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1.发明申请ACETYL MIMIC COMPOUNDS FOR THE INHIBITION OF ISOPRENYL-S-CYSTEINYL METHYLTRANSFERASE 审中-公开用于抑制异丙肾上腺素甲基衍生物的乙酰胆碱化合物公开(公告)号：US20110053901A1
公开(公告)日：2011-03-03
申请号：US12867796
申请日：2009-02-13
申请人： Seung-Yub Lee , Michael Voronkov , Peter Wolanin
发明人： Seung-Yub Lee , Michael Voronkov , Peter Wolanin
IPC分类号： A61K31/5375 , C07D211/72 , A61K31/44 , C07C279/02 , A61K31/22 , C07D257/04 , A61K31/41 , A61K31/155 , C07C257/00 , A61K31/18 , C07C311/01 , A61K31/4164 , C07D233/00 , C07C321/02 , A61K31/195 , C07D265/30 , A61K31/445 , C07D211/60 , C07D233/38 , C07D239/24 , A61K31/505 , A61K31/56 , A61K31/40
CPC分类号： C07D233/88 , C07C323/57 , C07C323/58 , C07C323/59 , C07C323/60 , C07C327/42 , C07C335/08 , C07D207/22 , C07D207/34 , C07D213/74 , C07D233/70 , C07D235/14 , C07D239/42 , C07D249/04 , C07D257/04 , C07D263/48 , C07D265/30 , C07D277/42 , C07D295/215 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： Among other things, the present invention provides novel compounds capable of effectively inhibiting inflammatory responses that are mediated by G-proteins or GPCRs in neutrophils, macrophages and platelets. In particular, compounds of the present invention act as inhibitors of edema, inhibitors of erythema and inhibitors of MPO (myeloperoxidase), pharmaceutical compositions containing the same compounds and the use thereof for the treatment of diseases that may benefit from edema, erythema and MPO inhibition, such as inflammation (acute or chronic), asthma, autoimmune diseases, and chronic obstructive pulmonary disease (COPD) (e.g., emphysema, chronic bronchitis and small airways disease, etc.), inflammatory responses of the immune system, skin diseases (e.g., reducing acute skin irritation for patients suffering from rosacea, atopic dermatitis, seborrheic dermatitis, psoriasis), irritable bowel syndrome (e.g., Chron's disease and ulcerative colitis, etc.), and central nervous system disorders (e.g., Parkinson's disease).
摘要翻译： 除此之外，本发明提供能够有效抑制嗜中性粒细胞，巨噬细胞和血小板中G蛋白或GPCR介导的炎症反应的新型化合物。 特别地，本发明的化合物作为水肿抑制剂，红斑抑制剂和MPO抑制剂（髓过氧化物酶），含有相同化合物的药物组合物及其用于治疗可能受益于水肿，红斑和MPO抑制的疾病的用途 例如炎症（急性或慢性），哮喘，自身免疫疾病和慢性阻塞性肺病（COPD）（例如肺气肿，慢性支气管炎和小气道疾病等），免疫系统的炎症反应，皮肤疾病（例如 对于患有酒渣鼻，特应性皮炎，脂溢性皮炎，牛皮癣的患者，肠易激综合征（例如，Chron氏病和溃疡性结肠炎等）以及中枢神经系统疾病（例如帕金森氏病））减少急性皮肤刺激。
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公开(公告)号：US11802107B2
公开(公告)日：2023-10-31
申请号：US18075399
申请日：2022-12-05
发明人： Michael Voronkov , Eduardo Perez , Jason Healy , Jose Fernandez
IPC分类号： C07C275/20 , A61P29/00 , A61K9/00 , C07C233/47 , C07D205/04 , C07D207/16 , C07D213/80 , C07D221/00 , C07D239/42 , C07D241/28 , C07C233/04
CPC分类号： C07C275/20 , A61K9/0014 , A61P29/00 , C07C233/04 , C07D205/04 , C07D207/16 , C07D213/80 , C07D221/00 , C07D239/42 , C07D241/28
摘要： The present invention provides compounds useful in treating or preventing inflammation, acne, bacterial conditions and promoting the appearance of healthy skin and compositions including these compounds.
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公开(公告)号：US09486441B2
公开(公告)日：2016-11-08
申请号：US12427743
申请日：2009-04-21
申请人： Scott Vafai , Michael Voronkov , Maxwell Stock , Jeffry B. Stock , Seung-Yub Lee , Zhu Li , Haoming Gu
发明人： Scott Vafai , Michael Voronkov , Maxwell Stock , Jeffry B. Stock , Seung-Yub Lee , Zhu Li , Haoming Gu
IPC分类号： A61K31/405
CPC分类号： A61K31/405
摘要： The present invention provides compounds and/or compositions that modulate PP2A methylation and/or activity and methods for preparing the same, which are useful for modulating the demethylation of PP2A, modulating the methylation of PP2A and/or modulating the activity of PP2A.
摘要翻译： 本发明提供调节PP2A甲基化和/或活性的化合物和/或组合物及其制备方法，其可用于调节PP2A的去甲基化，调节PP2A的甲基化和/或调节PP2A的活性。
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4.发明授权公开(公告)号：US09415026B2
公开(公告)日：2016-08-16
申请号：US12945813
申请日：2010-11-12
申请人： Jeffry B. Stock , Maxwell Stock
发明人： Jeffry B. Stock , Maxwell Stock
IPC分类号： A01N37/12 , A01N37/44 , A61K31/195 , A61K31/165
CPC分类号： A61K38/05 , A61K9/0014 , A61K9/007 , A61K31/165 , A61K31/198 , A61K31/341 , A61K31/381 , A61K31/4045 , A61K31/5375 , Y02A50/478 , Y02A50/481
摘要： Disclosed herein are methods of inactivating and/or decolonizing bacteria on a surface. The present invention also discloses methods for treatment of epithelial conditions caused or aggravated by bacteria, such as acne vulgaris, in a subject in need thereof. The present invention additionally discloses inventive compounds and compositions that exhibit anti-bacterial and/or anti-inflammatory effects.
摘要翻译： 本文公开了在表面上灭活和/或非殖民细菌的方法。 本发明还公开了在有需要的受试者中治疗由细菌如寻常痤疮引起或加重的上皮状况的方法。 本发明还公开了具有抗细菌和/或抗炎作用的本发明化合物和组合物。
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公开(公告)号：US20130310559A1
公开(公告)日：2013-11-21
申请号：US13760627
申请日：2013-02-06
申请人： Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen , Jinglong Chen
发明人： Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen , Jinglong Chen
IPC分类号： C07D217/26 , C07D209/48 , C07D333/24 , C07D295/145 , C07C243/34 , C07C321/18 , C07D207/16
CPC分类号： A61K31/197 , A61K9/0014 , C07C243/34 , C07C321/18 , C07C323/59 , C07C335/08 , C07C2601/02 , C07C2601/14 , C07D207/16 , C07D209/18 , C07D209/48 , C07D217/26 , C07D243/34 , C07D295/145 , C07D307/54 , C07D333/24
摘要： Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.
摘要翻译： 除此之外，本发明提供能够有效调节炎症反应的新型异戊二烯基化合物和包含这些异戊二烯基化合物的药物，化妆品，药妆和局部组合物。 本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或病症。 本发明的促炎症化合物可用于治疗或预防与抑制炎性反应相关的疾病或病症。 因此，本发明还提供了用于治疗或预防与炎症相关的疾病或病症的方法以及可用于治疗或预防与抑制炎性反应相关的疾病或病症的方法。
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公开(公告)号：US20050277694A1
公开(公告)日：2005-12-15
申请号：US11151174
申请日：2005-06-13
申请人： Jeffry Stock , Joel Gordon , Maxwell Stock , Greg Stock
发明人： Jeffry Stock , Joel Gordon , Maxwell Stock , Greg Stock
IPC分类号： A61K31/198 , A61K31/20
CPC分类号： A61K31/198 , A61K8/46 , A61K31/20 , A61K45/06 , A61K2800/75 , A61K2800/782 , A61Q19/00 , C07C323/59
摘要： The present invention relates to pharmaceutical, cosmetic and cosmeceutical topical compositions containing polyisoprenyl-protein inhibitor compounds and methods useful in the promotion of healthy epithelium and the treatment of epithelial-related conditions
摘要翻译： 本发明涉及含有聚异戊二烯基蛋白抑制剂化合物的药物，化妆品和药妆外用组合物以及用于促进健康上皮和治疗上皮相关病症的方法
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公开(公告)号：US20230174467A1
公开(公告)日：2023-06-08
申请号：US18075399
申请日：2022-12-05
发明人： Michael Voronkov , Eduardo Perez , Jason Healy , Jose Fernandez
IPC分类号： C07C275/20 , A61P29/00 , A61K9/00 , C07C233/47 , C07D205/04 , C07D207/16 , C07D213/80 , C07D221/00 , C07D239/42 , C07D241/28
CPC分类号： C07C275/20 , A61P29/00 , A61K9/0014 , C07C233/47 , C07D205/04 , C07D207/16 , C07D213/80 , C07D221/00 , C07D239/42 , C07D241/28
摘要： The present invention provides compounds useful in treating or preventing inflammation, acne, bacterial conditions and promoting the appearance of healthy skin and compositions including these compounds.
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公开(公告)号：US20170266161A1
公开(公告)日：2017-09-21
申请号：US15346636
申请日：2016-11-08
发明人： SCOTT VAFAI , Michael Voronkov , Maxwell Stock , Jeffry B. Stock , Seung-Yub Lee , Zhu Li , Haoming Gu
IPC分类号： A61K31/405
CPC分类号： A61K31/405
摘要： The present invention provides compounds and/or compositions that modulate PP2A methylation and/or activity and methods for preparing the same, which are useful for modulating the demethylation of PP2A, modulating the methylation of PP2A and/or modulating the activity of PP2A.
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公开(公告)号：US09744147B2
公开(公告)日：2017-08-29
申请号：US15151221
申请日：2016-05-10
发明人： Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen , Jinglong Chen
IPC分类号： A61K31/197 , C07C323/59 , C07C335/08 , A61K9/00 , C07D209/18 , C07D209/48 , C07D217/26 , C07D295/145 , C07D307/54 , C07D333/24 , C07C243/34 , C07C321/18 , C07D207/16 , C07D243/34
CPC分类号： A61K31/197 , A61K9/0014 , C07C243/34 , C07C321/18 , C07C323/59 , C07C335/08 , C07C2601/02 , C07C2601/14 , C07D207/16 , C07D209/18 , C07D209/48 , C07D217/26 , C07D243/34 , C07D295/145 , C07D307/54 , C07D333/24
摘要： Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.
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公开(公告)号：US08372884B2
公开(公告)日：2013-02-12
申请号：US12616781
申请日：2009-11-12
申请人： Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen , Jinglong Chen
发明人： Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen , Jinglong Chen
IPC分类号： A61K31/195 , C07C323/59
CPC分类号： A61K31/197 , A61K9/0014 , C07C243/34 , C07C321/18 , C07C323/59 , C07C335/08 , C07C2601/02 , C07C2601/14 , C07D207/16 , C07D209/18 , C07D209/48 , C07D217/26 , C07D243/34 , C07D295/145 , C07D307/54 , C07D333/24
摘要： Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.
摘要翻译： 除此之外，本发明提供能够有效调节炎症反应的新型异戊二烯基化合物和包含这些异戊二烯基化合物的药物，化妆品，药妆和局部组合物。 本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或病症。 本发明的促炎症化合物可用于治疗或预防与抑制炎症反应相关的疾病或病症。 因此，本发明还提供了用于治疗或预防与炎症相关的疾病或病症的方法以及可用于治疗或预防与抑制炎性反应相关的疾病或病症的方法。
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