H02K3/14 ,  H02K15/04

    摘要： An integrated coil assembly (10), a multi-phase linear motor having the integrated coil assembly (10) and a method (100) for forming the integrated coil assembly (10) are described. The integrated coil assembly (10) has multi-phase coils with each multi-phase coil (20) having a number of coil loops based upon the number of electrical phases of current required by the multi-phase linear motor. The coil loops of different multi-phase coils are interweaved at two opposing portions (11,12) and are substantially parallel at two other opposing portions (13,14). In the method (100), different wire dispensers wind coil loops for different electrical phase for each multi-phase coil (20). However, the same wire dispenser winds coil loops that are for the same electrical phase for different multi-phase coils (20). The coil loops for each multi-phase coil (20) are wound before the coil loops of another multi-phase coil (20) are wound.

    Biochip for sorting and lysing biological samples
    5.
    发明申请
    Biochip for sorting and lysing biological samples 审中-公开
    用于分选和裂解生物样品的生物芯片

    公开(公告)号：US20090155877A1

    公开(公告)日：2009-06-18

    申请号：US11631667

    申请日：2005-07-05

    申请人： Ciprian Iliescu ,  Guolin Xu ,  Francis Eng-Hock Tay

    发明人： Ciprian Iliescu ,  Guolin Xu ,  Francis Eng-Hock Tay

    IPC分类号： C12N13/00 ,  C12M1/00

    CPC分类号： B01L3/502761 ,  B01L3/502707 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0424 ,  B03C5/005 ,  B03C5/026 ,  B03C2201/26 ,  C12M47/04 ,  C12M47/06

    摘要： A biochip (100) for lysing and/or cell separation is formed to provide a sealed chamber for biological fluid. A conductive layer (140) bonded between upper (130) and lower (150) insulating layers is etched to form a microfluidic channel (250) between two electrodes (190, 200). The microfluidic channel connects a fluid inlet (11) and fluid outlet (120). The electrodes (190, 200) form an un-even electric field in the channel (250) to generate a dielectrophoretic force on the cells/particles within the sample fluid. A voltage source applies a suitable voltage to separate and/or lyse cells within the fluid.

    摘要翻译： 形成用于裂解和/或细胞分离的生物芯片（100），以提供用于生物流体的密封室。 蚀刻结合在上（130）和下（150）绝缘层之间的导电层（140），以在两个电极（190,200）之间形成微流体通道（250）。 微流体通道连接流体入口（11）和流体出口（120）。 电极（190,200）在通道（250）中形成非均匀电场，以在样品流体内的细胞/颗粒上产生介电电泳力。 电压源施加合适的电压以分离和/或溶解流体内的细胞。

    Method and system for cell and/or nucleic acid molecules isolation
    6.
    发明申请
    Method and system for cell and/or nucleic acid molecules isolation 审中-公开
    用于细胞和/或核酸分子分离的方法和系统

    公开(公告)号：US20070092876A1

    公开(公告)日：2007-04-26

    申请号：US10535334

    申请日：2003-11-10

    申请人： Guolin Xu

    发明人： Guolin Xu

    IPC分类号： C12Q1/68 ,  C12N1/08

    CPC分类号： C12N15/1003 ,  C12Q1/6806 ,  C12Q2521/537

    摘要： The present invention relates to methods and system for tissue cell and/or nucleic acid molecule isolation. In particular, to a method for isolating nucleic acid molecules from tissue samples comprising: i) treating a tissue sample with at least one enzyme for tissue dissociation; ii) adding a lytic solution; and iii) isolating nucleic acid molecules. The method further comprises a step of applying hydrodynamic shear force to the product of step (i). The methods and/or system according to the invention are adaptable for use with micromechanical and/or automated processes.

    摘要翻译： 本发明涉及用于组织细胞和/或核酸分子分离的方法和系统。 特别地，涉及从组织样品中分离核酸分子的方法，包括：i）用至少一种酶处理组织样品用于组织解离; ii）加入溶解液; 和iii）分离核酸分子。 该方法还包括向步骤（i）的产物施加流体力学剪切力的步骤。 根据本发明的方法和/或系统适用于微机械和/或自动化过程。

    MICROFLUIDIC SEPARATION SYSTEM
    10.
    发明申请
    MICROFLUIDIC SEPARATION SYSTEM 有权
    微流体分离系统

    公开(公告)号：US20120024770A1

    公开(公告)日：2012-02-02

    申请号：US12673160

    申请日：2008-08-13

    申请人： Jackie Y. Ying ,  Guolin Xu ,  Yoke San Daniel Lee

    发明人： Jackie Y. Ying ,  Guolin Xu ,  Yoke San Daniel Lee

    IPC分类号： B03C1/035 ,  B81B1/00

    CPC分类号： B03C1/32 ,  B03C1/002 ,  B03C1/01 ,  B03C1/0332 ,  B03C1/0335 ,  B03C1/035 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/22 ,  B03C2201/26 ,  G01N35/0098

    摘要： A microfluidic separation system, which comprises a magnetic separator, which itself comprises a magnetic energy source; first and second magnetically conductive members leading from the magnetic energy source and having respective terminal ends that are separated by a gap over which a magnetic field is applied due to the magnetic energy source. The separation system further comprises a microfluidic chip for insertion into the gap, which comprises a body defining channels on respective faces of the body; and an exterior lining that seals the plurality of channels to allow separate test sample volumes to circulate in at least two of the channels. Upon insertion of the chip into the gap, a first test sample volume is confined to circulating closer to the terminal end of the first member and a second test sample volume is confined to circulating closer to the terminal end of the second member.

    摘要翻译： 微流体分离系统，其包括磁分离器，其本身包括磁能源; 第一和第二导电构件，其从磁能源引出并且具有由由于磁能源而施加磁场的间隙分开的相应末端。 分离系统还包括用于插入到间隙中的微流体芯片，其包括在主体的相应面上限定通道的主体; 以及密封多个通道以允许单独的测试样品体积在至少两个通道中循环的外部衬里。 当将芯片插入到间隙中时，第一测试样本体积被限制为更靠近第一构件的终端循环，并且第二测试样本体积被限制为更靠近第二构件的终端循环。