公开(公告)号：US4391909A

公开(公告)日：1983-07-05

申请号：US259595

申请日：1981-05-01

申请人： Franklin Lim

发明人： Franklin Lim

IPC分类号： A61F2/02 ,  A61K9/16 ,  A61K9/50 ,  A61K35/12 ,  A61K35/39 ,  A61K35/407 ,  A61K38/00 ,  A61K39/44 ,  B01J13/08 ,  B01J13/14 ,  B01J13/16 ,  C12N5/00 ,  C12N5/071 ,  C12N11/04 ,  C12N11/10

CPC分类号： A61K35/407 ,  A61F2/022 ,  A61K35/39 ,  A61K39/44 ,  A61K9/1652 ,  A61K9/5031 ,  A61K9/5036 ,  A61K9/5073 ,  B01J13/08 ,  B01J13/14 ,  B01J13/16 ,  C12N11/04 ,  C12N5/0012 ,  C12N5/0671 ,  C12N5/0677 ,  C12N2533/30 ,  C12N2533/32 ,  C12N2533/74

摘要： Tissue cells such as islet of Langerhans cells or liver cells are encapsulated within a spheroidal semipermeable membrane comprising a polysaccharide having acidic groups cross-linked with a polymer having a molecular weight greater than 3,000. The cells within the microcapsules are viable, healthy, physiologically active and capable of ongoing metabolism. The encapsulated cells are useful for implantation in a mammalian body to produce substances and effect chemical changes characteristic of the cells in vivo tissue.

摘要翻译： 组织细胞例如胰岛细胞或肝细胞的胰岛素包封在球状半透膜内，其包含具有与分子量大于3,000的聚合物交联的酸性基团的多糖。 微胶囊内的细胞是可行的，健康的，生理活性的并且能够持续代谢。 包封的细胞可用于植入哺乳动物体内以产生物质并影响细胞体内组织的特征化学变化。

公开(公告)号：US4324683A

公开(公告)日：1982-04-13

申请号：US606166

申请日：1975-08-20

申请人： Franklin Lim ,  Richard D. Moss

发明人： Franklin Lim ,  Richard D. Moss

IPC分类号： A61K9/50 ,  A61K38/16 ,  A61K38/42 ,  A61K38/43 ,  B01D67/00 ,  B01D69/02 ,  B01D69/14 ,  B01J13/02 ,  B01J13/16 ,  C08G69/26 ,  C08G69/28 ,  C12N11/04

CPC分类号： B01D67/0006 ,  A61K38/42 ,  A61K38/443 ,  A61K38/45 ,  A61K38/47 ,  A61K38/50 ,  A61K9/5031 ,  A61K9/5089 ,  B01D67/0088 ,  B01D69/02 ,  B01D69/141 ,  B01J13/16 ,  C08G69/26 ,  C08G69/28 ,  C12N11/04 ,  Y10T428/2989

摘要： A two step interfacial polymerization process for encapsulating operative chemically active substances in high quality semipermeable membranes. An emulsion is formed wherein the discontinuous phase contains the substance to be encapsulated and a first monomer. When a second monomer is added to the continuous phase, an imperfect membrane forms about the droplets of the discontinuous phase. Removal of the continuous phase, followed by resuspension of the raw microcapsules and addition of a second portion of second monomer, causes further polymerization strengthening the membranes and "patching" macroporous defects in them. The choice of solvents and control of reaction conditions such as pH, maximize the yield of operable labile substance encapsulated. A method of encapsulating a very high concentration of hemoglobin is also disclosed. Adaption of the two step process provides a method for forming and controlling the pore sizes in the membranes of a number of known prior art encapsulation processes.

摘要翻译： 用于在高质量半透膜中包封有效的化学活性物质的两步界面聚合方法。 形成乳液，其中不连续相含有待包被的物质和第一单体。 当将第二单体加入到连续相中时，不连续的膜围绕不连续相的液滴形成。 连续相的去除，然后重悬悬浮原始微胶囊并加入第二部分第二单体，进一步聚合加强膜并“修补”其中的大孔缺陷。 溶剂的选择和反应条件如pH的控制，使包封的可操作不稳定物质的产率最大化。 还公开了一种封装非常高浓度的血红蛋白的方法。 两步法的适应提供了一种用于形成和控制多种已知现有技术封装方法的膜中的孔径的方法。

公开(公告)号：US4177810A

公开(公告)日：1979-12-11

申请号：US881033

申请日：1978-02-24

申请人： Albert J. Gourlandt

发明人： Albert J. Gourlandt

IPC分类号： A61D1/02 ,  A61M5/00

CPC分类号： A61D1/025

摘要： A pneumatic injection apparatus featuring a fluid actuated drive and control system is disclosed. The apparatus, in its various aspects, has a modular construction so that it may be quickly disassembled, both mechanically and pneumatically, for easy maintenance and repair. Thus, for example, a retention means against which an animal part is placed for injection, is pneumatically connected through a release manifold mechanism to permit the retention means to be pneumatically decoupled from the remainder of the apparatus both quickly and easily. The pneumatic drive system is provided with a shock absorbing system to reduce the forces and stresses to which the various syringe elements of the system are subjected. Additionally, a fluid flow path is provided from a presettable counter to the retention means whereby a gas flow is provided when the preset count has been reached.

摘要翻译： 公开了一种具有流体驱动的驱动和控制系统的气动注射装置。 该装置在各个方面具有模块化结构，使得其可以机械地和气动地快速拆卸，以便于维护和修理。 因此，例如，动物部件被放置用于注射的保持装置通过释放歧管机构气动连接，以允许保持装置快速且容易地与装置的其余部分气动地分离。 气动驱动系统设置有减震系统，以减小系统的各种注射器元件所经受的力和应力。 此外，从预设的计数器向保持装置提供流体流动路径，从而当达到预设计数时提供气流。

公开(公告)号：US3938354A

公开(公告)日：1976-02-17

申请号：US343042

申请日：1973-03-20

申请人： Ivan L. Lehman

发明人： Ivan L. Lehman

IPC分类号： B04B5/04 ,  B04B9/12 ,  F16C3/02 ,  F16D3/72 ,  F16F15/10 ,  F16C1/00

CPC分类号： F16C3/02 ,  B04B5/0414 ,  B04B9/12 ,  F16D3/72 ,  F16F15/10 ,  B04B2009/085 ,  Y10T403/7047

摘要： A flexible shaft transmitting the rotational motion of a motor shaft to a rotor adapter is protected from deformation by a shaft protector which connects the flexible shaft to the motor shaft. The shaft protector is concentric about and completely protects the flexible shaft as it extends from the motor shaft to the rotor adapter. The end of the flexible shaft connected to the rotor adapter and the rotor adapter itself are free to move within the lumen defined by the shaft protector. The shaft protector, however, prevents permanent deformation of the flexible shaft by preventing the flexible shaft from bending to a point at which permanent deformation would occur.In one important embodiment of the invention, a rotor adapter is provided with a plurality of grooves which prevent the rotor from jamming on to the rotor adapter.

摘要翻译： 将电动机轴的旋转运动传递到转子适配器的柔性轴通过将柔性轴连接到电动机轴的轴保护器来防止变形。 轴保护器在其从电动机轴延伸到转子适配器时同心并且完全保护柔性轴。 连接到转子适配器和转子适配器本身的柔性轴的端部在由轴保护器限定的内腔内自由移动。 然而，轴保护器通过防止柔性轴弯曲到将发生永久变形的点来防止柔性轴的永久变形。

公开(公告)号：US4446957A

公开(公告)日：1984-05-08

申请号：US343427

申请日：1982-01-28

申请人： Jerry L. Dohse ,  Peter A. Hess

发明人： Jerry L. Dohse ,  Peter A. Hess

IPC分类号： G07F5/02 ,  G07F11/44

CPC分类号： G07F5/02 ,  G07F11/44

摘要： A coin operated gumball dispensing slide mechanism is disclosed which has a coin slide slidable over a base plate. The coin slide has a gumball dispensing wall, an aperture for passage of a gumball from a reservoir to the gumball dispensing wall, an actuator for moving the coil slide, a shoulder, and a portion defining a coin receiving slot. The coin slide is slidably mounted on a base plate which has a flexibly mounted locking dog for abutting the shoulder and locking the coin slide until a coin inserted into the slot disables the dog. When the coin is in the slot, moving the actuator moves the slide and the gumball is dispensed while the shoulder pushes the coin to a coin receiving aperture in the base plate and while a gate portion of the base plate intrudes on the gumball aperture to prevent gumballs from entering it during operation of the slide.

摘要翻译： 公开了一种投币式手摇式配送滑动机构，其具有可在基板上滑动的硬币滑块。 硬币滑块具有一个gumball分配壁，一个用于将琴口从储存器通过到gumball分配壁的孔，用于移动线圈滑块的致动器，肩部和限定硬币接收槽的部分。 硬币滑块可滑动地安装在基板上，该基板具有柔性安装的锁定爪，用于抵靠肩部并锁定硬币滑块，直到插入插槽的硬币禁用狗。 当硬币位于槽中时，移动致动器移动滑块，并且当肩部将硬币推入基板中的硬币接收孔时，并且基板的门部分侵入孔壁上以防止 在幻灯片操作期间进入它的gumballs。

公开(公告)号：US4386895A

公开(公告)日：1983-06-07

申请号：US320881

申请日：1981-11-13

申请人： Lester A. Sodickson

发明人： Lester A. Sodickson

IPC分类号： B01J13/04 ,  B28B1/54

CPC分类号： B01J13/046

摘要： Disclosed is an apparatus for producing capsules of the type which are formed by immersing liquid droplets in a gelling agent. The apparatus comprises a rotor disposed about a central axis of rotation which houses a reservoir for holding the liquid to be formed into capsules, and conduits which lead to ports spaced uniformly on the circumference of a circle. When the rotor is actuated, spheroidal droplets of the capsule-forming material take shape at the ports and are propelled radially outwardly into a gelling agent contained in a reservoir which comprises an annular surface spaced radially apart from the ports.

摘要翻译： 公开了一种用于生产通过将液滴浸入胶凝剂中形成的胶囊的装置。 该装置包括围绕中心旋转轴线设置的转子，其容纳用于保持要形成为胶囊的液体的储存器，以及导向在圆周上均匀间隔开的端口的导管。 当转子被致动时，胶囊形成材料的球形液滴在端口处形成并被径向向外推进到包含在储存器中的胶凝剂中，该储存器包括与端口径向分开的环形表面。

公开(公告)号：US4352883A

公开(公告)日：1982-10-05

申请号：US024600

申请日：1979-03-28

申请人： Franklin Lim

发明人： Franklin Lim

IPC分类号： A01N1/00 ,  A01N1/02 ,  A61F2/02 ,  A61J3/07 ,  A61K9/16 ,  A61K9/50 ,  A61K9/62 ,  A61K31/44 ,  A61K33/44 ,  A61K35/12 ,  A61K35/39 ,  A61K35/407 ,  A61K35/50 ,  A61K38/00 ,  A61K38/28 ,  A61K38/43 ,  A61K39/44 ,  A61L27/00 ,  A61L27/20 ,  A61L27/36 ,  B01J13/04 ,  B01J13/08 ,  B01J13/14 ,  B01J13/16 ,  B01J20/32 ,  C12N1/00 ,  C12N5/00 ,  C12N5/02 ,  C12N5/071 ,  C12N11/02 ,  C12N11/04 ,  C12P21/04 ,  C12N11/10

CPC分类号： C12N11/04 ,  A01N1/02 ,  A01N1/0231 ,  A61F2/022 ,  A61K35/39 ,  A61K39/44 ,  A61K9/1652 ,  A61K9/5031 ,  A61K9/5036 ,  A61K9/5073 ,  A61L27/20 ,  A61L27/36 ,  B01J13/04 ,  B01J13/08 ,  B01J13/14 ,  B01J13/16 ,  C12M25/16 ,  C12N5/0012 ,  C12N5/0671 ,  C12N5/0677 ,  A61K2035/128 ,  A61K38/00 ,  C12N2533/30 ,  C12N2533/32 ,  C12N2533/74

摘要： A core material such as living tissue, individual cells, hormones, enzymes or antibodies is encapsulated in a semipermeable membrane that is permeable to small molecules for contact with the core material but is impermeable to potentially deleterious large molecules. Encapsulation may be carried out by suspending the core material in an aqueous medium containing a water soluble gum that can be reversibly gelled, forming the suspension into droplets, contacting the droplets with a solution of multivalent cations to gel the droplets as discrete, shape-retaining, water insoluble temporary capsules and cross-linking a surface layer of the temporary capsules to produce a semipermeable membrane around the capsules. Optionally the gel within the membrane may be reliquified by removing multivalent cations from the gel.

摘要翻译： 诸如活组织，单细胞，激素，酶或抗体之类的核心材料被包封在半透膜中，所述半透膜能够渗透小分子以与核心材料接触，但对潜在有害的大分子是不可渗透的。 封装可以通过将核心材料悬浮在含有水溶性胶质的水性介质中进行，所述水性介质可以被可逆地胶凝，将悬浮液形成液滴，使液滴与多价阳离子的溶液接触以使液滴凝固成离散的形状保持 ，水不溶性临时胶囊，并交联临时胶囊的表层，以在胶囊周围产生半透膜。 任选地，通过从凝胶中除去多价阳离子可以使膜内的凝胶被再次化。

公开(公告)号：US4322311A

公开(公告)日：1982-03-30

申请号：US143932

申请日：1980-04-25

申请人： Franklin Lim ,  Richard D. Moss

发明人： Franklin Lim ,  Richard D. Moss

IPC分类号： A61K9/50 ,  B01J13/16 ,  G01N33/537 ,  G01N33/549 ,  G01N33/74 ,  B01J13/02

CPC分类号： A61K9/5089 ,  A61K9/5031 ,  B01J13/16 ,  G01N33/5375 ,  G01N33/549 ,  G01N33/74 ,  Y10S424/07

摘要： A process for producing microcapsules of controlled porosity containing a chemically active core material. A core material such as a biologically active material and a first monomer in aqueous solution are emulsified in a hydrophobic solvent. A monomer complementary to the first and soluble in the continuous, hydrophobic phase of the emulsion is added to initiate interfacial polymerization about the aqueous droplets. During the course of the reaction, the affinity of the continuous phase for the first monomer is varied by adding a solvent to the continuous phase to vary its polarity. The continuous phase may be relatively nonpolar at the outset and a polar solvent may be added to increase its affinity for the first monomer, or it may be relatively polar at the outset and a nonpolar (or less polar) solvent may be added. This technique allows production of microcapsules having a selected pore size so that, for example, encapsulated material cannot escape, yet lower molecular weight materials can diffuse through the capsule wall.

摘要翻译： 一种用于生产含有化学活性芯材料的受控孔隙微胶囊的方法。 核心材料如生物活性材料和水溶液中的第一单体在疏水性溶剂中乳化。 添加与第一种互补并且可溶于乳液的连续疏水相的单体以引发关于水滴的界面聚合。 在反应过程中，连续相对第一单体的亲和力通过向连续相中加入溶剂以改变其极性来改变。 连续相可以在开始时相对非极性，并且可以加入极性溶剂以增加其对第一单体的亲和力，或者其可以在开始时相对极性并且可以加入非极性（或更小的极性）溶剂。 该技术允许生产具有选定孔径的微胶囊，使得例如包封的材料不能逸出，但较低分子量的材料可以扩散通过胶囊壁。

公开(公告)号：US4298345A

公开(公告)日：1981-11-03

申请号：US25497

申请日：1979-03-30

申请人： Lester A. Sodickson ,  Franklin Lim

发明人： Lester A. Sodickson ,  Franklin Lim

IPC分类号： G01N21/86 ,  G01N33/52 ,  G01N1/14 ,  G01N21/27

CPC分类号： G01N21/8483 ,  G01N33/528

摘要： Chemical analysis of a sample with reagents spotted on a fibrous or porous medium employs a medium pretreated both with reagents and with conditioning agent. The conditioning agent increases the degree to which the liquid reactants wet the medium. One form of pretreated medium has different reagents located predominantly within different selected zones.Liquid is applied to the medium, typically as diluted sample, at a rate selected to enhance formation of repeatable spots. In one embodiment the liquid is applied by flowing it onto a wick element seated on the medium. The wick is disc-like and small relative to the spot which the reactants form on the medium. The disc can be pretreated to carry reagent, which the liquid transfers to the medium.The analysis instrument receives a reaction medium between selectively recessed upper and lower surfaces aligned in opposition at the reaction spot being analyzed.The analysis can, depending on the analytical reaction, the medium and the precision required, proceed while the reactants are wet or can measure a reaction product after the reactants are dry. A single point analysis can also be made.

摘要翻译： 使用在纤维或多孔介质上点样的试剂的样品的化学分析采用预处理试剂和调理剂的培养基。 调理剂增加液体反应物湿润介质的程度。 一种形式的预处理介质具有主要位于不同选择区域内的不同试剂。 将液体通常以稀释的样品施加到介质上，速率被选择以增强可重复斑点的形成。 在一个实施例中，通过将液体流动到坐在介质上的芯片元件上来施加液体。 相对于反应物在介质上形成的点，芯是盘状的和小的。 该盘可以预处理以携带试剂，液体转移到介质中。

公开(公告)号：US4277040A

公开(公告)日：1981-07-07

申请号：US920679

申请日：1978-07-14

申请人： Julius M. Christoffel, Jr.

发明人： Julius M. Christoffel, Jr.

IPC分类号： B64C31/06 ,  A63H27/08

CPC分类号： A63H27/08 ,  Y10T403/347 ,  Y10T403/4611

摘要： In a collapsible kite structure, a snap lock connecting assembly comprising at least two suitably rigid sticks or struts and at least one detachable bracing stick or strut, in combination with a snap lock connecting unit. The snap lock includes a fastening body portion attached to a stiffening stick, such as a wing stick of said kite, and a resilient, flexible, hollow retainer body portion configured to securely receive and resiliently hold an end part of a bracing strut. The retainer body portion of the snap lock has a longitudinal slot through the side thereof for forced passage therethrough of an end part of the bracing stick whereby the end of the bracing strut may be detachably retained in a secure position within said hollow retainer body. In a preferred embodiment the retainer body portion of the snap lock has a bead or other interengaging structure to enhance the secure retention of the end of the detachable bracing stick within the retainer body.

摘要翻译： 在可折叠的风筝结构中，快速锁定连接组件包括至少两个适当刚性的棒或支柱以及至少一个可拆卸的支撑棒或支柱，其与卡扣连接单元组合。 卡扣锁包括附接到加强棒（例如所述风筝的翼杆）上的紧固主体部分以及被构造成可靠地容纳和弹性地保持支撑支柱的端部的弹性柔性中空的保持器本体部分。 卡扣锁的保持器主体部分具有穿过其一侧的纵向狭槽，用于强制地穿过支撑杆的端部，由此支撑支柱的端部可以可拆卸地保持在所述中空保持器主体内的安全位置。 在优选实施例中，卡扣锁的保持器主体部分具有珠或其它相互接合的结构，以增强可拆卸支撑棒的端部在保持器主体内的牢固保持。